Faculty Collaboration Database

Effect of surgical alteration of the rat gastrointestinal tract on the growth and development of Hymenolepis diminuta. J Parasitol 2001 Aug;87(4):721-4

Date

09/06/2001

Pubmed ID

11534632

DOI

10.1645/0022-3395(2001)087[0721:EOSAOT]2.0.CO;2

Scopus ID

2-s2.0-0034844980 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

Eight groups of rats were used to study the involvement of the enteric (ENS) and central (CNS) nervous systems in the development of Hymenolepis diminuta using surgical intestinal transection, or CNS denervation, or both procedures. The transection procedure was used to isolate the ENS of the small intestine from either orad and/or caudal portions of the alimentary system, while the CNS denervation was used to eliminate direct visceral efferent inputs from the CNS. Nine days after the surgical procedures, all rats were infected with 35 cysticercoids of H. diminuta. On 20 days postinfection, the infection intensity, tapeworm dry weight, tapeworm morphology, intestine length, and intestinal wet weight were recorded. Only the combination of the duodenal and ileal transections with a CNS denervation reduced infection intensity and prevented the increased intestinal length normally observed in infected rats. In contrast, none of the various intestinal transection procedures alone or CNS denervation alone had any effect on the survival, ability to produce oncospheres or morphology of the tapeworms. In conclusion, tapeworm survival is decreased when both CNS and ENS inputs into the small intestine are altered or absent.

Author List

Dwinell KL, Bass P, Telford GL, Oaks JA

MESH terms used to index this publication - Major topics in bold

Animals
Central Nervous System
Duodenum
Enteric Nervous System
Hymenolepiasis
Hymenolepis
Ileum
Intestine, Small
Male
Rats
Rats, Sprague-Dawley