Calcium crystals in osteoarthritis. Curr Opin Rheumatol 2002 May;14(3):298-302
Date
05/01/2002Pubmed ID
11981330DOI
10.1097/00002281-200205000-00018Scopus ID
2-s2.0-0036229809 (requires institutional sign-in at Scopus site) 27 CitationsAbstract
Osteoarthritis is the most common form of arthritis in adults and its incidence increases with age. More than 50% of people aged 65 and older have radiographic changes of knee osteoarthritis. Calcium crystals, including calcium pyrophosphate dihydrate and basic calcium phosphate crystals, are also common in the elderly. Not surprisingly, osteoarthritis and crystal arthropathy frequently coexist. The question of a role for calcium crystals in causing or worsening osteoarthritis has been pondered for many years. Progress in understanding the interrelationships between calcium crystals and osteoarthritis has been slowed by our limited knowledge of the pathogenesis of both osteoarthritis and calcium crystal-induced arthritis and our limited ability to accurately detect calcium crystals. Nonetheless, there are good data from clinical and laboratory studies supporting an important role for calcium crystals in osteoarthritis.
Author List
Jaovisidha K, Rosenthal AKAuthor
Ann K. Rosenthal MD Associate Dean, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
CalciumHumans
Models, Biological
Osteoarthritis
Severity of Illness Index
