Dietary sodium modification and experimental radiation nephropathy. Int J Radiat Biol 2002 Oct;78(10):903-11
Date
12/06/2002Pubmed ID
12465655DOI
10.1080/09553000210155897Scopus ID
2-s2.0-0036797112 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
PURPOSE: To determine whether suppression of the renin-angiotensin system (RAS) with high dietary sodium (salt) has the same beneficial effect on radiation nephropathy as suppression of the RAS with angiotensin-converting-enzyme (ACE) inhibitors or angiotensin II (AII) receptor antagonists.
MATERIALS AND METHODS: Normal and irradiated rats were placed on high- or low-salt diets and assessed for effects on blood pressure, on AII levels and on the development of radiation nephropathy.
RESULTS: In unirradiated animals, a high-salt diet suppressed AII and caused hypertension, while a low-salt diet produced no detectable effects. Use of a high-salt diet 3-9 weeks after irradiation exacerbated radiation-induced hypertension but attenuated the development of radiation nephropathy. Continuous use of a high-salt diet slowed the progression of radiation nephropathy, but eventually exacerbated radiation-induced hypertension and accelerated renal failure. Use of a high-salt diet in animals with established radiation nephropathy was deleterious. A low-salt diet had no effect on the development of radiation nephropathy.
CONCLUSIONS: These studies provide further support for the hypothesis that the beneficial effect of AII receptor antagonists, ACE inhibitors and high dietary sodium in the prophylaxis of radiation nephropathy is due to their suppression of the RAS, not to their anti-hypertensive effects.
Author List
Moulder JE, Fish BL, Cohen EPMESH terms used to index this publication - Major topics in bold
Angiotensin Receptor AntagonistsAngiotensin-Converting Enzyme Inhibitors
Animals
Bone Marrow Transplantation
Diet, Sodium-Restricted
Dose-Response Relationship, Drug
Kidney
Male
Rats
Renin-Angiotensin System
Sodium Chloride
Time Factors
