Faculty Collaboration Database

A unique collision tumor in breast: invasive ductal carcinoma and mucosa-associated lymphoid tissue lymphoma. Arch Pathol Lab Med 2004 Jan;128(1):99-101

Date

12/25/2003

Pubmed ID

14692838

DOI

10.5858/2004-128-99-AUCTIB

Scopus ID

2-s2.0-0346368240 (requires institutional sign-in at Scopus site)   31 Citations

Abstract

We report an extraordinary case of a collision tumor consisting of invasive ductal carcinoma with adjacent malignant lymphoma presenting as a single mass in the breast. A 79-year-old woman presented with a breast mass. A core biopsy performed at an outside hospital was interpreted as medullary carcinoma. On review of the breast core biopsy, a diagnosis of a synchronous malignant lymphoma and invasive ductal carcinoma was rendered. The patient underwent lumpectomy and axillary dissection. The excised specimen revealed a 2.1-cm, moderately differentiated invasive ductal carcinoma, partially surrounded by malignant lymphoma with areas where both tumors were intermixed. All 27 axillary lymph nodes were extensively involved by lymphoma, and 1 lymph node demonstrated metastatic carcinoma. The morphology and results of immunohistochemistry, flow cytometry, and cytogenetic analysis were consistent with extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue.

Author List

Susnik B, Jordi Rowe J, Redlich PN, Chitambar C, Chang CC, Kampalath B

Authors

Christopher Chitambar MBBS Emeritus Professor in the Biophysics department at Medical College of Wisconsin
Philip N. Redlich PhD, MD Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Breast Neoplasms
Carcinoma, Ductal, Breast
Female
Humans
Lymphoma, B-Cell, Marginal Zone