Medical College of Wisconsin
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The reaction between nitrite and hemoglobin: the role of nitrite in hemoglobin-mediated hypoxic vasodilation. J Inorg Biochem 2005 Jan;99(1):237-46

Date

12/16/2004

Pubmed ID

15598504

DOI

10.1016/j.jinorgbio.2004.10.034

Scopus ID

2-s2.0-10444220188 (requires institutional sign-in at Scopus site)   162 Citations

Abstract

The reaction between nitrite and hemoglobin has been studied for over a century. However, recent evidence indicating nitrite is a latent vasodilatory agent that can be activated by its reaction with deoxyhemoglobin has led to renewed interest in this reaction. In this review we survey, in the context of our own recent studies, the chemical reactivity of nitrite with oxyhemoglobin, deoxyhemoglobin and methemoglobin, and place these reactions in both a physiological and pharmacological/therapeutic context.

Author List

Kim-Shapiro DB, Gladwin MT, Patel RP, Hogg N

Author

Neil Hogg PhD Senior Associate Dean, Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Hemoglobins
Humans
Hypoxia
Nitrites
Oxygen
Vasodilation