Faculty Collaboration Database

[Endogenic opioid peptides and antiarrhythmic effect of adaptation to stress]. Patol Fiziol Eksp Ter 2004(4):11-4

Date

12/01/2004

Pubmed ID

15568495

Scopus ID

2-s2.0-21644449806 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

Adaptation of rats to repeated short-term immobilization increases cardiac resistance to an arrhythmogenic action of coronary artery occlusion (10 min) and reperfusion (10 min) in rats anesthetized with ketamine and artificially ventilated. We examined the role of opioid receptors and endogenous opioid peptides in the development of this antiarrhythmic effect produced in response to repeated periods of immobilization stress. We found that repeated daily stress during a 15-day period resulted in an increase of leu-enkephalin in blood plasma, in the suprarenal gland and myocardium. Adaptation to stress also resulted in an increase in beta-endorphinl-31 in blood plasma, the hypophysis, hypothalamus and midbrain. Pretreatment with selective mu, delta and cappa opioid receptor (OR) antagonists had no effect on the incidence of occlusion and reperfusion-induced arrhythmias in non-adapted control rats. However, pretreatment with the selective muOR antagonist CTAP (0.5 mg/kg) intravenously completely abrogated the antiarrhythmic effect of adaptation. Selective delta and cappa receptor antagonists did not affect the antiarrhythmic effect of adaptation. Prior administration of the selective muOR agonist DALDA (0.1 mg/kg) decreased the incidence of occlusion and reperfusion-evoked arrhythmias in non-adapted rats. This effect was abolished by pretreatment with the selective muOR antagonist CTAP (0.5 mg/kg). These data suggest that mu opioid receptors and endogenous opioid peptides play an important role in the antiarrhythmic effect of adaptation to stress in rats.

Author List

Maslov LN, Naryzhnaia NV, Krylatov AV, Gross GJ

MESH terms used to index this publication - Major topics in bold

Adaptation, Psychological
Animals
Disease Models, Animal
Heart Rate
Male
Myocardial Reperfusion Injury
Narcotic Antagonists
Opioid Peptides
Rats
Rats, Wistar
Stress, Psychological