Use of polylactide resorbable film as a barrier to postoperative peridural adhesion in an ovine dorsal laminectomy model. Neurosurg Focus 2004 Mar 15;16(3):E2
Date
06/17/2004Pubmed ID
15198490DOI
10.3171/foc.2004.16.3.3Scopus ID
2-s2.0-4143128629 (requires institutional sign-in at Scopus site) 29 CitationsAbstract
OBJECT: The purpose of this study was to evaluate the performance of a resorbable polylactide film in the sheep posterior spine in the presence of a combined laminectomy and durotomy defect.
METHODS: A resorbable polylactide film was used to cover the combined defects in the eight sheep used in this study. Two surgical levels were performed in each animal, with randomly assigned control and treated sites. Each surgical level consisted of a full laminectomy followed by a needle-induced durotomy. The treated levels received a resorbable polylactide film cut to size and tucked in under the laminar defect. At 8 to 10 weeks postoperatively, results of myelography and visual dye infiltration showed complete healing of the durotomies for all sites. In addition, evaluation of gross dissection based on volume and tenacity scores as well as histological findings indicates decreased posterior dural adhesions for sites treated with resorbable polylactide film.
CONCLUSIONS: The results of this investigation support previous studies in which the use of a resorbable polylactide film was found to be effective in reducing posterior dural adhesions in the spine with no apparent safety issues related to impaired dural healing.
Author List
Klopp LS, Welch WC, Tai JW, Toth JM, Cornwall GB, Turner ASAuthor
Jeffrey M. Toth PhD Associate Dean for Research in the School of Dentistry department at Marquette UniversityMESH terms used to index this publication - Major topics in bold
Absorbable ImplantsAnimals
Disease Models, Animal
Dissection
Dura Mater
Fibrosis
Laminectomy
Lumbar Vertebrae
Materials Testing
Myelography
Polyesters
Postoperative Complications
Sheep
Thoracic Vertebrae
Tissue Adhesions
Wound Healing
