Role of ATP dependent potassium channels in myocardial ischaemia. Cardiovasc Res 1992 Nov;26(11):1011-6
Date
11/01/1992Pubmed ID
1291076DOI
10.1093/cvr/26.11.1011Scopus ID
2-s2.0-85047679140 (requires institutional sign-in at Scopus site) 127 CitationsAbstract
Recently, a class of potassium (K) channels has been discovered which are regulated by the intracellular level of ATP. These channels have been termed ATP dependent K channels (KATP) and have been found to exist in the heart, skeletal muscle, pancreatic beta cells, brain, and smooth muscle. In this article, we discuss the function of the KATP channel in the ischaemic myocardium and present evidence to suggest that activation of these channels may, on the one hand, result in a marked cardioprotective effect from reversible or irreversible electrical, functional or biochemical damage or, on the other hand, have the potential to produce electrical instability and a proarrhythmic effect. The therapeutic potential of potassium channel modulators is also discussed.
Author List
Gross GJ, Auchampach JAAuthor
John A. Auchampach PhD Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Action PotentialsAdenosine Triphosphate
Coronary Circulation
Heart Rate
Humans
Myocardial Infarction
Myocardial Ischemia
Potassium Channels
