Faculty Collaboration Database

Role of endogenous opioid receptor agonists in regulation of heart resistance to the arrhythmogenic action of short-term ischemia and reperfusion. Bull Exp Biol Med 2005 Feb;139(2):172-5

Date

07/20/2005

Pubmed ID

16027798

DOI

10.1007/s10517-005-0239-9

Scopus ID

2-s2.0-25144507759 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

Preliminary selective block of mu-, delta1-, delta2-, and kappa-opioid receptors had no effect on the incidence of ventricular arrhythmias during 10-min coronary occlusion-reperfusion in ketamine-narcotized rats. Repetitive short-term immobilization of rats for 2 weeks improved heart resistance to the arrhythmogenic action of coronary occlusion and reperfusion. Selective mu-opioid receptor antagonist CTAP completely abolished, while selective delta- and kappa-opioid receptor antagonists did not modulate the antiarrhythmic effect of adaptation. Probably, endogenous agonists of mu-opioid receptors play an important role in the adaptive improvement of heart resistance to arrhythmogenic factors, but are insignificant for the modulation of heart resistance to the arrhythmogenic action of short-term local ischemia-reperfusion in non-adapted animals.

Author List

Maslov LN, Lishmanov YB, Naryzhnaya NV, Budankova EV, Stakheev DL, Solenkova NV, Barzakh EI, Oeltgen PR, Gross GJ

MESH terms used to index this publication - Major topics in bold

Adaptation, Physiological
Animals
Arrhythmias, Cardiac
Heart
Myocardial Reperfusion Injury
Narcotic Antagonists
Opioid Peptides
Rats
Receptors, Opioid