IgG autoantibodies to type VII collagen and an exclusive IgG3 reactivity to the laminin alpha3 chain in a patient with an autoimmune subepidermal blistering disease. J Am Acad Dermatol 2005 Sep;53(3):517-22
Date
08/23/2005Pubmed ID
16112366DOI
10.1016/j.jaad.2005.05.001Scopus ID
2-s2.0-23944434751 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
We describe a patient with widespread skin lesions and circulating IgG autoantibodies to both type VII collagen and laminin 5. Although autoantibodies to type VII collagen belonged to IgG2, IgG3, and IgG4 subclasses, laminin 5 was targeted exclusively by IgG3 autoantibodies. Interestingly, despite the presence of IgG3 autoantibodies, the patient's serum failed to fix complement to the dermoepidermal junction. In addition, these autoantibodies did not recruit and activate leukocytes or induce dermoepidermal separation in skin sectioned by cryostat. We report a most unusual case of an autoimmune subepidermal blistering with an exclusive IgG3 reactivity to laminin 5.
Author List
Baican A, Hirako Y, Lazarova Z, Yancey KB, Zillikens D, Sitaru CMESH terms used to index this publication - Major topics in bold
Autoimmune DiseasesBlister
Cell Adhesion Molecules
Collagen Type VII
Erythema
Humans
Immunoglobulin G
Laminin
Male
Microscopy, Fluorescence
Middle Aged
Skin
