Pharmacogenomics and the future of drug therapy. Pediatr Clin North Am 2006 Aug;53(4):591-619
Date
07/29/2006Pubmed ID
16872995DOI
10.1016/j.pcl.2006.05.008Scopus ID
2-s2.0-33746189515 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
With the completion of the human genome project, many investigators are striving to translate the resulting wealth of new information into new and improved clinical practices. Pharmacogenomics represents one of the most promising of these applications for adult- and pediatric-based therapies. This article provides a historical perspective, but most importantly, uses this background to illustrate important principles of the field. The application of pharmacogenomics to asthma therapy is presented as an example of the current status of pharmacogenomics as it is being applied to an important pediatric health problem. Finally, a discussion of future promises and challenges to the application of pharmacogenomics is presented, including economic and ethical issues.
Author List
Hines RN, McCarver DGMESH terms used to index this publication - Major topics in bold
Adrenal Cortex HormonesAdrenergic beta-2 Receptor Agonists
Asthma
Drug Therapy
Forecasting
Humans
Leukotriene Antagonists
Pharmacogenetics
Polymorphism, Genetic
Signal Transduction
