Faculty Collaboration Database

Sympathetic afferent nerve activity of right heart origin. Am J Physiol 1975 Oct;229(4):911-5

Date

10/01/1975

Pubmed ID

1190333

DOI

10.1152/ajplegacy.1975.229.4.911

Scopus ID

2-s2.0-0016804611 (requires institutional sign-in at Scopus site)   16 Citations

Abstract

Six mongrel dogs anesthetized with sodium pentobarbital and paralyzed with gallamine triethiodide were studied on total cardiopulmonary bypass. This study verified the existence of right heart mechanoreceptors whose afferent nerves traverse the upper thoracic white rami communicantes. these mechanoreceptors were studied by observing changes in average maximum, and total nerve spike frequency when right atrial and right ventricular systolic and diastolic pressures were altered by means of intracardiac balloons. Receptors that responded to volume and pressure changes were found in both the right atrium and right ventricle. Nerve activity in these afferents increased with increasing right atrial and right ventricular pressures. These mechanoreceptors were more responsive in the upper physiological ranges of right heart pressures. In most nerve fibers studied, maximum activity occurred during both right atrial and right ventricular diastole.

Author List

Kostreva DR, Zuperku EJ, Purtock RV, Coon RL, Kampine JP

Author

Edward J. Zuperku PhD, MS Emeritus Professor in the Anesthesiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Dogs
Heart
Heart Rate
Mechanoreceptors
Neurons
Neurons, Afferent
Pressure
Sympathetic Nervous System