Remote preconditioning-endocrine factors in organ protection against ischemic injury. Endocr Metab Immune Disord Drug Targets 2007 Sep;7(3):167-75
Date
09/28/2007Pubmed ID
17897043DOI
10.2174/187153007781662585Scopus ID
2-s2.0-34848911579 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
Cardiovascular disease is the leading cause of death in the United States and developing world. Experimental and clinical studies have demonstrated that a number of interventions including brief periods of ischemia or hypoxia and certain endogenous factors such as opioids, bradykinin, growth factors or pharmacological agents are capable of protecting the heart against post-ischemic contractile dysfunction, arrhythmias and myocardial infarction. This conventional cardioprotection occurs via an autocrine or paracrine action in which these protective factors are released from the heart to act upon itself. Over the last ten years, a growing body of evidence indicates that a brief ischemic insult on one organ releases endogenous factors that protect other organs against a prolonged ischemic insult. This phenomenon, termed remote preconditioning or preconditioning at a distance, implicates an endocrine action, and may involve humoral or neural-endocrine signaling. This review will summarize the endocrine factors identified and implicated in this inter-organ cytoprotection.
Author List
Bolte CS, Liao S, Gross GJ, Schultz Jel JMESH terms used to index this publication - Major topics in bold
AdenosineAnimals
Endocrine Glands
History, 20th Century
Humans
Ischemia
Ischemic Preconditioning
Neurosecretory Systems
Nitric Oxide
