The molecular basis of congenital heart disease. Semin Thorac Cardiovasc Surg 2007;19(3):228-37
Date
11/07/2007Pubmed ID
17983950DOI
10.1053/j.semtcvs.2007.07.013Scopus ID
2-s2.0-35748971489 (requires institutional sign-in at Scopus site) 45 CitationsAbstract
Clinically relevant congenital heart disease affects 1% of all live births. It is the leading cause of birth defects-related death in the United States, claiming more than 6000 lives per year. Despite the many advances in our understanding of cardiac development, the fundamental etiology for the majority of cases of congenital heart disease (CHD) remains unknown. Although causal links have been established, including maternal diabetes, exposure to drugs, and genetic variants in a few genes, these, at best, explain a small fraction of cases. Elucidating the molecular basis of CHD presents several challenges. While CHD has an increased risk of recurrence within families, suggesting genes are at play, CHD occurs with variable expressivity. Several chromosomal abnormalities clearly associate with CHD; however, many children with these same chromosomal abnormalities have normal hearts. Thus, the etiology cannot be explained by simple Mendelian genetics. Abnormal cardiac development occurs through a process that is complex, possibly involving both genetic and environmental risk factors. Because the majority of cases occur without known cause, the molecular basis of CHD is an active and evolving discussion.
Author List
Mitchell ME, Sander TL, Klinkner DB, Tomita-Mitchell AAuthors
Michael Edward Mitchell MD Chief, Professor in the Surgery department at Medical College of WisconsinAoy Tomita Mitchell PhD Professor in the Surgery department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
EndocardiumGene Expression
Heart
Heart Defects, Congenital
Humans
Molecular Biology
Neural Crest
Pericardium
Stem Cells
Vascular Endothelial Growth Factor A
