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Pronounced dependence of ventricular endocardial QRS potentials on ventricular volume. Br Heart J 1978 Aug;40(8):891-901

Date

08/01/1978

Pubmed ID

687490

Pubmed Central ID

PMC483504

DOI

10.1136/hrt.40.8.891

Scopus ID

2-s2.0-0018159488 (requires institutional sign-in at Scopus site)   23 Citations

Abstract

To evalulate the relation between ventricular endocardial potentials (QRS amplitude) and ventricular dimensions, left and right ventricular endocardial potentials were recorded with hook electrodes in anaesthetised open-chest dogs during transfusion and withdrawal of blood. Left ventricular end-diastolic diameter was measured by ultrasonic crystals, and end-diastolic volume was determined by thermodilution. In each dog, left ventricular endocardial potentials, whether recorded from anterior or posterolateral walls, decreased linearly as left ventricular end-diastolic diameter or volume increased, and vice versa. With an average increase in left ventricular end-diastolic diameter from 40.1 +/- 1.7 to 44.6 +/- 1.8 mm, left ventricular endocardial potentials decreased from 32.8 +/- 2.5 to 23.5 +/- 2.3 mV (P less than 0.001); and for an increase in left ventricular end-diastolic volume from 1.36 "/- 1.25 to 3.43 +/- 0.58 ml/kg left ventricular endocardial potentials decreased from 36.2 +/- 6.6 to 14.9 +/- 4.3 mV (P less than 0.001). Changes in right ventricular endocardial potentials paralleled the changes in left ventricular endocardial potentials. These findings indicate that acute changes in ventricular dimensions influence endocardial potentials considerably, and suggest a potential clinical application for detecting acute changes in ventricular volume.

Author List

Lekven J, Chatterjee K, Tyberg JV, Stowe DF, Mathey DG, Parmley WW

Author

David F. Stowe PhD, MA, MA Emeritus Professor in the Anesthesiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Action Potentials
Animals
Cardiac Output
Diastole
Dogs
Electrocardiography
Endocardium
Heart
Hematocrit
Stroke Volume
Ventricular Function