Effect of arterial PCO2 on 2-[1-14C]deoxy-D-glucose uptake by feline cerebral arteries. J Appl Physiol (1985) 1986 Oct;61(4):1288-92
Date
10/01/1986Pubmed ID
3096936DOI
10.1152/jappl.1986.61.4.1288Scopus ID
2-s2.0-0022930456 (requires institutional sign-in at Scopus site)Abstract
The effect of high and low arterial CO2 on the glucose utilization of nine major cerebral arteries was studied in cats anesthetized with pentothal using the quantitative 2-[1-14C]deoxy-D-glucose autoradiographic technique. All nine cerebral arteries from animals subjected to an arterial partial pressure of CO2 (PCO2) of 20 Torr utilized significantly more (P less than 0.025) glucose than the group subjected to an arterial PCO2 of 60 Torr. Mean relative glucose utilization of the 20-Torr PCO2 group was 105 +/- 9.5 mumol X 100g-1 X min-1 (+/- SE, n = 18) as compared with 49 +/- 6 mumol X 100g-1 X min-1 (+/- SE, n = 26) for the 60-Torr PCO2 group. This study demonstrates that blood vessels can be studied in vivo using the 2-[1-14C]deoxy-D-glucose autoradiographic technique. It also demonstrates that a physiological stimulus like CO2 can produce measurable changes in glucose utilization of cerebral arteries in vivo.
Author List
Kostreva DR, McNeely J, Zuperku EJAuthor
Edward J. Zuperku PhD, MS Emeritus Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAutoradiography
Carbon Dioxide
Carbon Radioisotopes
Cats
Cerebral Arteries
Deoxy Sugars
Deoxyglucose
Organ Specificity
Partial Pressure
