Role of cannabinoids and endocannabinoids in cerebral ischemia. Curr Pharm Des 2008;14(23):2347-61
Date
09/11/2008Pubmed ID
18781985Pubmed Central ID
PMC2581413DOI
10.2174/138161208785740054Scopus ID
2-s2.0-52949119940 (requires institutional sign-in at Scopus site) 109 CitationsAbstract
The human costs of stroke are very large and growing; it is the third largest cause of death in the United States and survivors are often faced with loss of ability to function independently. There is a large need for therapeutic approaches that act to protect neurons from the injury produced by ischemia and reperfusion. The goal of this review is to introduce and discuss the available data that endogenous cannabinoid signaling is altered during ischemia and that it contributes to the consequences of ischemia-induced injury. Overall, the available data suggest that inhibition of CB1 receptor activation together with increased CB2 receptor activation produces beneficial effects.
Author List
Hillard CJAuthor
Cecilia J. Hillard PhD Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBrain Ischemia
Cannabinoid Receptor Modulators
Cannabinoids
Endocannabinoids
Humans
Neurons
Receptor, Cannabinoid, CB1
Receptor, Cannabinoid, CB2
Reperfusion Injury
Signal Transduction
Stroke
United States
