Ecto-nucleoside triphosphate pyrophosphohydrolase activity and calcium pyrophosphate dihydrate crystal deposition disease. Adv Exp Med Biol 1986;195 Pt A:153-6
Date
01/01/1986Pubmed ID
3014830DOI
10.1007/978-1-4684-5104-7_23Scopus ID
2-s2.0-0022498946 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
Articular cartilage contains any ectoenzyme activity, NTP-PPH, which is capable of generating PPi from NTP substrates. The PPi generated is from the cleavage of the alpha-beta pyrophosphate bond of NTP and does not result from the effects of NTP catabolites. NTP-PPH activity is expressed on human skin fibroblasts in culture and is significantly increased in subjects with CPPD deposition. In addition, cultured fibroblasts from subjects with CPPD disease have higher intracellular PPi concentrations compared to cells from normals and patients with OA. These results support the hypothesis that alterations in PPi metabolism provide the metabolic basis for CPPD deposition.
Author List
Wortmann RL, Ryan LM, Karas B, McCarthy DJAuthor
Lawrence M. Ryan MD Emeritus Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adenine NucleotidesAnimals
Calcium Pyrophosphate
Calculi
Cartilage, Articular
Diphosphates
Dogs
Organ Culture Techniques
Purines
Pyrophosphatases
