Prophylactic antibiotics in surgery. Annu Rev Med 1993;44:385-93
Date
01/01/1993Pubmed ID
8476258DOI
10.1146/annurev.me.44.020193.002125Scopus ID
2-s2.0-0027461914 (requires institutional sign-in at Scopus site) 44 CitationsAbstract
Prophylactic antibiotics can decrease the incidence of postoperative wound infections in indicated procedures. The accepted indications for administering prophylactic antibiotics have been clean-contaminated procedures and prosthesis insertion, but new indications are evolving that consider wound contamination together with anesthetic risk and relative duration of the operation. A prophylactic antibiotic is chosen on the basis of its activity against endogenous flora likely to be encountered, its toxicity, and its cost, in that order. Potent antibiotics used for serious infections are generally not used for prophylaxis. A maximum dose of a prophylactic antibiotic is given preoperatively so that effective tissue concentration is present at and after the time of incision. In the absence of infection, antibiotics should not be continued beyond the operative day. Regimens for specific procedures are discussed.
Author List
Ludwig KA, Carlson MA, Condon REAuthor
Kirk A. Ludwig MD Chief, Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Anti-Bacterial AgentsHumans
Risk Factors
Surgical Wound Infection
Time Factors
