Epoxygenase metabolites. Epithelial and vascular actions. Mol Biotechnol 2000 Nov;16(3):233-51
Date
03/17/2001Pubmed ID
11252808DOI
10.1385/MB:16:3:233Scopus ID
2-s2.0-0034467906 (requires institutional sign-in at Scopus site) 43 CitationsAbstract
Cytochrome P450 (CYP450) epoxygenase enzymes demonstrate organ and cell specific expression and each CYP450 enzyme isoform produces a distinct pattern of epoxyeicosatrienoic acids (EETs). Investigations are beginning to describe the regulation of specific tissue CYP450 epoxygenase isoforms that may be associated with alterations in organ function that occur during various physiological and pathophysiological states. The main biological actions of EETs are their ability to affect epithelial ion transport and vascular smooth muscle cell function. This chapter focuses on the organ localization and production of EETs and the action of EETs on epithelial and vascular smooth muscle cells.
Author List
Imig JDMESH terms used to index this publication - Major topics in bold
Arachidonic AcidsBiological Transport
Brain
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System
Kidney
Liver
Muscle, Smooth, Vascular
Myocardium
Potassium Channels
Sodium
