Faculty Collaboration Database

Antagonism of neurotensin induced miosis by thyrotropin-releasing hormone (TRH) in rabbits. Neuropeptides 1988;12(4):225-8

Date

11/01/1988

Pubmed ID

3148872

DOI

10.1016/0143-4179(88)90059-5

Scopus ID

2-s2.0-0023739427 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

In previous studies we have shown that thyrotropin-releasing hormone (TRH) antagonizes many of the neural effects of neurotensin (NT). This study, evaluated the ability of TRH and two TRH analogs: 3 methyl-His-TRH and Phe2-TRH to affect NT-induced miosis in rabbits. In confirmation of previous findings, NT (30 micrograms) produced a significant miosis. The high (60 micrograms), but not the low (30 micrograms) dose of TRH significantly antagonized NT (30 micrograms)-induced miosis. Of interest was the observation that 3 methyl-His-TRH and Phe2-TRH were more effective than native TRH in blocking NT-induced miosis. The inhibitory effect of 3 methyl-His-TRH on the miotic response to NT exhibited long duration (approximately 60 min) when compared to native TRH and Phe2-TRH. TRH or the TRH congeners had no appreciable effects on pupillary diameter when administered alone. These findings indicate that TRH antagonizes the miotic response to NT, and suggest a hitherto undescribed peptide-peptide interaction involved in regulation of iris motility.

Author List

Hernandez DE, Simons KB, Spampinato D, Jennes L

MESH terms used to index this publication - Major topics in bold

Animals
Male
Neurotensin
Pupil
Rabbits
Thyrotropin-Releasing Hormone