Faculty Collaboration Database

Effects of simulated intraoperative electrophysiological testing on function of the canine left ventricle. Ann Thorac Surg 1988 Nov;46(5):556-62

Date

11/01/1988

Pubmed ID

3190330

DOI

10.1016/s0003-4975(10)64696-6

Scopus ID

2-s2.0-0023804438 (requires institutional sign-in at Scopus site)   8 Citations

Abstract

With the increasing application of arrhythmia surgery, intraoperative electrophysiological study is done frequently, although its potential to cause acute depression of cardiac function remains unresolved. This study examines the acute effects of simulated electrophysiological testing on left ventricular function. Seven dogs were anesthetized with sodium pentobarbital and instrumented for measurement of heart rate, mean aortic pressure, cardiac output (CO), and systemic vascular resistance (SVR). Systolic pressure-dimension work loops were analyzed over varying preloads. Contractility was assessed from the end-systolic pressure-dimension relationship (Ees) and from preload recruitable stroke work (PRSW). After the collection of control data, electrophysiological testing was simulated by pacing at 200 beats per minute for 30 seconds, fibrillating for 15 seconds, and finally defibrillating with a 10-J countershock. Data were recorded after 3 and 6 simulations of ventricular fibrillation (VF3, VF6). Mean heart rate and mean aortic pressure did not vary significantly during the course of the experiment. CO decreased from a control value of 2.7 +/- 0.2 L/min (+/- the standard error of the mean) to 2.0 +/- 0.1 (p less than 0.05) after VF3 and remained significantly depressed after VF6. SVR increased from a control value of 3,231 +/- 211 dyne sec cm-5 to 3,976 +/- 305 dyne sec cm-5 after VF3 (p = not significant) and increased further to 4,774 +/- 442 dyne sec cm-5 after VF6 (p less than 0.05). Neither Ees nor PRSW varied significantly even after 6 EP simulations, thereby indicating that contractility was unchanged during the experiment.(ABSTRACT TRUNCATED AT 250 WORDS)

Author List

Cole BN, Nicolosi AC, Uygur IJ, Jackson D, Spotnitz HM

MESH terms used to index this publication - Major topics in bold

Animals
Arrhythmias, Cardiac
Dogs
Electrophysiology
Intraoperative Period
Myocardial Contraction
Ventricular Function