Faculty Collaboration Database

Effect of sequencing on combined toxicity of renal irradiation and cisplatin. NCI Monogr 1988(6):35-9

Date

01/01/1988

Pubmed ID

3352781

Scopus ID

2-s2.0-0023853623 (requires institutional sign-in at Scopus site)   15 Citations

Abstract

We are using a rat model to study the effects of sequencing on the combined toxicity of renal irradiation and cisplatin (cis-Pt). Unanesthetized female WAG/RijMCW rats were given bilateral kidney irradiation (20 Gy in 9 fractions), preceded or followed by single ip doses of cis-Pt. Renal irradiation causes an increase in the acute toxicity of cis-Pt given 3-9 months after irradiation. Low-dose cis-Pt given immediately before irradiation, or as long as 9 months after irradiation, causes a decrease in the latent period for radiation nephritis and an increase in its severity. When given 3.7 to 7.7 months prior to irradiation, cis-Pt has a less severe effect on radiation nephritis. The greatest enhancement of radiation nephritis is seen for cis-Pt given 3 months after irradiation. Additive effects of cis-Pt and radiation on renal function can explain much, but not all, of the combined toxicity.

Author List

Moulder JE, Fish BL

MESH terms used to index this publication - Major topics in bold

Animals
Cisplatin
Combined Modality Therapy
Creatinine
Female
Kidney
Radiation Dosage
Rats
Time Factors