Effect of total-body irradiation with bone marrow transplantation on toxicity of cisplatin. NCI Monogr 1988(6):29-33
Date
01/01/1988Pubmed ID
3281032Scopus ID
2-s2.0-0023870457 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
In defined-flora, barrier-maintained rats (WAG/RijMCW males), radiation nephritis is the principal late toxicity seen after high-dose-rate, total-body irradiation (TBI) when hematologic toxicity is prevented by bone marrow transplantation. Pneumonitis develops only if rats are exposed to a conventional environment during and after bone marrow transplantation. Low-dose-rate TBI gives similar toxicity at doses twice as large. Rats surviving for 9 months after TBI show decreased tolerance for cisplatin. This decreased tolerance is related to dose and dose rate and is seen for radiation doses that show little or no renal toxicity. Evidence suggests that the decrease in renal tolerance is due to decreased renal platinum clearance in the irradiated kidneys.
Author List
Moulder JE, Fish BL, Holcenberg JS, Cheng MMESH terms used to index this publication - Major topics in bold
AnimalsBone Marrow Transplantation
Cisplatin
Kidney
Lethal Dose 50
Male
Metabolic Clearance Rate
Radiation Dosage
Rats
Whole-Body Irradiation
