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Dye-mediated photolysis of human neuroblastoma cells: implications for autologous bone marrow transplantation. Blood 1986 Jul;68(1):32-6

Date

07/01/1986

Pubmed ID

3521764

DOI

10.1182/blood.v68.1.32.bloodjournal68132

Scopus ID

2-s2.0-0022511895 (requires institutional sign-in at Scopus site)   71 Citations

Abstract

Cells from three different human neuroblastoma cell lines and normal human bone marrow cells were exposed to the lipophilic fluorescent dye, merocyanine 540 (MC 540), and white light. In vitro clonogenic tumor cells were inactivated up to 25,000 times more rapidly than multipotent hematopoietic progenitor cells (CFU-GEMM). It is conceivable that this pronounced difference in sensitivity to MC 540-mediated photolysis can be exploited for the selective killing of residual neuroblastoma cells in autologous remission marrow grafts.

Author List

Sieber F, Rao S, Rowley SD, Sieber-Blum M

Author

Fritz Sieber PhD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Bone Marrow
Bone Marrow Transplantation
Cell Line
Cell Survival
Hematopoietic Stem Cells
Humans
Neoplastic Stem Cells
Neuroblastoma
Photolysis
Pyrimidinones
Transplantation, Autologous