Faculty Collaboration Database

Warm ischemic damage to the epiphyseal growth plate: a rabbit model. J Hand Surg Am 1987 Jan;12(1):54-61

Date

01/01/1987

Pubmed ID

3805644

DOI

10.1016/s0363-5023(87)80160-0

Abstract

Warm ischemic growth plate damage was produced in the hindlimbs of 33 New Zealand white rabbits, who were 7 weeks old, by isolating the knee joint on a popliteal vascular pedicle. Zero, 3, 7, and 12 hours of warm ischemia were produced by pedicle occlusion. The 0- and 3-hour ischemic groups showed mild growth disturbances related to the surgical model and were not statistically different at 90 days postoperatively. The 7- and 12-hour ischemia groups showed severe growth disturbances and were statistically different from the 0- and 3-hour groups at all periods measured (p less than 0.05). Large central growth plate lesions were apparent by histologic examination. Twelve hours of ischemia produced a histologic picture identical to growth plate infarction. Increased warm ischemic time correlated with more severe growth retardation and evidence of increased damage to the central area of the growth plate histologically.

Author List

Stark RH, Matloub HS, Sanger JR, Cohen EB, Lynch K

Authors

Hani S. Matloub MD Emeritus Professor in the Plastic Surgery department at Medical College of Wisconsin
James R. Sanger MD Professor in the Plastic Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Femur
Growth Plate
Hot Temperature
Ischemia
Models, Biological
Rabbits
Tibia