Ischemic Preconditioning And Myocardial Infarction: An Update and Perspective. Drug Discov Today Dis Mech 2007;4(3):165-174
Date
08/15/2008Pubmed ID
18701939Pubmed Central ID
PMC2515553DOI
10.1016/j.ddmec.2007.10.005Scopus ID
2-s2.0-47049090546 (requires institutional sign-in at Scopus site) 28 CitationsAbstract
Myocardial infarction is the leading cause of mortality in Western societies with annual expenditures of $431.8 billion spent on coronary artery disease in man. Therapeutics to combat infarction from myocardial injury, based on studies of ischemic preconditioning (IPC), are currently in progress. Hence, this review provides an update on IPC, including general and molecular mechanisms responsible for IPC and the effects of IPC in models of aging or disease. A summary of therapeutics shown to possess efficacy in preclinical and clinical trials and future directions of studies regarding cardiac IPC are also discussed.
