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CURRICULUM VITAE

Daniel J. Stein MD
Assistant Professor
Department of Medicine
Division of Gastroenterology

OFFICE ADDRESS:
Froedtert Hospital
9200 W Wisconsin Ave
Milwaukee, WI 53226

CITIZENSHIP:  United States

EDUCATION:
8/1989 - 5/1994 Diploma, Cudahy High School, Cudahy, WI
8/1994 - 5/1998 BS - Biology, Marquette University, Milwaukee, WI
8/1999 - 5/2003 M.D., Creighton University School of Medicine, Omaha, NE

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
7/1/2003 - 6/30/2006 Internal Medicine Resident, Internal Medicine, Unviversity of Arizona, Tucson, AZ
7/1/2007 - 6/30/2010 Gastroenterology and Hepatology Fellowship, Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI
11/1/2009 - 12/1/2009 Visiting Inflammatory Bowel Disease Fellow, Gastroenterology, University of Chicago, Chicago, IL

FACULTY APPOINTMENTS:
7/1/2010 - Present Assistant Professor, Internal Medicine , Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI
7/1/2010 - Present Gastroenterology and Hepatology, Children's Hospital of Wisconsin, Milwaukee, WI 53226
7/1/2011 - Present Gastroenterology and Hepatology, Clement J. Zabolki Vetrens Affairs Hospital , Milwaukee , WI

ADMINISTRATIVE APPOINTMENTS:
7/1/2006 - 6/30/2007 Chief Resident , University of Arizona Internal Medicine, Tucson, AZ
8/2013 - Present Access Champion, Internal Medicine, Gastroenterology and Hepatology, Froedtert and the Medical College of Wisconsin, Milwaukee, WI

AWARDS AND HONORS:
1998 - Present Magna Cum Laude , Marquette University
1998 - Present Phi Beta Kappa , Marquette University
5/2000 - 8/2000 Crohn’s and Colitis Foundation of America: 2000 Solvay Pharmaceuticals Student Research Fellowship “Selective Leukocyte Binding by Microvascular Endothelial Cells in Crohn’s Disease” , Medical College of Wisconsin
10/2005 - Present Selected Attendee to 3rd Annual Choosing a Career in Academic Gastroenterology Conference, Medical College of Wisconsin – Division of Gastroenterology and Hepatology
2005 - 2007 Associate Representative, American College of Physicians
2006 - 2007 Chief Resident Internal Medicine , University of Arizona Internal Medicine Residency Program
2008 - Present Attendee , IBD Mentoring Program for GI Fellows
2010 - Present Fellowship2Leadership, Salix Fellows Program, DDW

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
7/1/2007 - Present American College of Gastroenterology (Member)
7/1/2007 - Present Crohn's and Colitis Foundation of America (Member)
7/1/2007 - Present American Society for Gastrointestinal Endoscopists (Member)
7/1/2007 - Present American Gastroenterology Association
8/1/2011 - Present Milwaukee GI Society (Member)

LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
6/1/2010 - Present Crohn's and Colitis Medical Advisory Board Milwaukee, Crohn's and Colitis Foundation of America, Milwaukee Chapter
3/2012 - Present Co-Director, Medical College of Wisconsin Inflammatory Bowel Disease Annual Update

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
1. Probiotics and Inflammatory Bowel Disease, Crohn’s and Colitis Foundation of America – Milwaukee Chapter Monthly Meeting , Milwaukee, WI, 5/10/2010 - Present
2. New Therapies in IBD, Crohn’s and Colitis Foundation of America – Milwaukee Chapter Monthly Meeting , Milwaukee, WI, 6/7/2010 - Present
3. Inflammatory Bowel Disease and The Endoscopy Lab, Froedtert Lutheran Memorial Hospital Gastroenterology Nursing Education Program , Milwaukee, WI, 8/3/2010 - Present
4. Update on the IBD Center , Digestive Disease Center Board Meeting , Milwaukee, WI, 10/2010 - Present
5. Lunch and Learn “The Celiac Iceberg” , Plank Road Clinic, Milwaukee, WI, 3/3/2011 - Present
6. Lunch and Learn “The Celiac Iceberg” , Sunnyslope Clinic, Milwaukee, WI, 3/16/2011 - Present
7. Lunch and Learn “The Celiac Iceberg” , Lincoln Avenue Clinic, Milwaukee, WI, 4/13/2011 - Present
8. Optimizing Therapy in Crohn's Disease, Medical College of Wiscons Inflammatory Bowel Disease Update, Medical College of Wisconsin, 3/31/2012 - Present
9. Management of Inflammatory Bowel Disease for the Internist, Internal Medicine Resident Lecture, Medical College of Wisconsin, 1/2013 - Present
10. Autonomic Dysfunction and the Gut, Milwaukee Autonomic Support Group, Milwaukee, WI, 2/2013 - Present
11. Optimizing Therapy for Crohn's Disease, Pharmacy Department Meeting, Froedtert Hospital, 2/10/2014 - Present
12. IBD and the Endoscopy Lab, Building a Better Team - Share Your Knowledge, Froedtert Hospital, 2/12/2014 - Present
13. Modern Disease Management in IBD, Allergy and Immunology Grand Rounds, Children's Hospital of Wisconsin, 3/7/2014
 
Regional
1. Therapeutic Drug Monitoring In Inflammatory Bowel Disease Patients, Medical College of Wisconsin IBD Update, Milwaukee WI, 4/13/2012 - Present
2. Optimizing Therapy for Inflammatory Bowel Disease, Grand Rounds St. Agnes Hospital , Fond Du Lac, Wisconsin, 5/31/2012 - Present
3. Celiac Disease and Gluten Sensitivity , Medical College of Wisconsin Internal Medicine Grand Rounds, Milwaukee, WI, 4/5/2013 - Present
4. Disease and Drug Monitoring in Inflammatory Bowel Disease, MCW IBD Annual Update, Crowne Plaza Hotel - Wauwatosa, WI, 3/15/2014 - Present
 
National
1. Inflammatory Bowel Disease Patients on Immunosuppressive Therapy in Endoscopic Remission Have a High Rate of Post Inflammatory Bowel Disease-Irritable Bowel Syndrome which is Associated with a Diminished Quality of Life. , Digestive Disease Week 2012, San Diego, CA, 5/20/2012 - Present
 
COMMITTEE SERVICE:
Medical College
2011 - Present Interviewer , Internal Medicine Residency Program Applicants , Medical College of Wisconsin
2011 - Present Interviewer , Incoming Gastroenterology Fellowship Program Applicants , Medical College of Wisconsin
6/1/2012 - Present Co-Director M2 GI and Nutrition Subunit, Discovery Curriculum, Medical College of Wisconsin
 
MEDICAL COLLEGE TEACHING ACTIVITIES:
Medical Student Education
6/1/2010 - Present M4 Inflammatory Bowel Disease Rotation Attending
6/1/2010 - Present M3 Board Review: GI and Hepatology Review
6/1/2011 - Present M4 Clinics Rotation Attending
1/1/2013 - Present M1 Clinical Apprenticeship Preceptor
1/9/2014 Pathology of the Esophagus and Stomach - Case Presentation
1/16/2014 - Present Case of Weight Loss and Diarrhea
1/21/2014 - Present C. Difficle Colitis
1/21/2014 - Present Miscellaneous Disorders of the GI Tract
1/21/2014 - Present Approach to Diarrhea
1/22/2014 - Present Celiac Disease
1/23/2014 - Present Tumors of the Large and Small Bowel - Case based discussion
1/23/2014 - Present Introduction to Inflammatory Bowel Disease
4/9/2014 - Present Two Cases of Nausea, Vomiting and Weight Loss
4/9/2014 - Present USMLE Board Review
 
Resident and Fellow Education
6/1/2010 - Present GI Fellow Board Review: IBD and Infections of the GI Tract
6/1/2010 - Present IBD and Clinics Rotation Attending
7/1/2012 - Present Internal Medicine Noon Report Faculty
4/2013 - Present Introduction to Endoscopy for First Year Surgical Resident
12/16/2013 - Present Introduction to Inflammatory Bowel Disease
 
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Medical Students
Medical College of Wisconsin, 7/1/2012 - 5/1/2013 M4 Student Advisor
 

BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Stein DJ et al. Impact of prior irregular infliximab dosing on performance of long-term infliximab maintenance therapy in Crohn's disease. Inflamm Bowel Dis. 2010 Jul;16(7):1173-9
2. Rafiee P et al. Thalidomide inhibits inflammatory and angiogenic activation of human intestinal microvascular endothelial cells (HIMEC). Am J Physiol Gastrointest Liver Physiol. 2010 Feb;298(2):G167-76
3. Nguyen DM, El-Serag HB, Henderson L, Stein DJ, Bhattacharyya A, Sampliner RE. Medication usage and the risk of neoplasia in patients with Barrett's esophagus. Clin Gastroenterol Hepatol. 2009 Dec;7(12):1299-304.
4. Stein DJ, Hashem B. El-Serag, M.D., M.P.H., John Kuczynski, M.D., Jennifer R. Kramer Ph.D., M.P.H., Richard E. Sampliner, M.D. The Association of Barrett's Esophagus and Body Mass Index. Alimentary Pharmacology & Therapeutics. 2005 Nov 15;22(10):1005-10.
5. Fons ME, Stein DJ, Patel A, Ferrer MS, Ammon H, Mackinnon AC, Komorowski RA, Yan BC Extracolonic gastrointestinal tract morphologic findings in a case of pseudomembranous collagenous colitis. Ann Diagn Pathol. 2012 Jun 1:
6. Bautista MC, Otterson MF, Zadvornova Y, Naik AS, Stein DJ, Venu N, Perera LP Surgical Outcomes in the Elderly with Inflammatory Bowel Disease are Similar to Those in the Younger Population. Dig Dis Sci. 2013 Jul 9:
7. Perera LP, Ananthakrishnan AN, Guilday C, Remshak K, Zadvornova Y, Naik AS, Stein DJ, Massey BT Dyssynergic defecation: a treatable cause of persistent symptoms when inflammatory bowel disease is in remission. Dig Dis Sci. 2013 Dec;58(12):3600-5
 
Books, Chapters, and Reviews
1. In press. Gastrointestinal Emergencies Third Edition. 2013. "Complications of Upper Gastrointestinal Endoscopy" Daniel J. Stein MD and Reza Shaker MD
 
Abstracts
1. Long-Term Clinical Outcomes Following Surgery in Crohn's Disease Patients on Combination Immunosuppression: Impact of Anastomotic Reconstruction on Quality of Life and Healthcare Utilization Daniel Stein, Yelena Zadvornova, Emery C. Lin, Amar S. Naik, Lilani P. Perera, Nanda Venu, Mary F. Otterson, David G. Binion. Digestive Disease Week 2013 Orlando, FL.
2. Outcomes in IBD Patients WHO Are Exposed to a Subsequent Anti-TNF Agent Following Anti-TNF Drug Induced Lupus-Like Reaction. Mukund Venu, Amar Dodda, Jason E. Gonzaga, Amar S. Naik, Nanda Venu, Lilani P. Perera, Daniel Stein. Digestive Disease Week 2013 Orlando, FL.
3. Development of Irritable Bowel Syndrome Symptoms in Quiescent Inflammatory Bowel Disease: Significant Association With Presence of Psychiatric Illness and Early Onset IBD. Mark Radigan, Corinne Guilday, Alexis Visotcky, Benson T. Massey, Daniel Stein, Amar S. Naik, Nanda Venu, Kari Best, Susan Skaros, Lilani P. Perera. Digestive Disease Week 2013 Orlando, FL.
4. Concomitant Use of Immunomodulator Therapy Results in Higher Serum Infliximab Levels Compared to Monotherapy Without Lowering Serum Haca Levels Corinne Guilday, Daniel Eastwood, Yelena Zadvornova, Daniel Stein, Amar S. Naik, Kari Best, Susan Skaros, Lilani P. Perera. Digestive Disease Week 2013 Orlando, FL.
5. Proximal Colon Retroflexion With Adult Versus Pediatric Colonoscopes A. Aziz Aadam, Kia Saeian, Benson T. Massey, Daniel J. Stein, Laura Ashley, Nanda Venu, Mukund Venu, Young Oh. Digestive Disease Week 2013 Orlando, FL.
6. Mucosal Healing by Individual Anti TNF Agent in Crohn's Disease in Tertiary Care Setting Zainab Ashir, Corinne Guilday, Yelena Zadvornova, Daniel Stein, Amar S. Naik, Nanda Venu, Kari Best, Susan Skaros, Kia Saeian, Lilani P. Perera. Digestive Disease Week 2013 Orlando, FL.
7. Factors Associated With 30 Day Re-Admission in Inflammatory Bowel Disease Amar S. Naik, Yelena Zadvornova, Daniel Stein, Nikhil Shastri, Mukund Venu, Kari Best, Lilani P. Perera, Kia Saeian, Nanda Venu. Digestive Disease Week 2013 Orlando, FL.
8. Mazen Issa, Yelena Zadvornova, Amar S. Naik, Daniel J. Stein, Nanda Venu, Lilani P. Perera High Rates of Escalation and Termination of Adalimumab Therapy and Patients Exposed to Infliximab . Digestive Disease Week 2011 Chicago, IL : Mo1226 -- 2011 AGA Poster of Distinction
9. Selamawit Tarekegn, Kristin Oimoen, Yelena Zadvornova, Daniel Eastwood, Mazen Issa, Amar S. Naik, Daniel J. Stein, Nanda Venu, Lilani P. Perera Biologics Are Superior to Immunomodulators in Prevention of Post-Operative Recurrence of Crohn's Disease Digestive Disease Week 2011 Chicago, IL Mo1243 -- 2011
10. Amar S. Naik, Yelena Zadvornova, Sarah J. Lundeen, Daniel J. Stein, Nanda Venu, Mary F. Otterson, Mazen Issa, Lilani P. Perera Abdominal Venous Thrombosis Following Inflammatory Bowel Disease Related Surgeries While On Dalteparin Prophylaxis. Digestive Disease Week 2011 Chicago, IL Su1213 -- 2011
11. Adeeti Chiplunker, Yelena Zadvornova, Mazen Issa, Daniel J. Stein, Lilani P. Perera, Nanda Venu, Amar S. Naik Factors Associated with Repeat Hospitalizations in Inflammatory Bowel Disease Digestive Disease Week 2011 Chicago, IL. Tu1264 -- 2011
12. Mazen Issa, Yelena Zadvornova, Daniel J. Stein, Nanda Venu, Lilani P. Perera1, David G. Binion, Amar S. Naik Long-Term Use of Purine Analogues in Inflammatory Bowel Disease: A Single Referral Center Experience Digestive Disease Week 2011 Chicago, IL Tu1293 -- 2011
13. Roy Liu, Kristin Oimoen, Yelena Zadvornova, Jessica Pruszynski, Amar S. Naik, Daniel J. Stein, Nanda Venu, Lilani P. Perera Advanced Age At Diagnosis Does Not Negatively Impact Health Related Quality of Life in IBD: Performance of SIBDQ in a Longterm Cohort Study: Digestive Disease Week 2011 Chicago, IL Tu1312 -- 2011
14. Agnes Libot, Mazen Issa, Yelena Zadvornova, Daniel J. Stein, Nanda Venu, Lilani P. Perera, Amar S. Naik Initial Vancomycin Monotherapy Is Associated with Higher Rates of Subsequent Clostridium Difficile Infection in Inflammatory Bowel Disease Population Digestive Disease Week 2011 Chicago, IL Oral Presentation
15. Daniel J. Stein, Benson T. Massey, Thangam Venkatesan, Richard Komorowski and Walter J. Hogan. Chronic Idiopathic Enterocolitis (CIE): Maintaining a Corticosteroid Free Response with Immunosuppressive Therapy. Digestive Disease Week, New Orleans, May 2010.
16. Kwiatt, James T., Stein, Daniel J., Naik, Amar S., Ananthakrishnan, Ashwin N., Perera, Lilani P. The 2009 Influenza Pandemic: Seasonal and H1N1 Influenza Vaccination Rates are Increasing in an IBD Population in 2009. Digestive Disease Week, New Orleans, May 2010.
17. Zadvornova Y, Ashwin N Ananthakrishnan, Stein DJ, Skaros S, Johnson K, Naik AS, Perera LP, Issa M. Infliximab monotherapy vs. combined infliximab-immunomodulator therapy in ulcerative colitis. Digestive Disease Week, New Orleans, May 2010.
18. Naik AS, Zadvornova Y, Issa M, Skaros S, Ward S, Ward A, Johnson K, Tyler K, Stein DJ, Perera LP, Ashwin N Ananthakrishnan. Tubular adenoma and low grade dysplasia in inflammatory bowel disease: Who is at risk? Digestive Disease Week, New Orleans, May 2010.
19. Daniel J. Stein, Ashwin Ananthakrishnan, Alex Ulitsky, Amar Naik, Charles Marn, Gary Sudakoff, Mary F Otterson, Lilani Perera, David G Binion, Mazen Issa, Pre-operative small bowel follow through detects more strictures on a per stricture analysis than CT enterography when compared to intra-operative findings in patients with Crohn's disease. American College of Gastroenterology annual meeting, San Diego, October 2009.
20. Dawn B. Beaulieu, Ashwin N. Ananthakrishnan, Yelena Zadvornova, Daniel J. Stein, Rachel Mepani, Stephen J. Antonik, Susan Skaros, Kathryn Johnson, Amar S. Naik, Lilani P. Perera, David G. Binion Seasonal Variation in HRQoL and Disease Activity in Patients with Inflammatory Bowel Disease: A Tertiary Care Center Experience,. Digestive Disease Week, Chicago, June 2009
21. Dawn B. Beaulieu, Ashwin N. Ananthakrishnan, Yelena Zadvornova, Daniel J. Stein, Rachel Mepani, Stephen J. Antonik, Susan Skaros, Kathryn Johnson, Amar S. Naik1, Lilani P. Perera1, David G. Binion. Does Duration of Disease Impact Health Related Quality of Life (HRQoL) in Inflammatory Bowel Disease? Digestive Disease Week, Chicago, June 2009
22. Daniel J. Stein, Mazen Issa, Sue Skaros, Josh F Knox, Kathryn Lemke, Jeanne Emmons, Mary F Otterson, Ashwin N Ananthakrishnan, David G Binion. "History of interrupted infliximab dosing significantly diminishes efficacy during long-term maintenance therapy in Crohn's Disease." Gastroenterology. 134(4), Suppl 1: A-666, 2008.
23. Daniel J. Stein, HB El-Serag, J Kuczynski, JR Kramer, and RE Sampliner. "The Association of Barrett's Esophagus and Body Mass Index." American College of Gastroenterology 70th Annual Scientific Meeting. October 30 - November 2, 2005. Honolulu, Hawaii. A587
24. Daniel J. Stein, W Diaz-Calderon, and GL Woods. "Fibrosing Cholestatic Hepatitis: A Rare Complication After Renal Transplant." American College of Physicians - Arizona Chapter Annual Meeting. Tucson, AZ. October 1-2, 2005.
25. Daniel J. Stein, R Chiou, B Houghton, G Ochuba. "An Unusual Case of Abdominal Pain and Urethritis." 2003 American College of Physicians Annual Session. San Diego, CA. April 3-5.
26. Daniel J. Stein, P Rafiee, A Taras, TH Lamirand, PJ Fisher, H Ogawa, GL Telford, MF Otterson, CP Johnson, Binion DG,: Thalidomide inhibits inflammatory and angiogenic activation of human intestinal microvascular endothelial cells (HIMEC). Gastroenterology, 120: A278, 2001.
27. S Kugathasan, A Taras, Daniel J. Stein, PJ Fisher, TH Lamirand, RL Truitt, DG Binion,: Infliximab binds human monocytes, but not mucosal T cells in vitro: no direct anti-T cell mechanism of action. Gastroenterology, 118: A110, 2000.
28. S Kugathasan, Daniel J. Stein, RL Truitt, DG Binion,: Distinct mucosal T cell phenotypes in early and late pediatric Crohn's disease (CD): Increased naïve T cells are found in late, but not early CD. Gastroenterology, 118: A347, 2000.
29. DG Binion, KS Ramanujam, PJ Fisher, S Fu, MT Rivera, Daniel J. Stein, KT Wilson,: Loss of inducible nitric oxide synthase (iNOS) expression in inflammatory bowel disease (IBD) human intestinal microvascular endothelial cells (HIMEC) underlies leukocyte hyper adhesion.Gastroenterology, 116: A668, 1999.
30. S Kugathasan, Daniel J. Stein, MT Rivera, B Seetharam, DG Binion,: Plasma Transcobalamin II (TC II) is elevated in children with established, but not newly diagnosed Crohn's disease (CD): Acquired alteration in microvascular expression. Gastroenterology, 116: A755, 1999.
31. P Rafiee, PJ Fisher, Daniel J. Stein, CP Johnson, DG Binion,: ICAM-1, but not VCAM-1 expression is blocked with tyrosine phosphorylation inhibitors in activated human intestinal microvascular endothelial cells (HIMEC): Potential role of ERK and p38 MAPK. Gastroenterology, 116: A920, 1999.
32. MT Rivera, PJ Fisher, Daniel J. Stein, T Condon, J Tami, WE Shanahan, CF Bennett, DG Binion. Antisense oligonucleotides, but not steroids, inhibit human intestinal microvascular endothelial cell (HIMEC) adhesion molecule expression and leukocyte binding: A novel therapeutic strategy in intestinal inflammation. Gastroenterology, 116: A669, 1999.
33. Perera LP, Zadvornova Y, Binion DG, Guilday C, Stein DJ, Naik AS, Venu N, Best K, Skaros S. Long term outcomes of crohn’s disease patients on maintenance anti-TNF-α therapy. Presented as a poster at Digestive Disease Week 2012.
34. Durability of Anti TNF α therapy in Ulcerative Colitis: Switching is an Effective Strategy in a Small Subset of patients. Perera LP, Zadvornova Y, Saeian K, Guilday C, Stein DJ, Naik AS, Venu N, Best K, Skaros S. Digestive Disease Week 2012