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CURRICULUM VITAE

David A. Margolis MD
Professor
Department of Pediatrics
Division of Hematology/Oncology

OFFICE ADDRESS:
MACC Fund Research Center
8701 Watertown Plank Rd
Milwaukee, WI 53226

CITIZENSHIP:  U.S.A.

EDUCATION:
1981 - 1985 BS, Indiana University, Bloomington, IN
1985 - 1989 MD, University of Wisconsin, Madison, WI

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
1986 Fellow, Summer Psychiatry, University of Wisconsin Medical School, Milwaukee, WI
1989 - 1992 Resident, Pediatrics, Children’s Hospital of Wisconsin, Milwaukee, WI
1992 - 1995 Fellow, Pediatrics, Hematology/Oncology, Medical College of , Milwaukee , WI
1993 - 1999 Postdoctoral Trainee, Molecular Genetics Laboratory, In the laboratory of Jack Gorski, Ph.D., BloodCenter of Southeastern Wisconsin, Milwaukee, WI

FACULTY APPOINTMENTS:
1992 - 1995 Instructor, Medical College of Wisconsin, Milwaukee, WI
1995 - 2001 Assistant Professor, Pediatrics, Hematology/Oncology/BMT, Medical College of Wisconsin, Milwaukee, WI
1999 - Present Associate Investigator, Pediatrics, Hematology/Oncology/BMT, The Blood Center of Southeastern Wisconsin, Blood Research Institute, Milwaukee, WI
2001 - 2008 Associate Professor, Pediatrics, Hematology/Oncology/BMT, Medical College of Wisconsin, Milwaukee, WI
2008 - Present Professor, Pediatrics, Hematology/Oncology/BMT, Medical College of Wisconsin, Milwaukee, WI

ADMINISTRATIVE APPOINTMENTS:
2006 - 2009 Interim Bone Marrow Transplant Program Director, Medical College of Wisconsin, Milwaukee, WI
2009 - Present FACT Accredited Blood and Marrow Transplant Program Director, Pediatrics, Hematology/Oncology/BMT , Medical College of Wisconsin, Milwaukee, WI
2011 - Present CSG Board of Directors, Children's Specialty Group, Milwaukee, WI
2013 - Present Associate Chair, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI

EDUCATIONAL ADMINISTRATIVE APPOINTMENTS:
2012 - Present Associate Director, Pediatrics, Residency Program, Medical College of Wisconsin, Milwaukee, WI

HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS:
1998 - Present Program Director, Pediatrics, FACT Accreditied Bone Marrow Transplantation Program, Children’s Hospital of Wisconsin, Milwaukee, WI
2010 - Present Medical Director, Pediatrics, Hematology/Oncology/BMT, Children’s Hospital of Wisconsin, Milwaukee, WI

RESEARCH ADMINISTRATIVE APPOINTMENTS:
2001 - Present Medical Director, Lymphocyte Propagation Laboratory, Froedtert Hospital/Medical College of Wisconsin, 8701 West Watertown Plank Rd., Milwaukee, WI 53226
2001 - Present Medical Director, Cell Processing Laboratory, Froedtert Hospital/Medical College of Wisconsin, 8701 West Watertown Plank Rd., Milwaukee , WI

HOSPITAL STAFF PRIVILEGES:
8/1992 - Present Children’s Hospital of Wisconsin, 9200 W. Wisconsin Ave., Milwaukee, WI 53226
5/2000 - Present Froedtert Hospital (Affiliate), 9200 W. Wisconsin Ave., Milwaukee, WI 53226

SPECIALTY BOARDS AND CERTIFICATION:
Board Certified
Issue DateExpiration
Pediatrics
10/1992
12/2006
Sub-Board Certification – Hematology/ Oncology
4/2010
12/2015
 
Licensure
Number Issue DateExpiration
Wisconsin License
7/1/1990
10/31/2015
 
AWARDS AND HONORS:
1985 Phi Beta Kappa, Indiana University
1988 Alpha Omega Alpha, University of Wisconsin
2006 - 2007 Top 5 Teachers for Residents, Medical College of Wisconsin
2006 - Present Best Doctors of America
2006 - 2007 Top 5 Teachers for Students, Medical College of Wisconsin
2010 - 2011 Medical Student Teacher Award (M3: Pediatrics), Medical College of Wisconsin
2010 - 2011 Medical Student Teacher Award (M1-M2: Biochemistry), Medical College of Wisconsin

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
The Society of Pediatric Research (Honorary)
Children’s Oncology Group (Professional)
American Society of Blood and Bone Marrow Transplantation (Professional)
American Society of Hematology (Professional)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Journal Review
New England Journal of Medicine
Journal of Pediatrics
Biology of Blood and Marrow Transplantation
Transplantation
Journal of Immunology
American Journal of Pediatric Hematology/ Oncology
Blood
Bone Marrow Transplantation
Pediatric Blood and Cancer

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
1997 - Present Member, Medical Advisory Board, Make a Wish Foundation
2009 - Present Member, Medical Advisory Board, Aplastic Anemia & MDS International Foundation (AA&MDSIF)
Chair, Patient Education Council (PEC), Aplastic Anemia & MDS International Foundation (AA&MDSIF)

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Characterization of the Promyelocytic Zinc Finger Gene
Source:
Zink the Zebra Foundation
Role:
Prinicpal Investigator
Dates:
8/1/1995 - 6/30/2017
 
Title:
Unrelated Donor Hematopoietic Cell Transplatation for Children with Severe Sickle Cell Disease Using a Reduced Intensity Conditioning Regimen #601
Source:
National Childhood Cancer Foundation
Role:
Principal Investigator
Dates:
12/12/2008 - 4/17/2013
 
Title:
Multi-Center, Open Label, Randomized Trial Comparing Single Versus Double Umbilical Cord Blood (UCB) Transplatation in Pediatric Patients with High Risk Leukemia and Myelodysplasia #501
Source:
National Childhood Cancer Foundation
Role:
Principal Investigator
Dates:
12/12/2008 - 12/20/2012
 
Title:
Transplant Research Database for Hematopoietic Stem Cell Transplantation and Marrow Toxic Injuries
Source:
National Marrow Donor Program
Role:
Principal Investigator
Dates:
7/1/2009 - 6/30/2017
 
Title:
CMX 001-305 - A Multicenter Open-label Study of CMX001 Treatment of Serious Diseases or Conditions Caused by dsDNA Viruses
Source:
Chimerix
Role:
Principal Investigator
Dates:
1/13/2011 - 1/12/2014
 
Non-Peer Review
Title:
BMT Research Fund
Source:
Sam Memorial "HOOT" Fund
Role:
Prinicpal Investigator
Dates:
8/8/1997 - 11/15/2012
 
Prior
Peer Review
Title:
Immune Reconstitution After Bone Marrow Transplant: Identification and Characterization of the T-cells Associated with Graft Versus Host Disease, Graft Versus Leukemia and Immune Competence
Source:
Children’s Hospital Foundation, Children’s Hospital of Wisconsin
Role:
Principal Investigator
Dates:
1995 - 1997
Direct Funds:
$48,000 (Supplies and Technical Support )
 
Title:
Immune Reconstitution After Bone Marrow Transplant: Identification and Characterization of the T-cells Associated with Graft Versus Host Disease, Graft Versus Leukemia and Immune Competence
Source:
Cancer Center of the Medical College of Wisconsin and the Will Ross Foundation
Role:
Co-Principal Investigator
PI:
Bryon Johnson, PhD
Dates:
1997
Direct Funds:
$10,000 (supplies)
 
Title:
Analysis of WT1 Expression and Function in Pediatric Leukemias
Source:
Cancer Center of the Medical College of Wisconsin
Role:
Co-Principal Investigator
PI:
Jennifer Morris, PhD
Dates:
1997
Direct Funds:
$25,000 (Post-Doctoral Fellow)
 
Title:
Molecular and Cellular Analysis of T-cells During Donor Leukocyte Infusions
Source:
National Institute of Health K08 CA77330-01A1
Role:
Principal Investigator
Dates:
9/1998 - 9/2003
Direct Funds:
$330,000 (Salary Support - $50,000 per year, Supply Support - $10,000 per year x 2 years then $20,000 per year)
 
Non-Peer Review
Title:
Hematology Training Grant
Source:
National Institute of Health Training Grant #HL07209 - The Blood Center of Southeastern Wisconsin, Milwaukee, WI
Role:
Post-Doctoral Fellow
Dates:
6/15/1995 - 6/15/1996
Direct Funds:
$30,000 (salary support)
 
Title:
Hematology Training Grant
Source:
NIH Training Grant #HL07209 - The Blood Center of Southeastern Wisconsin, Milwaukee, WI
Role:
Post-Doctoral Fellow
Dates:
6/15/1996 - 6/15/1997
Direct Funds:
$32,000 (salary support)
 
Title:
Analysis of WT1 Expression and Function in Pediatric Leukemias
Source:
Japanese Government Grant-in-Aid for International Collaborative Research
Role:
Co- Investigator (Haruo Sugiyama, M.D., Ph. D.)
Dates:
1997 - 1998
Direct Funds:
$10,000 (travel expenses)
 
INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
1. Cord Blood Transplantation: Who, What, Where, When and Why?, St. Vincent Hospital, Green Bay, WI, 1999
 
Regional
1. Prevention of Invasive Fungal Infections in BMT Recipients, Fujisawa Health Care Sponsored Workshop, Atlanta, GA, 1999
2. Pediatric Bone Marrow Transplantation, American Society for Histocompatibility and Immunogenetics Regional Workshop, Milwaukee, WI, 2000
3. The Workshop on Haploidentical Stem Cell Transplantation, Miltenyi Biotech and Nexell Therapeutics Sponsored Workshop, Chicago, IL, 2000
4. Pediatric Leukemia and Bone Marrow Transplantation, Panelist - Leukemia Research Foundation Town Hall Meeting, Chicago, IL, 2003
5. Pediatric Leukemia and Bone Marrow Transplantation, Panelist, Leukemia Research Foundation Town Hall Meeting, Chicago, IL, 2005
6. Blood Banking Aspects of Bone Marrow Transplantation, Wisconsin Association of Blood Banks Annual Meeting, WI, 2006
7. Living with Aplastic Anemia, MDS or PHN, Regional Patient and Family Conferences, San Francisco, CA, 2011
 
National
1. Molecular Biology in Clinical Oncology, American Association of Cancer Research sponsored workshop, Aspen, CO, 1993
2. Epidemiology and Clinical Trial Design Workshop, Berlex Oncology Foundation sponsored Workshop, Cape Cod, MA, 1994
3. Alternative Donor Bone Marrow Transplantation for Severe Aplastic Anemia, International Bone Marrow Transplant Registry (IBMTR) Conference, Keystone, CO, 2001
4. Alternative Donor Transplants for Pediatric Acute Leukemia: Comparing Marrow Donors, Cord Blood Donors, and Haploidentical Donors, Session Chair, Pediatric Malignancies Session, Annual IBMTR Conference, Keystone, CO, 2002
5. Immune Reconstitution Following Alternative Donor Hematopoietic Progenitor Cell Transplants: Patterns, Packages and Problems From a Single Institution Experience, Grand Rounds - Pediatric Branch, National Cancer Institute, Bethesda, MD, 2002
6. Conventional and Alternative Donor Transplantation for Severe Aplastic Anemia, National Institutes of Health (NIH) Bone Marrow Failure Scientific Symposium, Bethesda, MD, 2005
7. CPOE in Pediatric Oncology and Bone Marrow Transplantation, Eclipsys User Network Annual Conference, 2006
8. My Patient has Severe Aplastic Anemia. What do I do now?, Association of Pediatric Hematology/Oncology Nurses Annual Meeting, Hartford, CT, 2006
9. Pediatric Issues Regarding Severe Aplastic Anemia & Myelodysplasia, Aplastic Anemia & MDS International Foundation Bone Marrow Failure Scientific Symposium - Patient and Family Conference, Las Vegas, NV, 7/2007
10. Pediatric Issues Regarding Severe Aplastic Anemia & Myelodysplasia, Aplastic Anemia & MDS International Foundation Bone Marrow Failure Scientific Symposium - Patient and Family Conference, Bethesda, MD, 7/2008
11. Aplastic Anemia 101 and Everything You Wanted to Ask Your Child’s Doctor, Aplastic Anemia & MDS International Foundation Bone Marrow Failure Scientific Symposium - Patient and Family Conference, Indianapolis, IN, 7/2009
12. Pediatric Issues: An Intimate Q&A Session for Parents of Pediatric Patients, Aplastic Anemia & MDS International Foundation Bone Marrow Failure Scientific Symposium - Patient and Family Conference, Bethesda, MD, 7/2010
13. Aplastic Anemia 101, Aplastic Anemia & MDS International Foundation Bone Marrow Failure Scientific Symposium - Patient and Family Conference, Bethesda, MD, 7/2010
14. Bone Marrow Transplantation for Aplastic Anemia, Aplastic Anemia & MDS International Foundation Patient & Family Conference - Living with Aplastic Anemia, MDS or PNH, San Francisco, CA, 7/2011
15. Hematopoietic Progenitor Cell Transplants for Severe Aplastic Anemia in Children: Are We Ready for “Prime Time”?, Aplastic Anemia & MDS International Foundation Bone Marrow Failure Scientific Symposium - Hematopoietic Cell Transplantation for Aplastic Anemia, MDs & PHN Session, Bethesda, MD, 3/2012
 
PEER REVIEWED WORKSHOPS/PRESENTATIONS:
National
1. Cameron C, Woodliff J, McOlash L, Hari P, Bredeson C, Margolis D, Truitt RL, Use of a potassium channel blocker to inhibit effector-memory T cells isolated from recipients of allogeneic BMSCT, American Society of Hematology (ASH) 38th Annual Meeting - Poster Presentation, San Francisco, CA, 12/2008
2. Keever-Taylor CA, Konings S, Heidtke SM, Zeng H, Wieczorek SA, Tsao A, Margolis DA, Improved Cell Viability, Viable Cell Recovery and Faster Engraftment of Products Thawed Using a Premixed Solution of Human Serum Albumin and Dextran 40 Compared to Sequential Addition During the Thawing Procedure, American Society of Hematology (ASH) 40th Annual Meeting - Poster Presentation, Orlando, FL, 12/2010
3. Mehta PA, Davies SM, Duncan C, Guinan E, Klein E, Edwards S, Lehmann L, Margolis D, Williams D, Boulad F, Chemotherapy-only prepartive regimen for alternative donor hematopoietic stem cell transplantation for patients with Fanconi anemia, American Society for Blood and Marrow Transplantation (ASBMT) BMT Tandem Meetings - Poster Presentation, San Diego, CA, 2/2012
4. Mehta P, Davies S, Guinan E, Klein E, Lehmann L, Margolis D, Duncan C, Williams D, Boulad F, Multi-instituitional study of chemotherapy-only preparative regimen (without radiation) for alternative donor heamtopoietic stem cell transplantation for patients with fanconi anemia, an interim report, American Society of Hematology /Oncology (ASPHO) 25th Annual Meeting - Poster Presentation, New Orleans, LA, 4/2012
 
International
1. Mulberry M, Casper J, Margolis D, Talano J , A Case Report of a Pediatric Patient with T Cell Acute Lymphoblastic Leukemia (ALL) CR2 with Neurologic Deficits Secondary to Enterovirus Encephalitis with Substantial Recovery of Function Post Umbilical Cord Transplantation, 8th Annual International Umbilical Cord Blood Transplantation Symposium , San Francisco, CA, 6/2010
2. Mehta PA, Davies SM, Duncan C, Guinan E, Klein E, Edwards S, Lehmann L, Margolis D, Williams D, Boulad F, Chemotherapy-only prepartive regimen for alternative donor hematopoietic stem cell transplantation for patients with Fanconi anemia, Combined Annual Meetings of the American Society of Blood and Marrow Transplantation (ASBMT) and the International Bone Marrow Transplant Registry (IBMTR)/Autologous Blood and Marrow Transplant Registry (ABMTR) - Poster Presentation, San Diego, CA, 2/2012
 
COMMITTEE SERVICE:
Medical College
1997 - Present Member, Department of Pediatrics Residency Selection Committee, Medical College of Wisconsin
2009 - Present Member, Leadership Committee, Hematology/Oncology/BMT, Pediatrics, Medical College of Wisconsin
2009 - Present Member, Embryonic Stem Cell Research Oversight Committee, Medical College of Wisconsin
2010 - 2012 Member, CSG Marketing and Education Committee, Children's Specialty Group
2011 - Present Member, CSG Finance Committee, Children's Specialty Group
 
Hospital
1995 - Present Member, Tumor Board Committee, Children’s Hospital of Wisconsin
1998 - 2007 Member, Pharmacy and Therapeutics Committee, Children’s Hospital of Wisconsin
1999 - 2002 Member, Children’s Hospital Foundation Grant Reviewer, Children’s
2000 - 2004 Member, Nutrition Support Committee, Children’s Hospital of Wisconsin
2005 - Present Member, Informatics Physician Support Team, Children’s Hospital of Wisconsin
2007 - Present Member, Medical Records Committee, Children’s Hospital of Wisconsin
2011 - Present Elected Member, Board of Directors, Children’s Specialty Group
2011 - Present Member (voting), Pharmacy and Therapeutics committee of the Medical Staff, Children’s Hospital of Wisconsin
 
MEDICAL COLLEGE TEACHING ACTIVITIES:
Community/Lay Public
2005 Preceptor for SPUR Program for College Students
2007 Preceptor for SPUR Program for College Students
 
Medical Student Education
1993 - 1994 M2 Physical Diagnosis Course Preceptor
1996 - Present Biochemistry Small & Large Group Facilitator (M1)
1999 Pediatrics Summer Externship Program Preceptor
2000 - Present Medical Microbiology Lecturer
2000 - Present Ongoing Student Shadowing Experiences
2000 Visiting Summer Extern (New York Medical College) Preceptor
2002 Pediatrics Summer Externship Program Preceptor
2003 - Present Annual General Pediatric Ward Attending for Junior Medical Students (one-three months/year)
2007 Student Oncology Interest Group Advisor
2008 - Present GURU Program
2009 Summer Student Research Co-Preceptor
 
Resident and Fellow Education
1995 - Present Attending Physician, Hematology/Oncology/Transplant Unit Round with residents (and students) 24-32 weeks/year Interact with residents regarding bone marrow transplant patients daily
1995 - Present Resident Noon Conference Series, Surviving the Hematology/Oncology/Transplant Unit (provided annually to MCW interns)
1998 - Present Hematology/Oncology/Transplant Fellows Seminar Series Topics presented include Veno-occlusive disease, Selecting a Bone Marrow Donor, Indications for Bone Marrow Transplantation
1998 - 2005 Critical Care Fellows Core Conference Annual presentation on Graft vs. Host/Graft vs. Leukemia
2003 - Present Annual General Pediatric Ward Attending for General Inpatient Ward Team (one month/year)
2005 - Present Co-developer, Resident education website for HOT Unit rotation
2009 - 2011 Resident Teaching Advisor, Hematology/Oncology/Transplant Unit
 
EXTRAMURAL TEACHING (e.g. at Marquette, UWM, etc.):
Community/Lay Public
1999 - 2001 BloodCenter of Wisconsin, Preceptor for a summer students in my laboratory (College Student Education)
2004 BloodCenter of Wisconsin, Preceptor for a summer student doing clinical research (College Student Education)
 
Continuing Medical Education
1995 - Present Children's Hospital of Wisconsin, Hematology/Oncology/Transplant Unit Nursing Orientation - Child with Anemia, Veno-Occlusive Disease, and Graft vs. Host Disease
1997 - Present BloodCenter of Wisconsin, Transfusion Medicine Lecture Series (Ancillary Staff Education) - Pediatric Bone Marrow Transplantation
1999 - Present Children's Hospital of Wisconsin, Critical Care Services Nursing Orientation Series Children’s Hospital of Wisconsin Care of the Critically Ill Child with Cancer (annual)
 
Postdoctoral Fellow Education
1998 - 2005 BloodCenter of Wisconsin, Organizer, Combined Laboratory Journal Club Truitt and Gorski Laboratories Provided monthly for postdoctoral fellows, faculty and MSTP Students
 
COMMUNITY SERVICE ACTIVITIES:
1998 - 2004 Co-Chair, JCC/Rainbow Day Camp Committee
1998 - Present Make a Wish Foundation Medical Advisory Board
2012 - Present Jewish Community Center Board of Directors


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Bonadio WA, Margolis D, Tovar M. Enterobacter cloacae bacteremia in children: a review of 30 cases in 12 years. Clin Pediatr (Phila). 1991 May;30(5):310-3.
2. Chusid MJ, Russler SK, Mohr BA, Margolis DA, Hillery CA, Kehl KC. Unsuspected brucellosis diagnosed in a child as a result of an outbreak of laboratory-acquired brucellosis. Pediatr Infect Dis J. 1993 Dec;12(12):1031-3.
3. Margolis DA, Werlin SL, Murray KJ, Strother DR. Pancreatitis associated with brain tumor therapy. Am J Pediatr Hematol Oncol. 1994 Nov;16(4):301-4.
4. Beutler E, Westwood B, Melemed A, Dal Borgo P, Margolis D. Three new exon 10 glucose-6-phosphate dehydrogenase mutations. Blood Cells Mol Dis. 1995;21(1):64-72.
5. Margolis D, Camitta B, Pietryga D, Keever-Taylor C, Baxter-Lowe LA, Pierce K, Kupst MJ, French J 3rd, Truitt R, Lawton C, Murray K, Garbrecht F, Flomenberg N, Casper J. Unrelated donor bone marrow transplantation to treat severe aplastic anaemia in children and young adults. Br J Haematol. 1996 Jul;94(1):65-72.
6. Kawanishi Y, Passweg J, Drobyski WR, Rowlings P, Cook-Craig A, Casper J, Pietryga D, Garbrecht F, Camitta B, Horowitz M, Juckett M, Margolis D, Flomenberg N, Keever-Taylor CA. Effect of T cell subset dose on outcome of T cell-depleted bone marrow transplantation. Bone Marrow Transplant. 1997 Jun;19(11):1069-77.
7. Margolis D, Yassai M, Hletko A, McOlash L, Gorski J. Concurrent or sequential delta and beta TCR gene rearrangement during thymocyte development: individual thymi follow distinct pathways. J Immunol. 1997 Jul 15;159(2):529-33.
8. Juckett M, Rowlings P, Hessner M, Keever-Taylor C, Burns W, Camitta B, Casper J, Drobyski WR, Hanson G, Horowitz M, Lawton C, Margolis J, Peitryga D, Vesole D. T cell-depleted allogeneic bone marrow transplantation for high-risk non-Hodgkin's lymphoma: clinical and molecular follow-up. Bone Marrow Transplant. 1998 May;21(9):893-9.
9. Link CJ Jr, Burt RK, Traynor AE, Drobyski WR, Seregina T, Levy JP, Gordon L, Rosen ST, Burns WH, Camitta B, Casper J, Horowitz M, Juckett M, Lawton C, Margolis D, Pietryga D, Rowlings P, Taylor C, Furtado M, Stefka J, Gupta-Burt S, Kaiser H, Vesole DH. Adoptive immunotherapy for leukemia: donor lymphocytes transduced with the herpes simplex thymidine kinase gene for remission induction. HGTRI 0103. Hum Gene Ther. 1998 Jan 1;9(1):115-34.
10. Manley TJ, Chusid MJ, Rand SD, Wells D, Margolis DA. Reversible parkinsonism in a child after bone marrow transplantation and lipid-based amphotericin B therapy. Pediatr Infect Dis J. 1998 May;17(5):433-4.
11. Drobyski WR, Hessner MJ, Klein JP, Kabler-Babbitt C, Vesole DH, Margolis DA, Keever-Taylor CA. T-cell depletion plus salvage immunotherapy with donor leukocyte infusions as a strategy to treat chronic-phase chronic myelogenous leukemia patients undergoing HLA-identical sibling marrow transplantation. Blood. 1999 Jul 15;94(2):434-41.
12. Walters MC, Storb R, Patience M, Leisenring W, Taylor T, Sanders JE, Buchanan GE, Rogers ZR, Dinndorf P, Davies SC, Roberts IA, Dickerhoff R, Yeager AM, Hsu L, Kurtzberg J, Ohene-Frempong K, Bunin N, Bernaudin F, Wong WY, Scott JP, Margolis D, Vichinsky E, Wall DA, Wayne AS, Pegelow C, Redding-Lallinger R, Wiley J, Klemperer M, Mentzer WC, Smith FO, Sullivan KM. Impact of bone marrow transplantation for symptomatic sickle cell disease: an interim report. Multicenter investigation of bone marrow transplantation for sickle cell disease. Blood. 2000 Mar 15;95(6):1918-24.
13. Strasser SI, Shulman HM, Flowers ME, Reddy R, Margolis DA, Prumbaum M, Seropian SE, McDonald GB. Chronic graft-versus-host disease of the liver: presentation as an acute hepatitis. Hepatology. 2000 Dec;32(6):1265-71.
14. Margolis DA, Casper JT, Segura AD, Janczak T, McOlash L, Fisher B, Miller K, Gorski J. Infiltrating T cells during liver graft-versus-host disease show a restricted T-cell repertoire. Biol Blood Marrow Transplant. 2000;6(4):408-15.
15. Keever-Taylor CA, Klein JP, Eastwood D, Bredeson C, Margolis DA, Burns WH, Vesole DH. Factors affecting neutrophil and platelet reconstitution following T cell-depleted bone marrow transplantation: differential effects of growth factor type and role of CD34(+) cell dose. Bone Marrow Transpl. 2001 Apr;27(8):791-800.
16. Epperson DE, Margolis DA, McOlash L, Janczak T, Barrett AJ. In vitro T-cell receptor V beta repertoire analysis may identify which T-cell V beta families mediate graft-versus-leukaemia and graft-versus-host responses after human leucocyte antigen-matched sibling stem cell transplantation. Br J Haematol. 2001 Jul;114(1):57-62.
17. Whelan HT, Smits RL Jr, Buchman EV, Whelan NT, Turner SG, Margolis DA, Cevenini V, Stinson H, Ignatius R, Martin T, Cwiklinski J, Philippi AF, Graf WR, Hodgson B, Gould L, Kane M, Chen G, Caviness J. Effect of NASA light-emitting diode irradiation on wound healing. J Clin Laser Med Surg. 2001 Dec;19(6):305-14.
18. Keever-Taylor CA, Margolis D, Konings S, Sandford GR, Nicolette CA, Lawendowski C, Burns WH. Cytomegalovirus-specific cytolytic T-cell lines and clones generated against adenovirus-pp65-infected dendritic cells. Biol Blood Marrow Transplant. 2001;7(5):247-56.
19. Keever-Taylor CA, Bredeson C, Loberiza FR, Casper JT, Lawton C, Rizzo D, Burns WH, Margolis DA, Vesole DH, Horowitz M, Zhang MJ, Juckett M, Drobyski WR. Analysis of risk factors for the development of GVHD after T cell-depleted allogeneic BMT: effect of HLA disparity, ABO incompatibility, and method of T-cell depletion. Biol Blood Marrow Transplant. 2001;7(11):620-30.
20. Drobyski WR, Klein J, Flomenberg N, Pietryga D, Vesole DH, Margolis DA, Keever-Taylor CA. Superior survival associated with transplantation of matched unrelated versus one-antigen-mismatched unrelated or highly human leukocyte antigen-disparate haploidentical family donor marrow grafts for the treatment of hematologic malignancies: establishing a treatment algorithm for recipients of alternative donor grafts. Blood. 2002 Feb 1;99(3):806-14.
21. Whelan HT, Connelly JF, Hodgson BD, Barbeau L, Post AC, Bullard G, Buchmann EV, Kane M, Whelan NT, Warwick A, Margolis D. NASA light-emitting diodes for the prevention of oral mucositis in pediatric bone marrow transplant patients. J Clin Laser Med Surg. 2002 Dec;20(6):319-24.
22. Keever-Taylor CA, Behn B, Konings S, Orentas R, Davies B, Margolis D. Suppression of EBV release from irradiated B lymphoblastoid cell-lines: superior activity of ganciclovir compared with acyclovir. Cytotherapy. 2003;5(4):323-35.
23. Kasow KA, Bonfim C, Asch J, Margolis DA, Jenkins J, Tamburro RF, Handgretinger R, Horwitz EM. Malignant infantile osteopetrosis and primary pulmonary hypertension: a new combination? Pediatr Blood Cancer. 2004 Feb;42(2):190-4.
24. Orentas RJ, Schauer DW Jr, Ellis FW, Walczak J, Casper JT, Margolis DA. Monitoring and modulation of Epstein-Barr virus loads in pediatric transplant patients. Pediatr Transplant. 2003 Aug;7(4):305-14.
25. Abed N, Casper JT, Camitta BM, Margolis D, Trost B, Orentas R, Chang CC. Evaluation of histogenesis of B-lymphocytes in pediatric EBV-related post-transplant lymphoproliferative disorders. Bone Marrow Transplant. 2004 Feb;33(3):321-7.
26. Rosenblum MD, LaBelle JL, Chang CC, Margolis DA, Schauer DW, Vesole DH. Efficacy of alemtuzumab treatment for refractory T-cell large granular lymphocytic leukemia. Blood. 2004 Mar 1;103(5):1969-71.
27. Eells JT, Wong-Riley MT, VerHoeve J, Henry M, Buchman EV, Kane MP, Gould LJ, Das R, Jett M, Hodgson BD, Margolis D, Whelan HT. Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy. Mitochondrion. 2004 Sep;4(5-6):559-67.
28. Dincer AP, Gottschall J, Margolis DA. Splenic rupture in a parental donor undergoing peripheral blood progenitor cell mobilization. J Pediatr Hematol Oncol. 2004 Nov;26(11):761-3.
29. Conlon JD, Dauenhauer M, Tonkovic-Capin V, Talano J, Margolis D, Drolet BA, Fairley JA. Voriconazole-induced blistering in the setting of graft versus host disease: A report of 2 patients. J Am Acad Dermatol. 2008 Mar;58(3):484-7.
30. Talano JM, Casper JT, Camitta BM, Keever-Taylor CA, Murray KJ, Eapen M, Pierce KL, Margolis DA. Alternative donor bone marrow transplant for children with Philadelphia chromosome ALL. Bone Marrow Transpl. 2006 Jan;37(2):135-41.
31. Webber KA, Kos L, Holland KE, Margolis DA, Drolet BA. Intertriginous eruption associated with chemotherapy in pediatric patients. Arch Dermatol. 2007 Jan;143(1):67-71.
32. Desmet KD, Paz DA, Corry JJ, Eells JT, Wong-Riley MT, Henry MM, Buchmann EV, Connelly MP, Dovi JV, Liang HL, Henshel DS, Yeager RL, Millsap DS, Lim J, Gould LJ, Das R, Jett M, Hodgson BD, Margolis D, Whelan HT. Clinical and experimental applications of NIR-LED photobiomodulation. Photomed Laser Surg. 2006 Apr;24(2):121-8.
33. Eggleston B, Patience M, Edwards S, Adamkiewicz T, Buchanan GR, Davies SC, Dickerhoff R, Donfield S, Feig SA, Giller RH, Haight A, Horan J, Hsu LL, Kamani N, Lane P, Levine JE, Margolis D, Moore TB, Ohene-Frempong K, Redding-Lallinger R, Roberts IA, Rogers ZR, Sanders JE, Scott JP, Sleight B, Thompson AA, Sullivan KM, Walters MC, Multicenter Study of HCT for SCA Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia. Br J Haematol. 2007 Feb;136(4):673-6.
34. Zhu F, Ramadan G, Davies B, Margolis DA, Keever-Taylor CA. Stimulation by means of dendritic cells followed by Epstein-Barr virus-transformed B cells as antigen-presenting cells is more efficient than dendritic cells alone in inducing Aspergillus f16-specific cytotoxic T cell responses. Clin Exp Immunol. 2008 Feb;151(2):284-96.
35. Walters MC, Hardy K, Edwards S, Adamkiewicz T, Barkovich J, Bernaudin F, Buchanan GR, Bunin N, Dickerhoff R, Giller R, Haut PR, Horan J, Hsu LL, Kamani N, Levine JE, Margolis D, Ohene-Frempong K, Patience M, Redding-Lallinger R, Roberts IA, Rogers ZR, Sanders JE, Scott JP, Sullivan KM, Multicenter Study of Bone Marrow Transplantation for Sickle Cell Disease Pulmonary, gonadal, and central nervous system status after bone marrow transplantation for sickle cell disease. Biol Blood Marrow Transplant. 2010 Feb;16(2):263-72.
36. Zhu F, Xu H, Tsao A, Margolis DA, Keever-Taylor CA. Generation of cytotoxic T-cell lines using overlapping pentadecapeptides derived from conserved regions of the adenovirus hexon protein. J Gen Virol. 2010 Jun;91(Pt 6):1577-89.
37. Woodard P, Carpenter PA, Davies SM, Gross TG, He W, Zhang MJ, Horn BN, Margolis DA, Perentesis JP, Sanders JE, Schultz KR, Seber A, Woods WG, Eapen M. Unrelated donor bone marrow transplantation for myelodysplastic syndrome in children. Biol Blood Marrow Transplant. 2011 May;17(5):723-8.
38. Anderson L, Gregg D, Margolis D, Casper J, Talano J. Focal nodular hyperplasia in pediatric allogeneic hematopoietic cell transplant: case series. Bone Marrow Transpl. 2010 Aug;45(8):1357-9.
39. Mayer AN, Dimmock DP, Arca MJ, Bick DP, Verbsky JW, Worthey EA, Jacob HJ, Margolis DA. A timely arrival for genomic medicine. Genet Med. 2011 Mar;13(3):195-6.
40. Worthey EA, Mayer AN, Syverson GD, Helbling D, Bonacci BB, Decker B, Serpe JM, Dasu T, Tschannen MR, Veith RL, Basehore MJ, Broeckel U, Tomita-Mitchell A, Arca MJ, Casper JT, Margolis DA, Bick DP, Hessner MJ, Routes JM, Verbsky JW, Jacob HJ, Dimmock DP. Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease. Genet Med. 2011 Mar;13(3):255-62.
41. Hodgson BD, Margolis DM, Salzman DE, Eastwood D, Tarima S, Williams LD, Sande JE, Vaughan WP, Whelan HT. Amelioration of oral mucositis pain by NASA near-infrared light-emitting diodes in bone marrow transplant patients. Support Care Cancer. 13. Hodgson BD, Margolis DM, Salzman DE, Eastwood D, Tarima S, Williams LD, Sande JE, Vaughan WP, Whelan HT. Amelioration of oral mucositis pain by NASA near-infrared light-emitting diodes in bone marrow transplant patients. Support Care Cancer. 2012 Jul;20(7):1405-15. doi: 10.1007/s00520-011-1223-8. Epub 2011 Jul 3.
42. Biank VF, Sheth MK, Talano J, Margolis D, Simpson P, Kugathasan S, Stephens M. Association of Crohn's disease, thiopurines, and primary epstein-barr virus infection with hemophagocytic lymphohistiocytosis. J Pediatr. 2011 Nov;159(5):808-12. doi: 10.1016/j.jpeds.2011.04.045. Epub 2011 Jun 30.
43. Sultan M, Ramprasad J, Jensen MK, Margolis D, Werlin S Endoscopic Diagnosis of Pediatric Acute Gastrointestinal Graft Versus Host Disease. J Pediatr Gastroenterol Nutr. 2012 Oct;55(4):417-20
44. Verbsky JW, Baker MW, Grossman WJ, Hintermeyer M, Dasu T, Bonacci B, Reddy S, Margolis D, Casper J, Gries M, Desantes K, Hoffman GL, Brokopp CD, Seroogy CM, Routes JM Newborn screening for severe combined immunodeficiency; the Wisconsin experience (2008-2011). J Clin Immunol. 2012 Feb;32(1):82-8.
45. Marsh RA, Rao K, Satwani P, Lehmberg K, Müller I, Li D, Kim MO, Fischer A, Latour S, Sedlacek P, Barlogis V, Hamamoto K, Kanegane H, Milanovich S, Margolis DA, Dimmock D, Casper J, Douglas DN, Amrolia PJ, Veys P, Kumar AR, Jordan MB, Bleesing JJ, Filipovich AH. Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes. Blood. 2013 Feb 7;121(6):877-83. doi: 10.1182/blood-2012-06-432500. Epub 2012 Nov 6.
46. Buchbinder D, Hsieh L, Puthenveetil G, Soni A, Stites J, Huynh V, Kirov I, Neudorf S, Rubin E, Sender L, Torno L, Margolis D, Childs R, Moore T, Nugent D Successful autologous cord blood transplantation in a child with acquired severe aplastic anemia. Pediatr Transplant. 2013 May;17(3):E104-7
47. Jacob HJ, Abrams K, Bick DP, Brodie K, Dimmock DP, Farrell M, Geurts J, Harris J, Helbling D, Joers BJ, Kliegman R, Kowalski G, Lazar J, Margolis DA, North P, Northup J, Roquemore-Goins A, Scharer G, Shimoyama M, Strong K, Taylor B, Tsaih SW, Tschannen MR, Veith RL, Wendt-Andrae J, Wilk B, Worthey EA Genomics in clinical practice: lessons from the front lines. Sci Transl Med. 2013 Jul 17;5(194):194cm5
48. Eckrich MJ, Ahn KW, Champlin RE, Coccia P, Godder K, Horan J, Margolis D, Deeg HJ, Eapen M. Effect of race on outcomes after allogeneic hematopoietic cell transplantation for severe aplastic anemia. Am J Hematol.2013 Oct 3.doi: 10.1002/ajh.23594.
 
Books, Chapters, and Reviews
1. Margolis DA, Camitta B. Clinical correlation of glucocorticoid receptor content in childhood acute lymphoblastic leukemia. In: Gametchu B, ed. Glucocorticoid Receptor Structure and Leukemic Cell Responses. New York, NY: Springer-Verlag; 1995: 155-162.
2. Margolis DA, Camita BM. Hematopoietic stem cell transplantation for severe aplastic anemia. Curr Opin Hematol. 1998 Nov;5(6):441-4.
3. Margolis DA, Casper J. Allogeneic transplantation for acute myeloid leukemia in children. In: Forman SJ, Blum KG, Donnell Thomas E, ed. Hematopoietic cell transplantation. 2nd ed. Oxford: Blackwell Science Ltd.; 1999: Ch 71.
4. Margolis DA, Casper JT. Alternative-donor hematopoietic stem-cell transplantation for severe aplastic anemia. Semin Hematol. 2000 Jan;37(1):43-55.
5. Margolis D, Casper J. Allogeneic Transplantaiton for Acute Myeloid Leukemia in Children. In: Blume KG, Forman SJ, Appelbaum FR, eds. Thomas' Hematopoietic Cell Transplantation, 3rd Edition. Oxford: Blackwell Science Ltd.; 2004: Ch 76.
6. Talano JA, Margolis DA. Recent molecular and cellular advances in pediatric bone marrow transplantation. Pediatr Clin North Am. 2006 Aug;53(4):685-98.
7. Talano JM, Casper J, Margolis DA. Hematopoietic Cell Transplantation for Childhood Acute Myeloid Leukemia. In: Blum KG, Forman SJ, eds. Thomas' Hematopoietic Cell Transplantation, 4th edition. Oxford: Blackwell Science Ltd.; 2007: Ch 54.
 
Editorials, Letters to Editor, Other
1. Barklage NE, Jefferson JW, Margolis D. Do monoamine oxidase inhibitors alter carbamazepine blood levels? J Clin Psychiatry. 1992 Jul;53(7):258.
 
Abstracts
1. Last 5 years listed - additional abstracts available upon request
2. Zhu F, Ramadan G, Davies B, Margolis DA, Keever-Taylor CA. Stimulation by means of dendritic cells followed by Epstein-Barr virus-transformed B cells as antigen-presenting cells is more efficient than dendritic cells along in inducing Aspergillus f16-specific cytotoxic T cell responses. Clin Exp Immunol. 2008 Feb;151(2):284-96.
3. Cameron C, Woodliff J, McOlash L, Hari P, Bredeson C, Margolis D, Truitt RL. Use of a potassium channel blocker to inhibit effector-memory T cells isolated from recipients of allogeneic BMSCT. Blood (American Society of Hematology Annual Meeting Abstracts). 2008 Nov;112(11):1154.
4. Talano JA, Brown J, McArthur J, Mulberry M, Eastwood D, Ahn KW, Casper JT, Margolis DA. Analysis of the incidence and characteristics of venoocclusive disease (VOD) of the liver in pediatric hematopoietic progenitor cell transplant (HPCT) patients with heparin alone vs. heparin and ursodiol prophylaxis at the Medical College of Wisconsin. Blood (American Society of Hematology Annual Meeting Abstracts). 2009 Nov;114(22):4306.
5. Keever-Taylor CA, Konings S, Heidtke SM, Zeng H, Wieczorek SA, Tsao A, Margolis DA. Improved Cell Viability, Viable Cell Recovery and Faster Engraftment of Products Thawed Using a Premixed Solution of Human Serum Albumin and Dextran 40 Compared to Sequential Addition During the Thawing Procedure. Blood (American Society of Hematology Annual Meeting Abstracts). 2010 Nov;116:2248.
6. Mehta P, Davies S, Guinan E, Klein E, Lehmann L, Margolis D, Duncan C, Williams D, Boulad F. Multi-instituitional study of chemotherapy-only preparative regimen (without radiation) for alternative donor heamtopoietic stem cell transplantation for patients with fanconi anemia, an interim report. 2012 ASPHO Abstracts. Pediatr. Blood Cancer. 2012 Apr 16; 58:1020(poster 503).
7. Mehta PA, Davies SM, Duncan C, Guinan E, Klein E, Edwards S, Lehmann L, Margolis D, Williams D, Boulad F. Chemotherapy-only prepartive regimen for alternative donor hematopoietic stem cell transplantation for patients with Fanconi anemia. Biol Blood Marrow Transplant. 2012 Feb; 18(2,suppl):S301-S302.
 
Database, Video, or Other Research/Clinical Contributions
1. Blue Sky Broadcast. 2010. Aplastic Anemia 101 [webcast]. Retrieved from http://www.aamds.org/webcast/aplastic-anemia-101-0.