1. Liu S, Wilcox DA, Sieber-Blum M, Wong-Riley M Developing neural crest cells in culture: correlation of cytochrome oxidase activity with SSEA-1 and dopamine-beta-hydroxylase immunoreactivity. Brain Res. 1990 Dec 10;535(2):271-80

2. Wilcox DA, Wautier JL, Pidard D, Newman PJ A single amino acid substitution flanking the fourth calcium binding domain of alpha IIb prevents maturation of the alpha IIb beta 3 integrin complex. J Biol Chem. 1994 Feb 11;269(6):4450-7

3. Wilcox DA, Paddock CM, Lyman S, Gill JC, Newman PJ Glanzmann thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb. Role of the GPIIb amino terminus in integrin subunit association. J Clin Invest. 1995 Apr;95(4):1553-60

4. Wilcox DA, Olsen JC, Ishizawa L, Griffith M, White GC 2nd Integrin alphaIIb promoter-targeted expression of gene products in megakaryocytes derived from retrovirus-transduced human hematopoietic cells. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9654-9

5. Shiraga M, Ritchie A, Aidoudi S, Baron V, Wilcox D, White G, Ybarrondo B, Murphy G, Leavitt A, Shattil S Primary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signaling. J Cell Biol. 1999 Dec 27;147(7):1419-30

6. Wilcox DA, Olsen JC, Ishizawa L, Bray PF, French DL, Steeber DA, Bell WR, Griffith M, White GC 2nd Megakaryocyte-targeted synthesis of the integrin beta(3)-subunit results in the phenotypic correction of Glanzmann thrombasthenia. Blood. 2000 Jun 15;95(12):3645-51

7. Shi Q, Wilcox DA, Fahs SA, Kroner PA, Montgomery RR Expression of human factor VIII under control of the platelet-specific alphaIIb promoter in megakaryocytic cell line as well as storage together with VWF. Mol Genet Metab. 2003 May;79(1):25-33

8. Wilcox DA, White GC 2nd Gene therapy for platelet disorders: studies with Glanzmann's thrombasthenia. J Thromb Haemost. 2003 Nov;1(11):2300-11

9. Yarovoi HV, Kufrin D, Eslin DE, Thornton MA, Haberichter SL, Shi Q, Zhu H, Camire R, Fakharzadeh SS, Kowalska MA, Wilcox DA, Sachais BS, Montgomery RR, Poncz M Factor VIII ectopically expressed in platelets: efficacy in hemophilia A treatment. Blood. 2003 Dec 1;102(12):4006-13

10. Wilcox DA, Shi Q, Nurden P, Haberichter SL, Rosenberg JB, Johnson BD, Nurden AT, White GC 2nd, Montgomery RR Induction of megakaryocytes to synthesize and store a releasable pool of human factor VIII. J Thromb Haemost. 2003 Dec;1(12):2477-89

11. Niemeyer GP, Boudreaux MK, Goodman-Martin SA, Monroe CM, Wilcox DA, Lothrop CD Jr Correction of a large animal model of type I Glanzmann's thrombasthenia by nonmyeloablative bone marrow transplantation. Exp Hematol. 2003 Dec;31(12):1357-62

12. Shi Q, Wilcox DA, Morateck PA, Fahs SA, Kenny D, Montgomery RR Targeting platelet GPIbalpha transgene expression to human megakaryocytes and forming a complete complex with endogenous GPIbbeta and GPIX. J Thromb Haemost. 2004 Nov;2(11):1989-97

13. Fang J, Hodivala-Dilke K, Johnson BD, Du LM, Hynes RO, White GC 2nd, Wilcox DA Therapeutic expression of the platelet-specific integrin, alphaIIbbeta3, in a murine model for Glanzmann thrombasthenia. Blood. 2005 Oct 15;106(8):2671-9

14. Shi Q, Wilcox DA, Fahs SA, Weiler H, Wells CW, Cooley BC, Desai D, Morateck PA, Gorski J, Montgomery RR Factor VIII ectopically targeted to platelets is therapeutic in hemophilia A with high-titer inhibitory antibodies. J Clin Invest. 2006 Jul;116(7):1974-82

15. Shi Q, Wilcox DA, Fahs SA, Fang J, Johnson BD, DU LM, Desai D, Montgomery RR Lentivirus-mediated platelet-derived factor VIII gene therapy in murine haemophilia A. J Thromb Haemost. 2007 Feb;5(2):352-61

16. Ghevaert C, Wilcox DA, Fang J, Armour KL, Clark MR, Ouwehand WH, Williamson LM Developing recombinant HPA-1a-specific antibodies with abrogated Fcgamma receptor binding for the treatment of fetomaternal alloimmune thrombocytopenia. J Clin Invest. 2008 Aug;118(8):2929-38

17. Shi Q, Fahs SA, Wilcox DA, Kuether EL, Morateck PA, Mareno N, Weiler H, Montgomery RR Syngeneic transplantation of hematopoietic stem cells that are genetically modified to express factor VIII in platelets restores hemostasis to hemophilia A mice with preexisting FVIII immunity. Blood. 2008 Oct 1;112(7):2713-21

18. Mendoza SA, Fang J, Gutterman DD, Wilcox DA, Bubolz AH, Li R, Suzuki M, Zhang DX TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress. Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H466-76

19. Gao C, Boylan B, Fang J, Wilcox DA, Newman DK, Newman PJ Heparin promotes platelet responsiveness by potentiating αIIbβ3-mediated outside-in signaling. Blood. 2011 May 5;117(18):4946-52

20. Fang J, Jensen ES, Boudreaux MK, Du LM, Hawkins TB, Koukouritaki SB, Cornetta K, Wilcox DA Platelet gene therapy improves hemostatic function for integrin alphaIIbbeta3-deficient dogs. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9583-8

1. Wilcox, D. A., White II, G.C. Gene therapy for platelet disorders. In: Platelets. A.D. Michelson (ed.), Academic Press, San Diego, Chapter 61: 927-37, 2002.

2. Wilcox, D.A. White II, G.C. Gene therapy for platelet disorders: studies with glanzmann's thrombasthenia. Journal of Thrombosis and Haemostasis. 1: 2300-2311, 2003.

3. Wilcox, D. A., White II, G.C: Gene therapy for platelet disorders. In: Platelets. Second Edition, A.D. Michelson (ed.), Academic Press, San Diego, Chapter 71: 1313-1325, 2007.

1. Co-inventor , Methods and Compositions for Enhancing Cell Adhesion Properties. U.S. Patent Application No. 11/118,712; International No. PCT/US2005/015120. U.S. Patent No. 7,939,326 awarded May 10, 2011

1. Wilcox DA, Sieber-Blum M. Monoclonal antibody, B-1A11, to a cell surface epitope recognizes a subpopulation of early neural crest cells. Society for Neuroscience Abstracts. 1989;15 a:352.3

2. Wilcox DA, Wautier JL, Pidard D, Newman PJ. An amino acid substitution within the fourth calcium-binding region of GPIIb results in degradation of the integrin GPIIb-IIIa and type I glanzmann thrombasthenia. Circulation. 1992;86 a:2713

3. Valentin N, Wilcox DA, Newman PJ. Disruption of the GPIIIa cys5-cys435 disulfide bonded-loop: effects on the PlA1 epitope and GPIIb-IIIa complex formation. Blood. 1993;82 a:826

4. Wilcox, D. A., Gill, J., and Newman, P. J. Glanzmann thrombasthenia resulting from a single amino acid substitution flanking the fibrinogen gamma-chain dodecapeptide-binding domain on GPIIb, Blood. 82 a:824, 1993.

5. Wilcox, D. A., Olsen, J. C., and White II, G.C. Retrovirus mediated gene therapy for glanzmann thrombasthenia: tissue-specific transcription and synthesis of the GPIIIa PlA2 alloantigen within cells homozygous for PlA1, Blood. 88 a:108, 1996.

6. Wilcox, D. A., Olsen, J. C., Ishizawa, L., Bray, P.F., French, D.L., Bell, W.R., Griffith, M., and White II, G.C. Phenotypic correction of Glanzmann's thrombasthenia following megakaryocyte-targeted synthesis of the integrin β3-subunit, Blood. 90 a:1236, 1997.

7. Wilcox, D. A., Hodivala-Dilke, K.M., Hynes, R.O., and White II, G.C. Of mice and men: detection of a functional murine IIb3 heterodimer complex on the surface of megakaryocytes derived from retrovirus transduced bone marrow cells from β3-knockout mice, Blood. 92 a:2885, 1998.

8. Wilcox, D. A., Hodivala-Dilke, K.M., Steeber, D.A., Shattil, S.J., Hynes, R.O., and White II, G.C. Expression of a functional murine αIIβ-human β3 heterodimer complex on the surface of megakaryocytes derived from β3 3-knockout mice, Thrombosis and Haemostasis. 82 a:1168, 1999.

9. Shiraga, M., Richie, A., Aidoudi, S., Baron, V., Wilcox, D., White, G., Ybarrando, B., Murphy, G., Leavitt, A., and Shattil, S.A. A role for transcription factor NF-E2 in the regulation of integrin alphaIIb-beta3 signaling, Blood. 94 a:2750, 1999.

10. Wilcox, D.A., Rosenberg, J.B., White II, G.C., and Montgomery, R.R. Factor VIII (FVIII) trafficks to megakaryocyte alpha-granules following retroviral transduction of human CD34+ cells, Blood. 94 a:1962, 1999.

11. Wilcox, D.A., Rosenberg, J.B., Johnson, B.D., and Montgomery, R.R. Storage of factor VIII (FVIII) in the alpha granules of human platelets following retroviral transduction and transplantation of human CD34+ cells into nod-scid mice, Blood. 96 a:3467, 2000.

12. Wilcox, D. A., Kiem, H.-P., Johnson, B.D., Nash, R.A., Catalfamo, J.L., and Boudreaux, M.K. Transgene expression targeted in canine megakaryocytes as a model for gene therapy of lineage-specific disorders, Thrombosis and Haemostasis. 86 a:5757, 2001.

13. Boudreaux, M.K., Niemeyer, G.P., Wilcox, D.A., Brawner, W.R., Lothrop, Jr., C.D. Correction of type I glanzmann's thrombathenia in great pyrenees dogs by nonmyeloablative marrow transplantation, Blood. 98 a:721, 2001.

14. Shi, Q., Fahs, S.A., Wilcox, D.A., Kroner, P.A., Montgomery, R.R. Endothelial, platelet, and hepatic-specific expression of human FVIII and the effect of von Willebrand factor, Blood. 100 a:1906, 2002.

15. Wilcox, D.A., Hodivala-Dilke, K.M., Johnson, B.D., Hynes, R.O., and White II , G.C. Lineage-Specific Correction of glanzmann thrombasthenia by expression of a functional hybrid murine-human IIb3 integrin complex on the surface of platelets of b3 knockout mice, Blood. 100 a:3419, 2002.

16. Wilcox, D.A., Targeting transgene expression in canine megkaryocytes derived from lentivirus-transduced G-CSF mobilized CD34+ peripheral blood cells, Blood. 100 a:1713, 2002.

17. Wilcox, D.A., Hodivala-Dilke, K.M., Johnson, B.D., Hynes, R.O.,White II , G.C. Therapeutic expression of a platelet-specific integrin, aIIbβ3, Molecular Therapy. 7 a:398, 2003.

18. Wilcox, D.A., Targeting transgene expression in canine megakaryocytes, Molecular Therapy. 7 a:1127, 2003.

19. Wilcox, D.A., Hodivala-Dilke, K.M., Johnson, B.D., Hynes, R.O., and White II , G.C. Lineage-Specific Correction of a hemorrhagic disorder affecting platelets: gene therapy for glanzmann thrombasthenia, Journal of Thrombosis and Haemostasis. 1 a:130, 2003.

20. Yarovoi, H., Kufrin, D., Eslin, D.E., Zhu, H., Camire, R. Wilcox, D., Montgomery, R.R., Kowalska, M.A., Poncz, M. A transgenic mouse model demonstrates the efficacy of factor FVIII ectopically expressed in platelets for Haemophilia A treatment. Journal of Thrombosis and Haemostasis. 1 a:131, 2003.

21. Wilcox, D.A., Shi, Q., Nurden, P., Haberichter, S.L., Rosenberg, J.B., Johnson, B.D., Nurden, A.T., White II, G.C., Montgomery, R.R. EM localization and agonist-induced release of human FVIII from megakaryocytes transduced with a FVIII transgene, Blood. 102 a:297, 2003.

22. Yarovoi, H., King, M., Eslin, D.E., Haberichter, S.L., Shi, Q., Kowalska, M.A., Wilcox, D., Sachais, B.S., Montgomery, R.R., , Poncz, M. Demonstration that platelet-expressed human B-domainless Factor VIII can ameliorate the bleeding diathesis in a murine model of Haemophilia A. Blood. 102 a:175, 2003.

23. Shi, Q., Wilcox, D.A., Morateck, P., Fahs, S.A., Kenny, D., Montgomery, R.R. Targeting platelet GPIb transgene expression to megakaryocytes using a lentiviral vector and its potential for gene therapy of bernard soulier syndrome, Blood. 102 a:1029, 2003.

24. Patel, M., Wilcox D.A.., Giddings, A.M., McKay, T.R., Olsen, J.C. Modification of HEK 293 Cell Integrin Expression Profile Allows Convenient Large-Scale Roller Bottle Production of Lentiviral Vectors, Molecular Therapy. 9 a:81, 2004.

25. Du, L.M., Wilcox, D.A. Gene Therapy for Platelet Disorders: Targeting Transgene Expression in Canine Platelets, Molecular Therapy. 9 a:919, 2004.

26. Fang, J, Johnson, B.D., Wilcox, D.A. Assessing the Risk from Transfer of an Integrin β3 Gene that Encodes a Naturally Occurring Polymorphism Associated with Acute Coronary Thrombosis, Molecular Therapy. 9, a:920, 2004.

27. Yoshida, T., Gomez, J., Gama, V., Wickramasekera, N.T., Wilcox, D.A., Matsuyama, S. Bax inhibiting peptides (BIPs) derived from Ku70 suppress chemotherapy induced-cell death of megakaryoocytes, Blood. 104, a:1262, 2004.

28. Shi, Q., Wilcox, D.A., Fahs, S.A., Fang J, Johnson, B.D., Weiler, H., Montgomery, R.R. Lentivirus-Mediated Platelet-Specific Gene Therapy for Hemophilia A, Blood. 104, a:2974, 2004.

29. Wilcox, D.A., Fang, J., Du, L.M., and Boudreaux, M.K. Drug-selectable as well as therapeutic gene transfer into hematopoietic stem cells may be essential for gene therapy of inherited bleeding disorders in large animals, Molecular Therapy. 11, a:340, 2005.

30. Wilcox, D.A., Fang, J., Johnson, B.D., Valentin, N. Modulating murine platelet function by expressing integrin αIIbβ3 locked-in its high affinity state, Journal of Thrombosis and Haemostasis. 3 a:OR108, 2005.

31. Boylan, B., Wilcox, D.A., Newman, D.K., Kahn, M.L., Newman, P.J. Immunodepletion of GPVI from human platelets circulating in NOD/SCID mice: development of a novel animal model for evaluating the therapeutic efficacy of compounds that affect human platelet function and survival, Journal of Thrombosis and Haemostasis. 3 a:OR284, 2005.

32. Shi, Q., Wilcox, D.A., Fahs, S.A., Weiler, H., Montgomery, R.R. Platelet-derived factor VIII (FVIII) is protected from inhibitor inactivation - an approach for gene therapy of hemophilia A even in the presence of FVIII inhibitors, Journal of Thrombosis and Haemostasis. 3 a:H05, 2005.

33. Shi, Q., Wilcox, D.A., Fahs, S.A., Fang J, Johnson, B.D., Weiler, H., Montgomery, R.R. Murine hemophilia A is phenotypically corrected by platelet-expressed factor VIII even in the absence of detectable plasma FVIII, Journal of Thrombosis and Haemostasis. 3 a:OR186, 2005.

34. Wilcox, D.A., Fang, J., Lily M. Du, L.M., and Boudreaux, M.K. Phenotypic correction of a canine model for glanzmann thrombasthenia demonstrates efficacy for using platelets to deliver therapeutics at the site of vascular injury, Blood. 106, a:3045, 2005.

35. Wilcox, D.A., Therapeutic expression of IIb3 in murine and canine models of glanzmann thrombasthenia, Subcommittee Meeting on Platelets, Annual Meeting of the American Society of Hematology, Atlanta, GA, Blood. 106, Invited Presentation, 2005.

36. Shi, Q., Wilcox, D.A., Fahs, S.A., Cooley, B.C., Desai, D., Weiler, H., Morateck, P.A., Montgomery, R.R. Platelet-derived factor VIII (FVIII) corrects the murine hemophilia A phenotype even in the presence of FVIII inhibitors, Blood. 106, a:457, 2005.

37. Wilcox, D.A., Gene therapy for inherited platelet bleeding disorders, Annual Conference of the Haematology Society of Australia and New Zealand, Hobart, Tasmania, (Invited Presentation), October 15-18 2006.

38. Wilcox, D.A., Targeting Coagulation Factor VIII to platelets for gene therapy of Hemophilia A, Annual Conference of the Haematology Society of Australia and New Zealand, Hobart, Tasmania, (Invited Presentation), October 15-18 2006.

39. Fang, J., Jensen, E.S., Du, L.M., Boudreaux, M.K., Wilcox, D.A., Intravenous immunoglobulin (IVIG) diminishes immune-mediated clearance of platelets expressing an integrin IIb3 transgene product that restores hemostasis in a canine model for Glanzmann Thrombasthenia, Blood. 108, a:3263, 2006.

40. Shi, Q., Fahs, S.A., Wilcox, D.A., Weiler, H., Haberichter, S.L., Montgomery, R.R., Endothelial and Platelet FVIII/VWF Expression - Divergence in Clinical Effect in Murine Models of Hemophilia A with and without FVIII Inhibitory Antibodies, Blood. 108, a:3286, 2006.

41. Wilcox, D.A., Fang, J., Jensen, E.S., Du, L.M., and Boudreaux, M.K. Thereapeutic expression of a platelet-specific integrin restores hemostasis in dogs with glanzmann thrombasthenia, Molecular Therapy. , a:767, 2007.

42. Shi, Q., Fahs, S.A., Wilcox, D.A., Morateck, P.A., Montgomery, R.R. Transplant bone marrow that is genetically modified to express FVIII only in platelets can restore hemostasis to hemophilia A mice on a strong inhibitor background, Journal of Thrombosis and Haemostasis. a:P-W-232, 2007.

43. Ghevaert C., Wilcox, D.A., Fang, J., Ouwehand, W.H., Williamson, L.M. Recombinant human HPA-1A antibodies for treatment of feto-maternal allo-immune thrombocytopenia (FMAIT): proof of principle in an in vivo murine model, Journal of Thrombosis and Haemostasis. a:O-T-025, 2007.

44. Wilcox, D.A., Fang, J., Jensen, E.S., Du, L.M., and Boudreaux, M.K. Correction of haemorrhagic disorders affecting platelets: gene therapy restores hemostasis within a canine model for glanzmann thrombasthenia, Journal of Thrombosis and Haemostasis. a:O-S-024, 2007.

45. Qizhen Shi, Scot A Fahs, David A Wilcox, Erin L Kuether, Hartmut Weiler and Robert R Montgomery. In the Presence of Pre-existing Factor VIII (FVIII) Immunity, Hematopoietic Stem Cells (HSC) that Are Genetically Modified to Express FVIII in Platelets Were Successfully Transplanted into Hemophilic Mice Under Myeloablative and Various Non-myeloablative Conditions, Blood. a: 768, 2007.

46. Gomez JA, Gama V, Yoshida T, Stapleton M, Paddock C, Wilcox D, Newman P, Matsuyama S, Blockade of chemotherapy-induced thrombocytopenia by Bax Inhibiting Peptides (BIPs) in mouse model. Blood, a:281 2007.

47. David A. Wilcox, Juan Fang Eric S. Jensen, Lily M. Du, Mary K. Boudreaux. Hematopoietic stem cell gene therapy for inherited platelet bleeding disorders, Blood Cells, Molecules, and Diseases. 40,(2) a:291, 2008.

48. Ghevaert C., Wilcox, D.A., Fang, J., Armour, K.L., Clark, M.R., Ouwehand, W.H., Williamson, L.M. Recombinant Human HPA-1A Antibodies for Treatment of Fetomaternal AlloimmuneThrombocytopenia (FMAIT) : Proof of Principle in an in Vivo Murine Model and Human Volunteer Studies. Blood a:85, 2008.

49. Wilcox, D.A., Fang, J., North, P., Nurden P., Nurden A.T., Valentin, N. High Mortality in Mice with Platelets Expressing Integrin αIIbβ3 Locked-In Its High Affinity State, Blood a:1832, 2008.

50. David A. Wilcox, Lily M. Du, Sandra L. Haberichter, Paula M. Jacobi, Juan Fang, Eric S. Jensen, Qizhen Shi and Robert R. Montgomery. Platelet Targeted Expression of Coagulation Factor VIII (FVIII) Shows efficacy for using the dog as a large animal model for gene therapy of hemophilia A. Blood a:3525, 2008.

51. D.A. Wilcox, J. Fang, P. North, P. Nurden, A.T. Nurden, N. Valentin. There is a high mortality rate in mice when platelet integrin alphaIIbbeta3 is locked-in its high affinity state, J Thromb Haemost, 7, a:OC-TH-097, 2009.

52. C. Gao, B. Boylan, J. Fang, D.A. Wilcox, D.K. Newman, P.J. Newman. Antibody-independent, αIIbβ3-mediated activation of human platelets by unfractionated heparin, J Thromb Haemost, 7, a:AS-TH-009, 2009.

53. Qizhen Shi, Erin L. Kuether, Scot A. Fahs, Jocelyn Schroeder, David A. Wilcox, and Robert R. Montgomery. Sustained phenotypic correction of murine hemophilia A with pre-existing anti-FVIII immunity using lentivirus-mediated platelet-specific FVIII gene transfer. (Oral Presentation). Blood a:29, 2009.

54. Lily M. Du, Timothy C. Nichols, Sandra L. Haberichter, Paula M. Jacobi, Eric S. Jensen, Juan Fang, Qizhen Shi, Robert R. Montgomery, and David A. Wilcox. Platelet-Targeted Expression of Human BDD-FVIII Reduces Bleeding in Canine Hemophilia A. (Oral Presentation). Blood a:691, 2009.

55. Qizhen Shi, Erin L. Kuether, Jocelyn A. Schroeder, Scot A. Fahs, David A. Wilcox, and Robert R. Montgomery. The Important Role of Von Willebrand Factor In Platelet-Derived FVIII Gene Therapy of Murine Hemophilia A In The Presence of Inhibitors. Blood a:2201, 2010

56. Lily M. Du, Helen W.G. Franck, Elizabeth P. Merricks, Paquita Nurden, Eric S. Jensen, Sandra L. Haberichter, Troy B. Hawkins, Paula M. Jacobi, Juan Fang, Sevasti B. Koukouritaki, Alan T. Nurden, Qizhen Shi, Robert R. Montgomery, and David A. Wilcox. De novo synthesis & storage of Human FVIII in platelets reduces bleeding in canine Hemophilia A. Blood a:2198, 2010.

57. Lily M. Du, Helen W.G. Franck, Elizabeth P. Merricks, Paquita Nurden, Eric S. Jensen, Sandra L. Haberichter, Troy B. Hawkins, Paula M. Jacobi, Juan Fang, Sevasti B. Koukouritaki, Alan T. Nurden, Qizhen Shi, Robert R. Montgomery, and David A. Wilcox. Gene therapy targeting synthesis of coagulation factor viii in platelets reduces bleeding in canine hemophilia a. Awarded Best Abstract in Basic Research to be presented at the American Society for Bone Marrow Transplant, Hawaii a:3, Feb 19, 2011.