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CURRICULUM VITAE

Jill A. Gershan PhD
Assistant Professor
Department of Pediatrics
Division of Hematology/Oncology

OFFICE ADDRESS:
MACC Fund Research Center
8701 Watertown Plank Rd
Milwaukee, WI 53226

CITIZENSHIP:  US

EDUCATION:
8/1971 - 8/1975 BSN, University of Wisconsin, Madison, WI
8/1978 - 5/1980 MSN, University of Southern California, Long Beach, CA
8/1992 - 1/2000 PhD, Marquette University, Milwaukee, WI

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
5/2000 - 9/2002 Post-Doctoral Fellow, Blood Research Institute, Blood Center of SE WI, Milwaukee, WI
9/2002 - 7/2006 Post-Doctoral Fellow, Pediatrics, Hematology/Oncology/BMT, Medical College of Wisconsin, Milwaukee, WI
7/2006 - 7/2008 Research Scientist I, Pediatrics, Hematology/Oncology/BMT, Medical College of Wisconsin, Milwaukee, WI

FACULTY APPOINTMENTS:
8/1980 - 5/1982 Assistant Professor, College of Nursing, Marquette University, Milwaukee, WI
5/1982 - 5/1990 Adjunct Assistant Professor, College of Nursing, Marquette University, Milwaukee, WI
7/2008 - Present Assistant Professor, Pediatrics, Hematology/Oncology/BMT, Medical College of Wisconsin, Milwaukee, WI

AWARDS AND HONORS:
5/1995 Arthur J. Schmitt Fellowship, Marquette University
5/1996 Arthur J. Schmitt Fellowship, Marquette University
5/1997 Reverend John P. Raynor, S.J., Fellowship, Marquette University

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
2006 - Present American Association of Cancer Research (Member)
2008 - Present Society for Immunotherapy of Cancer (Member)

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Optimizing Immunotherapy for Neuroblastoma after BMT
Source:
NIH/NCI
Role:
Co-Investigator
PI:
Bryon Johnson
Dates:
5/1/2009 - 4/30/2014
Direct Funds:
$750,000
 
Title:
In vivo analysis of metastatic progenitor cells
Source:
American Cancer Society
Role:
Principal Investigator
PI:
Jill Gershan
Dates:
1/1/2012 - 12/31/2012
Direct Funds:
$30,000
 
Title:
Optimizing immunotherapy for multiple myeloma
Source:
CTSI
Role:
Principal Investigator
PI:
Jill Gershan
Dates:
2/1/2012 - Present
Direct Funds:
$20,000
 
Title:
Transient Lymphodepletion and PD-1/PD-L1 Blockade to Treat Myeloma"
Source:
Multiple Myeloma Research Foundation
Role:
Collaborator
PI:
Bryon Johnson
Dates:
2012 - 2014
Direct Funds:
$200,000
 
Non-Peer Review
Title:
Cell-Based Vaccines for Breast Cancer in the FVB/N (MMTV/Neu) Mouse Model
Source:
Medical College of Wisconsin Cancer Center
Role:
Investigator
PI:
Jill Gershan
Dates:
2010 - 2013
Direct Funds:
$150,000
 
Title:
Combining Blockade of T Cell Immune Inhibitory Pathways with Enhanced Cross-presentation as a Strategy to Break Immune Tolerance to Tumor Antigens
Source:
Rebecca Slye Foundation/MCW
Role:
Investigator
PI:
Jill Gershan
Dates:
2/10/2011 - 3/10/2012
Direct Funds:
$15,000
 
Title:
Fibroblastic Growth Factor-1 Induces Breast Cancer Metastasis
Source:
Cedarburg Junior Woman’s Club
Role:
Investigator
PI:
Jill Gershan
Dates:
7/1/2011 - 6/30/2012
Direct Funds:
$4,000
 
Prior
Peer Review
Title:
Transfection of Immune Co-Stimulatory Molecules in Head and Neck Cancer Cells
Source:
American Cancer Society Institutional Research Grant
Role:
Co-Investigator
PI:
Rimas Orentas
Dates:
7/1/2004 - 6/30/2005
 
Title:
Cell-Based Vaccines Derived from Patients with Breast Cancer
Source:
Medical College of Wisconsin Cancer Center
Role:
Co-Investigator
PI:
Rimas Orentas
Dates:
7/1/2005 - 6/30/2007
Direct Funds:
$150,000
 
Title:
Cell-Based Vaccines for Breast Cancer in the FVB/N (MMTV/Neu) Mouse Model
Source:
Medical College of Wisconsin Cancer Center
Role:
Investigator
PI:
Jill Gershan
Dates:
7/1/2007 - 6/30/2010
Direct Funds:
$141,667 (total for all years)
 
Non-Peer Review
Title:
EMT and Metastasis
Source:
MACC Fund/MCW
Role:
Investigator
PI:
Jill Gershan
Dates:
7/1/2010 - 6/31/2011
Direct Funds:
$20,000
 
PEER REVIEWED WORKSHOPS/PRESENTATIONS:
Regional
1. Gershan JA, Karrer K, An Open Reading Frame with Similarity to the Retroviral/Retrotransposon Integrase is Eliminated during DNA Rearrangement, 31st Annual Midwest Protozoology Conference, Chicago, IL, 1999
2. Kearl, T., Jing, W., Gershan, JA., and Johnson, BD., PD-1/PD-L1 Blockade after Lymphodepletion to Treat Myeloma, Milwaukee Regional Research Forum, Milwaukee WI, 2012 - Present
 
National
1. Gershan JA, Karrer K, An Open Reading Frame with Similarity to Integrase is Eliminated during DNA Rearrangement in Tetrahymena Thermophila, Federation of American Societies for Experimental Biology (FASEB) Meeting, Saxton River, VT, 1999
2. Gershan JA, Aster R, The Molecular Basis for High Expression of A1 Antigen on Platelets in Some Normal Individuals, American Society of Hematology (ASH) Meeting, Orlando, FL, 2001
3. Gershan JA, Weber J, Orentas R, Delivery of Plasmid DNA to the Nucleus Using Non-viral Gene Transfection in Tumor Cell Lines and Primary Tumor, American Society of Gene Therapy (ASGCT) Annual Meeting, Minneapolis, MN, 2004
4. Jurgens L, Gershan JA, Weber J, Orentas R, Electro-Tranfection of Epstein-Barr Virus LMP-2 Specific TCRs Provides a Non-Viral Means To Transfer Antigen Specific T-Cell Receptors to Activated PBMC Populations, American Society of Gene Therapy (ASGCT) Annual Meeting, Minneapolis, MN, 2004
5. Gershan JA, Behnke S, Weber J, Yan X, Orentas R, Transgene expression in nucleofected cancer cell lines is enhanced by cell division, American Association of Cancer Research (AACR) Meeting, Anaheim, CA, 2005
6. Gershan JA, Orentas R, In Vitro Expansion and Immortalization of Primary Tumor Cells, American Association of Cancer Research (AACR) Meeting, Miami, FL, 2006
7. Gershan JA, Orentas R, In Vitro Immortalization and Expansion of Primary Tumor Cells, Advances in Breast Cancer Symposium, Northwestern University, Chicago, IL, 2007
8. Gershan JA, Liska A, Johnson B, Exposure to T cell suppressive supernatant from MIF producing tumor cells confers suppression to non-suppressive cells, American Association of Cancer Research (AACR) Meeting, Miami, FL, 2008
9. Gershan JA, Palen K, Orentas R, In vitro expansion of FVB/N Tg MMTVneu primary tumor cells, American Association of Cancer Research (AACR) Meeting, San Diego, CA, 2008
10. Gershan JA, Johnson B, Palen K, Weber J, Epithelial NeuhighCD24high FVB MMTV-Neu primary mammary tumor cells have enhanced tumorigenicity and NeulowCD24low fibroblastoid tumor cells upregulate mesenchymal and metastasis associated genes, American Association of Cancer Research (AACR) Meeting, Miami, FL, 2010
 
International
1. Palen, K., Johnson, BD., and Gershan, JA., Properties Associated with Aggressive Cancer Progression in Primary Clonal Epithelial and Mesenchymal-like Murine Mammary Tumor Cells, AACR Annual Meeting, Chicago IL, 2012 - Present
2. Palen, K., Phillips, AA., Johnson, BD., and Gershan, JA., The Effect of Tumor-derived Arginase Activity on T Cell Suppression and Tumor Progression, SITC Annual Meeting, Washington D.C., 2012 - Present
 
COMMITTEE SERVICE:
Medical College
2007 - Present Member, Clinical Immunotherapy (Cell-Based Vaccines) Committee, Pediatrics, Medical College of Wisconsin
2008 - Present Cancer Center Safety Fire Marshall, Medical College of Wisconsin
1/27/2012 - Present Member, Cancer Center Space Committee, Medical College of Wisconsin
2012 - Present Member, Cancer Center Grant Review Committee, Medical College of Wisconsin
2012 - Present Member, CTSI Grant Review, Medical College of Wisconsin
 
MEDICAL COLLEGE TEACHING ACTIVITIES:
Community/Lay Public
11/17/2008 Breast Cancer Showhouse Board of Directors Presentation: Breast Cancer Vaccines
12/1/2008 MACC Scientific Board Advisory Meeting Development of an Allogeneic Human Cell-based Neuroblastoma Vaccine
 
Medical Student Education
1/31/2012 Faculty Facilitator for the M3 Intersession on Professionalism
 
Continuing Medical Education
3/3/2009 Immunology Research Group-Work In Progress: Cell-based Vaccines
 
EXTRAMURAL TEACHING (e.g. at Marquette, UWM, etc.):
Continuing Medical Education
8/2001 Advanced Course in Immunology: American Association of Immunologists, Stanford University, Stanford, CA
 
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
High School Students
Medical College of Wisconsin, 9/2005 - 3/2006 Research Mentor for Divine Savior Holy Angel senior high school student
Medical College of Wisconsin, 9/2006 - 3/2007 Research Mentor for Divine Savior Holy Angel senior high school student
Katie McShane and Rachael Wilkenson, Medical College of Wisconsin, 9/2009 - 4/2010 High School Science Fair Project
Asia Henderson, Medical College of Wisconsin, 6/1/2012 - 8/1/2012 ROADS Program
 
Undergraduate Students
Aaron Phillips, Medical College of Wisconsin, 5/20/2012 - 8/1/2012 SPUR Program
 
COMMUNITY SERVICE ACTIVITIES:
Leukemia and Lymphoma Society
American Cancer Society
American Heart Association


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Gershan JA. Intracoronary Streptokinase: A New Frontier in Reducing Myocardial Ischemia. Critical Care Quarterly. 1981 Sept;29-33.
2. Gershan JA. Effect of positive end-expiratory pressure on pulmonary capillary wedge pressure. Heart Lung. 1983 Mar;12(2):143-8.
3. Gershan JA, Jiricka MK. Percutaneous transluminal coronary angioplasty. Focus Crit Care. 1984 Aug;11(4):28-35.
4. Gershan JA. Judaic ethical beliefs and customs regarding death and dying. Crit Care Nurse. 1985 Jan-Feb;5(1):32-4.
5. Gershan JA, Freeman CM, Ross MC, Greenlee K, Smejkal C, Brukwitzki G, Schneider K, Jiricka MK, Johnson DJ, Anderson C. The Research Committee, Greater Milwaukee Area Chapter of the American Association of Critical-Care Nurses. Fluid volume deficit: validating the indicators. Heart Lung. 1990 Mar;19(2):152-6.
6. Gershan JA, Karrer KM. A family of developmentally excised DNA elements in Tetrahymena is under selective pressure to maintain an open reading frame encoding an integrase-like protein. Nucleic Acids Res. 2000 Nov 1;28(21):4105-12.
7. Wuitschick JD, Gershan JA, Lochowicz AJ, Li S, Karrer KM. A novel family of mobile genetic elements is limited to the germline genome in Tetrahymena thermophila. Nucleic Acids Res. 2002 Jun 1;30(11):2524-37.
8. Gershan JA, Johnson BD, Weber J, Schauer DW, Natalia N, Behnke S, Burns K, Maloney KW, Warwick AB, Orentas RJ. Immediate transfection of patient-derived leukemia: a novel source for generating cell-based vaccines. Genet Vaccines Ther. 2005 Jun 21;3(1):4.
9. Johnson BD, Gershan JA, Natalia N, Zujewski H, Weber JJ, Yan X, Orentas RJ. Neuroblastoma cells transiently transfected to simultaneously express the co-stimulatory molecules CD54, CD80, CD86, and CD137L generate antitumor immunity in mice. J Immunother. 2005 Sep-Oct;28(5):449-60.
10. Zhou Q, Yan X, Gershan J, Orentas RJ, Johnson BD. Expression of macrophage migration inhibitory factor by neuroblastoma leads to the inhibition of antitumor T cell reactivity in vivo. J Immunol. 2008 Aug 1;181(3):1877-86.
11. Jing W, Gershan JA, Johnson BD. Depletion of CD4 T cells enhances immunotherapy for neuroblastoma after syngeneic HSCT but compromises development of antitumor immune memory. Blood. 2009 Apr 30;113(18):4449-57
12. Jing W, Yan X, Hallett WH, Gershan JA, Johnson BD. Depletion of CD25⁺ T cells from hematopoietic stem cell grafts increases posttransplantation vaccine-induced immunity to neuroblastoma. Blood. 2011 Jun 23;117(25):6952-62
13. Palen KA, Jing W, Weber JJ, Tilkens SB, Chan AM, Johnson BD, Gershan JA. Separation and Characterization of Epithelial and Mesenchymal-like Murine Mammary Tumor Cells Reveals Epithelial Cell Differentiation Plasticity and Enhanced Tumorigenicity of Epithelial-enriched Tumor Cells. Cancer Microenviron. 2012 Jan 12. http://www.springerlink.com/content/36u01k35821t21k3/fulltext.pdf.
14. Barr KM, Jing W, Hallett WHD, Gershan JA, and Johnson BD. Examining T Cells at Vaccine Sites of Tumor-Bearing Hosts Provides Insights into Dysfunctional T Cell Immunity. Journal of Immunotherapy. 2012 in press.
15. Kearl TJ, Jing W, Gershan JA, Johnson BD Programmed Death Receptor-1/Programmed Death Receptor Ligand-1 Blockade after Transient Lymphodepletion to Treat Myeloma. J Immunol. 2013 Apr 24:
16. Barr KM, Jing W, Hallett WH, Gershan JA, Johnson BD Examining T cells at vaccine sites of tumor-bearing hosts provides insights to dysfunctional T-cell immunity. J Immunother. 2013 Jan;36(1):41-51
17. Wang L, Cossette SM, Rarick KR, Gershan J, Dwinell MB, Harder DR, Ramchandran R Astrocytes directly influence tumor cell invasion and metastasis in vivo. PLoS One. 2013;8(12):e80933
 
Books, Chapters, and Reviews
1. Jill Gershan, Andrew Chan, Magdalena Chrzanowska-Wodnicka, Bryon Johnson, Qing Robert Miao and Ramani Ramchandran (2013). Endothelial and Accessory Cell Interactions in Neuroblastoma Tumor Microenvironment, Research Directions in Tumor Angiogenesis, Dr. Jianyuan Chai (Ed.), ISBN: 978-953-51-0963-1, InTech, DOI: 10.5772/55486. Available from: http://www.intechopen.com/books/research-directions-in-tumor-angiogenesis/endothelial-and-accessory-cell-interactions-in-neuroblastoma-tumor-microenvironment
 
Abstracts
1. Gershan JA, Aster R. The Molecular Basis for High Expression of A1 Antigen on Platelets in Some Normal Individuals. Blood. 2001.
2. Gershan JA, Weber J, Orentas R. Delivery of Plasmid DNA to the Nucleus Using Non-viral Gene Transfection in Tumor Cell Lines and Primary Tumor. Mol Ther. 2004;9(S59–S60)
3. Jurgens L, Gershan JA, Weber J, Orentas R, Electro-Tranfection of Epstein-Barr Virus LMP-2 Specific TCRs Provides a Non-Viral Means To Transfer Antigen Specific T-Cell Receptors to Activated PBMC Populations. Mol Ther. 2004;9(S306–S306)
4. Gershan JA, Behnke S, Weber J, Yan X, Orentas R, Transgene expression in nucleofected cancer cell lines is enhanced by cell division. AACR Meeting Abstracts. 2005;1425-a
5. Gershan JA, Palen K, Orentas R. In vitro expansion of FVB/N Tg MMTVneu primary tumor cells. AACR Meeting Abstracts. 2008;1831
6. Gershan J, Palen K, Johnson B. Fibroblast Growth Factor-1 Induces Epithelial Tumor Cell Plasticity Toward a Mesenchymal Phenotype. J Immunother. 2011 Nov-Dec;34(9):662-723