CURRICULUM VITAE
Monica Thakar MD
Monica Thakar MD
Assistant Professor
Department of Pediatrics
Division of Hematology/Oncology
Department of Pediatrics
Division of Hematology/Oncology
OFFICE ADDRESS: |
MACC Fund Research Center |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
CITIZENSHIP: USA |
EDUCATION: |
1993 - 1997 BS - Biology, University of South Carolina, Columbia, SC |
1997 - 2001 MD, Medical University of South Carolina, Charleston, SC |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
2001 - 2004 Intern and Resident, Pediatrics, University of Chicago, Chicago, IL |
2004 - 2007 Fellow, Pediatrics, Hematology-Oncology, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA |
2007 - 2008 Senior Fellow, Pediatrics, Hematology-Oncology, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA |
FACULTY APPOINTMENTS: |
2008 - 2009 Research Associate, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA |
2008 - 2009 Acting Instructor , Pediatrics, University of Washington, Seattle, WA |
2010 - Present Affiliate Member, Fred Hutchinson Cancer Research Center, Seattle, WA |
2010 - Present Assistant Professor, Pediatrics, Hematology/Oncology/BMT, Medical College of Wisconsin, Milwaukee, WI |
HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS: |
2007 - 2009 Medical Staff, Seattle Children's Hospital, Seattle, WA |
2008 - 2009 Medical Staff, University of Washington, Seattle, WA |
2008 - 2009 Medical Staff, Seattle Cancer Care Alliance, Seattle, WA |
2010 - Present Medical Staff, Children's Hospital of Wisconsin, Milwaukee, WI |
HOSPITAL STAFF PRIVILEGES: |
2007 - 2009 Medical Staff, Seattle Children’s Hospital, Seattle, WA |
2008 - 2009 Medical Staff, University of Washington Medical Center, Seattle, WA |
2008 - 2009 Medical Staff, Seattle Cancer Care Alliance, Seattle, WA |
2010 - Present Medical Staff, Pediatrics, Hematology/Oncology/BMT, Children’s Hospital of Wisconsin, Milwaukee, WI |
SPECIALTY BOARDS AND CERTIFICATION: |
Board Certified | Issue Date | Expiration |
General Pediatrics | 2006 | 2015 |
Board-Eligible, Pediatric Hematology-Oncology | 2008 | None |
Licensure | Number | Issue Date | Expiration |
Medical License | 2004 | 2013 | |
Federal DEA License | 2004 | 2012 | |
Medical License | 2010 | 2012 | |
AWARDS AND HONORS: |
1993 - 1997 Dean’s List, South Carolina Honors College, University of South Carolina |
1993 - 1997 Valedictorian Full-Tuition Scholarship, University of South Carolina |
1995 Howard Hughes Undergraduate Research Award in Ecology, University of South Carolina |
1997 SC Experimental Program to Stimulate Competitive Research (SC EPSCoR) Grant in Developmental Biology, University of South Carolina |
2006 Loan Repayment Award, NIH |
2007 Travel Award, American Society of Hematology Annual Meeting |
2007 Travel Award, Fanconi Anemia Research Fund Annual Meeting |
2007 Fellows’ Research Day Award, Seattle Children’s Hospital |
2008 Clinical Research Training Institute Workshop Attendance (declined), American Society of Hematology |
2008 Cancer Research Clinical Training Workshop Attendance, American Society of Clinical Oncology/American Association of Cancer Research |
2008 Travel Award, Fanconi Anemia Research Fund Annual Meeting |
2008 Clinical Training Course Attendance (declined), American Society for Blood and Marrow Transplantation (ASBMT) |
2011 - 2012 Clinical Research Scholars Program, Clinical and Translational Research Institute (CTSI) |
2011 Travel Award, Fanconi Anemia Research Fund Annual Meeting |
2012 - Present Young Investigator Travel Award - 2nd International Workshop on the Biology, Prevention, and Treatment of Relapse After Hematopoietic Stem Cell Transplantation Meeting, NIH |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
2005 - Present American Society of Hematology (ASH) (Member) |
2006 - 2009 American Society of Clinical Oncology (ASCO) (Associate Member) |
2006 - Present American Society for Blood and Marrow Transplantation (ASBMT) (Member) |
2007 - 2009 American Association for the Advancement of Science (AAAS) (Sponsored Member) |
2008 - Present American Society of Pediatric Hematology-Oncology (ASPHO) (Member) |
2008 - Present Pediatric Blood and Marrow Transplant Consortium (PBMTC) (Member) |
2008 - Present Children’s Oncology Group (COG) (Member) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Journal Review |
2010 - Present Journal of Pediatric Hematology and Oncology |
2011 - Present Pediatric Blood and Cancer |
2011 - Present Biology of Blood and Marrow Transplantation |
2012 - Present Annals of Hematology |
LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2008 - 2009 Protocol Reviewer, Clinical Investigator’s Meeting, Fred Hutchinson Cancer Research Center, Seattle, WA |
2008 - 2009 Head, Transplantation Biology/Marrow Failure Monthly Clinical Research Meeting, Fred Hutchinson Cancer Research Center, Seattle, WA |
2010 - Present Member, Bone Marrow Transplant QI Program Committee, Medical College of Wisconsin |
2010 - Present Member, Scholarship Oversight Committee for Sam Milanovich, MD, Medical College of Wisconsin, Pediatric Hematology/Oncology Fellowship Program |
2011 - 2013 Advisor and Mentor, Medical School Discovery Curriculum for Haley Robinson, Medical College of Wisconsin |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2010 Co-Chair, Session on Pediatric Alternative Donor Transplantation, American Society of Hematology Annual Meeting, Orlando, FL |
2010 Member, Abstract Review Committee for Alternative Donor Transplantation, American Society of Hematology Annual Meeting |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
National |
1. HLA-haploidentical hematopoietic cell transplantation for Fanconi Anemia, Collaborator/Multi-Institutional Annual Mixed Chimerism Meeting, Seattle, WA, 5/2007 |
2. Pre-emptive donor natural killer cell donor lymphocyte infusion early after nonmyeloablative, HLA-haploidentical hematopoietic cell transplantation, Collaborator/Multi-Institutional Annual Mixed Chimerism Meeting, Seattle, WA, 5/2008 |
3. CD3-Depleted donor lymphocyte infusions after canine MHC-haploidentical nonmyeloablative hematopoietic cell transplantation, Collaborator/Multi-Institutional Annual Mixed Chimerism Meeting, Seattle, WA, 5/2008 |
4. Workshop for Transplantation of Bone Marrow Failure and Acute Myeloid Leukemia in Fanconi Anemia, Invited Participant, 20th Annual Fanconi Anemia Research Fund Annual Symposium, Eugene, OR, 10/2008 |
5. Endocrinopathy in Fanconi Anemia, 1st Annual Brazil Fanconi Anemia Family Meeting and Educational Symposium, Curitiba, Brazil, 11/2009 |
6. Severe aplastic anemia, Data Managers Conference, American Society of Blood and Marrow Transplantation Annual Meeting, Orlando, FL, 1/2010 |
7. Update on Protocol 2230, Collaborator/Multi-Institutional Annual Mixed Chimerism Meeting, Seattle, WA, 5/2010 |
8. Update on Protocol 2230, Collaborator/Multi-Institutional Annual Mixed Chimerism Meeting, Seattle, WA, 5/2011 - 5/2010 |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
National |
1. Thakar MS, Liedel JL, Rubin CM, Brown M, Bacha EA, Kahana MD, FVIIa for Peri-Operative Bleeding in the PICU and NICU, Pediatric Academic Society Meeting, San Francisco, CA, 5/2004 |
2. Thakar MS, Gooley TA, Santos EB, Storb RF, Sandmaier BM, High-dose methotrexate as part of a novel immunosuppressive regimen in canine MHC-haploidentical hematopoietic cell transplantation, American Society of Hematology Annual Meeting - Poster Presentation, Orlando, FL, 12/2006 |
3. Thakar MS, Woolfrey AE, Kletzel M, Frangoul H, Pulsipher M, Sandmaier B, Storb, Flowers M, Kurre P, Kiem HP, HLA-matched unrelated donor stem cell transplantation using low-dose total body irradiation and fludarabine for Fanconi Anemia patients with aplastic anemia, Nineteenth Annual Fanconi Anemia Research Fund Scientific Symposium - Poster Presentation, Chicago, IL, 10/2007 |
4. Thakar MS, Storer B, Chauncey T, MD, Pulsipher M, Maloney D, Storb R, Sandmaier B, Reversal of low chimerism following non-myeloablative hematopoietic cell transplantation using pentostatin and donor lymphocyte infusions, American Society of Hematology Annual Meeting, Atlanta, GA, 12/2007 |
5. Thakar MS, Storer B, Storb R, Shizuru J. Niederwieser D, Pulsipher M, Sahebi F, Sorror M, Chen Y, Georges G, Maloney D, Woolfrey A, Sandmaier BM, Treatment of pediatric high-risk malignancies using non-myeloablative (NM) hematopoietic cell transplantation (HCT): a multi-institutional experience, American Society of Blood and Marrow Transplantation Tandem Meetings, Orlando, FL, 2/2010 |
International |
1. Wilbur DS, Hamilin DK, Chyan MK, Thakar MS, Pantelias AA, Santos EB, Pagel JM, Press OW, Sandmaier BM, 211At-Labeling Using Dianionic Decaborate Cage Moieties Provides High Labeling Efficiency and High In Vivo Stability, Workshop on Alpha Emitting Radionucleotides in Therapy, Aachen, Germany, 4/2007 |
COMMITTEE SERVICE: |
Medical College |
2010 - Present Member, Scholarship Oversight Committee for Sam Milanovich, MD, Hematology/Oncology/BMT, Pediatrics, Medical College of Wisconsin |
2010 - Present Member, Bone Marrow Transplant QI Program Committee, Medical College of Wisconsin |
MEDICAL COLLEGE TEACHING ACTIVITIES: |
Resident and Fellow Education |
2010 - Present Pediatric Residency Core Curriculum Lecture Series, Pediatric Hematology/Oncology Rotation - Introduction to Bone Marrow Transplantation |
2010 - Present Pediatric Residency Core Curriculum Lecture Series, Pediatric Hematology/Oncology Rotation - Immunodeficiencies |
Continuing Medical Education |
1/2010 Pediatric Hematology/Oncology/BMT Tumor Board - Non-Myeloablative Transplants |
12/2010 Pediatric Hematology/Oncology/BMT Tumor Board - Role of transplantation for refractory Hodgkin Lymphoma |
2/2011 Pediatric Surgery Basic Science Lecture Series - Non-myeloablative hematopoietic cell transplantation |
5/2011 Pediatric Allergy/Immunology Grand Rounds - The role of transplantation for primary immune deficiencies |
6/2011 Pediatric Hematology/Oncology/BMT Tumor Board - Adoptive immunotherapy in oncology and BMT |
EXTRAMURAL TEACHING (e.g. at Marquette, UWM, etc.): |
Continuing Medical Education |
6/2007 Fred Hutchinson Cancer Research Center, Program in Transplantation Biology, Clinical Research Division Work-in-Progress Seminar - High-dose post-transplant methotrexate as part of a novel immunosuppressive regimen in canine MHC-haploidentical hematopoietic cell transplantation |
6/2007 Seattle Children’s Hospital, Division of Pediatric Hematology/Oncology Research Seminar - Canine MHC-haploidentical hematopoietic cell transplantation |
7/2008 Fred Hutchinson Cancer Research Center, Non-myeloblative Transplantation Research Staff Didactic Series Presentation - Major histocompatibility complex: the alphabet soup |
7/2008 Fred Hutchinson Cancer Research Center, Non-myeloablative transplantation research staff didactic series - Major histocompatibility complex: the alphabet soup |
10/2008 Fred Hutchinson Cancer Research Center, Program in Transplantation Biology, Clinical Research Division Work-in-Progress Seminar - Update of studies in canine MHC-haploidentical non-myeloablative hematopoietic cell transplantation |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Fox CW, Martin JD, Thakar MS, Mousseau TA. Clutch Size Manipulations in Two Seed Beetles, Stator limbatus (horn) and S. beali Johnson: Consequences for Fitness. Oecologia. 1996 Oct;108(1):88-94 |
2. Fox CW, Thakar MS, Mousseau TA. Egg Size Plasticity in a Seed Beetle: An Adaptive Maternal Effect. The American Naturalist. 1997 Jan;149(1):149-163 |
3. Nakamae H, Wilbur DS, Hamlin DK, Thakar MS, Santos EB, Fisher DR, Kenoyer AL, Pagel JM, Press OW, Storb R, Sandmaier BM. Biodistributions, myelosuppression, and toxicities in mice treated with an anti-CD45 antibody labeled with the alpha-emitting radionuclides bismuth-213 or astatine-211. Cancer Res. 2009 Mar 15;69(6):2408-15 |
4. Thakar MS, Zhang XB, Beard BC, Sale GE, Santos EB, Peterson L, Kiem HP, Sandmaier BM. Transmission and expansion of HOXB4-induced leukemia in two immunosuppressed dogs: implications for a new canine leukemia model. Exp Hematol. 2009 Oct;37(10):1157-66 |
5. Wilbur DS, Thakar MS, Hamlin DK, Santos EB, Chyan MK, Nakamae H, Pagel JM, Press OW, Sandmaier BM. Reagents for astatination of biomolecules. 4. Comparison of maleimido-closo-decaborate(2-) and meta-[(211)At]astatobenzoate conjugates for labeling anti-CD45 antibodies with [(211)At]astatine. Bioconjug Chem. 2009 Oct 21;20(10):1983-91 |
6. Thakar MS, Forman SJ. ASH evidence-based guidelines: is there a role for second allogeneic transplant after relapse? Hematology Am Soc Hematol Educ Program. 2009:414-8 |
7. Thakar MS, Santos EB, Fricker S, Bridger G, Storb R, Sandmaier BM. Plerixafor-moblized stem cells alone are capable of inducing early engraftment across the MHC-haploidentical canine barrier. Blood. 2010 Jan 28;115(4):916-7 |
8. Thakar MS, Santos EB, Gooley TA, Sale G, Storb R, Kiem HP, Sandmaier BM. Evaluation of posttransplant methotrexate to facilitate engraftment in the canine major histocompatibility complex-haploidentical nonmyeloablative transplant model. Transplantation. 2010 Jul 15;90(1):14-22 |
9. Thakar MS, Kurre P, Storb R, Kletzel M, Frangoul H, Pulsipher MA, Leisenring W, Flowers ME, Sandmaier BM, Woolfrey A, Kiem HP. Treatment of Fanconi anemia patients using fludarabine and low-dose TBI, followed by unrelated donor hematopoietic cell transplantation. Bone Marrow Transplant. 2011 Apr;46(4):539-44 |
10. Rajasekaran K, Chu H, Kumar P, Xiao Y, Tinguely M, Samarakoon A, Kim TW, Li X, Thakar MS, Zhang J, Malarkannan S. Transforming growth factor-beta-activated kinase 1 regulates natural killer cell-mediated cytotoxicity and cytokine production. J Biol Chem. 2011 Sep 9;286(36):31213-24 |
11. Chen Y, Fukuda T, Thakar MS, Kornblit BT, Storer BE, Santos EB, Storb R, Sandmaier BM. Immunomodulatory effects induced by cytotoxic T lymphocyte antigen 4 immunoglobulin with donor peripheral blood mononuclear cell infusion in canine major histocompatibility complex-haplo-identical non-myeloablative hematopoietic cell transplantation. Cytotherapy. 2011 Nov;13(10):1269-80 |
12. Malarkannan S, Awasthi A, Rajasekaran K, Kumar P, Schuldt KM, Bartoszek A, Manoharan N, Goldner NK, Umhoefer CM, Thakar MS. IQGAP1: A Regulator of Intracellular Spacetime Relativity. J Immunol. 2012 Mar 1;188(5):2057-63 |
13. Kumar P, Bartoszek AE, Moran TM, Gorski J, Bhattacharyya S, Navidad JF, Thakar MS, Malarkannan S. High-throughput Detection Method for Influenza Virus. J Vis Exp. 2012 Feb 4;(60)e3623 |
14. Verbsky J, Thakar M, Routes J. The Wisconsin approach to newborn screening for severe combined immunodeficiency. J Allergy Clin Immunol. 2012 Mar;129(3):622-7 |
15. Kumar P, Rajasekaran K, Palmer JM, Thakar MS, Malarkannan S. IL-22: An Evolutionary Missing-Link Authenticating the Role of the Immune System in Tissue Regeneration. J Cancer. 2013;4(1):57-65. doi: 10.7150/jca.5048. Epub 2012 Dec 25. |
16. Palmer JM, Rajasekaran K, Thakar MS, Malarkannan S. Clinical relevance of natural killer cells following hematopoietic stem cell transplantation. J Cancer. 2013;4(1):25-35. doi: 10.7150/jca.5049. Epub 2012 Dec 5. |
17. Palmer JM, Rajasekaran K, Thakar MS, Malarkannan S Clinical relevance of natural killer cells following hematopoietic stem cell transplantation. J Cancer. 2013;4(1):25-35 |
18. Kumar P, Rajasekaran K, Palmer JM, Thakar MS, Malarkannan S IL-22: An Evolutionary Missing-Link Authenticating the Role of the Immune System in Tissue Regeneration. J Cancer. 2013;4(1):57-65 |
19. Ayas M, Saber W, Davies SM, Harris RE, Hale GA, Socie G, Lerademacher J, Thakar M, Deeg HJ, Al-Seraihy A, Battiwalla M, Camitta BM, Olsson R, Bajwa RS, Bonfim CM, Pasquini R, Macmillan ML, George B, Copelan EA, Wirk B, Al Jefri A, Fasth AL, Guinan EC, Horn BN, Lewis VA, Slavin S, Stepensky P, Bierings M, Gale RP Allogeneic Hematopoietic Cell Transplantation for Fanconi Anemia in Patients With Pretransplantation Cytogenetic Abnormalities, Myelodysplastic Syndrome, or Acute Leukemia. J Clin Oncol. 2013 Apr 1: |
20. Thakar MS, Bonfim C, Sandmaier BM, O'Donnell P, Ribeiro L, Gooley T, Deeg HJ, Flowers ME, Pasquini R, Storb R, Woolfrey AE, Kiem HP Cyclophosphamide-based in vivo T-cell depletion for HLA-haploidentical transplantation in Fanconi anemia. Pediatr Hematol Oncol. 2012 Sep;29(6):568-78 |
21. Kumar P, Thakar MS, Ouyang W, Malarkannan S IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection. Mucosal Immunol. 2013 Jan;6(1):69-82 |
Books, Chapters, and Reviews |
1. Malarkannan S, Awasthi T, Rajasekaran K, Kumar P, Schuldt KM, Bartoszek A, Manoharan N, Goldner NK, Umhoefer CM, Thakar MS. IQGAP1: A Regulator of Intracellular Spacetime Relativity. J Immunol. 2012 Mar 1;188(5):2057-63 |
Abstracts |
1. Thakar MS, Liedel JL, Rubin CM, Brown M, Bacha EA, Kahana MD. FVIIa for peri-operative bleeding in the PICU and NICU. PAS Annual Meeting Program with Abstracts-on-Line. 2004 May;Abstract #1749:http://www.abstracts2view.com/pasall/view.php?nu=PAS4L1_3128 |
2. Thakar MS, Gooley TA, Santos EB, Storb RF, Sandmaier BM. High-Dose Methotrexate as Part of a Novel Immunosuppressive Regimen in Canine MHC-Haploidentical Hematopoietic Cell Transplantation. Blood (ASH Annual Meeting Abstracts). 2006 Nov;108:3180 |
3. Thakar MS, Storer B, Chauncey T, MD, Pulsipher M, Maloney D, Storb R, Sandmaier B. Reversal of Low Chimerism Following Nonmyeloablative Hematopoietic Cell Transplantation Using Pentostatin and Donor Lymphocyte Infusions. Blood (ASH Annual Meeting Abstracts). 2007 Nov;110:480 |
4. Wilbur D, Hamilin D, Nakamae H, Thakar MS, Santos E, Pantelias A, Kenoyer A, Pagel J, Press O, Storb R, Sandmaier B. Comparison of biodistributions, myelosuppression and toxicity in mice of an anti-CD45 antibody labeled with the α-emitters 213Bi or 211At. AACR Meeting Abstracts. 2008 Apr;2008:3160 |
5. Nakamae H, Wilbur D, Hamlin D, Thakar MS, Santos E, Fisher D, Kenoyer A, Pagel J, Press O, Storb R, Sandmaier B. Evaluation of Toxicity and Tissue Radiation Doses obtained in Mice with an Anti-CD45 Monoclonal Antibody (mAb) labeled with the Alpha-Emitting Radionuclides, Astatine-211 or Bismuth-213. Blood (ASH Annual Meeting Abstracts). 2008 Nov;112:3270 |
6. Thakar MS, Storer B, Storb R, Shizuru J, Niederwieser D, Pulsipher M, Sahebi F, Sorror M, Chen Y, Georges G, Maloney D, Woolfrey A, Sandmaier B. Treatment of pediatric high-risk malignancies using non-myeloablative (NM) hematopoietic cell transplantation (HCT): a multi-institutional experience. Biology of Blood and Marrow Transplantation. 2010 Feb;16,(2, Suppl 2):S246-S247. |
7. Kornblit B, Hwang B, Storer B, Thakar MS, Santos EB, Nash R, Sandmaier B. Peripheral blood stem cell mobilization with single agent plerixafor induces FoxP3 expression in donor T cells and enables durable long term hematopoietic engraftment across mismatched major histocompatibility complex barriers. Blood (ASH Annual Meeting Abstracts). 2011 Dec;118(21):1891 |
8. Thakar MS, Schuldt K, Bartlett B, Malarkannan S. Lenalidomide augments NKG2D-mediated cytokine production but not cytotoxicity from NK cells. Blood(ASH Annual Meeting Abstracts). 2011 Dec;118(21):1918 |
