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CURRICULUM VITAE

Nancy Wandersee PhD
Assistant Professor
Department of Pediatrics
Division of Hematology/Oncology

OFFICE ADDRESS:
MACC Fund Research Center
8701 Watertown Plank Rd
Milwaukee, WI 53226

CITIZENSHIP:  USA

EDUCATION:
8/1982 - 5/1986 B.S., Clarkson University, Potsdam, NY
7/1986 - 8/1995 Ph.D., University of Iowa, Iowa City, IA

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
8/1983 - 5/1985 Research Assistant, Department of Biology, Clarkson University, Potsdam, NY
6/1984 - 8/1984 Undergraduate Summer Research Program, Department of Biology, University of Connecticut, Storrs, CT
8/1984 - 5/1986 Undergraduate Research, Department of Biology, Clarkson University, Potsdam, NY
7/1986 - 7/1987 Graduate Research, Department of Internal Medicine, University of Iowa, Iowa City, IA
7/1987 - 5/1989 Graduate Research, Department of Pediatrics, University of Iowa, Iowa City, IA
2/1988 - 4/1988 Graduate Research and Training, Centre Paul Lamarque, Cliniques St. Eloi, Montpellier, France
5/1989 - 6/1995 Doctoral Research, Department of Internal Medicine, University of Iowa, Iowa City, IA
6/1995 - 12/2000 Postdoctoral Fellowship , The Jackson Laboratory, Bar Harbor, ME

FACULTY APPOINTMENTS:
1/2001 - 3/2004 Research Scientist I, Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI
6/2002 Visiting Investigator, The Jackson Laboratory, Bar Harbor, ME
3/2004 - Present Research Scientist II, Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI
8/2004 - Present Assistant Professor, Department of Pediatrics, Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI

AWARDS AND HONORS:
5/1986 - Present Gamma Sigma Epsilon
5/1986 - Present Phi Kappa Phi
5/1986 - Present Outstanding Undergraduate Research Award, Sigma Xi, Clarkson University
7/1996 - 6/1999 NIH individual NRSA fellowship

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
5/1986 - 5/1987 Phi Kappa Phi National Honor Society
5/1986 - Present Sigma Xi Scientific Research Society
5/1986 - 5/1987 Gamma Sigma Epsilon Chemistry Honor Society
7/1997 - Present American Association for the Advancement of Science
1/1998 - Present American Society of Hematology

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Journal Review
3/2004 - Present Blood
1/2005 - Present American Journal of Hematology
3/2007 - 2007 French National Research Agency (ANR) funding program for rare diseases
4/2009 - Present Journal of Applied Physiology
2/2010 - Present AJP-Heart and Circulatory Physiology

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
3/2007 Reviewer, French National Research Agency (ANR) funding program for rare diseases

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Nociceptive Mechanisms Underlying Sickle Cell Pain
Source:
NIH, R01 HL098086-01, NS070711-01
Role:
Co-Investigator (5% effort)
PI:
Cheryl Hillery, MD and Cheryl Stucky, PhD
Dates:
9/30/2009 - 9/29/2013
Direct Funds:
$1,200,000 (total for all years)
 
Non-Peer Review
Title:
Vascular Dysfunction in Murine Models of Hemolytic Anemia
Source:
MACC Fund
PI:
Nancy Wandersee
Dates:
7/1/2011 - 6/30/2012
Direct Funds:
$35,000
 
Pending
Peer Review
Title:
Cytokine Mediators of Normal and Sickle Red Blood Cell Physiology
Source:
NIH/NHLBI
Role:
Co-Investigator (20% effort)
PI:
Cheryl Hillery, MD and Amittha Wickrema, PhD
Dates:
12/1/2011 - 11/30/2016
Direct Funds:
$515,079 (total for all years)
 
Title:
Hemoglobin-binding peptides in Sickle Cell Disease
Source:
NIH/NHLBI
Role:
Principal Investigator (40% effort)
PI:
Neil Hogg, PhD, Nancy Wandersee, PhD, and Cheryl Hillery,
Dates:
12/1/2011 - 11/30/2016
Direct Funds:
$1,617,665 (total for all years)
 
Title:
Center for Translational Research in Hemostasis and Thrombosis-U54 project: Coagulation and Inflammation in Sickle Cell Disease
Source:
NIH/NHLBI
Role:
Co-Investigator (20% effort)
PI:
Cheryl Hillery, MD
Dates:
7/1/2012 - 6/30/2017
Direct Funds:
$737,980 (total for all years)
 
Prior
Peer Review
Title:
Heritable alpha-spectrin deficiencies in the mouse
Source:
NIH individual NRSA fellowship
Role:
Principal Investigator (75% effort)
PI:
Nancy Wandersee
Dates:
7/1/1996 - 6/30/1999
Direct Funds:
$82,200 (total for all years)
 
Title:
Mechanisms of stroke in a mouse model of heritable hemolytic anemia
Source:
AHA Northland Affiliate Beginning Grant-In-Aid
Role:
Principal Investigator (39% effort)
PI:
Nancy Wandersee
Dates:
7/1/2002 - 6/30/2004
Direct Funds:
$90,000 (total for all years)
 
Title:
Mechanisms of vascular injury in murine heritable hemolytic anemia
Source:
AHA National Center Scientist Development Grant, # 0530073N
Role:
Principal Investigator (35% effort)
PI:
Nancy Wandersee
Dates:
1/1/2005 - 12/31/2009
Direct Funds:
$236,364 (total for all years)
 
Title:
Midwest Basic and Translational Research Program (BTRP)
Source:
NIH, U54 HL090503
Role:
Co-Investigator (Project 4), Core Leader (Animal Core), BCW Subcontract PI (20% effort)
PI:
Cheryl Hillery, MD
Dates:
7/15/2008 - 3/31/2012
Direct Funds:
$858,200 (total for all years, Project 4 and Animal Core)
 
Non-Peer Review
Title:
Stroke in murine models of hemolytic anemia
Source:
MACC fund
Role:
Principal Investigator (65% effort)
PI:
Nancy Wandersee
Dates:
7/1/2005 - 6/30/2007
Direct Funds:
$40,000 ($20,000 per year)
 
Title:
Stroke in murine models of hemolytic anemia
Source:
MACC fund
Role:
Principal Investigator (65% effort)
PI:
Nancy Wandersee
Dates:
7/1/2007 - 6/30/2008
Direct Funds:
$30,000
 
Title:
Stroke in murine models of hemolytic anemia
Source:
MACC fund
Role:
Principal Investigator (45% effort)
PI:
Nancy Wandersee
Dates:
7/1/2008 - 6/30/2009
Direct Funds:
$30,000
 
Title:
Stroke in murine models of hemolytic anemia
Source:
MACC fund
Role:
Principal Investigator (45% effort)
PI:
Nancy Wandersee
Dates:
7/1/2009 - 6/30/2010
Direct Funds:
$15,000
 
Title:
Vascular Dysfunction in Murine Models of Hemolytic Anemia
Source:
MACC Fund
Role:
Principal Investigator (45% effort)
PI:
Nancy Wandersee
Dates:
7/1/2010 - 6/30/2011
Direct Funds:
$35,000
 
Title:
Stroke in murine models of hemolytic anemia
Source:
MACC fund
Role:
Principal Investigator (45% effort)
Dates:
7/1/2010 - 6/30/2011
Direct Funds:
$35,000
 
INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
1. Stroke in Mice with Severe Hemolytic Anemia: Searching for the Culprit(s), Invited Speaker, Research in Progress Seminar Series, Blood Research Institute, Milwaukee, WI, 3/2002 - Present
2. When Good Red Cells Go Bad, Invited Speaker, Research in Progress Seminar Series, Blood Research Institute, Milwaukee, WI, 2/2003 - Present
 
National
1. Thrombosis and Stroke in Mice with Severe Hemolytic Anemia: Searching for the Source of the Problem, Guest Speaker, Departmetn of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, 5/2000 - Present
2. Stroke in Mice with Severe Hemolytic Anemia: Searching for the Culprit(s), Visiting Investigator Presentation, The Jackson Laboratory, Bar Harbor, ME, 6/2002 - Present
3. Red Cell Adhesion, Red Cell Hemolysis and Vascular Dysfunction: a Bad Combination, Guest Speaker, Red Cell Club Meetings, Chicago IL, 10/2005 - Present
 
International
1. Vascular Dysfunction in Murine Models of Hemolytic Anemia, Invited Oral Presentation, American Society of Hematology Meetings, Atlanta, GA, 12/2007 - Present
2. Vascular Dysfunction in a Murine Model of Severe Hemolysis, Invited poster and oral presentation, American Heart Association Research Symposium, New Orleans, LA, 11/2008 - Present
3. A Novel Hemoglobin-Binding Agent Reduces Plasma Free Hemoglobin and Partially Improves Vascular Function in Murine Hemolytic Anemia, Invited Oral Presentation, American Society of Hematology Meetings, Orlando, FL, 4/2011 - Present
4. Effect of a Novel Hemoglobin-Binding Peptide on Cell-Free Hemoglobin and Vascular Dysfunction in Murine Hemolytic Anemia, Invited Education Program Presentation, American Association of Blood Banks Annual Meeting and CTTXPO, San Diego, CA, 10/2011 - Present
 
PEER REVIEWED WORKSHOPS/PRESENTATIONS:
Regional
1. Nancy J. Wandersee, John C. Lee, Tamma M. Kaysser, Rod T. Bronson, Jane E. Barker, Transfer of sph/sph bone marrow to +/+ mice duplicates the pathophysiology of sph/sph mice, Poster, American Heart Association Northeast Affiliate Meeting, Gorham, NH, 5/1997 - Present
2. Michelle A. Stapleton, Joseph Italiano, Nancy J. Wandersee, Platelet number and function correlate with cardiac thrombosis in mice with severe hereditary spherocytosis, Poster, Midwest Platelet Conference, Milwaukee, WI, 10/2004 - Present
 
National
1. Nancy J. Wandersee, Anne C. Frei, Deron W. Jones, Timothy C. Flewelen, Neil Hogg, Kirkwood A. Pritchard, Jr., Cheryl A. Hillery, Hao Xu, A novel hemoglobin-binding agent reduces plasma free hemoglobin and partially improves vascular function in murine hemolytic anemia, Poster, Red Cell Club Meetings, Cincinatti, OH, USA, 10/2010 - Present
2. Nancy J. Wandersee, Madelyn S. Hanson, Anne C. Frei, Deron W. Jones, Dawn M. Retherford, Sandra L. Holzhauer, Timothy C. Flewelen, Kirkwood A. Pritchard, Jr., Cheryl A. Hillery, Hao Xu, Neil Hogg, A novel hemoglobin-binding agent reduces cell-free hemoglobin and restores NO-dependent vascular function in murine hemolytic anemia, Poster, Symposium on Cardiopulmonary Complications of Sickle Cell Disease, Cincinatti, OH, USA, 6/2011 - Present
 
International
1. Nancy J. Wandersee, John C. Lee, Tamma M. Kaysser, Rod T. Bronson, Jane E. Barker, sph/sph bone marrow implanted in +/+ mice duplicates the pathophysiology of sph/sph mice, Poster, Gordon Research Conference on Red Cells, Tilton, NH, USA , 7/1997 - Present
2. Nancy J. Wandersee, John C. Lee, Tamma M. Kaysser, Rod T. Bronson, Jane E. Barker, sph/sph bone marrow implanted in +/+ mice duplicates the pathophysiology of sph/sph mice, Poster, American Society of Hematology Meetings, San Diego, CA, USA, 12/1997 - Present
3. Nancy J. Wandersee, Amanda N. Roesch, Nancy R. Hamblen, Jos de Vos, Martin A. van der Valk, Rod T. Bronson, Peter Demant, Jane E. Barker, A new mouse mutant with severe hereditary elliptocytosis is deficient in erythroid alpha spectrin, Poster, American Society of Hematology Meetings, Miami, FL, USA , 12/1998 - Present
4. Jane E. Barker, Nancy J. Wandersee, The genesis of thrombi in mice with hereditary spherocytosis is ameliorated by post-natal injections of normal marrow, Poster, American Society of Hematology Meetings, Miami, FL, USA, 12/1998 - Present
5. Nancy J. Wandersee, Connie S. Birkenmeier, Elaine J. Gifford, Jane E. Barker, Identification of three mutations in the murine erythroid alpha spectrin gene causing hereditary spherocytosis in mice, Poster, American Society of Hematology Meetings, Miami, FL, USA , 12/1998 - Present
6. Nancy J. Wandersee, Jonathan F. Tait, Jane E. Barker, Thrombosis in mice with hereditary spherocytosis does not correlate with the level of red blood cell phosphatidylserine exposure, Poster, American Society of Hematology Meetings, New Orleans, LA, USA , 12/1999 - Present
7. Nancy J. Wandersee, Scott C. Olson, Sandra L. Holzmann, Jane E. Barker, Cheryl A. Hillery, Increased erythrocyte adhesion in mice with hereditary spherocytosis, Poster, American Society of Hematology Meetings, San Francisco, CA, USA , 12/2000 - Present
8. Nancy J. Wandersee, John C. Lee, Susan A. Deveau, Jane E. Barker, The presence of normal red blood cells in young mice with hereditary spherocytosis ameliorates thrombosis in the adult, Poster, American Society of Hematology Meetings, San Francisco, CA, USA , 12/2000 - Present
9. Nancy J. Wandersee, Nyama M. Sillah, Nicholas A. Watkin, J. Paul Scott, Willem H. Ouwehand, Cheryl A. Hillery, Single chain antibody fragments derived from a human phage display library preferentially bind sickle red blood cells and inhibit sickle cell adhesion, Poster, American Society of Hematology Meetings, Orlando, FL, USA , 12/2001 - Present
10. Nancy J. Wandersee, Rowena C. Punzalan, Nicholas A. Watkins, Willem H. Ouwehand, Philip S. Low, Cheryl A. Hillery, Role of erythrocyte hydration in adhesion of RBCs to thrombospondin-1, Poster, Gordon Research Conference on Red Cells, Il Ciocco, Italy, 5/2003 - Present
11. Nancy J. Wandersee, Rowena C. Punzalan, Nyama M. Sillah, Michael P. Rettig, Michael D. Kennedy, J. Paul Scott, Philip S. Low, Cheryl A. Hillery, Modulation of erythrocyte adhesion by changes in cellular tonicity and volume, Poster, American Society of Hematology Meetings, San Diego, CA, USA , 12/2004 - Present
12. Michelle A. Stapleton, Joseph Italiano, Nancy J. Wandersee, Platelet number and function correlate with cardiac thrombosis in mice with severe hereditary spherocytosis, Poster, Gordon Research Conference on Cell Biology of Megakaryocytes and Platelets, Santa Ynez, CA, USA, 3/2005 - Present
13. Anne C. Schraufnagel, Barb Piknova, Kirkwood A. Pritchard, Jr., Neil Hogg, Nancy J. Wandersee, Nitric oxide scavenging, abnormal vasoregulation and oxidative damage in sph/sph mice with severe hereditary spherocytosis: possible consequences of hemolysis, Poster, American Society of Hematology Meetings, Atlanta, GA, USA, 12/2005 - Present
14. Anne C. Frei, YiHe Guo, Deron W. Jones, Kirkwood A. Pritchard, Jr., Karen A. Fagan, Neil Hogg, Nancy J. Wandersee, Vascular dysfunction in a murine model of severe hemolysis, Poster, American Heart Special Research Symposium [for AHA grant awardees], New Orleans, Louisiana, USA, 11/2008 - Present
15. Nancy J. Wandersee, Teresa Uy, Dawn Retherford, Aziz Noon-Abdullah, Anne C. Frei, Amanda M. Brandow, Cheryl L. Stucky, Cheryl A. Hillery, Mechanical hypersensitivity occurs in a mouse models of sickle cell disease. , Poster, American Society of Hematology Meetings, San Francisco, CA, USA, 12/2008 - Present
16. Nancy J. Wandersee, Teresa Uy, Marie-Elizabeth Barabas, Dawn Retherford, Aziz Noon-Abdullah, Amanda M. Brandow, Cheryl L. Stucky, Cheryl A. Hillery, Mechanical hypersensitivity occurs in mouse models of hemolytic anemia, Poster, Gordon Research Conference on Red Cells, Biddeford, ME, USA, 7/2009 - Present
 
COMMITTEE SERVICE:
Medical College
1/2005 - 12/2007 Member, Institutional Animal Care and Use Committee, Medical College of Wisconsin
7/2006 - 9/2008 Member, Scholarship Oversight Committee for Dr. Teresa Uy, Department of Pediatrics, Division of Hematology/Oncology, Medical College of Wisconsin
2009 - 2010 Fellowship Applicant Selection Committee, Pediatric Hematology, Oncology, BMT, Pediatrics, Medical College of Wisconsin
2011 - Present Member, AUA SmartForm PI/SS Focus Group, Medical College of Wisconsin
 
MEDICAL COLLEGE TEACHING ACTIVITIES:
Community/Lay Public
3/2004 Animal Resource Center Lecture Series, Joint Seminar with Cheryl Hillery: Sickle Cell Disease and Hereditary Spherocytosis: When Good Red Cells Go Bad
2008 - 2012 Summer for Sickle Cell Science Program, Provide lectures and training to the three students selected each year for the program
 
Resident and Fellow Education
1/2010 Hematology/Oncology Fellows Lecture Series, Hematology: Red Blood Cell Enzymopathies and Cytoskeletal Disorders
 
Continuing Medical Education
7/2003 Department of Pediatrics Noon Conference, Seminar: When Good Red Cells Go Bad
10/2005 Children's Research Institute Noon Academic Conference, Seminar: Red Cell Adhesion, Red Cell Hemolysis, and Vascular Dysfunction: a Bad Combination
2/2008 Children's Research Institute Noon Academic Conference, Seminar: Vascular Dysfunction in a Murine Model of Severe Hemolysis
 
EXTRAMURAL TEACHING (e.g. at Marquette, UWM, etc.):
Community/Lay Public
9/1983 - 5/1985 Clarkson University, Potsdam, NY, Tutored biology students in organic and inorganic chemistry
 
Medical Student Education
9/1983 - 5/1985 Clarkson University, Potsdam, NY, Tutored biology students in organic and inorganic chemistry
 
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Medical Students
Josalyn Funches, MCW, 6/2006 - 8/2006 Multicultural Summer Research Training Program
Neha Hasan, MCW, 6/2008 - 8/2008 ROADS program and Sickle Cell Summer for Science Training Program
Bartholomew A Sillah, MCW, 6/2008 - 8/2008 ROADS program and Sickle Cell Summer for Science Training Program
Aziz Noon-Abdullah, MCW, 6/2008 - 8/2008 ROADS program and Sickle Cell Summer for Science Training Program
Brittany Mays, MCW, 6/2009 - 8/2009 ROADS program and Sickle Cell Summer for Science Training Program
Rebecca Ruechel, MCW, 6/2009 - 8/2009 ROADS program and Sickle Cell Summer for Science Training Program
Soumya Gokuli, MCW, 6/2009 - 8/2009 ROADS program and Sickle Cell Summer for Science Training Program
MCW, 2009 - 2012 Mentoring for Sickle Cell Summer for Science Training Program
Stephanie Mayes, MCW, 6/2010 - 8/2010 ROADS program and Sickle Cell Summer for Science Training Program
Shane Donovan, MCW, 6/2010 - 8/2010 ROADS program and Sickle Cell Summer for Science Training Program
Soumya Gokuli, MCW, 6/2010 - 8/2010 ROADS program and Sickle Cell Summer for Science Training Program
Kenechi Obiora, Medical College of Wisconsin, 6/2011 - 8/2011 ROADS program and Sickle Cell Summer for Science Training Program
Chour Xiong, Medical College of Wisconsin, 6/2011 - 8/2011 ROADS program and Sickle Cell Summer for Science Training Program
Alfred Xiong, Medical College of Wisconsin, 6/2011 - 8/2011 ROADS program and Sickle Cell Summer for Science Training Program
 
Clinical/Research Fellows
Dr. Teresa Uy, Medical College of Wisconsin, 7/2006 - 9/2008 Member, Scholarship Oversight Committee
 
Faculty
MCW, 2006 - Present Provide informal “mentoring” for animal protocol submissions and addenda to 6 different investigators
Dr. Qizhen Shi, MCW, 6/2008 - Present Member, Faculty Mentoring Committee
 
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
High School Students
John Lee, The Jackson Laboratory, 5/1996 - 8/1996 Mentor, Summer Student
Amanda Roesch, The Jackson Laboratory, 6/1998 - 8/1998 Mentor, Summer Student
Nyama Sillah, Blood Research Institute, 6/2002 - 8/2002 Mentor, Summer Student
Nyama Sillah, Blood Research Institute, 6/2003 - 8/2003 Mentor, Summer Student
Nyama Sillah, Blood Research Institute, 6/2004 - 8/2004 Mentor, Summer Student
 
Undergraduate Students
University of Iowa, 9/1990 - 1/1995 Mentor, Multiple rotating undergraduate and 1st year graduate students
 
Medical Students
University of Iowa, Iowa City, IA, 9/1990 - 1/1995 Mentor, Multiple rotating undergraduate and 1st year graduate students
John Lee, The Jackson Laboratory, Bar Harbor, ME, 5/1996 - 8/1996 Mentor
Amanda Roesch , The Jackson Laboratory, Bar Harbor, ME, 6/1998 - 8/1998 Mentor
Nyama Sillah, Blood Research Institute, Milwaukee, WI, 6/2002 - 8/2004 Mentor
 
PROGRAMMATIC DEVELOPMENTS:
Educational Programs
Student
8/2005 - 8/2010 Supplied with normal and hereditary spherocytosis mouse blood samples to teach red blood cell membrane proteins and red blood cell ghost preparation for University of Notre General Biology Course
 
 
 
 

BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Glauber JG et al. 5'-flanking sequences mediate butyrate stimulation of embryonic globin gene expression in adult erythroid cells. Mol Cell Biol. 1991 Sep;11(9):4690-7
2. Wandersee NJ et al. Intronic and flanking sequences are required to silence enhancement of an embryonic beta-type globin gene. Mol Cell Biol. 1996 Jan;16(1):236-46
3. Kaysser TM et al. Thrombosis and secondary hemochromatosis play major roles in the pathogenesis of jaundiced and spherocytic mice, murine models for hereditary spherocytosis. Blood. 1997 Dec 1;90(11):4610-9
4. Wandersee NJ et al. Hematopoietic cells from -spectrin-deficient mice are sufficient to induce thrombotic events in hematopoietically ablated recipients. Blood. 1998 Dec 15;92(12):4856-63
5. Barker JE et al. Thrombosis in heritable hemolytic disorders. Curr Opin Hematol. 1999 Mar;6(2):71-5
6. Wandersee NJ et al. Erythroid phosphatidyl serine exposure is not predictive of thrombotic risk in mice with hemolytic anemia. Blood Cells Mol Dis. 2000 Feb;26(1):75-83
7. Barker JE et al. Amelioration of severe hereditary spherocytosis in nonablated adult mice by marrow transplantation. Exp Hematol. 2000 Aug;28(8):985-92
8. Wandersee NJ et al. Defective spectrin integrity and neonatal thrombosis in the first mouse model for severe hereditary elliptocytosis. Blood. 2001 Jan 15;97(2):543-50
9. Wandersee NJ et al. Reduced incidence of thrombosis in mice with hereditary spherocytosis following neonatal treatment with normal hematopoietic cells. Blood. 2001 Jun 15;97(12):3972-5
10. Wandersee NJ et al. Murine recessive hereditary spherocytosis, sph/sph, is caused by a mutation in the erythroid alpha-spectrin gene. Hematol J. 2000;1(4):235-42
11. Wandersee NJ et al. Mutations in the murine erythroid alpha-spectrin gene alter spectrin mRNA and protein levels and spectrin incorporation into the red blood cell membrane skeleton. Blood. 2003 Jan 1;101(1):325-30
12. Wandersee NJ et al. Increased erythrocyte adhesion in mice and humans with hereditary spherocytosis and hereditary elliptocytosis. Blood. 2004 Jan 15;103(2):710-6
13. Wandersee NJ et al. Erythrocyte adhesion is modified by alterations in cellular tonicity and volume. Br J Haematol. 2005 Nov;131(3):366-77
14. Frei AC et al. Vascular dysfunction in a murine model of severe hemolysis. Blood. 2008 Jul 15;112(2):398-405
15. Campanella ME et al. Characterization of glycolytic enzyme interactions with murine erythrocyte membranes in wild-type and membrane protein knockout mice. Blood. 2008 Nov 1;112(9):3900-6
16. Sabina RL et al. Ca2+-CaM activation of AMP deaminase contributes to adenine nucleotide dysregulation and phosphatidylserine externalization in human sickle erythrocytes. Br J Haematol. 2009 Feb;144(3):434-45
17. Patel-Hett S et al. The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation. Blood. 2011 Aug 11;118(6):1641-52
18. Hillery CA et al. Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease. Blood. 2011 Jun 27:
19. Hanson MS, Xu H, Flewelen TC, Holzhauer SL, Retherford D, Jones DW, Frei AC, Pritchard KA Jr, Hillery CA, Hogg N, Wandersee NJ A NOVEL HEMOGLOBIN-BINDING PEPTIDE REDUCES CELL-FREE HEMOGLOBIN IN MURINE HEMOLYTIC ANEMIA. Am J Physiol Heart Circ Physiol. 2012 Nov 2:
 
Books, Chapters, and Reviews
1. Barker JE, Wandersee NJ: Thrombosis in heritable hemolytic disorders. Curr Opin Hematol 6:71-75, 1999.
 
Abstracts
1. WANDERSEE, N.J., Yang, S., Ginder, G.D.: Silencing of embryonic globin gene expression is mediated by both 5' and 3' flanking sequences. Blood 80:244a, 1992. (Oral, American Society of Hematology Meetings, Anaheim, CA, 12/1992)
2. WANDERSEE, N.J., Ferris, R.C., Ginder, G.D.: Enhancer silencing of an erythroid beta-type globin gene requires both flanking and intervening sequence elements. Blood 84:506a, 1994. (Oral, American Society of Hematology Meetings, Nashville, TN, 12/1994)
3. WANDERSEE, N.J., Lee, J.C., Kaysser, T.M., Bronson, R.T., Barker, J.E.: Transfer of sph/sph bone marrow to +/+ mice duplicates the pathophysiology of sph/sph mice. (Poster, American Heart Association Northeast Affiliate Meeting, Gorham, New Hampshire, 5/1997)
4. WANDERSEE, N.J., Lee, J.C., Kaysser, T.M., Bronson, R.T., Barker, J.E.: Sph/sph bone marrow implanted in +/+ mice duplicates the pathophysiology of sph/sph mice. (Poster, Gordon Research Conference on Red Cells, Tilton, New Hampshire, 7/1997)
5. WANDERSEE, N.J., Lee, J.C., Kaysser, T.M., Bronson, R.T., Barker, J.E.: Sph/sph bone marrow implanted in +/+ mice duplicates the pathophysiology of sph/sph mice. Blood 90:5a, 1997. (Poster, American Society of Hematology Meetings, San Diego, CA, 12/1997)
6. WANDERSEE, N.J., Roesch, A.N., Hamblen, N.R., de Moes, J., van der Valk, M.A., Bronson, R.T., Demant, P., Barker, J.E.: A new spontaneous mouse mutant with severe hereditary elliptocytosis is deficient in erythroid alpha spectrin. Blood 92:8a, 1998. (Poster, American Society of Hematology Meetings, Miami, FL, 12/1998)
7. WANDERSEE, N.J., Birkenmeier, C.S., Gifford, E.J., Barker, J.E.: Identification of three mutations in the murine erythroid alpha spectrin gene causing hereditary spherocytosis in mice. Blood 92:8a, 1998. (Poster, American Society of Hematology Meetings, Miami, FL, 12/1998)
8. Barker, J.E., WANDERSEE, N.J.: The genesis of thrombi in mice with hereditary spherocytosis is ameliorated by post-natal injections of normal marrow. Blood 92:10a, 1998. (Poster, American Society of Hematology Meetings, Miami, FL, 12/1998)
9. WANDERSEE, N.J., Tait, J.F., Barker, J.E.: Thrombosis in mice with hereditary spherocytosis does not correlate with the level of red blood cell phosphatidylserine exposure. Blood 94:190a, 1999. (Poster, American Society of Hematology Meetings, New Orleans, LA, 12/1999)
10. WANDERSEE, N.J., Lee, J.C., Deveau, S.A., Barker, J.E.: The presence of normal red blood cells in young mice with hereditary spherocytosis ameliorates thrombosis in the adult. Blood 96:594a, 2000. (Poster, American Society of Hematology Meetings, San Francisco, CA, 12/2000)
11. WANDERSEE, N.J., Olson, S.C., Holzmann, S.L., Barker, J.E., Hillery, C.A.: Increased erythrocyte adhesion in mice with hereditary spherocytosis and hereditary elliptocytosis. Blood 96:594a, 2000. (Poster, American Society of Hematology Meetings, San Francisco, CA, 12/2000)
12. WANDERSEE, N.J., Sillah, N.M., Watkins, N.A., Scott, J.P., Ouwehand ,W.H., Hillery, C.A.: Single chain antibody fragments derived from a human phage display library preferentially bind sickle red blood cells and inhibit sickle cell adhesion. Blood 98:484a, 2001. (Poster, American Society of Hematology Meetings, Orlando, FL, 12/2001)
13. Hillery, C.A., Sillah, N.M., WANDERSEE, N.J., Holzmann, S.L., Gavazova, S., Foster, T.D., Scott, J.P., Montgomery, R.R., Saunthararajah, Y., DeSimone, J.: Effect of fetal hemoglobin induction by decitabine on erythrocyte adhesion, coagulation parameters and markers of inflammation in patients with sickle cell disease. Blood 100:25a, 2002. (Oral by Dr. Hillery, American Society of Hematology Meetings, Philadelphia, PA, 12/2002)
14. WANDERSEE, N.J., Punzalan, R.C., Watkins, N.A., Ouwehand, W.H., Low, P.S., Hillery, C.A.: Role of erythrocyte hydration in adhesion of RBCs to thrombospondin-1. (Poster, Gordon Research Conference on Red Cells, Il Ciocco, Italy, 5/2003)
15. Hillery, C.A., Foster, T.D., Holzhauer, S.L., Scott, J.P., Panepinto, J.P., Trost, B.A., Mohandas, N., Degen, J.L., WANDERSEE, N.J.: Fibrinogen Deficiency Decreases Hepatic Infarction in a Stem Cell Transplant Model of Murine Sickle Cell Disease. Blood 102:81a-82a, 2003. (Oral by Dr. Hillery, American Society of Hematology Meetings, San Diego, CA, 12/2003)
16. Hillery, C.A., Foster, T.D., Holzhauer, S.L., Scott, J.P., Panepinto, J.P., Mohandas, N., Mackman , N, WANDERSEE, N.J.: Tissue factor deficiency decreases sickle cell-induced vascular stasis in a hematopoietic stem cell transplant model of murine sickle cell disease. Blood 104:236a, 2004. (Oral by Dr. Hillery, American Society of Hematology Meetings, San Diego, CA, 12/2004)
17. WANDERSEE, N.J., Punzalan, R.C., Sillah, N.M., Rettig, M.P., Kennedy, M.D., Scott, J.P., Low, P.S., Hillery, C.A.: Modulation of erythrocyte adhesion by changes in cellular tonicity and volume. Blood 104:440a, 2004. (Poster, American Society of Hematology Meetings, San Diego, CA, 12/2004)
18. Low, P.S., Campanella, E.M., Anong, W.A., WANDERSEE, N.J., Hillery, C.A., Chishti, A.: Characterization of glycolytic enzyme complexes on murine erythrocyte membranes. Blood 104:438a, 2004. (Poster by Dr. Low, American Society of Hematology Meetings, San Diego, CA, 12/2004)
19. Stapleton, M.A., Italiano, J., WANDERSEE, N.J.: Platelet number and function correlate with cardiac thrombosis in mice with severe hereditary spherocytosis. (Poster, Midwest Platelet Conference, Milwaukee, WI, 10/2004; also, Poster, Gordon Research Conference on Cell Biology of Megakaryocytes and Platelets, Santa Ynez, CA, 3/2005)
20. Schraufnagel, A.C., Piknova, B., Pritchard, K.A. Jr., Hogg, N., WANDERSEE, N.J.: Nitric oxide scavenging, abnormal vasoregulation and oxidative damage in sph/sph mice with severe hereditary spherocytosis: possible consequences of red blood cell hemolysis. Blood 106:474a, 2005. (Poster, American Society of Hematology Meetings, Atlanta, GA, 12/2005)
21. Sabina, R.L., WANDERSEE, N.J., Hillery, C.A.: AMP deaminase activation contributes to accelerated adenine nucleotide pool depletion during periods of energy imbalance in sickle cell erythrocytes. Blood 106:476a, 2005. (Poster by Dr. Sabina, American Society of Hematology Meetings, Atlanta, GA, 12/2005)
22. Pritchard, K.A. Jr., Besch, T.L., Wang, J., Xu, H., Jones, D.W., Foster, T.D., Holzhauer, S.L., Oldham, K.T., WANDERSEE, N.J., Hillery, C.A.: Differential effects of Lovastatin and allopurinol therapy in a murine model of sickle cell disease. Blood 106:654a, 2005. (Poster by Dr. Pritchard, American Society of Hematology Meetings, Atlanta, GA, 12/2005)
23. Shi, Q., Weiler, H., Haberichter, S.L., Cooley, B.C., Fahs, S.A., Desai, D., WANDERSEE, N.J., Jozwiak, M.A., Montgomery, R.R.: Transgenic targeting of human FVIII expression to endothelial cells corrects the murine hemophilia A phenotype and re-establishes a releasable pool of FVIII together with vWF. Blood 106:855a, 2005. (Poster by Dr. Shi, American Society of Hematology Meetings, Atlanta, GA, 12/2005)
24. Uy, T., WANDERSEE, N.J., Hillery, C.A.: Modifications of the coagulation system alter inflammation in murine sickle cell disease. Blood 108:365a, 2006. (Poster by Dr. Uy, American Society of Hematology Meetings, Orlando, FL, 12/2006)
25. WANDERSEE, N.J., Frei, A.C., Holzhauer, S.L., Scott, J.P., Pritchard, K.A., Fagan, K.A., Hogg, N., Hillery, C.A.: Vascular dysfunction in murine models of hemolytic anemia. Blood 110:846, 2007. (Oral, American Society of Hematology Meetings, Atlanta, GA, 12/2007)
26. WANDERSEE, N.J., Uy, T., Retherford, D., Noon-Abdullah, A., Frei, A.C., Brandow, A.M., Stucky, C.M., Hillery C.A.: Increased Sensitivity to Mechanical Allodynia in a Mouse Model of Sickle Cell Disease. Blood 112:202a, 2008. (Poster, American Society of Hematology Meetings, San Francisco, CA, 12/2008)
27. Guo, Y., Uy, T., WANDERSEE, N.J., Scott, J.P., Weiler, H., Holzhauer, S.L., Retherford, D., Foster, T.D., Hillery, C.A. The Protein C Pathway in Human and Murine Sickle Cell Disease: Changes in Protein C, Thrombomodulin (TM), and Endothelial Protein C Receptor (EPCR) at Baseline and during Acute Vaso-occlusion. Blood 112:859a, 2008. (Oral by Dr. Guo, American Society of Hematology Meetings, San Francisco, CA, 12/2008)
28. Frei, A.C., Guo Y., Jones, D.W., Pritchard, K.A., Jr., Fagan, K.A., Hogg, N., Wandersee, N.J.: Vascular dysfunction in a murine model of severe hemolysis. (Poster Presentation, American Heart Special Research Symposium [for AHA grant awardees], New Orleans, LA, Nov 2008)
29. WANDERSEE, N.J., Uy, T., Barabas, M.-E., Retherford, D., Noon-Abdullah, A., Brandow, A.M., Stucky, C.M., Hillery C.A.: Mechanical Hypersensitivity Occurs in Mouse Models of Hemolytic Anemia. (Poster, Gordon Research Conference on Red Cells, Biddeford, ME, 6/2009)