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Alfred C. Nicolosi MD Online Profile

Alfred C. Nicolosi MD

Professor
Medical College of Wisconsin
Department: Surgery
Division: Cardiothoracic
Program: Cardiothoracic Surgery


Research Experience

  • Heart Aneurysm
  • Heart-Assist Devices
  • Mechanoreceptors
  • Myocardial Ischemia
  • Myocardial Stunning
  • Ventricular Function
  • gadolinium

    • Clinical Expertise

  • Cardiovascular Physiology
  • Circulatory and Respiratory Physiology
  • Specialties, Surgical
  • Thoracic Surgery

    • Publications

  • Dizziness leads to an unexpected diagnosis. (Pagel PS, Johnson KR, Nicolosi AC) J Cardiothorac Vasc Anesth 2012 Oct;26(5):975-7 PMID 22480633
  • A large artery exiting the proximal aortic root: anatomic variation or physiologic compensatory response? (Pagel PS, Eiseman MS, Johnson KY, Nicolosi AC) J Cardiothorac Vasc Anesth 2013 Apr;27(2):410-2 PMID 22425482
  • The mysterious case of an absent true lumen in a patient with a type-A aortic dissection. (Pagel PS, Eiseman MS, Murtaza G, Nicolosi AC) J Cardiothorac Vasc Anesth 2012 Oct;26(5):970-2 PMID 21684766
  • Anterior mitral leaflet injury after debridement? (Pagel PS, Loveday RK, Murtaza G, Nicolosi AC) J Cardiothorac Vasc Anesth 2012 Aug;26(4):748-50 PMID 21620731
  • Sudden cardiac death resulting from acute coronary artery aneurysm occlusion: successful resuscitation and treatment of an adolescent boy with previously unrecognized Kawasaki disease. (Hadid D, Plambeck CJ, Nicolosi AC, Markan S, Pagel PS) Int Anesthesiol Clin 2011;49(2):42-51 PMID 21441798
  • A large mass on a newly implanted pulmonary artery catheter: thrombus, vegetation, or an anatomic explanation? (Loveday RK, Wanta BT, Nicolosi AC, Pagel PS) J Cardiothorac Vasc Anesth 2012 Feb;26(1):175-7 PMID 20864360
  • Necessitating, recurrent pseudoaneurysm of the left ventricle. (Marla R, Nicolosi AC) Ann Thorac Surg 2010 Feb;89(2):642 PMID 20103372
  • Gadolinium decreases inflammation related to myocardial ischemia and reperfusion injury. (Strande JL, Routhu KV, Hsu A, Nicolosi AC, Baker JE) J Inflamm (Lond) 2009;6:34 PMID 20003243
  • Use of ECMO to temporize circulatory instability during severe Brugada electrical storm. (Pagel PS, Lilly RE, Nicolosi AC) Ann Thorac Surg 2009 Sep;88(3):982-3 PMID 19699933
  • Mechanism of myocardial protection by pressure-volume unloading involves stretch-induced pathophysiology. (Nicolosi AC) J Thorac Cardiovasc Surg 2009 Jul;138(1):262 PMID 19577112
  • Supravalvular aortic membrane with severe aortic regurgitation: an unusual presentation in adults. (Marla R, Woods T, Lilly RE, Nicolosi AC, Masroor S) J Heart Valve Dis 2009 May;18(3):347-8 PMID 19557996
  • Surgical repair of long-standing mitral valve prolapse: a case report and brief review of the literature. (Pagel PS, Haider N, Butler EG, Nicolosi AC) WMJ 2009 Feb;108(1):44-7 PMID 19326636
  • A cavity in the left ventricular outflow tract: a disastrous consequence of tooth decay? (Young M, Markan S, Hansen TN, Iqbal Z, Nicolosi AC, Pagel PS) J Cardiothorac Vasc Anesth 2010 Jun;24(3):513-5 PMID 19285432
  • To flow or not to flow: that is the question in this chronic aortic dissection. (Patel K, Lindenbaum L, Plambeck CJ, Marla R, Nicolosi AC, Pagel PS) J Cardiothorac Vasc Anesth 2008 Oct;22(5):788-9 PMID 18922445
  • Sudden onset of sharp left-sided chest pain and hemoptysis in a young man with a history of childhood aortic coarctation repair. (Patel K, Ruttum DM, Olund TJ, Gandhi SD, Tisol WB, Nicolosi AC, Pagel PS) J Cardiothorac Vasc Anesth 2009 Apr;23(2):256-8 PMID 18834811
  • New rocking motion of a prosthetic aortic valve: an unexpected echocardiographic finding 1 month after implantation. (Nelson RY, Markan S, Iqbal Z, Nicolosi AC, Lilly RE, Pagel PS) J Cardiothorac Vasc Anesth 2009 Aug;23(4):561-3 PMID 18834779
  • A patient with chronic hemodialysis-dependent end-stage renal disease presenting with mild dyspnea on exertion and a harsh systolic murmur. (John A, Robinson DA, Markan S, Nicolosi AC, Pagel PS) J Cardiothorac Vasc Anesth 2009 Apr;23(2):253-5 PMID 18834768
  • Gadolinium limits myocardial infarction in the rat: dose-response, temporal relations and mechanisms. (Nicolosi AC, Strande JL, Hsu A, Fu X, Su J, Gross GJ, Baker JE) J Mol Cell Cardiol 2008 Feb;44(2):345-51 PMID 18083188
  • Near total eclipse of the aortic valve: an echocardiographic penumbra caused by a mechanical mitral valve prosthesis and its clinical implications. (Vandrovec SM, Butler EG, May JA, Iqbal Z, Gandhi SD, Nicolosi AC, Pagel PS) J Cardiothorac Vasc Anesth 2007 Aug;21(4):610-1 PMID 17678800
  • Perioperative implications of charcot-marie-tooth disease during coronary artery bypass graft surgery. (Shankar V, Markan S, Gandhi SD, Iqbal Z, Novalija J, Nicolosi AC, Pagel PS) J Cardiothorac Vasc Anesth 2007 Aug;21(4):567-9 PMID 17678787
  • A widened mediastinum in a patient with a left parasternal stab wound. (Iqbal Z, Gandhi SD, Markan S, Nicolosi AC, Pagel PS) J Cardiothorac Vasc Anesth 2007 Apr;21(2):307-9 PMID 17418756
  • Effects of gadolinium on regionally stunned myocardium: temporal considerations. (Nicolosi AC, Kwok CS, Logan B) J Surg Res 2007 May 15;139(2):286-91 PMID 17270216
  • Antagonists of stretch-activated ion channels restore contractile function in hamster dilated cardiomyopathy. (Nicolosi AC, Kwok CS, Bosnjak ZJ) J Heart Lung Transplant 2004 Aug;23(8):1003-7 PMID 15312831
  • A novel approach to the management of tracheoinnominate artery fistula. (Gasparri MG, Nicolosi AC, Almassi GH) Ann Thorac Surg 2004 Apr;77(4):1424-6 PMID 15063280
  • Mitochondrial sources of H2O2 generation play a key role in flow-mediated dilation in human coronary resistance arteries. (Liu Y, Zhao H, Li H, Kalyanaraman B, Nicolosi AC, Gutterman DD) Circ Res 2003 Sep 19;93(6):573-80 PMID 12919951
  • Mechanism of thrombin-induced vasodilation in human coronary arterioles. (Bosnjak JJ, Terata K, Miura H, Sato A, Nicolosi AC, McDonald M, Manthei SA, Saito T, Hatoum OA, Gutterman DD) Am J Physiol Heart Circ Physiol 2003 Apr;284(4):H1080-6 PMID 12595282
  • Diabetes mellitus impairs vasodilation to hypoxia in human coronary arterioles: reduced activity of ATP-sensitive potassium channels. (Miura H, Wachtel RE, Loberiza FR Jr, Saito T, Miura M, Nicolosi AC, Gutterman DD) Circ Res 2003 Feb 7;92(2):151-8 PMID 12574142
  • Perioperative considerations in the patient with a left ventricular assist device. (Nicolosi AC, Pagel PS) Anesthesiology 2003 Feb;98(2):565-70 PMID 12552217
  • Gadolinium attenuates regional stunning in the canine heart in vivo. (Nicolosi AC, West G, Markley JG, Logan B, Olinger GN) J Thorac Cardiovasc Surg 2002 Jul;124(1):57-62 PMID 12091809
  • Increased incidence of radial artery calcification in patients with diabetes mellitus. (Nicolosi AC, Pohl LL, Parsons P, Cambria RA, Olinger GN) J Surg Res 2002 Jan;102(1):1-5 PMID 11792144
  • Gadolinium prevents stretch-mediated contractile dysfunction in isolated papillary muscles. (Nicolosi AC, Kwok CS, Contney SJ, Olinger GN, Bosnjak ZJ) Am J Physiol Heart Circ Physiol 2001 Mar;280(3):H1122-8 PMID 11179055
  • Levosimendan enhances cardiac performance after cardiopulmonary bypass: a prospective, randomized placebo-controlled trial. (Nijhawan N, Nicolosi AC, Montgomery MW, Aggarwal A, Pagel PS, Warltier DC) J Cardiovasc Pharmacol 1999 Aug;34(2):219-28 PMID 10445673
  • Effects of postischemic left ventricular pressure-volume unloading on contractile recovery and myocardial blood flow in the regionally stunned canine heart. (Nicolosi AC, Markley JG, Olinger GN) J Thorac Cardiovasc Surg 1999 Jul;118(1):181-8 PMID 10384201
  • Atrial fibrillation after cardiac surgery: a major morbid event? (Almassi GH, Schowalter T, Nicolosi AC, Aggarwal A, Moritz TE, Henderson WG, Tarazi R, Shroyer AL, Sethi GK, Grover FL, Hammermeister KE) Ann Surg 1997 Oct;226(4):501-11; discussion 511-3 PMID 9351718
  • Effects of left heart assist on geometry and function of the interventricular septum. (Markley JG, Nicolosi AC) Ann Thorac Surg 1996 Dec;62(6):1752-8 PMID 8957382
  • Assessment of right ventricular function in swine using sonomicrometry and conductance. (Nicolosi AC, Hettrick DA, Warltier DC) Ann Thorac Surg 1996 May;61(5):1381-7; discussion 1387-8 PMID 8633946
  • Intraoperative epiaortic ultrasound during cardiac surgery. (Nicolosi AC, Aggarwal A, Almassi GH, Olinger GN) J Card Surg 1996 Jan-Feb;11(1):49-55 PMID 8775335
  • Late development of esophageal compression from a vascular ring. (Nicolosi AC, Cambria RA) Ann Thorac Surg 1995 Nov;60(5):1413-5 PMID 8526642
  • Reactivity of human saphenous veins at arterial perfusion pressures. (Rusch NJ, Wooldridge TA, Kulig CC, Almassi GH, Nicolosi AC, Olinger GN, Boerboom LE) J Thorac Cardiovasc Surg 1995 Oct;110(4 Pt 1):1005-12 PMID 7475128
  • Effects of perfusion-induced edema on diastolic stress-strain relations in intact swine papillary muscle. (Detwiler PW, Nicolosi AC, Weng ZC, Spotnitz HM) J Thorac Cardiovasc Surg 1994 Sep;108(3):467-76 PMID 8078339
  • Cardiac tamponade secondary to giant lymph node hyperplasia (Castleman's disease) (Nicolosi AC, Almassi GH, Komorowski R) Chest 1994 Feb;105(2):637-9 PMID 8306790
  • Quantitative effects of myocardial edema on the left ventricular pressure-volume relation. Influence of cardioplegia osmolarity over two hours of ischemic arrest. (Hsu DT, Weng ZC, Nicolosi AC, Detwiler PW, Sciacca R, Spotnitz HM) J Thorac Cardiovasc Surg 1993 Oct;106(4):651-7 PMID 8412259
  • Effects of crystalloid, blood, and University of Wisconsin perfusates on weight, water content, and left ventricular compliance in an edema-prone, isolated porcine heart model. (Weng ZC, Nicolosi AC, Detwiler PW, Hsu DT, Schierman SW, Goldstein AH, Spotnitz HM) J Thorac Cardiovasc Surg 1992 Mar;103(3):504-13 PMID 1545549
  • Reply to invited letter concerning: Simulated left ventricular aneurysm and aneurysm repair in swine (J Thorac Cardiovasc Surg 1990;100:793-4) (Nicolosi AC, Spotnitz HM) J Thorac Cardiovasc Surg 1991 Nov;102(5):799 PMID 1943200
  • Simulated left ventricular aneurysm and aneurysm repair in swine. (Nicolosi AC, Weng ZC, Detwiler PW, Spotnitz HM) J Thorac Cardiovasc Surg 1990 Nov;100(5):745-55 PMID 2146447
  • Effects of simulated intraoperative electrophysiological testing on function of the canine left ventricle. (Cole BN, Nicolosi AC, Uygur IJ, Jackson D, Spotnitz HM) Ann Thorac Surg 1988 Nov;46(5):556-62 PMID 3190330
  • Quantitative analysis of regional systolic function with left ventricular aneurysm. (Nicolosi AC, Spotnitz HM) Circulation 1988 Oct;78(4):856-62 PMID 3168193
  • Quantitative analysis of regional systolic function with left ventricular aneurysm. (Nicolosi AC, Spotnitz HM) Curr Surg 1988 Sep-Oct;45(5):387-9 PMID 3246163