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Allan M. Roza MD Online Profile

Allan M. Roza MD

Professor
Medical College of Wisconsin
Department: Surgery
Division: Transplant Surgery
Program: Kidney


Publications

  • Reactive oxygen and reactive nitrogen as signaling molecules for caspase 3 activation in acute cardiac transplant rejection. (Pieper GM, Nilakantan V, Nguyen TK, Hilton G, Roza AM, Johnson CP) Antioxid Redox Signal 2008 Jun;10(6):1031-40 PMID 18327972
  • The complex role of iNOS in acutely rejecting cardiac transplants. (Pieper GM, Roza AM) Free Radic Biol Med 2008 Apr 15;44(8):1536-52 PMID 18291116
  • Early mortality rates in older kidney recipients with comorbid risk factors. (Kauffman HM, McBride MA, Cors CS, Roza AM, Wynn JJ) Transplantation 2007 Feb 27;83(4):404-10 PMID 17318072
  • A murine model of invasive aspergillosis: variable benefit of interferon-gamma administration under in vitro and in vivo conditions. (Johnson CP, Edmiston CE Jr, Zhu YR, Adams MB, Roza AM, Kurup V) Surg Infect (Larchmt) 2005;6(4):397-407 PMID 16433604
  • Post-translational modification of manganese superoxide dismutase in acutely rejecting cardiac transplants: role of inducible nitric oxide synthase. (Nilakantan V, Halligan NL, Nguyen TK, Hilton G, Khanna AK, Roza AM, Johnson CP, Adams MB, Griffith OW, Pieper GM) J Heart Lung Transplant 2005 Oct;24(10):1591-9 PMID 16210135
  • Hierarchical change in antioxidant enzyme gene expression and activity in acute cardiac rejection: role of inducible nitric oxide synthase. (Nilakantan V, Zhou X, Hilton G, Roza AM, Adams MB, Johnson CP, Pieper GM) Mol Cell Biochem 2005 Feb;270(1-2):39-47 PMID 15792352
  • Protective mechanisms of a metalloporphyrinic peroxynitrite decomposition catalyst, WW85, in rat cardiac transplants. (Pieper GM, Nilakantan V, Chen M, Zhou J, Khanna AK, Henderson JD Jr, Johnson CP, Roza AM, Szabó C) J Pharmacol Exp Ther 2005 Jul;314(1):53-60 PMID 15784653
  • Treatment with {alpha}-phenyl-N-tert-butylnitrone, a free radical-trapping agent, abrogates inflammatory cytokine gene expression during alloimmune activation in rat cardiac allografts. (Pieper GM, Nilakantan V, Zhou X, Khanna AK, Johnson CP, Roza AM, Adams MB, Hilton G, Felix CC) J Pharmacol Exp Ther 2005 Feb;312(2):774-9 PMID 15347735
  • Inhibition of nitrosylation, nitration, lymphocyte proliferation, and gene expression in acute and delayed cardiac allograft rejection by an orally active dithiocarbamate. (Pieper GM, Khanna AK, Kampalath BN, Felix CC, Hilton G, Johnson CP, Adams MB, Roza AM) J Cardiovasc Pharmacol 2004 Apr;43(4):522-30 PMID 15085063
  • Spatial distribution and temporal onset of NF-kB activation and inducible nitric oxide synthase within pancreatic islets in the pre-diabetic stage of genetic, diabetic-prone BB rats: attenuation by drug intervention decreases inflammatory cell infiltration and incidence of diabetes. (Pieper CM, Roza AM, Henderson JD Jr, Zhu YR, Lai CS) Inflamm Res 2004 Jan;53(1):22-30 PMID 15021977
  • Variable efficacy of N6-(1-iminoethyl)-L-lysine in acute cardiac transplant rejection. (Pieper GM, Nilakantan V, Hilton G, Zhou X, Khanna AK, Halligan NL, Felix CC, Kampalath B, Griffith OW, Hayward MA, Roza AM, Adams MB) Am J Physiol Heart Circ Physiol 2004 Feb;286(2):H525-34 PMID 14715498
  • A dithiocarbamate analogue decreases intraislet cell infiltration and the incidence of diabetes mellitus in the genetic diabetes-prone BB rat. (Pieper GM, Henderson JD Jr, Roza AM, Lai CS) Pancreas 2004 Jan;28(1):e16-25 PMID 14707744
  • Beta tryptase levels are not elevated in patients undergoing liver transplantation. (Woehlck HJ, Johnson CP, Roza AM, Adams MB) Liver Transpl 2003 Sep;9(9):980-2 PMID 12942461
  • Mechanisms of the protective action of diethyldithiocarbamate-iron complex on acute cardiac allograft rejection. (Pieper GM, Nilakantan V, Hilton G, Halligan NL, Felix CC, Kampalath B, Khanna AK, Roza AM, Johnson CP, Adams MB) Am J Physiol Heart Circ Physiol 2003 May;284(5):H1542-51 PMID 12679325
  • Non-heme iron protein: a potential target of nitric oxide in acute cardiac allograft rejection. (Pieper GM, Halligan NL, Hilton G, Konorev EA, Felix CC, Roza AM, Adams MB, Griffith OW) Proc Natl Acad Sci U S A 2003 Mar 18;100(6):3125-30 PMID 12624190
  • Transplant tumor registry: donor related malignancies. (Myron Kauffman H, McBride MA, Cherikh WS, Spain PC, Marks WH, Roza AM) Transplantation 2002 Aug 15;74(3):358-62 PMID 12177614
  • Prolonging organ allograft survival: potential role of nitric oxide scavengers. (Pieper GM, Khanna AK, Roza AM) BioDrugs 2002;16(1):37-45 PMID 11909000
  • A ruthenium (III) polyaminocarboxylate complex, a novel nitric oxide scavenger, enhances graft survival and decreases nitrosylated heme protein in models of acute and delayed cardiac transplant rejection. (Pieper GM, Roza AM, Adams MB, Hilton G, Johnson M, Felix CC, Kampalath B, Darkes M, Wanggui Y, Cameron B, Fricker SP) J Cardiovasc Pharmacol 2002 Mar;39(3):441-8 PMID 11862124
  • Adenocarcinoma arising in a transplanted pancreas. (Roza AM, Johnson C, Juckett M, Eckels D, Adams M) Transplantation 2001 Sep 27;72(6):1156-7 PMID 11579317
  • Antioxidant treatment inhibits activation of myocardial nuclear factor kappa B and inhibits nitrosylation of myocardial heme protein in cardiac transplant rejection. (Pieper GM, Olds C, Hilton G, Lindholm PF, Adams MB, Roza AM) Antioxid Redox Signal 2001 Feb;3(1):81-8 PMID 11291601
  • A novel scavenger of nitric oxide decreases heme protein nitrosylation and prolongs graft survivial during cardiac transplant rejection. (Pieper GM, Roza AM, Adams MB, Johnson M, Hilton G, Felix CC, Fricker SP) J Heart Lung Transplant 2001 Feb;20(2):157 PMID 11250230
  • Effects of intestinal transplantation on postprandial motility and regulation of intestinal transit. (Johnson CP, Sarna SK, Zhu YR, Buchmann E, Bonham L, Telford GL, Roza AM, Adams MB) Surgery 2001 Jan;129(1):6-14 PMID 11150028
  • NOX 100, a nitric oxide scavenger, enhances cardiac allograft survival and promotes long-term graft acceptance. (Roza AM, Cooper M, Pieper G, Hilton G, Dembny K, Lai CS, Lindholm P, Komorowski R, Felix C, Johnson C, Adams M) Transplantation 2000 Jan 27;69(2):227-31 PMID 10670631
  • Reduction of myocardial nitrosyl complex formation by a nitric oxide scavenger prolongs cardiac allograft survival. (Pieper GM, Cooper M, Johnson CP, Adams MB, Felix CC, Roza AM) J Cardiovasc Pharmacol 2000 Jan;35(1):114-20 PMID 10630741
  • Clinical efficacy of the Abbott Tacrolimus II assay for the IMx. (Cannon RD, Wong SH, Hariharan S, Adams MB, Johnson CP, Roza AM, Pearson ML, Werner CL) Ann Clin Lab Sci 1999 Oct-Dec;29(4):299-302 PMID 10528829
  • Recurrent and de novo glomerular disease after renal transplantation: a report from Renal Allograft Disease Registry (RADR). (Hariharan S, Adams MB, Brennan DC, Davis CL, First MR, Johnson CP, Ouseph R, Peddi VR, Pelz CJ, Roza AM, Vincenti F, George V) Transplantation 1999 Sep 15;68(5):635-41 PMID 10507481
  • Renal transplantation for end-stage renal disease following bone marrow transplantation: a report of six cases, with and without immunosuppression. (Butcher JA, Hariharan S, Adams MB, Johnson CP, Roza AM, Cohen EP) Clin Transplant 1999 Aug;13(4):330-5 PMID 10485375
  • Pre-transplant identification of risk factors that adversely affect length of stay and charges for renal transplantation. (Johnson CP, Kuhn EM, Hariharan S, Hartz AJ, Roza AM, Adams MB) Clin Transplant 1999 Apr;13(2):168-75 PMID 10202613
  • Recurrent and de novo glomerular disease after renal transplantation: a report from renal allograft disease registry. (Hariharan S, Adams MB, Brennan DC, Davis CL, First MR, Johnson CP, Ouseph R, Peddi VR, Pelz C, Roza AM, Vincenti F, George V) Transplant Proc 1999 Feb-Mar;31(1-2):223-4 PMID 10083084
  • Acute torsion of the renal transplant after combined kidney-pancreas transplant. (Roza AM, Johnson CP, Adams M) Transplantation 1999 Feb 15;67(3):486-8 PMID 10030301
  • Prognostic value of intraoperative blood flow measurements in vascular access surgery. (Johnson CP, Zhu YR, Matt C, Pelz C, Roza AM, Adams MB) Surgery 1998 Oct;124(4):729-37; discussion 737-8 PMID 9780995
  • Heparin interferes with the determination of plasma nitric oxide by inhibition of enzymatic conversion of nitrate to nitrite by nitrate reductase. (Dembny KD, Roza AM, Johnson C, Adams MB, Pieper GM) Clin Chim Acta 1998 Jul 6;275(1):107-14 PMID 9706849
  • Electron spin resonance analysis of heme-nitrosyl and reduced iron-sulfur centered complexes in allogeneic, heterotopic cardiac transplants: effects of treatment with pyrrolidine dithiocarbamate. (Nakanishi AL, Roza AM, Adams MB, Seibel R, Moore-Hilton G, Kalyanaraman B, Pieper GM) Free Radic Biol Med 1998 Jul 15;25(2):201-7 PMID 9667497
  • Recurrent and de novo renal diseases after renal transplantation: a report from the renal allograft disease registry. (Hariharan S, Peddi VR, Savin VJ, Johnson CP, First MR, Roza AM, Adams MB) Am J Kidney Dis 1998 Jun;31(6):928-31 PMID 9631835
  • Pancreatic transplantation reverses endothelial dysfunction in experimental diabetes mellitus. (Pieper GM, Adams MB, Roza AM) Surgery 1998 Jan;123(1):89-95 PMID 9457228
  • Reversal by L-arginine of a dysfunctional arginine/nitric oxide pathway in the endothelium of the genetic diabetic BB rat. (Pieper GM, Siebeneich W, Moore-Hilton G, Roza AM) Diabetologia 1997 Aug;40(8):910-5 PMID 9267985
  • Chronic treatment with the 21-aminosteroid U74389F, an inhibitor of lipid peroxidation, does not prevent diabetic endothelial dysfunction. (Pieper GM, Jordan M, Roza AM) Cardiovasc Drugs Ther 1997 Jul;11(3):435-40 PMID 9310271
  • Management of severe pancreatitis in renal transplant recipients. (Slakey DP, Johnson CP, Cziperle DJ, Roza AM, Wittmann DH, Gray DW, Roake JA, Britton J, Morris PJ, Adams MB) Ann Surg 1997 Feb;225(2):217-22 PMID 9065299
  • Postprandial motor activity and its relationship to transit in the canine ileum. (Johnson CP, Sarna SK, Baytiyeh R, Zhu YR, Cowles VE, Telford GL, Roza AM, Adams MB) Surgery 1997 Feb;121(2):182-9 PMID 9037230
  • Chronic treatment in vivo with dimethylthiourea, a hydroxyl radical scavenger, prevents diabetes-induced endothelial dysfunction. (Pieper GM, Siebeneich W, Roza AM, Jordan M, Adams MB) J Cardiovasc Pharmacol 1996 Dec;28(6):741-5 PMID 8961070
  • Mechanisms for control of intestinal transit in short gut syndrome. (Johnson CP, Sarna SK, Zhu Y, Telford GL, Roza AM, Adams MB) Transplant Proc 1996 Oct;28(5):2702-5 PMID 8908017
  • Restoration of vascular endothelial function in diabetes. (Pieper GM, Jordan M, Adams MB, Roza AM) Diabetes Res Clin Pract 1996 Jul;31 Suppl:S157-62 PMID 8864654
  • Diabetic complications and the surgeon. (Adams MB, Johnson CP, Roza AM) Curr Probl Surg 1996 Mar;33(3):223-98 PMID 8595785
  • Evaluation of the mechanism of endothelial dysfunction in the genetically-diabetic BB rat. (Pieper GM, Moore-Hilton G, Roza AM) Life Sci 1996;58(9):PL147-52 PMID 8632717
  • Delayed gastroduodenal emptying is an important mechanism for control of intestinal transit in short-gut syndrome. (Johnson CP, Sarna SK, Zhu YR, Buchmann E, Bonham L, Telford GL, Roza AM, Adams MB) Am J Surg 1996 Jan;171(1):90-5; discussion 95-6 PMID 8554158
  • Syngeneic pancreatic islet transplantation reverses endothelial dysfunction in experimental diabetes. (Pieper GM, Jordan M, Adams MB, Roza AM) Diabetes 1995 Sep;44(9):1106-13 PMID 7657036
  • Detection by ESR of DMPO hydroxyl adduct formation from islets of Langerhans. (Pieper GM, Felix CC, Kalyanaraman B, Turk M, Roza AM) Free Radic Biol Med 1995 Aug;19(2):219-25 PMID 7649493
  • Peroxidative stress in diabetic blood vessels. Reversal by pancreatic islet transplantation. (Pieper GM, Jordan M, Dondlinger LA, Adams MB, Roza AM) Diabetes 1995 Aug;44(8):884-9 PMID 7621992
  • Highly variable gastric emptying in patients with insulin dependent diabetes mellitus. (Nowak TV, Johnson CP, Kalbfleisch JH, Roza AM, Wood CM, Weisbruch JP, Soergel KH) Gut 1995 Jul;37(1):23-9 PMID 7672674
  • Normalization of pancreatic exocrine enzymes by islet transplantation in diabetic rats. (Lee PC, Jordan M, Pieper GM, Roza AM) Biochem Cell Biol 1995 May-Jun;73(5-6):269-73 PMID 8829373
  • Effects of transection and reanastomosis on postprandial jejunal transit and contractile activity. (Johnson CP, Sarna SK, Cowles VE, Baytiyeh R, Zhu YR, Buchmann E, Bonham L, Roza AM, Adams MB) Surgery 1995 May;117(5):531-7 PMID 7740424
  • Pancreatic antioxidant enzyme activity in normoglycemic diabetic prone BB rats. (Roza AM, Pieper GM, Johnson CP, Adams MB) Pancreas 1995 Jan;10(1):53-8 PMID 7899460
  • Comparison of the effects of transection and extrinsic denervation on jejunal motor and absorptive function. (Johnson CP, Sarna SK, Cowles VE, Telford GL, Roza AM, Adams MB) Transplant Proc 1994 Jun;26(3):1652-4 PMID 8030074
  • Free radicals in pancreatic and cardiac allograft rejection. (Roza AM, Pieper G, Moore-Hilton G, Johnson CP, Adams MB) Transplant Proc 1994 Apr;26(2):544-5 PMID 8171545
  • Hydroxyethyl starch deferoxamine, a novel iron chelator, delays diabetes in BB rats. (Roza AM, Slakey DP, Pieper GM, Van Ye TM, Moore-Hilton G, Komorowski RA, Johnson CP, Hedlund BE, Adams MB) J Lab Clin Med 1994 Apr;123(4):556-60 PMID 7511676
  • Motor activity and transit in the autonomically denervated jejunum. (Johnson CP, Sarna SK, Cowles VE, Osborn JL, Zhu YR, Bonham L, Buchmann E, Baytiyeh R, Telford GL, Roza AM) Am J Surg 1994 Jan;167(1):80-8 PMID 8311144
  • Accelerated gastric emptying in diabetic rodents: effect of insulin treatment and pancreas transplantation. (Nowak TV, Roza AM, Weisbruch JP, Brosnan MR) J Lab Clin Med 1994 Jan;123(1):110-6 PMID 8288950
  • Delayed cardiac allograft rejection due to combined cyclosporine and antioxidant therapy. (Slakey DP, Roza AM, Pieper GM, Johnson CP, Adams MB) Transplantation 1993 Dec;56(6):1305-9 PMID 8278993
  • Inhibition of intestinal lipid peroxidation does not minimize morphologic damage. (Van Ye TM, Roza AM, Pieper GM, Henderson J Jr, Johnson CP, Adams MB) J Surg Res 1993 Nov;55(5):553-8 PMID 8231175
  • A prospective randomized comparison of quadruple versus triple therapy for first cadaver transplants with immediate function. (Slakey DP, Johnson CP, Callaluce RD, Browne BJ, Zhu YR, Roza AM, Adams MB) Transplantation 1993 Oct;56(4):827-31 PMID 8212201
  • Factors influencing weight gain after renal transplantation. (Johnson CP, Gallagher-Lepak S, Zhu YR, Porth C, Kelber S, Roza AM, Adams MB) Transplantation 1993 Oct;56(4):822-7 PMID 8212200
  • Tulopafant, a PAF receptor antagonist, increases capillary patency and prolongs survival in discordant cardiac xenotransplants. (O'Hair DP, Roza AM, Komorowski R, Moore G, McManus RP, Johnson CP, Adams MB, Pieper GM) J Lipid Mediat 1993 May;7(1):79-84 PMID 8395256
  • Prospective randomized comparison of quadruple vs triple therapy for first cadaver transplants with immediate function. (Johnson CP, Slakey DP, Callaluce RD, Browne BJ, Roza AM, Adams MB) Transplant Proc 1993 Feb;25(1 Pt 1):585-6 PMID 8438425
  • Changes in motility, transit time, and absorption following surgical transection of the jejunum. (Johnson CP, Cowles VE, Bonham L, Buchmann E, Telford GL, Roza AM, Adams MB, Sarna SK) Transplant Proc 1992 Jun;24(3):1110-2 PMID 1604541
  • Migrating myoelectric complexes in rat ileal isografts are reduced in the fasted but not the fed state. (Telford GL, Walgenbach-Telford S, McManus LL, Moore G, Johnson C, Roza AM, Adams MB, Sarna SK) Transplant Proc 1992 Jun;24(3):1124-5 PMID 1604548
  • Endotoxemia after small bowel transplantation. (Browne BJ, Johnson CP, Roza AM, Adams MB) Transplant Proc 1992 Jun;24(3):1107 PMID 1604539
  • Alterations in intestinal flora following small bowel transplantation. (Browne BJ, Johnson CP, Edmiston CE, Hlava MA, Moore G, Roza AM, Telford GL, Adams MB) Transplant Proc 1992 Jun;24(3):1102 PMID 1604535
  • Untreated diabetes mellitus promotes intestinal microbial overgrowth. (Roza AM, Edmiston CE Jr, Frantzides C, Moore GH, Nowak TV, Johnson CP, Adams MB) Am J Surg 1992 Apr;163(4):417-21 PMID 1558281
  • Platelet activating factor antagonist RP-59227 reduces vascular injury in discordant cardiac xenograft rejection. (O'Hair DP, Roza AM, Pieper GM, Komorowski R, Moore G, McManus RP, Adams MB) Transplant Proc 1992 Apr;24(2):702-3 PMID 1566490
  • Small bowel transplantation promotes bacterial overgrowth and translocation. (Browne BJ, Johnson CP, Edmiston CE, Hlava MA, Moore GH, Roza AM, Telford GL, Adams MB) J Surg Res 1991 Dec;51(6):512-7 PMID 1943089
  • Evaluation of renal transplant dysfunction using color Doppler sonography. (Johnson CP, Foley WD, Gallagher-Lepak S, Roza AM, Adams MB) Surg Gynecol Obstet 1991 Oct;173(4):279-84 PMID 1925897
  • Plasma IL-2 levels and diagnosis of renal transplant rejection. (Johnson CP, Chaharmohal A, Buchmann E, Roza AM, Adams MB) Transplant Proc 1990 Aug;22(4):1849-51 PMID 2389458
  • Treatment of transplant rejection in the presence of cytomegalovirus viremia. (O'Hair DP, Johnson CP, Roza AM, Adams MB) Transplant Proc 1990 Aug;22(4):1815-7 PMID 2167537
  • Elimination of OX8+ cells prolongs cardiac but not pancreatic allograft survival across minor (non-MHC) histocompatibility barriers. (Roza AM, Johnson CP, Adams MB, Naji A) Transplant Proc 1990 Apr;22(2):747-8 PMID 2327028
  • Simultaneous liver and pancreas procurement--a simplified method. (Johnson CP, Roza AM, Adams MB) Transplant Proc 1990 Apr;22(2):425-6 PMID 2326942
  • Local procurement with pulsatile perfusion gives excellent results and minimizes initial cost associated with renal transplantation. (Johnson CP, Roza AM, Adams MB) Transplant Proc 1990 Apr;22(2):385-7 PMID 2326927
  • Small bowel transplantation in the rat with immediate restoration of intestinal continuity. (Moore GH, Roza AM, Johnson CP, Telford GL, Adams MB) Microsurgery 1990;11(4):300-2 PMID 2255251
  • Renal transplantation in patients more than 65 years old. (Roza AM, Gallagher-Lepak S, Johnson CP, Adams MB) Transplantation 1989 Oct;48(4):689-90 PMID 2799924
  • Effect of prolonged monoclonal antibody administration on cardiac allograft survival in the rat. (Roza AM, Kimura H, Markmann J, Naji A) Scand J Immunol 1989 Sep;30(3):333-8 PMID 2675304
  • Effect of elimination of OX-19+ and OX-8+ T-cell subsets upon pancreatic allograft survival. (Roza AM, Markmann JF, Kimura H, Johnson CP, Adams MB, Naji A) J Surg Res 1989 Apr;46(4):395-9 PMID 2649744
  • An evaluation of early cyclosporine versus ALG therapy for primary cadaver renal allografts with immediate function. (Adams MB, Johnson CP, Roza AM) Transplant Proc 1989 Feb;21(1 Pt 2):1606-8 PMID 2652523
  • Living-related donors with bilateral multiple renal arteries. A twenty-year experience. (Roza AM, Perloff LJ, Naji A, Grossman RA, Barker CF) Transplantation 1989 Feb;47(2):397-9 PMID 2645725
  • Acute appendicitis in the renal allograft recipient. (Roza AM, Perloff LJ, Naji A, Jorkasky D, Grossman RA, Tomaszewski JE, Barker CF) Transplantation 1987 Nov;44(5):715-7 PMID 3318040
  • Acute renal allograft rejection: difficulty in diagnosis of histologically mild cases by MR imaging. (Mitchell DG, Roza AM, Spritzer CE, Pollack H, Arger PH, Alavi A, Jorkasky D, Barker CF, Tomaszewski J, Naji A) J Comput Assist Tomogr 1987 Jul-Aug;11(4):655-63 PMID 3298338
  • Transferrin--a poor measure of nutritional status. (Roza AM, Tuitt D, Shizgal HM) JPEN J Parenter Enteral Nutr 1984 Sep-Oct;8(5):523-8 PMID 6436525
  • Value of high-resolution computerized tomography in localizing diseased parathyroid glands. (Roza AM, Wexler MJ, Stein L, Goltzman D) Can J Surg 1984 Jul;27(4):334-6 PMID 6744137
  • The Harris Benedict equation reevaluated: resting energy requirements and the body cell mass. (Roza AM, Shizgal HM) Am J Clin Nutr 1984 Jul;40(1):168-82 PMID 6741850