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Amy W. Hudson PhD Online Profile

Amy W. Hudson PhD

Associate Professor
Medical College of Wisconsin
Department: Microbiology and Molecular Genetics


Research Experience

  • Antigen Presentation
  • Exanthema Subitum
  • Genes, MHC Class I
  • Herpesvirus 6, Human
  • Herpesvirus 7, Human
  • insulin-responsive glucose transport
  • synaptic vesicle recyling
  • viral immune evasion
  • HHV-6
  • HHV-7
  • membrane trafficking

    • Publications

  • The human herpesvirus-7 (HHV-7) U21 immunoevasin subverts NK-mediated cytoxicity through modulation of MICA and MICB. (Schneider CL, Hudson AW) PLoS Pathog 2011 Nov;7(11):e1002362 PMID 22102813
  • Insight into the mechanism of human herpesvirus 7 U21-mediated diversion of class I MHC molecules to lysosomes. (Glosson NL, Gonyo P, May NA, Schneider CL, Ristow LC, Wang Q, Hudson AW) J Biol Chem 2010 Nov 19;285(47):37016-29 PMID 20833720
  • Human herpesvirus 7 u21 downregulates classical and nonclassical class I major histocompatibility complex molecules from the cell surface. (May NA, Glosson NL, Hudson AW) J Virol 2010 Apr;84(8):3738-51 PMID 20106916
  • Human herpesvirus-6A and -6B encode viral immunoevasins that downregulate class I MHC molecules. (Glosson NL, Hudson AW) Virology 2007 Aug 15;365(1):125-35 PMID 17467766
  • Biochemical analysis of Angelman syndrome-associated mutations in the E3 ubiquitin ligase E6-associated protein. (Cooper EM, Hudson AW, Amos J, Wagstaff J, Howley PM) J Biol Chem 2004 Sep 24;279(39):41208-17 PMID 15263005
  • The ER-lumenal domain of the HHV-7 immunoevasin U21 directs class I MHC molecules to lysosomes. (Hudson AW, Blom D, Howley PM, Ploegh HL) Traffic 2003 Dec;4(12):824-37 PMID 14617346
  • The cell biology of antigen presentation. (Hudson AW, Ploegh HL) Exp Cell Res 2002 Jan 1;272(1):1-7 PMID 11740859
  • A human herpesvirus 7 glycoprotein, U21, diverts major histocompatibility complex class I molecules to lysosomes. (Hudson AW, Howley PM, Ploegh HL) J Virol 2001 Dec;75(24):12347-58 PMID 11711625
  • Identification of a nonneuronal isoform of synaptotagmin. (Hudson AW, Birnbaum MJ) Proc Natl Acad Sci U S A 1995 Jun 20;92(13):5895-9 PMID 7597049
  • Targeting of the "insulin-responsive" glucose transporter (GLUT4) to the regulated secretory pathway in PC12 cells. (Hudson AW, Fingar DC, Seidner GA, Griffiths G, Burke B, Birnbaum MJ) J Cell Biol 1993 Aug;122(3):579-88 PMID 8335686
  • Isoform-specific subcellular targeting of glucose transporters in mouse fibroblasts. (Hudson AW, Ruiz M, Birnbaum MJ) J Cell Biol 1992 Feb;116(3):785-97 PMID 1309819

    • Grants and Awards

  • Mechanisms of Immune Evasion by HHV-6 and HHV-7 U21 (#9204659 07/01/2007 - 06/30/2013) Sponsor: NIH Allergy and Infectious Diseases
  • Immune Evasion in a Humanized Mouse Model of HHV-6 Infection (#9207880 02/01/2013 - 01/31/2015) Sponsor: NIH Allergy and Infectious Diseases