Aron Geurts PhD Online Profile
Associate Professor
Medical College of Wisconsin
Department: Physiology
Program: Genetics
Research Experience
Animals, Genetically ModifiedBiotechnologyDNA Transposable ElementsGenetic EngineeringGenetic ResearchOrganisms, Genetically ModifiedPlasmidsRatsMethodologies and Techniques
Animals, Genetically ModifiedBiotechnologyCloning, MolecularEmbryonic Stem CellsGenetic VectorsOrganisms, Genetically ModifiedPlasmidsRats, Inbred BNRats, Inbred DahlRats, Inbred StrainsSequence Analysis, DNAMCW Program / Core Facilities
Rat Transgenic CorePublications
Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage. (Mattson DL, Lund H, Guo C, Rudemiller N, Geurts AM, Jacob H) Am J Physiol Regul Integr Comp Physiol 2013 Mar 15;304(6):R407-14 PMID 23364523 Rab38 modulates proteinuria in model of hypertension-associated renal disease. (Rangel-Filho A, Lazar J, Moreno C, Geurts A, Jacob HJ) J Am Soc Nephrol 2013 Feb;24(2):283-92 PMID 23291471 Heterozygous knockout of transforming growth factor-β1 protects Dahl S rats against high salt-induced renal injury. (Chen CC, Geurts AM, Jacob HJ, Fan F, Roman RJ) Physiol Genomics 2013 Feb 4;45(3):110-8 PMID 23249995 Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits. (Katter K, Geurts AM, Hoffmann O, Mátés L, Landa V, Hiripi L, Moreno C, Lazar J, Bashir S, Zidek V, Popova E, Jerchow B, Becker K, Devaraj A, Walter I, Grzybowksi M, Corbett M, Filho AR, Hodges MR, Bader M, Ivics Z, Jacob HJ, Pravenec M, Bosze Z, Rülicke T, Izsvák Z) FASEB J 2013 Mar;27(3):930-41 PMID 23195032 High-throughput phenotyping of avoidance learning in mice discriminates different genotypes and identifies a novel gene. (Maroteaux G, Loos M, van der Sluis S, Koopmans B, Aarts E, van Gassen K, Geurts A, NeuroBSIK Mouse Phenomics Consortium, Largaespada DA, Spruijt BM, Stiedl O, Smit AB, Verhage M) Genes Brain Behav 2012 Oct;11(7):772-84 PMID 22846151 Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension. (Feng D, Yang C, Geurts AM, Kurth T, Liang M, Lazar J, Mattson DL, O'Connor PM, Cowley AW Jr) Cell Metab 2012 Feb 8;15(2):201-8 PMID 22326221 Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells. (Wilber A, Ulloa Montoya F, Hammer L, Moriarity BS, Geurts AM, Largaespada DA, Verfaillie CM, McIvor RS, Lakshmipathy U) Stem Cells Int 2011;2011:717069 PMID 21977042 Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase. (Xu D, Guo H, Xu X, Lu Z, Fassett J, Hu X, Xu Y, Tang Q, Hu D, Somani A, Geurts AM, Ostertag E, Bache RJ, Weir EK, Chen Y) Hypertension 2011 Aug;58(2):303-9 PMID 21730301 The emerging role for rat models in gene discovery. (Dwinell MR, Lazar J, Geurts AM) Mamm Genome 2011 Aug;22(7-8):466-75 PMID 21732192 Creation and characterization of a renin knockout rat. (Moreno C, Hoffman M, Stodola TJ, Didier DN, Lazar J, Geurts AM, North PE, Jacob HJ, Greene AS) Hypertension 2011 Mar;57(3):614-9 PMID 21242461 Disruption of the neuregulin 1 gene in the rat alters HPA axis activity and behavioral responses to environmental stimuli. (Taylor SB, Taylor AR, Markham JA, Geurts AM, Kanaskie BZ, Koenig JI) Physiol Behav 2011 Aug 3;104(2):205-14 PMID 21092742 Gene targeting in the rat: advances and opportunities. (Jacob HJ, Lazar J, Dwinell MR, Moreno C, Geurts AM) Trends Genet 2010 Dec;26(12):510-8 PMID 20869786 Zinc-finger nucleases: new strategies to target the rat genome. (Geurts AM, Moreno C) Clin Sci (Lond) 2010 Oct;119(8):303-11 PMID 20615201 Efficient mammalian germline transgenesis by cis-enhanced Sleeping Beauty transposition. (Carlson DF, Geurts AM, Garbe JR, Park CW, Rangel-Filho A, O'Grady SM, Jacob HJ, Steer CJ, Largaespada DA, Fahrenkrug SC) Transgenic Res 2011 Feb;20(1):29-45 PMID 20352328 Generation of gene-specific mutated rats using zinc-finger nucleases. (Geurts AM, Cost GJ, Rémy S, Cui X, Tesson L, Usal C, Ménoret S, Jacob HJ, Anegon I, Buelow R) Methods Mol Biol 2010;597:211-25 PMID 20013236 Knockout rats via embryo microinjection of zinc-finger nucleases. (Geurts AM, Cost GJ, Freyvert Y, Zeitler B, Miller JC, Choi VM, Jenkins SS, Wood A, Cui X, Meng X, Vincent A, Lam S, Michalkiewicz M, Schilling R, Foeckler J, Kalloway S, Weiler H, Ménoret S, Anegon I, Davis GD, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Jacob HJ, Buelow R) Science 2009 Jul 24;325(5939):433 PMID 19628861 Progress and prospects in rat genetics: a community view. (Aitman TJ, Critser JK, Cuppen E, Dominiczak A, Fernandez-Suarez XM, Flint J, Gauguier D, Geurts AM, Gould M, Harris PC, Holmdahl R, Hubner N, Izsvák Z, Jacob HJ, Kuramoto T, Kwitek AE, Marrone A, Mashimo T, Moreno C, Mullins J, Mullins L, Olsson T, Pravenec M, Riley L, Saar K, Serikawa T, Shull JD, Szpirer C, Twigger SN, Voigt B, Worley K) Nat Genet 2008 May;40(5):516-22 PMID 18443588 Predicting preferential DNA vector insertion sites: implications for functional genomics and gene therapy. (Hackett CS, Geurts AM, Hackett PB) Genome Biol 2007;8 Suppl 1:S12 PMID 18047689 Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system. (Lu B, Geurts AM, Poirier C, Petit DC, Harrison W, Overbeek PA, Bishop CE) Mamm Genome 2007 May;18(5):338-46 PMID 17557177 Efficient transgenic rat production by a lentiviral vector. (Michalkiewicz M, Michalkiewicz T, Geurts AM, Roman RJ, Slocum GR, Singer O, Weihrauch D, Greene AS, Kaldunski M, Verma IM, Jacob HJ, Cowley AW Jr) Am J Physiol Heart Circ Physiol 2007 Jul;293(1):H881-94 PMID 17322424 Harnessing a high cargo-capacity transposon for genetic applications in vertebrates. (Balciunas D, Wangensteen KJ, Wilber A, Bell J, Geurts A, Sivasubbu S, Wang X, Hackett PB, Largaespada DA, McIvor RS, Ekker SC) PLoS Genet 2006 Nov 10;2(11):e169 PMID 17096595 Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers. (Geurts AM, Collier LS, Geurts JL, Oseth LL, Bell ML, Mu D, Lucito R, Godbout SA, Green LE, Lowe SW, Hirsch BA, Leinwand LA, Largaespada DA) PLoS Genet 2006 Sep 29;2(9):e156 PMID 17009875 Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon. (Geurts AM, Wilber A, Carlson CM, Lobitz PD, Clark KJ, Hackett PB, McIvor RS, Largaespada DA) BMC Biotechnol 2006;6:30 PMID 16800892 Structure-based prediction of insertion-site preferences of transposons into chromosomes. (Geurts AM, Hackett CS, Bell JB, Bergemann TL, Collier LS, Carlson CM, Largaespada DA, Hackett PB) Nucleic Acids Res 2006;34(9):2803-11 PMID 16717285 Target-site preferences of Sleeping Beauty transposons. (Liu G, Geurts AM, Yae K, Srinivasan AR, Fahrenkrug SC, Largaespada DA, Takeda J, Horie K, Olson WK, Hackett PB) J Mol Biol 2005 Feb 11;346(1):161-73 PMID 15663935 Transposon vectors for gene-trap insertional mutagenesis in vertebrates. (Clark KJ, Geurts AM, Bell JB, Hackett PB) Genesis 2004 Aug;39(4):225-33 PMID 15286994 Gene transfer into genomes of human cells by the sleeping beauty transposon system. (Geurts AM, Yang Y, Clark KJ, Liu G, Cui Z, Dupuy AJ, Bell JB, Largaespada DA, Hackett PB) Mol Ther 2003 Jul;8(1):108-17 PMID 12842434 Structure-function analysis of the inverted terminal repeats of the sleeping beauty transposon. (Cui Z, Geurts AM, Liu G, Kaufman CD, Hackett PB) J Mol Biol 2002 May 17;318(5):1221-35 PMID 12083513 Grants and Awards
Advanced Genetic Engineering Technology Development (#9207159 09/30/2011 - 06/30/2016) Sponsor: NIH Office of the DirectorCRE Rat For Psychiatric Disorders (#9206854 04/01/2011 - 06/30/2013) Sponsor: NIH Drug AbuseDiscovery and Functional Studies of Genes for T1D GWAS Susceptibility Loci (#9207699 09/15/2012 - 09/14/2016) Sponsor: NIH Diabetes, Digestive and Kidney Diseases
