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Bin Ren MD, PhD Online Profile

Bin Ren MD, PhD

Assistant Professor
Medical College of Wisconsin
Department: Medicine
Division: Hematology and Oncology
Program: Hematology


Research Experience

  • Angiogenesis Inducing Agents
  • Angiogenesis Inhibitors
  • Antigens, CD36
  • Breast Neoplasms
  • Lymphangiogenesis
  • Neoplasms
  • Neoplastic Stem Cells
  • Neovascularization, Pathologic
  • Receptors, Cytoplasmic and Nuclear
  • Skin Neoplasms
  • Thrombospondins
  • Ischemic Cardiovascular Disease
  • Tumor Angiogenesis
  • Lung Cancer
  • Molecular Signaling Transduction
  • Epigenetics
  • Angiogenesis, Arteriogenesis and Functional Vasculature Formation
  • Transcriptional Signaling

    • Publications

  • Lysophosphatidic acid suppresses endothelial cell CD36 expression and promotes angiogenesis via a PKD-1-dependent signaling pathway. (Ren B, Hale J, Srikanthan S, Silverstein RL) Blood 2011 Jun 2;117(22):6036-45 PMID 21441463
  • Role of synectin in lymphatic development in zebrafish and frogs. (Hermans K, Claes F, Vandevelde W, Zheng W, Geudens I, Orsenigo F, De Smet F, Gjini E, Anthonis K, Ren B, Kerjaschki D, Autiero M, Ny A, Simons M, Dewerchin M, Schulte-Merker S, Dejana E, Alitalo K, Carmeliet P) Blood 2010 Oct 28;116(17):3356-66 PMID 20631376
  • ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish. (Ren B, Deng Y, Mukhopadhyay A, Lanahan AA, Zhuang ZW, Moodie KL, Mulligan-Kehoe MJ, Byzova TV, Peterson RT, Simons M) J Clin Invest 2010 Apr;120(4):1217-28 PMID 20237411
  • A double hit to kill tumor and endothelial cells by TRAIL and antiangiogenic 3TSR. (Ren B, Song K, Parangi S, Jin T, Ye M, Humphreys R, Duquette M, Zhang X, Benhaga N, Lawler J, Khosravi-Far R) Cancer Res 2009 May 1;69(9):3856-65 PMID 19366809
  • Regulation of tumor angiogenesis by thrombospondin-1. (Ren B, Yee KO, Lawler J, Khosravi-Far R) Biochim Biophys Acta 2006 Apr;1765(2):178-88 PMID 16406676
  • Multiple signaling is involved in endostatin-mediated apoptosis in ECV 304 endothelial cells. (Ren B, Wang Y, Ndebele K, Zhi Q, Chen FH, Wang YZ, Parangi S) Front Biosci 2005;10:1089-97 PMID 15769608
  • The antiangiogenic and therapeutic implications of endostatin. (Ren B, Höti N, Rabasseda X, Wang YZ, Wu M) Methods Find Exp Clin Pharmacol 2003 Apr;25(3):215-24 PMID 12743627
  • Recombinant human endostatin is beneficial to endothelial cell growth exposed to mildly oxidized low-density lipoproteins. (Ren B, Wang Y, Rabasseda X, Wang YZ) Methods Find Exp Clin Pharmacol 2002 May;24(4):195-9 PMID 12092005

    • Grants and Awards

  • American Cancer Society Institutional Research Grant (#9206663 01/01/2011 - 12/31/2013) PI of Epigenetic Regulation of Endothelial Cell CD36 Transcription by Lysophosphatidic Acid and Angiogenesis in Breast Cancer in Diet-induced Obese Mice (#2207726)