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Cheryl A. Hillery MD

Cheryl A. Hillery MD


Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Hematology/Oncology
Program: Hematology

Research Experience

  • Anemia, Sickle Cell
  • Blood Platelets
  • Hemolysis
  • Oxidative Stress
  • Stroke
  • Thrombosis
  • Mechanisms of vaso-occlusion and vascular dysfunction in human and murine sickle cell disease, including roles of inflammation, coagulation pathways, hemolysis and oxidative injury.
  • Nociceptive mechanisms underlying sickle cell pain.
  • Clinical Expertise

  • Anemia, Sickle Cell
  • Blood Coagulation Disorders
  • Blood Platelet Disorders
  • Hematology
  • Hemostasis
  • Thrombosis
  • Publications

  • Dietary supplementation with docosahexanoic acid (DHA) increases red blood cell membrane flexibility in mice with sickle cell disease. (Wandersee NJ, Maciaszek JL, Giger KM, Hanson MS, Zheng S, Guo Y, Mickelson B, Hillery CA, Lykotrafitis G, Low PS, Hogg N) Blood Cells Mol Dis 2015 Feb;54(2):183-8 PMID 25488613
  • Sickle cell disease increases high mobility group box 1: a novel mechanism of inflammation. (Xu H, Wandersee NJ, Guo Y, Jones DW, Holzhauer SL, Hanson MS, Machogu E, Brousseau DC, Hogg N, Densmore JC, Kaul S, Hillery CA, Pritchard KA Jr) Blood 2014 Dec 18;124(26):3978-81 PMID 25339362
  • Cold hypersensitivity increases with age in mice with sickle cell disease. (Zappia KJ, Garrison SR, Hillery CA, Stucky CL) Pain 2014 Dec;155(12):2476-85 PMID 24953902
  • Association of pro-inflammatory high-density lipoprotein cholesterol with clinical and laboratory variables in sickle cell disease. (Ataga KI, Hinderliter A, Brittain JE, Jones S, Xu H, Cai J, Kim S, Pritchard KA, Hillery CA) Hematology 2014 May 6: PMID 24801127
  • Circulating membrane-derived microvesicles in redox biology. (Larson MC, Hillery CA, Hogg N) Free Radic Biol Med 2014 Aug;73:214-28 PMID 24751526
  • Anion exchange HPLC isolation of high-density lipoprotein (HDL) and on-line estimation of proinflammatory HDL. (Ji X, Xu H, Zhang H, Hillery CA, Gao HQ, Pritchard KA Jr) PLoS One 2014;9(3):e91089 PMID 24609013
  • Intravenous magnesium for pediatric sickle cell vaso-occlusive crisis: methodological issues of a randomized controlled trial. (Badaki-Makun O, Scott JP, Panepinto JA, Casper TC, Hillery CA, Dean JM, Brousseau DC, Pediatric Emergency Care Applied Research Network (PECARN) Magnesium in Sickle Cell Crisis (MAGiC) Study Group) Pediatr Blood Cancer 2014 Jun;61(6):1049-54 PMID 24443249
  • Inhibition of myeloperoxidase decreases vascular oxidative stress and increases vasodilatation in sickle cell disease mice. (Zhang H, Xu H, Weihrauch D, Jones DW, Jing X, Shi Y, Gourlay D, Oldham KT, Hillery CA, Pritchard KA Jr) J Lipid Res 2013 Nov;54(11):3009-15 PMID 23956444
  • N-acetyl lysyltyrosylcysteine amide inhibits myeloperoxidase, a novel tripeptide inhibitor. (Zhang H, Jing X, Shi Y, Xu H, Du J, Guan T, Weihrauch D, Jones DW, Wang W, Gourlay D, Oldham KT, Hillery CA, Pritchard KA Jr) J Lipid Res 2013 Nov;54(11):3016-29 PMID 23883583
  • Calcium-phosphate microprecipitates mimic microparticles when examined with flow cytometry. (Larson MC, Luthi MR, Hogg N, Hillery CA) Cytometry A 2013 Feb;83(2):242-50 PMID 23125136
  • A novel hemoglobin-binding peptide reduces cell-free hemoglobin in murine hemolytic anemia. (Hanson MS, Xu H, Flewelen TC, Holzhauer SL, Retherford D, Jones DW, Frei AC, Pritchard KA Jr, Hillery CA, Hogg N, Wandersee NJ) Am J Physiol Heart Circ Physiol 2013 Jan 15;304(2):H328-36 PMID 23125208
  • Patients with sickle cell disease have increased sensitivity to cold and heat. (Brandow AM, Stucky CL, Hillery CA, Hoffmann RG, Panepinto JA) Am J Hematol 2013 Jan;88(1):37-43 PMID 23115062
  • Sickle cell mice exhibit mechanical allodynia and enhanced responsiveness in light touch cutaneous mechanoreceptors. (Garrison SR, Kramer AA, Gerges NZ, Hillery CA, Stucky CL) Mol Pain 2012;8:62 PMID 22963123
  • Phosphatidylethanolamine is externalized at the surface of microparticles. (Larson MC, Woodliff JE, Hillery CA, Kearl TJ, Zhao M) Biochim Biophys Acta 2012 Dec;1821(12):1501-7 PMID 22960380
  • Effects of experimental asthma on inflammation and lung mechanics in sickle cell mice. (Pritchard KA Jr, Feroah TR, Nandedkar SD, Holzhauer SL, Hutchins W, Schulte ML, Strunk RC, Debaun MR, Hillery CA) Am J Respir Cell Mol Biol 2012 Mar;46(3):389-96 PMID 22033263
  • Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease. (Hillery CA, Kerstein PC, Vilceanu D, Barabas ME, Retherford D, Brandow AM, Wandersee NJ, Stucky CL) Blood 2011 Sep 22;118(12):3376-83 PMID 21708890
  • Methaemalbumin formation in sickle cell disease: effect on oxidative protein modification and HO-1 induction. (Hanson MS, Piknova B, Keszler A, Diers AR, Wang X, Gladwin MT, Hillery CA, Hogg N) Br J Haematol 2011 Aug;154(4):502-11 PMID 21595649
  • D-4F, an apoA-1 mimetic, decreases airway hyperresponsiveness, inflammation, and oxidative stress in a murine model of asthma. (Nandedkar SD, Weihrauch D, Xu H, Shi Y, Feroah T, Hutchins W, Rickaby DA, Duzgunes N, Hillery CA, Konduri KS, Pritchard KA Jr) J Lipid Res 2011 Mar;52(3):499-508 PMID 21131532
  • Pulmonary hypertension and NO in sickle cell. (Gladwin MT, Barst RJ, Castro OL, Gordeuk VR, Hillery CA, Kato GJ, Kim-Shapiro DB, Machado R, Morris CR, Steinberg MH, Vichinsky EP) Blood 2010 Aug 5;116(5):852-4 PMID 20688967
  • Ca2+-CaM activation of AMP deaminase contributes to adenine nucleotide dysregulation and phosphatidylserine externalization in human sickle erythrocytes. (Sabina RL, Wandersee NJ, Hillery CA) Br J Haematol 2009 Feb;144(3):434-45 PMID 19036100
  • Histopathology of experimentally induced asthma in a murine model of sickle cell disease. (Nandedkar SD, Feroah TR, Hutchins W, Weihrauch D, Konduri KS, Wang J, Strunk RC, DeBaun MR, Hillery CA, Pritchard KA) Blood 2008 Sep 15;112(6):2529-38 PMID 18579795
  • Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertension. (Ataga KI, Moore CG, Hillery CA, Jones S, Whinna HC, Strayhorn D, Sohier C, Hinderliter A, Parise LV, Orringer EP) Haematologica 2008 Jan;93(1):20-6 PMID 18166781
  • Genetic endothelial systems biology of sickle stroke risk. (Chang Milbauer L, Wei P, Enenstein J, Jiang A, Hillery CA, Scott JP, Nelson SC, Bodempudi V, Topper JN, Yang RB, Hirsch B, Pan W, Hebbel RP) Blood 2008 Apr 1;111(7):3872-9 PMID 18156497
  • Phase I study of magnesium pidolate in combination with hydroxycarbamide for children with sickle cell anaemia. (Hankins JS, Wynn LW, Brugnara C, Hillery CA, Li CS, Wang WC) Br J Haematol 2008 Jan;140(1):80-5 PMID 17991298
  • Erythrocyte adhesion is modified by alterations in cellular tonicity and volume. (Wandersee NJ, Punzalan RC, Rettig MP, Kennedy MD, Pajewski NM, Sabina RL, Paul Scott J, Low PS, Hillery CA) Br J Haematol 2005 Nov;131(3):366-77 PMID 16225657
  • Pathology of Berkeley sickle cell mice: similarities and differences with human sickle cell disease. (Manci EA, Hillery CA, Bodian CA, Zhang ZG, Lutty GA, Coller BS) Blood 2006 Feb 15;107(4):1651-8 PMID 16166585
  • Variation in hospitalizations and hospital length of stay in children with vaso-occlusive crises in sickle cell disease. (Panepinto JA, Brousseau DC, Hillery CA, Scott JP) Pediatr Blood Cancer 2005 Feb;44(2):182-6 PMID 15390359
  • The effect of magnesium on length of stay for pediatric sickle cell pain crisis. (Brousseau DC, Scott JP, Hillery CA, Panepinto JA) Acad Emerg Med 2004 Sep;11(9):968-72 PMID 15347549
  • Pathophysiology of stroke in sickle cell disease. (Hillery CA, Panepinto JA) Microcirculation 2004 Mar;11(2):195-208 PMID 15280092
  • Patient-controlled analgesia for sickle cell pain crisis in a pediatric emergency department. (Melzer-Lange MD, Walsh-Kelly CM, Lea G, Hillery CA, Scott JP) Pediatr Emerg Care 2004 Jan;20(1):2-4 PMID 14716157
  • Hypoxia-induced acute lung injury in murine models of sickle cell disease. (Pritchard KA Jr, Ou J, Ou Z, Shi Y, Franciosi JP, Signorino P, Kaul S, Ackland-Berglund C, Witte K, Holzhauer S, Mohandas N, Guice KS, Oldham KT, Hillery CA) Am J Physiol Lung Cell Mol Physiol 2004 Apr;286(4):L705-14 PMID 12972407
  • Increased erythrocyte adhesion in mice and humans with hereditary spherocytosis and hereditary elliptocytosis. (Wandersee NJ, Olson SC, Holzhauer SL, Hoffmann RG, Barker JE, Hillery CA) Blood 2004 Jan 15;103(2):710-6 PMID 12947004
  • Effects of 5-aza-2'-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease. (Saunthararajah Y, Hillery CA, Lavelle D, Molokie R, Dorn L, Bressler L, Gavazova S, Chen YH, Hoffman R, DeSimone J) Blood 2003 Dec 1;102(12):3865-70 PMID 12907443
  • PECAM-1 negatively regulates GPIb/V/IX signaling in murine platelets. (Rathore V, Stapleton MA, Hillery CA, Montgomery RR, Nichols TC, Merricks EP, Newman DK, Newman PJ) Blood 2003 Nov 15;102(10):3658-64 PMID 12893757
  • Delayed hemolytic transfusion reaction/hyperhemolysis syndrome in children with sickle cell disease. (Talano JA, Hillery CA, Gottschall JL, Baylerian DM, Scott JP) Pediatrics 2003 Jun;111(6 Pt 1):e661-5 PMID 12777582
  • L-4F, an apolipoprotein A-1 mimetic, dramatically improves vasodilation in hypercholesterolemia and sickle cell disease. (Ou J, Ou Z, Jones DW, Holzhauer S, Hatoum OA, Ackerman AW, Weihrauch DW, Gutterman DD, Guice K, Oldham KT, Hillery CA, Pritchard KA Jr) Circulation 2003 May 13;107(18):2337-41 PMID 12732610
  • Single-chain antibody fragments derived from a human synthetic phage-display library bind thrombospondin and inhibit sickle cell adhesion. (Watkins NA, Du LM, Scott JP, Ouwehand WH, Hillery CA) Blood 2003 Jul 15;102(2):718-24 PMID 12663449
  • Altered erythrocyte endothelial adherence and membrane phospholipid asymmetry in hereditary hydrocytosis. (Gallagher PG, Chang SH, Rettig MP, Neely JE, Hillery CA, Smith BD, Low PS) Blood 2003 Jun 1;101(11):4625-7 PMID 12560240
  • Clinical and hematologic benefits of partial splenectomy for congenital hemolytic anemias in children. (Rice HE, Oldham KT, Hillery CA, Skinner MA, O'Hara SM, Ware RE) Ann Surg 2003 Feb;237(2):281-8 PMID 12560788
  • Bleeding disorders: A common cause of menorrhagia in adolescents. (Bevan JA, Maloney KW, Hillery CA, Gill JC, Montgomery RR, Scott JP) J Pediatr 2001 Jun;138(6):856-61 PMID 11391329
  • Hydroxyurea therapy decreases the in vitro adhesion of sickle erythrocytes to thrombospondin and laminin. (Hillery CA, Du MC, Wang WC, Scott JP) Br J Haematol 2000 May;109(2):322-7 PMID 10848818
  • Low-molecular-weight heparin in thrombotic disease in children and adolescents. (Punzalan RC, Hillery CA, Montgomery RR, Scott CA, Gill JC) J Pediatr Hematol Oncol 2000 Mar-Apr;22(2):137-42 PMID 10779027
  • The carboxy-terminal cell-binding domain of thrombospondin is essential for sickle red blood cell adhesion. (Hillery CA, Scott JP, Du MC) Blood 1999 Jul 1;94(1):302-9 PMID 10381526
  • Potential therapeutic approaches for the treatment of vaso-occlusion in sickle cell disease. (Hillery CA) Curr Opin Hematol 1998 Mar;5(2):151-5 PMID 9570709
  • Type 2M von Willebrand disease: F606I and I662F mutations in the glycoprotein Ib binding domain selectively impair ristocetin- but not botrocetin-mediated binding of von Willebrand factor to platelets. (Hillery CA, Mancuso DJ, Evan Sadler J, Ponder JW, Jozwiak MA, Christopherson PA, Cox Gill J, Paul Scott J, Montgomery RR) Blood 1998 Mar 1;91(5):1572-81 PMID 9473222
  • Mechanisms of stroke in sickle cell disease: sickle erythrocytes decrease cerebral blood flow in rats after nitric oxide synthase inhibition. (French JA 2nd, Kenny D, Scott JP, Hoffmann RG, Wood JD, Hudetz AG, Hillery CA) Blood 1997 Jun 15;89(12):4591-9 PMID 9192784
  • Increased adhesion of erythrocytes to components of the extracellular matrix: isolation and characterization of a red blood cell lipid that binds thrombospondin and laminin. (Hillery CA, Du MC, Montgomery RR, Scott JP) Blood 1996 Jun 1;87(11):4879-86 PMID 8639862
  • Hydroxyurea therapy in children severely affected with sickle cell disease. (Scott JP, Hillery CA, Brown ER, Misiewicz V, Labotka RJ) J Pediatr 1996 Jun;128(6):820-8 PMID 8648542
  • Unsuspected brucellosis diagnosed in a child as a result of an outbreak of laboratory-acquired brucellosis. (Chusid MJ, Russler SK, Mohr BA, Margolis DA, Hillery CA, Kehl KC) Pediatr Infect Dis J 1993 Dec;12(12):1031-3 PMID 8108214
  • Activation-dependent changes in human platelet PECAM-1: phosphorylation, cytoskeletal association, and surface membrane redistribution. (Newman PJ, Hillery CA, Albrecht R, Parise LV, Berndt MC, Mazurov AV, Dunlop LC, Zhang J, Rittenhouse SE) J Cell Biol 1992 Oct;119(1):239-46 PMID 1527170
  • Fibrinogen binding to purified platelet glycoprotein IIb-IIIa (integrin alpha IIb beta 3) is modulated by lipids. (Smyth SS, Hillery CA, Parise LV) J Biol Chem 1992 Aug 5;267(22):15568-77 PMID 1639797
  • Phosphorylation of human platelet glycoprotein IIIa (GPIIIa). Dissociation from fibrinogen receptor activation and phosphorylation of GPIIIa in vitro. (Hillery CA, Smyth SS, Parise LV) J Biol Chem 1991 Aug 5;266(22):14663-9 PMID 1650365
  • Grants and Awards

  • Molecular & Cellular Mechanisms in Transfusion Medicine (#9204141 03/01/2006 - 11/30/2010) Sponsor: BloodCenter of Wisconsin
  • Last update: 03/27/2015