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Christopher M. Olsen PhD

Christopher M. Olsen PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Pharmacology

Member of the Neuroscience Research Center

Research Experience

  • Cocaine-Related Disorders
  • Exploratory Behavior
  • Motivation
  • Substance-Related Disorders
  • MCW Program / Core Facilities

  • Neuroscience Research Center
  • Publications

  • CaMKII activity in the ventral tegmental area gates cocaine-induced synaptic plasticity in the nucleus accumbens. (Liu X, Liu Y, Zhong P, Wilkinson B, Qi J, Olsen CM, Bayer KU, Liu QS) Neuropsychopharmacology 2014 Mar;39(4):989-99 PMID 24154664
  • Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound. (Mueller R, Dawson ES, Meiler J, Rodriguez AL, Chauder BA, Bates BS, Felts AS, Lamb JP, Menon UN, Jadhav SB, Kane AS, Jones CK, Gregory KJ, Niswender CM, Conn PJ, Olsen CM, Winder DG, Emmitte KA, Lindsley CW) ChemMedChem 2012 Mar 5;7(3):406-14 PMID 22267125
  • Stimulus dynamics increase the self-administration of compound visual and auditory stimuli. (Olsen CM, Winder DG) Neurosci Lett 2012 Mar 5;511(1):8-11 PMID 22249116
  • (3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addiction. (Lindsley CW, Bates BS, Menon UN, Jadhav SB, Kane AS, Jones CK, Rodriguez AL, Conn PJ, Olsen CM, Winder DG, Emmitte KA) ACS Chem Neurosci 2011 Aug 17;2(8):471-482 PMID 21927650
  • Natural rewards, neuroplasticity, and non-drug addictions. (Olsen CM) Neuropharmacology 2011 Dec;61(7):1109-22 PMID 21459101
  • Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5). (Olsen CM, Childs DS, Stanwood GD, Winder DG) PLoS One 2010;5(11):e15085 PMID 21152045
  • Operant sensation seeking in the mouse. (Olsen CM, Winder DG) J Vis Exp 2010(45): PMID 21113110
  • Operant sensation seeking engages similar neural substrates to operant drug seeking in C57 mice. (Olsen CM, Winder DG) Neuropsychopharmacology 2009 Jun;34(7):1685-94 PMID 19145223
  • Microarray analysis reveals distinctive signaling between the bed nucleus of the stria terminalis, nucleus accumbens, and dorsal striatum. (Olsen CM, Huang Y, Goodwin S, Ciobanu DC, Lu L, Sutter TR, Winder DG) Physiol Genomics 2008 Feb 19;32(3):283-98 PMID 17911379
  • Experience-dependent effects of cocaine self-administration/conditioning on prefrontal and accumbens dopamine responses. (Ikegami A, Olsen CM, D'Souza MS, Duvauchelle CL) Behav Neurosci 2007 Apr;121(2):389-400 PMID 17469929
  • A method for single-session cocaine self-administration in the mouse. (Olsen CM, Winder DG) Psychopharmacology (Berl) 2006 Jul;187(1):13-21 PMID 16767412
  • Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration. (Grueter BA, Gosnell HB, Olsen CM, Schramm-Sapyta NL, Nekrasova T, Landreth GE, Winder DG) J Neurosci 2006 Mar 22;26(12):3210-9 PMID 16554472
  • Prefrontal cortex D1 modulation of the reinforcing properties of cocaine. (Olsen CM, Duvauchelle CL) Brain Res 2006 Feb 23;1075(1):229-35 PMID 16460710
  • Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell. (Schramm-Sapyta NL, Olsen CM, Winder DG) Neuropsychopharmacology 2006 Jul;31(7):1444-51 PMID 16205778
  • Serotonergic neurotoxic metabolites of ecstasy identified in rat brain. (Jones DC, Duvauchelle C, Ikegami A, Olsen CM, Lau SS, de la Torre R, Monks TJ) J Pharmacol Exp Ther 2005 Apr;313(1):422-31 PMID 15634943
  • Chronic D1 agonist and ethanol coadministration facilitate ethanol-mediated behaviors. (D'Souza MS, Ikegami A, Olsen CM, Duvauchelle CL) Pharmacol Biochem Behav 2003 Sep;76(2):335-42 PMID 14592686
  • Cholinergic interneurons of the nucleus accumbens and dorsal striatum are activated by the self-administration of cocaine. (Berlanga ML, Olsen CM, Chen V, Ikegami A, Herring BE, Duvauchelle CL, Alcantara AA) Neuroscience 2003;120(4):1149-56 PMID 12927219
  • Intravenous ethanol/cocaine self-administration initiates high intake of intravenous ethanol alone. (Ikegami A, Olsen CM, Fleming SM, Guerra EE, Bittner MA, Wagner J, Duvauchelle CL) Pharmacol Biochem Behav 2002 Jul;72(4):787-94 PMID 12062567
  • Intra-prefrontal cortex injections of SCH 23390 influence nucleus accumbens dopamine levels 24 h post-infusion. (Olsen CM, Duvauchelle CL) Brain Res 2001 Dec 13;922(1):80-6 PMID 11730704
  • alpha-melanocyte-stimulating hormone and habituation of prey-catching behavior in the Texas toad, Bufo speciosus. (Olsen CM, Lovering AT, Carr JA) Horm Behav 1999 Aug;36(1):62-9 PMID 10433887
  • Grants and Awards

  • Operant Sensation Seeking in the Mouse (#9207399 04/01/2012 - 07/31/2015) Sponsor: NIH Drug Abuse
  • Mild TBI: Effects on addiction-related phenotypes and mesocorticolimbic function (#9209040 04/01/2015 - 03/31/2017) Sponsor: NIH Drug Abuse
  • Development of Food and Drug Self-Administration and Craving/Relapse Models in Knockout Rat Models (#9306141 06/05/2013 - 12/31/2015) Sponsor: Research Affairs Committee
  • Program for the Study of Neuronal Synaptic Plasticity in Health and Illness (#9520217 01/01/2012 - 12/31/2016) PI of PDE Inhibitor-Induced Activation of Epac Signaling in Cocaine Addiction (#5520294)
  • Last update: 05/08/2014