D. Gail McCarver MD Online Profile
Chief, Professor
Medical College of Wisconsin
Department: Pediatrics
Division: Pharmacogenetics
Program: Pharmacogenetics
Publications
The effect of CYP2D6 polymorphisms on the response to pain treatment for pediatric sickle cell pain crisis. (Brousseau DC, McCarver DG, Drendel AL, Divakaran K, Panepinto JA) J Pediatr 2007 Jun;150(6):623-6 PMID 17517247 Identification and functional analysis of a novel human CYP2E1 far upstream enhancer. (Shadley JD, Divakaran K, Munson K, Hines RN, Douglas K, McCarver DG) Mol Pharmacol 2007 Jun;71(6):1630-9 PMID 17353354 Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events. (Gaedigk A, Ndjountché L, Divakaran K, Dianne Bradford L, Zineh I, Oberlander TF, Brousseau DC, McCarver DG, Johnson JA, Alander SW, Wayne Riggs K, Steven Leeder J) Clin Pharmacol Ther 2007 Feb;81(2):242-51 PMID 17259947 Pharmacogenomics and the future of drug therapy. (Hines RN, McCarver DG) Pediatr Clin North Am 2006 Aug;53(4):591-619 PMID 16872995 Population-based analysis of methadone distribution and metabolism using an age-dependent physiologically based pharmacokinetic model. (Yang F, Tong X, McCarver DG, Hines RN, Beard DA) J Pharmacokinet Pharmacodyn 2006 Aug;33(4):485-518 PMID 16758333 Modeling interchild differences in pharmacokinetics on the basis of subject-specific data on physiology and hepatic CYP2E1 levels: a case study with toluene. (Nong A, McCarver DG, Hines RN, Krishnan K) Toxicol Appl Pharmacol 2006 Jul 1;214(1):78-87 PMID 16464483 Discovery of novel flavin-containing monooxygenase 3 (FMO3) single nucleotide polymorphisms and functional analysis of upstream haplotype variants. (Koukouritaki SB, Poch MT, Cabacungan ET, McCarver DG, Hines RN) Mol Pharmacol 2005 Aug;68(2):383-92 PMID 15858076 Alcohol dehydrogenase 2*3 affects alterations in offspring facial morphology associated with maternal ethanol intake in pregnancy. (Das UG, Cronk CE, Martier SS, Simpson PM, McCarver DG) Alcohol Clin Exp Res 2004 Oct;28(10):1598-606 PMID 15597094 Proximity of residence to trichloroethylene-emitting sites and increased risk of offspring congenital heart defects among older women. (Yauck JS, Malloy ME, Blair K, Simpson PM, McCarver DG) Birth Defects Res A Clin Mol Teratol 2004 Oct;70(10):808-14 PMID 15390315 Applicability of the principles of developmental pharmacology to the study of environmental toxicants. (McCarver DG) Pediatrics 2004 Apr;113(4 Suppl):969-72 PMID 15060189 Excess birth prevalence of Hypoplastic Left Heart syndrome in eastern Wisconsin for birth cohorts 1997-1999. (Cronk CE, Pelech AN, Malloy ME, McCarver DG) Birth Defects Res A Clin Mol Teratol 2004 Mar;70(3):114-20 PMID 15039925 Completeness of state administrative databases for surveillance of congenital heart disease. (Cronk CE, Malloy ME, Pelech AN, Miller RE, Meyer SA, Cowell M, McCarver DG) Birth Defects Res A Clin Mol Teratol 2003 Sep;67(9):597-603 PMID 14703780 Developmental expression of human hepatic CYP2C9 and CYP2C19. (Koukouritaki SB, Manro JR, Marsh SA, Stevens JC, Rettie AE, McCarver DG, Hines RN) J Pharmacol Exp Ther 2004 Mar;308(3):965-74 PMID 14634042 Human hepatic CYP2E1 expression during development. (Johnsrud EK, Koukouritaki SB, Divakaran K, Brunengraber LL, Hines RN, McCarver DG) J Pharmacol Exp Ther 2003 Oct;307(1):402-7 PMID 14500779 Genetic variability at the human FMO1 locus: significance of a basal promoter yin yang 1 element polymorphism (FMO1*6). (Hines RN, Luo Z, Hopp KA, Cabacungan ET, Koukouritaki SB, McCarver DG) J Pharmacol Exp Ther 2003 Sep;306(3):1210-8 PMID 12829732 Trichloroethylene decreases heat shock protein 90 interactions with endothelial nitric oxide synthase: implications for endothelial cell proliferation. (Ou J, Ou Z, McCarver DG, Hines RN, Oldham KT, Ackerman AW, Pritchard KA Jr) Toxicol Sci 2003 May;73(1):90-7 PMID 12657742 Genotyping and site-directed mutagenesis of a cytochrome P450 meander Pro-X-Arg motif critical to CYP4B1 catalysis. (Zheng YM, Henne KR, Charmley P, Kim RB, McCarver DG, Cabacungan ET, Hines RN, Rettie AE) Toxicol Appl Pharmacol 2003 Jan 15;186(2):119-26 PMID 12639503 The ontogeny of human drug-metabolizing enzymes: phase II conjugation enzymes and regulatory mechanisms. (McCarver DG, Hines RN) J Pharmacol Exp Ther 2002 Feb;300(2):361-6 PMID 11805192 The ontogeny of human drug-metabolizing enzymes: phase I oxidative enzymes. (Hines RN, McCarver DG) J Pharmacol Exp Ther 2002 Feb;300(2):355-60 PMID 11805191 Ethnic differences in allelic frequency of two flavin-containing monooxygenase 3 (FMO3) polymorphisms: linkage and effects on in vivo and in vitro FMO activities. (Park CS, Kang JH, Chung WG, Yi HG, Pie JE, Park DK, Hines RN, McCarver DG, Cha YN) Pharmacogenetics 2002 Jan;12(1):77-80 PMID 11773868 ADH2 and CYP2E1 genetic polymorphisms: risk factors for alcohol-related birth defects. (McCarver DG) Drug Metab Dispos 2001 Apr;29(4 Pt 2):562-5 PMID 11259352 Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans. (Whetstine JR, Yueh MF, McCarver DG, Williams DE, Park CS, Kang JH, Cha YN, Dolphin CT, Shephard EA, Phillips IR, Hines RN) Toxicol Appl Pharmacol 2000 Nov 1;168(3):216-24 PMID 11042094 Development of dapsone toxicity in patients with inflammatory dermatoses: activity of acetylation and hydroxylation of dapsone as risk factors. (Bluhm RE, Adedoyin A, McCarver DG, Branch RA) Clin Pharmacol Ther 1999 Jun;65(6):598-605 PMID 10391665 Knowledge and misconceptions among inner-city African-American mothers regarding alcohol and drug use. (Donnelly FM, Mowery JL, McCarver DG) Am J Drug Alcohol Abuse 1998 Nov;24(4):675-83 PMID 9849777 A genetic polymorphism in the regulatory sequences of human CYP2E1: association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake. (McCarver DG, Byun R, Hines RN, Hichme M, Wegenek W) Toxicol Appl Pharmacol 1998 Sep;152(1):276-81 PMID 9772223 Alcohol dehydrogenase-2*3 allele protects against alcohol-related birth defects among African Americans. (McCarver DG, Thomasson HR, Martier SS, Sokol RJ, Li T) J Pharmacol Exp Ther 1997 Dec;283(3):1095-101 PMID 9399981 Genetic polymorphisms in human drug metabolic enzymes. (Miller MS, McCarver DG, Bell DA, Eaton DL, Goldstein JA) Fundam Appl Toxicol 1997 Nov;40(1):1-14 PMID 9398483 Grants and Awards
Regulation of Drug Metabolizing Enzyme Ontogeny (#9205347 09/30/2008 - 03/30/2014) Sponsor: NIH General Medical SciencesDetermination of Human Hepatic CES1 and CES2 Age-dependent Developmental Expression patterns in postnatal Ages Birth to 18 years (#9207708 09/01/2012 - 06/30/2013) Sponsor: Consumer Specialty Products AssociationRole of CYP2E1 and ADH in Human TRI Teratogenicity (#9202248 09/30/2001 - 07/31/2009) Sponsor: NIH Environmental Health SciencesFactors Determining Bisphenol A Disposition in Human Infants (#9206119 02/01/2010 - 11/30/2013) Sponsor: NIH Environmental Health Sciences
