Medical College of Wisconsin
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David C. Warltier MD, PhD

Chairman, Professor

Institution: Medical College of Wisconsin
Department: Anesthesiology
Division: Administration
Program: Froedtert Hospital East


Publications

  • Impairment of endothelial-myocardial interaction increases the susceptibility of cardiomyocytes to ischemia/reperfusion injury. (Leucker TM, Ge ZD, Procknow J, Liu Y, Shi Y, Bienengraeber M, Warltier DC, Kersten JR) PLoS One 2013;8(7):e70088 PMID 23894596
  • Far red/near infrared light treatment promotes femoral artery collateralization in the ischemic hindlimb. (Lohr NL, Ninomiya JT, Warltier DC, Weihrauch D) J Mol Cell Cardiol 2013 Sep;62:36-42 PMID 23702287
  • Apolipoprotein A-1 mimetic D-4F enhances isoflurane-induced eNOS signaling and cardioprotection during acute hyperglycemia. (Baotic I, Ge ZD, Sedlic F, Coon A, Weihrauch D, Warltier DC, Kersten JR) Am J Physiol Heart Circ Physiol 2013 Jul 15;305(2):H219-27 PMID 23666677
  • Decreased tetrahydrobiopterin and disrupted association of Hsp90 with eNOS by hyperglycemia impair myocardial ischemic preconditioning. (Vladic N, Ge ZD, Leucker T, Brzezinska AK, Du JH, Shi Y, Warltier DC, Pratt PF Jr, Kersten JR) Am J Physiol Heart Circ Physiol 2011 Nov;301(5):H2130-9 PMID 21908789
  • Isoflurane differentially modulates mitochondrial reactive oxygen species production via forward versus reverse electron transport flow: implications for preconditioning. (Hirata N, Shim YH, Pravdic D, Lohr NL, Pratt PF Jr, Weihrauch D, Kersten JR, Warltier DC, Bosnjak ZJ, Bienengraeber M) Anesthesiology 2011 Sep;115(3):531-40 PMID 21862887
  • Endothelial-cardiomyocyte crosstalk enhances pharmacological cardioprotection. (Leucker TM, Bienengraeber M, Muravyeva M, Baotic I, Weihrauch D, Brzezinska AK, Warltier DC, Kersten JR, Pratt PF Jr) J Mol Cell Cardiol 2011 Nov;51(5):803-11 PMID 21791217
  • Cardiac-specific overexpression of GTP cyclohydrolase 1 restores ischaemic preconditioning during hyperglycaemia. (Ge ZD, Ionova IA, Vladic N, Pravdic D, Hirata N, Vásquez-Vivar J, Pratt PF Jr, Warltier DC, Pieper GM, Kersten JR) Cardiovasc Res 2011 Jul 15;91(2):340-9 PMID 21422102
  • History of post-traumatic stress disorder is associated with impaired neuropsychometric performance after coronary artery surgery. (Hudetz JA, Gandhi SD, Iqbal Z, Patterson KM, Byrne AJ, Warltier DC, Pagel PS) J Cardiothorac Vasc Anesth 2010 Dec;24(6):964-8 PMID 20494591
  • Isoflurane protects cardiomyocytes and mitochondria by immediate and cytosol-independent action at reperfusion. (Pravdic D, Mio Y, Sedlic F, Pratt PF, Warltier DC, Bosnjak ZJ, Bienengraeber M) Br J Pharmacol 2010 May;160(2):220-32 PMID 20423337
  • Preoperative dispositional optimism correlates with a reduced incidence of postoperative delirium and recovery of postoperative cognitive function in cardiac surgical patients. (Hudetz JA, Hoffmann RG, Patterson KM, Byrne AJ, Iqbal Z, Gandhi SD, Warltier DC, Pagel PS) J Cardiothorac Vasc Anesth 2010 Aug;24(4):560-7 PMID 20346702
  • Hyperglycemia adversely modulates endothelial nitric oxide synthase during anesthetic preconditioning through tetrahydrobiopterin- and heat shock protein 90-mediated mechanisms. (Amour J, Brzezinska AK, Jager Z, Sullivan C, Weihrauch D, Du J, Vladic N, Shi Y, Warltier DC, Pratt PF Jr, Kersten JR) Anesthesiology 2010 Mar;112(3):576-85 PMID 20124983
  • Postoperative delirium is associated with postoperative cognitive dysfunction at one week after cardiac surgery with cardiopulmonary bypass. (Hudetz JA, Patterson KM, Byrne AJ, Pagel PS, Warltier DC) Psychol Rep 2009 Dec;105(3 Pt 1):921-32 PMID 20099555
  • A history of alcohol dependence increases the incidence and severity of postoperative cognitive dysfunction in cardiac surgical patients. (Hudetz JA, Patterson KM, Byrne AJ, Iqbal Z, Gandhi SD, Warltier DC, Pagel PS) Int J Environ Res Public Health 2009 Nov;6(11):2725-39 PMID 20049218
  • Isoflurane postconditioning protects against reperfusion injury by preventing mitochondrial permeability transition by an endothelial nitric oxide synthase-dependent mechanism. (Ge ZD, Pravdic D, Bienengraeber M, Pratt PF Jr, Auchampach JA, Gross GJ, Kersten JR, Warltier DC) Anesthesiology 2010 Jan;112(1):73-85 PMID 19996950
  • Myocardial interstitial fluid inhibits proliferation and cardiomyocyte differentiation in pluripotent embryonic stem cells. (Van Orman JR, Weihrauch D, Warltier DC, Lough J) Am J Physiol Heart Circ Physiol 2009 Oct;297(4):H1369-76 PMID 19633209
  • Ketamine attenuates post-operative cognitive dysfunction after cardiac surgery. (Hudetz JA, Iqbal Z, Gandhi SD, Patterson KM, Byrne AJ, Hudetz AG, Pagel PS, Warltier DC) Acta Anaesthesiol Scand 2009 Aug;53(7):864-72 PMID 19422355
  • Enhancement of nitric oxide release from nitrosyl hemoglobin and nitrosyl myoglobin by red/near infrared radiation: potential role in cardioprotection. (Lohr NL, Keszler A, Pratt P, Bienengraber M, Warltier DC, Hogg N) J Mol Cell Cardiol 2009 Aug;47(2):256-63 PMID 19328206
  • Ketamine attenuates delirium after cardiac surgery with cardiopulmonary bypass. (Hudetz JA, Patterson KM, Iqbal Z, Gandhi SD, Byrne AJ, Hudetz AG, Warltier DC, Pagel PS) J Cardiothorac Vasc Anesth 2009 Oct;23(5):651-7 PMID 19231245
  • Morphine reduces the threshold of helium preconditioning against myocardial infarction: the role of opioid receptors in rabbits. (Pagel PS, Krolikowski JG, Amour J, Warltier DC, Weihrauch D) J Cardiothorac Vasc Anesth 2009 Oct;23(5):619-24 PMID 19231239
  • Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning. (Amour J, Brzezinska AK, Weihrauch D, Billstrom AR, Zielonka J, Krolikowski JG, Bienengraeber MW, Warltier DC, Pratt PF Jr, Kersten JR) Anesthesiology 2009 Feb;110(2):317-25 PMID 19194158
  • Transient receptor potential vanilloid type 4-deficient mice exhibit impaired endothelium-dependent relaxation induced by acetylcholine in vitro and in vivo. (Zhang DX, Mendoza SA, Bubolz AH, Mizuno A, Ge ZD, Li R, Warltier DC, Suzuki M, Gutterman DD) Hypertension 2009 Mar;53(3):532-8 PMID 19188524
  • Near infrared light protects cardiomyocytes from hypoxia and reoxygenation injury by a nitric oxide dependent mechanism. (Zhang R, Mio Y, Pratt PF, Lohr N, Warltier DC, Whelan HT, Zhu D, Jacobs ER, Medhora M, Bienengraeber M) J Mol Cell Cardiol 2009 Jan;46(1):4-14 PMID 18930064
  • Zeljko J. Bosnjak, Ph.D., recipient of the 2008 Excellence in Research Award. (Warltier DC) Anesthesiology 2008 Sep;109(3):371-3 PMID 18754138
  • Inhibition of glycogen synthase kinase or the apoptotic protein p53 lowers the threshold of helium cardioprotection in vivo: the role of mitochondrial permeability transition. (Pagel PS, Krolikowski JG, Pratt PF Jr, Shim YH, Amour J, Warltier DC, Weihrauch D) Anesth Analg 2008 Sep;107(3):769-75 PMID 18713881
  • The mechanism of helium-induced preconditioning: a direct role for nitric oxide in rabbits. (Pagel PS, Krolikowski JG, Pratt PF Jr, Shim YH, Amour J, Warltier DC, Weihrauch D) Anesth Analg 2008 Sep;107(3):762-8 PMID 18713880
  • Reactive oxygen species and mitochondrial adenosine triphosphate-regulated potassium channels mediate helium-induced preconditioning against myocardial infarction in vivo. (Pagel PS, Krolikowski JG, Pratt PF Jr, Shim YH, Amour J, Warltier DC, Weihrauch D) J Cardiothorac Vasc Anesth 2008 Aug;22(4):554-9 PMID 18662630
  • Treatment of acute postoperative hypertension in cardiac surgery patients: an efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2), a randomized, double-blind, placebo-controlled trial. (Singla N, Warltier DC, Gandhi SD, Lumb PD, Sladen RN, Aronson S, Newman MF, Corwin HL, ESCAPE-2 Study Group) Anesth Analg 2008 Jul;107(1):59-67 PMID 18635468
  • Simvastatin restores ischemic preconditioning in the presence of hyperglycemia through a nitric oxide-mediated mechanism. (Gu W, Kehl F, Krolikowski JG, Pagel PS, Warltier DC, Kersten JR) Anesthesiology 2008 Apr;108(4):634-42 PMID 18362595
  • Cognitive function in older diabetic subjects with a history of alcohol abuse. (Hudetz JA, Warltier DC) Psychol Rep 2007 Dec;101(3 Pt 2):1125-32 PMID 18361128
  • Diabetes abolishes sildenafil-induced cGMP-dependent protein kinase-I expression and cardioprotection. (Jamnicki-Abegg M, Weihrauch D, Chiari PC, Krolikowski JG, Pagel PS, Warltier DC, Kersten JR) J Cardiovasc Pharmacol 2007 Dec;50(6):670-6 PMID 18091584
  • Noble gases without anesthetic properties protect myocardium against infarction by activating prosurvival signaling kinases and inhibiting mitochondrial permeability transition in vivo. (Pagel PS, Krolikowski JG, Shim YH, Venkatapuram S, Kersten JR, Weihrauch D, Warltier DC, Pratt PF Jr) Anesth Analg 2007 Sep;105(3):562-9 PMID 17717207
  • Volume replacement therapy during major orthopedic surgery using Voluven (hydroxyethyl starch 130/0.4) or hetastarch. (Gandhi SD, Weiskopf RB, Jungheinrich C, Koorn R, Miller D, Shangraw RE, Prough DS, Baus D, Bepperling F, Warltier DC) Anesthesiology 2007 Jun;106(6):1120-7 PMID 17525586
  • Postoperative cognitive dysfunction in older patients with a history of alcohol abuse. (Hudetz JA, Iqbal Z, Gandhi SD, Patterson KM, Hyde TF, Reddy DM, Hudetz AG, Warltier DC) Anesthesiology 2007 Mar;106(3):423-30 PMID 17325499
  • Isoflurane preconditioning uncouples mitochondria and protects against hypoxia-reoxygenation. (Ljubkovic M, Mio Y, Marinovic J, Stadnicka A, Warltier DC, Bosnjak ZJ, Bienengraeber M) Am J Physiol Cell Physiol 2007 May;292(5):C1583-90 PMID 17215328
  • Inhibition of apoptotic protein p53 lowers the threshold of isoflurane-induced cardioprotection during early reperfusion in rabbits. (Venkatapuram S, Wang C, Krolikowski JG, Weihrauch D, Kersten JR, Warltier DC, Pratt PF Jr, Pagel PS) Anesth Analg 2006 Dec;103(6):1400-5 PMID 17122210
  • Ischemic preconditioning, myocardial stunning and anesthesia. (Toller WG, Kersten JR, Pagel PS, Warltier DC) Curr Opin Anaesthesiol 2000 Feb;13(1):35-40 PMID 17016277
  • Nitrous oxide and preconditioning. (Pagel PS, Warltier DC) Anesthesiology 2006 Sep;105(3):630; author reply 631 PMID 16932006
  • Mechanism of cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel activation by isoflurane in a heterologous expression system. (Bienengraeber M, Warltier DC, Bosnjak ZJ, Stadnicka A) Anesthesiology 2006 Sep;105(3):534-40 PMID 16931986
  • Extracellular signal-regulated kinases trigger isoflurane preconditioning concomitant with upregulation of hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression in rats. (Wang C, Weihrauch D, Schwabe DA, Bienengraeber M, Warltier DC, Kersten JR, Pratt PF Jr, Pagel PS) Anesth Analg 2006 Aug;103(2):281-8, table of contents PMID 16861403
  • Gender-specificity of delayed preconditioning by isoflurane in rabbits: potential role of endothelial nitric oxide synthase. (Wang C, Chiari PC, Weihrauch D, Krolikowski JG, Warltier DC, Kersten JR, Pratt PF Jr, Pagel PS) Anesth Analg 2006 Aug;103(2):274-80, table of contents PMID 16861402
  • Cardioprotection by volatile anesthetics: new applications for old drugs? (Pratt PF Jr, Wang C, Weihrauch D, Bienengraeber MW, Kersten JR, Pagel PS, Warltier DC) Curr Opin Anaesthesiol 2006 Aug;19(4):397-403 PMID 16829721
  • Alterations in regional vascular geometry produced by theoretical stent implantation influence distributions of wall shear stress: analysis of a curved coronary artery using 3D computational fluid dynamics modeling. (LaDisa JF Jr, Olson LE, Douglas HA, Warltier DC, Kersten JR, Pagel PS) Biomed Eng Online 2006;5:40 PMID 16780592
  • The influence of B-cell lymphoma 2 protein, an antiapoptotic regulator of mitochondrial permeability transition, on isoflurane-induced and ischemic postconditioning in rabbits. (Wang C, Neff DA, Krolikowski JG, Weihrauch D, Bienengraeber M, Warltier DC, Kersten JR, Pagel PS) Anesth Analg 2006 May;102(5):1355-60 PMID 16632808
  • Inhibition of glycogen synthase kinase enhances isoflurane-induced protection against myocardial infarction during early reperfusion in vivo. (Pagel PS, Krolikowski JG, Neff DA, Weihrauch D, Bienengraeber M, Kersten JR, Warltier DC) Anesth Analg 2006 May;102(5):1348-54 PMID 16632807
  • Role of Erk1/2, p70s6K, and eNOS in isoflurane-induced cardioprotection during early reperfusion in vivo. (Krolikowski JG, Weihrauch D, Bienengraeber M, Kersten JR, Warltier DC, Pagel PS) Can J Anaesth 2006 Feb;53(2):174-82 PMID 16434759
  • Anesthesiology residency programs for physician scientists. (Knight PR, Warltier DC) Anesthesiology 2006 Jan;104(1):1-4 PMID 16394681
  • Inhibition of mitochondrial permeability transition enhances isoflurane-induced cardioprotection during early reperfusion: the role of mitochondrial KATP channels. (Krolikowski JG, Bienengraeber M, Weihrauch D, Warltier DC, Kersten JR, Pagel PS) Anesth Analg 2005 Dec;101(6):1590-6 PMID 16301224
  • Axial stent strut angle influences wall shear stress after stent implantation: analysis using 3D computational fluid dynamics models of stent foreshortening. (LaDisa JF Jr, Olson LE, Hettrick DA, Warltier DC, Kersten JR, Pagel PS) Biomed Eng Online 2005;4:59 PMID 16250918
  • Isoflurane inhibits cardiac myocyte apoptosis during oxidative and inflammatory stress by activating Akt and enhancing Bcl-2 expression. (Jamnicki-Abegg M, Weihrauch D, Pagel PS, Kersten JR, Bosnjak ZJ, Warltier DC, Bienengraeber MW) Anesthesiology 2005 Nov;103(5):1006-14 PMID 16249675
  • Vascular endothelial growth factor is required for coronary collateral growth in the rat. (Toyota E, Warltier DC, Brock T, Ritman E, Kolz C, O'Malley P, Rocic P, Focardi M, Chilian WM) Circulation 2005 Oct 4;112(14):2108-13 PMID 16203926
  • Aggressive control of intraoperative blood glucose concentration: a shifting paradigm? (Kersten JR, Warltier DC, Pagel PS) Anesthesiology 2005 Oct;103(4):677-8 PMID 16192757
  • Morphine enhances isoflurane-induced postconditioning against myocardial infarction: the role of phosphatidylinositol-3-kinase and opioid receptors in rabbits. (Weihrauch D, Krolikowski JG, Bienengraeber M, Kersten JR, Warltier DC, Pagel PS) Anesth Analg 2005 Oct;101(4):942-9, table of contents PMID 16192500
  • Role of endothelial nitric oxide synthase as a trigger and mediator of isoflurane-induced delayed preconditioning in rabbit myocardium. (Chiari PC, Bienengraeber MW, Weihrauch D, Krolikowski JG, Kersten JR, Warltier DC, Pagel PS) Anesthesiology 2005 Jul;103(1):74-83 PMID 15983459
  • Cardioprotection by volatile anesthetics. (Bienengraeber MW, Weihrauch D, Kersten JR, Pagel PS, Warltier DC) Vascul Pharmacol 2005 Apr-May;42(5-6):243-52 PMID 15922257
  • Microfocal X-ray computed tomography post-processing operations for optimizing reconstruction volumes of stented arteries during 3D computational fluid dynamics modeling. (Ladisa JF Jr, Olson LE, Ropella KM, Molthen RC, Haworth ST, Kersten JR, Warltier DC, Pagel PS) Comput Methods Programs Biomed 2005 Aug;79(2):121-34 PMID 15894401
  • Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac ryanodine receptor in canine heart failure. (Xiao B, Jiang MT, Zhao M, Yang D, Sutherland C, Lai FA, Walsh MP, Warltier DC, Cheng H, Chen SR) Circ Res 2005 Apr 29;96(8):847-55 PMID 15790957
  • Antegrade iliac artery stent implantation for the temporal and spatial examination of stent-induced neointimal hyperplasia and alterations in regional fluid dynamics. (LaDisa JF Jr, Meier HT, Olson LE, Kersten JR, Warltier DC, Pagel PS) J Pharmacol Toxicol Methods 2005 Mar-Apr;51(2):115-21 PMID 15767204
  • Alterations in wall shear stress predict sites of neointimal hyperplasia after stent implantation in rabbit iliac arteries. (LaDisa JF Jr, Olson LE, Molthen RC, Hettrick DA, Pratt PF, Hardel MD, Kersten JR, Warltier DC, Pagel PS) Am J Physiol Heart Circ Physiol 2005 May;288(5):H2465-75 PMID 15653759
  • Isoflurane protects against myocardial infarction during early reperfusion by activation of phosphatidylinositol-3-kinase signal transduction: evidence for anesthetic-induced postconditioning in rabbits. (Chiari PC, Bienengraeber MW, Pagel PS, Krolikowski JG, Kersten JR, Warltier DC) Anesthesiology 2005 Jan;102(1):102-9 PMID 15618793
  • Haptoglobin expression and activity during coronary collateralization. (Lohr NL, Warltier DC, Chilian WM, Weihrauch D) Am J Physiol Heart Circ Physiol 2005 Mar;288(3):H1389-95 PMID 15550518
  • Circumferential vascular deformation after stent implantation alters wall shear stress evaluated with time-dependent 3D computational fluid dynamics models. (LaDisa JF Jr, Olson LE, Guler I, Hettrick DA, Kersten JR, Warltier DC, Pagel PS) J Appl Physiol (1985) 2005 Mar;98(3):947-57 PMID 15531564
  • Intravenous emulsified halogenated anesthetics produce acute and delayed preconditioning against myocardial infarction in rabbits. (Chiari PC, Pagel PS, Tanaka K, Krolikowski JG, Ludwig LM, Trillo RA Jr, Puri N, Kersten JR, Warltier DC) Anesthesiology 2004 Nov;101(5):1160-6 PMID 15505452
  • Protein kinase C inhibitors produce mitochondrial flavoprotein oxidation in cardiac myocytes. (Kohro S, Hogan QH, Warltier DC, Bosnjak ZJ) Anesth Analg 2004 Nov;99(5):1316-22; table of contents PMID 15502023
  • Preconditioning by isoflurane is mediated by reactive oxygen species generated from mitochondrial electron transport chain complex III. (Ludwig LM, Tanaka K, Eells JT, Weihrauch D, Pagel PS, Kersten JR, Warltier DC) Anesth Analg 2004 Nov;99(5):1308-15; table of contents PMID 15502022
  • Chronic hyperglycemia attenuates coronary collateral development and impairs proliferative properties of myocardial interstitial fluid by production of angiostatin. (Weihrauch D, Lohr NL, Mraovic B, Ludwig LM, Chilian WM, Pagel PS, Warltier DC, Kersten JR) Circulation 2004 May 18;109(19):2343-8 PMID 15136506
  • Isoflurane produces delayed preconditioning against myocardial ischemia and reperfusion injury: role of cyclooxygenase-2. (Tanaka K, Ludwig LM, Krolikowski JG, Alcindor D, Pratt PF, Kersten JR, Pagel PS, Warltier DC) Anesthesiology 2004 Mar;100(3):525-31 PMID 15108964
  • Mechanisms of cardioprotection by volatile anesthetics. (Tanaka K, Ludwig LM, Kersten JR, Pagel PS, Warltier DC) Anesthesiology 2004 Mar;100(3):707-21 PMID 15108989
  • Cyclooxygenase-2 mediates ischemic, anesthetic, and pharmacologic preconditioning in vivo. (Alcindor D, Krolikowski JG, Pagel PS, Warltier DC, Kersten JR) Anesthesiology 2004 Mar;100(3):547-54 PMID 15108967
  • Protein kinase C translocation and Src protein tyrosine kinase activation mediate isoflurane-induced preconditioning in vivo: potential downstream targets of mitochondrial adenosine triphosphate-sensitive potassium channels and reactive oxygen species. (Ludwig LM, Weihrauch D, Kersten JR, Pagel PS, Warltier DC) Anesthesiology 2004 Mar;100(3):532-9 PMID 15108965
  • Cardiac pharmacological preconditioning with volatile anesthetics: from bench to bedside? (Riess ML, Stowe DF, Warltier DC) Am J Physiol Heart Circ Physiol 2004 May;286(5):H1603-7 PMID 15072968
  • Cardioprotection by glucose-insulin-potassium: dependence on KATP channel opening and blood glucose concentration before ischemia. (LaDisa JF Jr, Krolikowski JG, Pagel PS, Warltier DC, Kersten JR) Am J Physiol Heart Circ Physiol 2004 Aug;287(2):H601-7 PMID 15044191
  • Mechanisms of myocardial protection produced by chronic ethanol consumption. (Pagel PS, Kersten JR, Warltier DC) Pathophysiology 2004 Apr;10(2):121-9 PMID 15006418
  • Stent design properties and deployment ratio influence indexes of wall shear stress: a three-dimensional computational fluid dynamics investigation within a normal artery. (LaDisa JF Jr, Olson LE, Guler I, Hettrick DA, Audi SH, Kersten JR, Warltier DC, Pagel PS) J Appl Physiol (1985) 2004 Jul;97(1):424-30; discussion 416 PMID 14766776
  • Influence of isoflurane on left atrial function in dogs with pacing-induced cardiomyopathy: evaluation with pressure-volume relationships. (Kehl F, Ladisa JF Jr, Hettrick DA, Kersten JR, Warltier DC, Pagel PS) J Cardiothorac Vasc Anesth 2003 Dec;17(6):709-14 PMID 14689410
  • An automated coronary artery occlusion device for stimulating collateral development in vivo. (Rys R, LaDisa JF Jr, Tessmer JP, Gu W, Kersten JR, Warltier DC, Pagel PS) J Pharmacol Toxicol Methods 2002 Sep-Oct;48(2):111-8 PMID 14565568
  • Three-dimensional computational fluid dynamics modeling of alterations in coronary wall shear stress produced by stent implantation. (LaDisa JF Jr, Guler I, Olson LE, Hettrick DA, Kersten JR, Warltier DC, Pagel PS) Ann Biomed Eng 2003 Sep;31(8):972-80 PMID 12918912
  • Reactive oxygen species are critical mediators of coronary collateral development in a canine model. (Gu W, Weihrauch D, Tanaka K, Tessmer JP, Pagel PS, Kersten JR, Chilian WM, Warltier DC) Am J Physiol Heart Circ Physiol 2003 Oct;285(4):H1582-9 PMID 12816750
  • N-acetylcysteine restores isoflurane-induced preconditioning against myocardial infarction during hyperglycemia. (Kehl F, Krolikowski JG, Weihrauch D, Pagel PS, Warltier DC, Kersten JR) Anesthesiology 2003 Jun;98(6):1384-90 PMID 12766647
  • Atrial pacing lead location alters the hemodynamic effects of atrial-ventricular delay in dogs with pacing induced cardiomyopathy. (Hettrick DA, Mittelstadt JR, Kehl F, Kress TT, Tessmer JP, Krolikowski JG, Kersten JR, Warltier DC, Pagel PS) Pacing Clin Electrophysiol 2003 Apr;26(4 Pt 1):853-61 PMID 12715846
  • Adenosine type 1 (A1) receptors mediate protection against myocardial infarction produced by chronic, intermittent ingestion of ethanol in dogs. (Kehl F, Krolikowski JG, LaDisa JF Jr, Kersten JR, Warltier DC, Pagel PS) Int J Cardiol 2003 Apr;88(2-3):175-82 PMID 12714196
  • Mechanical function of the left atrium: new insights based on analysis of pressure-volume relations and Doppler echocardiography. (Pagel PS, Kehl F, Gare M, Hettrick DA, Kersten JR, Warltier DC) Anesthesiology 2003 Apr;98(4):975-94 PMID 12657862
  • Mitochondrial adenosine triphosphate-regulated potassium channel opening acts as a trigger for isoflurane-induced preconditioning by generating reactive oxygen species. (Tanaka K, Weihrauch D, Ludwig LM, Kersten JR, Pagel PS, Warltier DC) Anesthesiology 2003 Apr;98(4):935-43 PMID 12657856
  • Expression of VEGF and angiopoietins-1 and -2 during ischemia-induced coronary angiogenesis. (Matsunaga T, Warltier DC, Tessmer J, Weihrauch D, Simons M, Chilian WM) Am J Physiol Heart Circ Physiol 2003 Jul;285(1):H352-8 PMID 12649074
  • Modifying cardiovascular risk in diabetes mellitus. (Gu W, Pagel PS, Warltier DC, Kersten JR) Anesthesiology 2003 Mar;98(3):774-9 PMID 12606925
  • Morphine enhances pharmacological preconditioning by isoflurane: role of mitochondrial K(ATP) channels and opioid receptors. (Ludwig LM, Patel HH, Gross GJ, Kersten JR, Pagel PS, Warltier DC) Anesthesiology 2003 Mar;98(3):705-11 PMID 12606915
  • Reactive oxygen species modulate coronary wall shear stress and endothelial function during hyperglycemia. (Gross ER, LaDisa JF Jr, Weihrauch D, Olson LE, Kress TT, Hettrick DA, Pagel PS, Warltier DC, Kersten JR) Am J Physiol Heart Circ Physiol 2003 May;284(5):H1552-9 PMID 12543642
  • Mechanism of preconditioning by isoflurane in rabbits: a direct role for reactive oxygen species. (Tanaka K, Weihrauch D, Kehl F, Ludwig LM, LaDisa JF Jr, Kersten JR, Pagel PS, Warltier DC) Anesthesiology 2002 Dec;97(6):1485-90 PMID 12459675
  • An intramyocardial catheter for repeated in vivo sampling of interstitial fluid. (Tessmer JP, Pagel PS, Weihrauch D, Ludwig LM, Chilian WM, Kersten JR, Warltier DC) J Pharmacol Toxicol Methods 2002 Mar-Apr;47(2):73-8 PMID 12459145
  • Protein tyrosine kinase-dependent modulation of isoflurane effects on cardiac sarcolemmal K(ATP) channel. (Stadnicka A, Kwok WM, Warltier DC, Bosnjak ZJ) Anesthesiology 2002 Nov;97(5):1198-208 PMID 12411806
  • Isoflurane does not produce a second window of preconditioning against myocardial infarction in vivo. (Kehl F, Pagel PS, Krolikowski JG, Gu W, Toller W, Warltier DC, Kersten JR) Anesth Analg 2002 Nov;95(5):1162-8, table of contents PMID 12401584
  • Stent implantation alters coronary artery hemodynamics and wall shear stress during maximal vasodilation. (LaDisa JF Jr, Hettrick DA, Olson LE, Guler I, Gross ER, Kress TT, Kersten JR, Warltier DC, Pagel PS) J Appl Physiol (1985) 2002 Dec;93(6):1939-46 PMID 12391052
  • Increases in coronary collateral blood flow produced by sevoflurane are mediated by calcium-activated potassium (BKCa) channels in vivo. (Kehl F, Krolikowski JG, Tessmer JP, Pagel PS, Warltier DC, Kersten JR) Anesthesiology 2002 Sep;97(3):725-31 PMID 12218541
  • Delta opioid agonists and volatile anesthetics facilitate cardioprotection via potentiation of K(ATP) channel opening. (Patel HH, Ludwig LM, Fryer RM, Hsu AK, Warltier DC, Gross GJ) FASEB J 2002 Sep;16(11):1468-70 PMID 12205051
  • Editorial view: anesthetic preconditioning: serendipity and science. (Warltier DC, Kersten JR, Pagel PS, Gross GJ) Anesthesiology 2002 Jul;97(1):1-3 PMID 12131096
  • Attitudes of anesthesiologists about addiction and its treatment: a survey of Illinois and Wisconsin members of the American Society of Anesthesiologists. (May JA, Warltier DC, Pagel PS) J Clin Anesth 2002 Jun;14(4):284-9 PMID 12088813
  • Propofol alters left atrial function evaluated with pressure-volume relations in vivo. (Kehl F, Kress TT, Mraovic B, Hettrick DA, Kersten JR, Warltier DC, Pagel PS) Anesth Analg 2002 Jun;94(6):1421-6, table of contents PMID 12031999
  • Reactive oxygen species contribute to contractile dysfunction following rapid ventricular pacing in dogs. (Gare M, Mraovic B, Kehl F, Kersten JR, Warltier DC, Pagel PS) Int J Cardiol 2002 May;83(2):125-31 PMID 12007684
  • Isoflurane-induced preconditioning is attenuated by diabetes. (Tanaka K, Kehl F, Gu W, Krolikowski JG, Pagel PS, Warltier DC, Kersten JR) Am J Physiol Heart Circ Physiol 2002 Jun;282(6):H2018-23 PMID 12003806
  • Prologue: nonclassical modalities of myocardial preconditioning. (Gross GJ, Warltier DC) Am J Physiol Heart Circ Physiol 2002 Jun;282(6):H1951-2 PMID 12003797
  • Angiostatin inhibits coronary angiogenesis during impaired production of nitric oxide. (Matsunaga T, Weihrauch DW, Moniz MC, Tessmer J, Warltier DC, Chilian WM) Circulation 2002 May 7;105(18):2185-91 PMID 11994253
  • The role of mitochondrial and sarcolemmal K(ATP) channels in canine ethanol-induced preconditioning in vivo. (Pagel PS, Krolikowski JG, Kehl F, Mraovic B, Kersten JR, Warltier DC) Anesth Analg 2002 Apr;94(4):841-8, table of contents PMID 11916782
  • Is isoflurane-induced preconditioning dose related? (Kehl F, Krolikowski JG, Mraovic B, Pagel PS, Warltier DC, Kersten JR) Anesthesiology 2002 Mar;96(3):675-80 PMID 11873044
  • Hyperglycemia prevents isoflurane-induced preconditioning against myocardial infarction. (Kehl F, Krolikowski JG, Mraovic B, Pagel PS, Warltier DC, Kersten JR) Anesthesiology 2002 Jan;96(1):183-8 PMID 11753019
  • Hyperglycemia reduces coronary collateral blood flow through a nitric oxide-mediated mechanism. (Kersten JR, Toller WG, Tessmer JP, Pagel PS, Warltier DC) Am J Physiol Heart Circ Physiol 2001 Nov;281(5):H2097-104 PMID 11668071
  • Desflurane, sevoflurane, and isoflurane affect left atrial active and passive mechanical properties and impair left atrial-left ventricular coupling in vivo: analysis using pressure-volume relations. (Gare M, Schwabe DA, Hettrick DA, Kersten JR, Warltier DC, Pagel PS) Anesthesiology 2001 Sep;95(3):689-98 PMID 11575543
  • Conscious sedation with midazolam or propofol does not alter left ventricular diastolic performance in patients with preexisting diastolic dysfunction: a transmitral and tissue Doppler transthoracic echocardiography study. (Gare M, Parail A, Milosavljevic D, Kersten JR, Warltier DC, Pagel PS) Anesth Analg 2001 Oct;93(4):865-71 PMID 11574347
  • The patient recovering from alcohol or drug addiction: special issues for the anesthesiologist. (May JA, White HC, Leonard-White A, Warltier DC, Pagel PS) Anesth Analg 2001 Jun;92(6):1601-8 PMID 11375854
  • Diabetes and hyperglycemia impair activation of mitochondrial K(ATP) channels. (Kersten JR, Montgomery MW, Ghassemi T, Gross ER, Toller WG, Pagel PS, Warltier DC) Am J Physiol Heart Circ Physiol 2001 Apr;280(4):H1744-50 PMID 11247788
  • Ethanol enhances the functional recovery of stunned myocardium independent of K(ATP) channels in dogs. (Gross ER, Gare M, Toller WG, Kersten JR, Warltier DC, Pagel PS) Anesth Analg 2001 Feb;92(2):299-305 PMID 11159220
  • K(ATP) channels mediate the beneficial effects of chronic ethanol ingestion. (Pagel PS, Toller WG, Gross ER, Gare M, Kersten JR, Warltier DC) Am J Physiol Heart Circ Physiol 2000 Nov;279(5):H2574-9 PMID 11045996
  • Sarcolemmal and mitochondrial adenosine triphosphate- dependent potassium channels: mechanism of desflurane-induced cardioprotection. (Toller WG, Gross ER, Kersten JR, Pagel PS, Gross GJ, Warltier DC) Anesthesiology 2000 Jun;92(6):1731-9 PMID 10839925
  • Isoflurane preconditions myocardium against infarction via activation of inhibitory guanine nucleotide binding proteins. (Toller WG, Kersten JR, Gross ER, Pagel PS, Warltier DC) Anesthesiology 2000 May;92(5):1400-7 PMID 10781287
  • Correlation of esophageal conductance measurements with aortic and left ventricular diameters and stroke volume. (Hettrick DA, Battocletti JH, Pagel PS, Vurek GG, Tessmer JP, Kersten JR, Warltier DC) IEEE Trans Biomed Eng 2000 Apr;47(4):559-64 PMID 10763303
  • Diabetes abolishes ischemic preconditioning: role of glucose, insulin, and osmolality. (Kersten JR, Toller WG, Gross ER, Pagel PS, Warltier DC) Am J Physiol Heart Circ Physiol 2000 Apr;278(4):H1218-24 PMID 10749717
  • Approaches to the prevention of perioperative myocardial ischemia. (Warltier DC, Pagel PS, Kersten JR) Anesthesiology 2000 Jan;92(1):253-9 PMID 10638923
  • Ischemia-induced coronary collateral growth is dependent on vascular endothelial growth factor and nitric oxide. (Matsunaga T, Warltier DC, Weihrauch DW, Moniz M, Tessmer J, Chilian WM) Circulation 2000 Dec 19;102(25):3098-103 PMID 11120701
  • Levosimendan, a new positive inotropic drug, decreases myocardial infarct size via activation of K(ATP) channels. (Kersten JR, Montgomery MW, Pagel PS, Warltier DC) Anesth Analg 2000 Jan;90(1):5-11 PMID 10624967
  • Mechanisms of postischemic contractile dysfunction. (Gross GJ, Kersten JR, Warltier DC) Ann Thorac Surg 1999 Nov;68(5):1898-904 PMID 10585101
  • Sevoflurane reduces myocardial infarct size and decreases the time threshold for ischemic preconditioning in dogs. (Toller WG, Kersten JR, Pagel PS, Hettrick DA, Warltier DC) Anesthesiology 1999 Nov;91(5):1437-46 PMID 10551596
  • Cloning and expression of canine glycoprotein Ibalpha. (Kenny D, Morateck PA, Fahs SA, Warltier DC, Montgomery RR) Thromb Haemost 1999 Oct;82(4):1327-33 PMID 10544923
  • Multifactorial basis for coronary collateralization: a complex adaptive response to ischemia. (Kersten JR, Pagel PS, Chilian WM, Warltier DC) Cardiovasc Res 1999 Jul;43(1):44-57 PMID 10536689
  • Isoflurane-enhanced recovery of canine stunned myocardium: role for protein kinase C? (Toller WG, Montgomery MW, Pagel PS, Hettrick DA, Warltier DC, Kersten JR) Anesthesiology 1999 Sep;91(3):713-22 PMID 10485783
  • Levosimendan enhances cardiac performance after cardiopulmonary bypass: a prospective, randomized placebo-controlled trial. (Nijhawan N, Nicolosi AC, Montgomery MW, Aggarwal A, Pagel PS, Warltier DC) J Cardiovasc Pharmacol 1999 Aug;34(2):219-28 PMID 10445673
  • Modulation of the adaptive response to myocardial ischemia by coexisting disease. (Kersten JR, Warltier DC) Am J Physiol 1999 Jun;276(6 Pt 2):H2268-70 PMID 10362711
  • Finite element model determination of correction factors used for measurement of aortic diameter via conductance. (Hettrick DA, Battocletti J, Ackmann J, Warltier DC) Ann Biomed Eng 1999 Mar-Apr;27(2):151-9 PMID 10199691
  • Changes in passive but not active mechanical properties predict recovery of function of stunned myocardium. (Schmeling TJ, Hettrick DA, Kersten JR, Pagel PS, Warltier DC) Ann Biomed Eng 1999 Mar-Apr;27(2):131-40 PMID 10199689
  • Sevoflurane selectively increases coronary collateral blood flow independent of KATP channels in vivo. (Kersten JR, Schmeling T, Tessmer J, Hettrick DA, Pagel PS, Warltier DC) Anesthesiology 1999 Jan;90(1):246-56 PMID 9915334
  • RSR13, a synthetic allosteric modifier of hemoglobin, enhances recovery of stunned myocardium in dogs. (Pagel PS, Hettrick DA, Montgomery MW, Kersten JR, Warltier DC) Adv Exp Med Biol 1998;454:527-31 PMID 9889932
  • Ischemia-induced coronary collateral angiogenesis. (Weihrauch D, Tessmer JP, Kersten JR, Pagel PS, Hettrick DA, Chilian WM, Warltier DC) Adv Exp Med Biol 1998;454:281-6 PMID 9889902
  • Cardiovascular effects of xenon in isoflurane-anesthetized dogs with dilated cardiomyopathy. (Hettrick DA, Pagel PS, Kersten JR, Tessmer JP, Bosnjak ZJ, Georgieff M, Warltier DC) Anesthesiology 1998 Nov;89(5):1166-73 PMID 9822005
  • Propofol, but not thiopentone or etomidate, enhances isoflurane-induced coronary vasodilatation in dogs. (Pagel PS, Hettrick DA, Kersten JR, Lowe D, Warltier DC) Can J Anaesth 1998 Aug;45(8):809-17 PMID 9793674
  • Desflurane and isoflurane produce similar alterations in systemic and pulmonary hemodynamics and arterial oxygenation in patients undergoing one-lung ventilation during thoracotomy. (Pagel PS, Fu JL, Damask MC, Davis RF, Samuelson PN, Howie MB, Warltier DC) Anesth Analg 1998 Oct;87(4):800-7 PMID 9768773
  • Dexmedetomidine produces similar alterations in the determinants of left ventricular afterload in conscious dogs before and after the development of pacing-induced cardiomyopathy. (Pagel PS, Hettrick DA, Kersten JR, Warltier DC) Anesthesiology 1998 Sep;89(3):741-8 PMID 9743413
  • Interpretation of nonpulsatile arterial pressure-flow relations during cardiopulmonary bypass. (Hettrick DA, Kersten JR, Pagel PS, Warltier DC) Anesth Analg 1998 Sep;87(3):743 PMID 9728869
  • Repetitive coronary artery occlusions induce release of growth factors into the myocardial interstitium. (Weihrauch D, Tessmer J, Warltier DC, Chilian WM) Am J Physiol 1998 Sep;275(3 Pt 2):H969-76 PMID 9724302
  • A novel alpha 2-adrenoceptor antagonist attenuates the early, but preserves the late cardiovascular effects of intravenous dexmedetomidine in conscious dogs. (Pagel PS, Proctor LT, Devcic A, Hettrick DA, Kersten JR, Tessmer JP, Farber NE, Schmeling WT, Warltier DC) J Cardiothorac Vasc Anesth 1998 Aug;12(4):429-34 PMID 9713732
  • Acute hyperglycemia abolishes ischemic preconditioning in vivo. (Kersten JR, Schmeling TJ, Orth KG, Pagel PS, Warltier DC) Am J Physiol 1998 Aug;275(2 Pt 2):H721-5 PMID 9683464
  • Cardiovascular effects of verapamil enantiomer combinations in conscious dogs. (Pagel PS, Hettrick DA, Lowe D, Gowrie PW, Kersten JR, Bosnjak ZJ, Warltier DC) Eur J Pharmacol 1998 May 8;348(2-3):213-21 PMID 9652336
  • Etomidate adversely alters determinants of left ventricular afterload in dogs with dilated cardiomyopathy. (Pagel PS, Hettrick DA, Kersten JR, Tessmer JP, Lowe D, Warltier DC) Anesth Analg 1998 May;86(5):932-8 PMID 9585271
  • RSR13, a synthetic modifier of hemoglobin-oxygen affinity, enhances the recovery of stunned myocardium in anesthetized dogs. (Pagel PS, Hettrick DA, Montgomery MW, Kersten JR, Steffen RP, Warltier DC) J Pharmacol Exp Ther 1998 Apr;285(1):1-8 PMID 9535987
  • In vivo measurement of real-time aortic segmental volume using the conductance catheter. (Hettrick DA, Battocletti J, Ackmann J, Linehan J, Warltier DC) Ann Biomed Eng 1998 May-Jun;26(3):431-40 PMID 9570226
  • Differential roles of myocardial Ca2+ channels and Na+/Ca2+ exchange in myocardial reperfusion injury in open chest dogs: relative roles during ischemia and reperfusion. (Smart SC, Sagar KB, Warltier DC) Cardiovasc Res 1997 Dec;36(3):337-46 PMID 9534854
  • Activation of adenosine triphosphate-regulated potassium channels: mediation of cellular and organ protection. (Kersten JR, Gross GJ, Pagel PS, Warltier DC) Anesthesiology 1998 Feb;88(2):495-513 PMID 9477071
  • Injury to the Ca2+ ATPase of the sarcoplasmic reticulum in anesthetized dogs contributes to myocardial reperfusion injury. (Smart SC, Sagar KB, el Schultz J, Warltier DC, Jones LR) Cardiovasc Res 1997 Nov;36(2):174-84 PMID 9463629
  • Cardiovascular effects of propofol in dogs with dilated cardiomyopathy. (Pagel PS, Hettrick DA, Kersten JR, Lowe D, Warltier DC) Anesthesiology 1998 Jan;88(1):180-9 PMID 9447871
  • Beta-adrenergic-blocking drugs: incredibly useful, incredibly underutilized. (Warltier DC) Anesthesiology 1998 Jan;88(1):2-5 PMID 9447848
  • Isoflurane and halothane do not alter the enhanced afterload sensitivity of left ventricular relaxation in dogs with pacing-induced cardiomyopathy. (Pagel PS, Hettrick DA, Kersten JR, Tessmer JP, Lowe D, Warltier DC) Anesthesiology 1997 Oct;87(4):952-62 PMID 9357899
  • The effects of isoflurane and halothane on left ventricular afterload in dogs with dilated cardiomyopathy. (Hettrick DA, Pagel PS, Kersten JR, Lowe D, Warltier DC) Anesth Analg 1997 Nov;85(5):979-86 PMID 9356087
  • Hemodynamic effects of repetitive cocaine administration. (Pagel PS, Warltier DC) Circulation 1997 Aug 5;96(3):1050 PMID 9264524
  • The leukocyte cell adhesion cascade and its role in myocardial ischemia-reperfusion injury. (Gumina RJ, Newman PJ, Kenny D, Warltier DC, Gross GJ) Basic Res Cardiol 1997 Aug;92(4):201-13 PMID 9342427
  • Isoflurane mimics ischemic preconditioning via activation of K(ATP) channels: reduction of myocardial infarct size with an acute memory phase. (Kersten JR, Schmeling TJ, Pagel PS, Gross GJ, Warltier DC) Anesthesiology 1997 Aug;87(2):361-70 PMID 9286901
  • Positive inotropic and lusitropic effects of triiodothyronine in conscious dogs with pacing-induced cardiomyopathy. (Jamall IN, Pagel PS, Hettrick DA, Lowe D, Kersten JR, Tessmer JP, Warltier DC) Anesthesiology 1997 Jul;87(1):102-9 PMID 9232140
  • Intracoronary levosimendan enhances contractile function of stunned myocardium. (Jamali IN, Kersten JR, Pagel PS, Hettrick DA, Warltier DC) Anesth Analg 1997 Jul;85(1):23-9 PMID 9212117
  • Levosimendan enhances left ventricular systolic and diastolic function in conscious dogs with pacing-induced cardiomyopathy. (Pagel PS, McGough MF, Hettrick DA, Lowe D, Tessmer JP, Jamali IN, Warltier DC) J Cardiovasc Pharmacol 1997 May;29(5):563-73 PMID 9213196
  • Temporal dependence of coronary collateral development. (Kersten JR, McGough MF, Pagel PS, Tessmer JP, Warltier DC) Cardiovasc Res 1997 May;34(2):306-12 PMID 9205544
  • Role of adenosine in isoflurane-induced cardioprotection. (Kersten JR, Orth KG, Pagel PS, Mei DA, Gross GJ, Warltier DC) Anesthesiology 1997 May;86(5):1128-39 PMID 9158363
  • Alterations in canine left ventricular-arterial coupling and mechanical efficiency produced by propofol. (Hettrick DA, Pagel PS, Warltier DC) Anesthesiology 1997 May;86(5):1088-93 PMID 9158358
  • Effects of isoflurane and propofol on arterial mechanical properties. (Hettrick DA, Pagel PS, Warltier DC) Anesth Analg 1997 Apr;84(4):940-1 PMID 9085995
  • Effects of levosimendan on left ventricular function: correlation with plasma concentrations in conscious dogs. (McGough MF, Pagel PS, Lowe D, Hettrick DA, Kersten JR, Warltier DC) J Cardiothorac Vasc Anesth 1997 Feb;11(1):49-53 PMID 9058220
  • Effects of physical parameters on the cylindrical model for volume measurement by conductance. (Hettrick DA, Battocletti JH, Ackmann JJ, Linehan JH, Warltier DC) Ann Biomed Eng 1997 Jan-Feb;25(1):126-34 PMID 9124727
  • Antibody to platelet/endothelial cell adhesion molecule-1 reduces myocardial infarct size in a rat model of ischemia-reperfusion injury. (Gumina RJ, el Schultz J, Yao Z, Kenny D, Warltier DC, Newman PJ, Gross GJ) Circulation 1996 Dec 15;94(12):3327-33 PMID 8989147
  • Increases in inotropic state without change in heart rate: combined use of dobutamine and zatebradine in conscious dogs. (Hettrick DA, Pagel PS, Lowe D, Tessmer JP, Warltier DC) Eur J Pharmacol 1996 Dec 5;316(2-3):237-44 PMID 8982692
  • Isoflurane and halothane produce similar alterations in aortic distensibility and characteristic aortic impedance. (Hettrick DA, Pagel PS, Warltier DC) Anesth Analg 1996 Dec;83(6):1166-72 PMID 8942580
  • In vitro and finite-element model investigation of the conductance technique for measurement of aortic segmental volume. (Hettrick DA, Battocletti JH, Ackmann JJ, Linehan JH, Warltier DC) Ann Biomed Eng 1996 Nov-Dec;24(6):675-84 PMID 8923987
  • Influence of levosimendan, pimobendan, and milrinone on the regional distribution of cardiac output in anaesthetized dogs. (Pagel PS, Hettrick DA, Warltier DC) Br J Pharmacol 1996 Oct;119(3):609-15 PMID 8894186
  • Mechanism of myocardial protection by isoflurane. Role of adenosine triphosphate-regulated potassium (KATP) channels. (Kersten JR, Schmeling TJ, Hettrick DA, Pagel PS, Gross GJ, Warltier DC) Anesthesiology 1996 Oct;85(4):794-807; discussion 27A PMID 8873550
  • Isoflurane, but not halothane, improves indices of diastolic performance in dogs with rapid ventricular, pacing-induced cardiomyopathy. (Pagel PS, Lowe D, Hettrick DA, Jamali IN, Kersten JR, Tessmer JP, Warltier DC) Anesthesiology 1996 Sep;85(3):644-54 PMID 8853096
  • Desflurane, sevoflurane, and isoflurane impair canine left ventricular-arterial coupling and mechanical efficiency. (Hettrick DA, Pagel PS, Warltier DC) Anesthesiology 1996 Aug;85(2):403-13 PMID 8712457
  • Comparison of the effects of levosimendan, pimobendan, and milrinone on canine left ventricular-arterial coupling and mechanical efficiency. (Pagel PS, Hettrick DA, Warltier DC) Basic Res Cardiol 1996 Jul-Aug;91(4):296-307 PMID 8874779
  • Levosimendan potentiates the inotropic actions of dopamine in conscious dogs. (McGough MF, Pagel PS, Lowe D, Hettrick DA, Warltier DC) J Cardiovasc Pharmacol 1996 Jul;28(1):36-47 PMID 8797134
  • Influence of volatile anesthetics on left ventricular afterload in vivo. Differences between desflurane and sevoflurane. (Lowe D, Hettrick DA, Pagel PS, Warltier DC) Anesthesiology 1996 Jul;85(1):112-20 PMID 8694356
  • Glyburide, a KATP channel antagonist, attenuates the cardioprotective effects of isoflurane in stunned myocardium. (Kersten JR, Lowe D, Hettrick DA, Pagel PS, Gross GJ, Warltier DC) Anesth Analg 1996 Jul;83(1):27-33 PMID 8659760
  • Comparison of the cardiovascular effects of two novel superoxide dismutase mimetics, SC-55858 and SC-54417, in conscious dogs. (Lowe D, Pagel PS, McGough MF, Hettrick DA, Warltier DC) Eur J Pharmacol 1996 May 23;304(1-3):81-6 PMID 8813587
  • Assessment of right ventricular function in swine using sonomicrometry and conductance. (Nicolosi AC, Hettrick DA, Warltier DC) Ann Thorac Surg 1996 May;61(5):1381-7; discussion 1387-8 PMID 8633946
  • Differential hemodynamic effects of the nitric oxide donor pirsidomine in comparison to SIN-1, nitroprusside and nitroglycerin. (Arkonac BM, Kersten JR, Wynsen JC, Nijhawan N, Warltier DC) Pharmacology 1996 Feb;52(2):92-100 PMID 8851630
  • Propofol alters left ventricular afterload as evaluated by aortic input impedance in dogs. (Lowe D, Hettrick DA, Pagel PS, Warltier DC) Anesthesiology 1996 Feb;84(2):368-76 PMID 8602668
  • Intracoronary amiloride prevents contractile dysfunction of postischemic "stunned" myocardium: role of hemodynamic alterations and inhibition of Na+/H+ exchange and L-type Ca2+ channels. (Smart SC, LoCurto A, el Schultz J, Sagar KB, Warltier DC) J Am Coll Cardiol 1995 Nov 1;26(5):1365-73 PMID 7594055
  • Desflurane and isoflurane exert modest beneficial actions on left ventricular diastolic function during myocardial ischemia in dogs. (Pagel PS, Hettrick DA, Lowe D, Tessmer JP, Warltier DC) Anesthesiology 1995 Nov;83(5):1021-35 PMID 7486153
  • Zatebradine, a specific bradycardic agent, alters the hemodynamic and left ventricular mechanical actions of levosimendan, a new myofilament calcium sensitizer, in conscious dogs. (Pagel PS, Harkin CP, Hettrick DA, Warltier DC) J Pharmacol Exp Ther 1995 Oct;275(1):127-35 PMID 7562540
  • Differential effects of isoflurane and halothane on aortic input impedance quantified using a three-element Windkessel model. (Hettrick DA, Pagel PS, Warltier DC) Anesthesiology 1995 Aug;83(2):361-73 PMID 7631959
  • Systemic and coronary hemodynamic actions and left ventricular functional effects of levosimendan in conscious dogs. (Harkin CP, Pagel PS, Tessmer JP, Warltier DC) J Cardiovasc Pharmacol 1995 Aug;26(2):179-88 PMID 7475041
  • Modulation of coronary collateral angiogenesis: a canine model of neovascularization induced by chronic ischemia. (Kersten JR, Warltier DC) J Card Surg 1995 Jul;10(4 Pt 1):354-7 PMID 7549194
  • Protamine inhibits coronary collateral development in a canine model of repetitive coronary occlusion. (Kersten JR, Pagel PS, Warltier DC) Am J Physiol 1995 Feb;268(2 Pt 2):H720-8 PMID 7532374
  • Relation of ultrasonic backscatter and acoustic propagation properties to myofibrillar length and myocardial thickness. (O'Brien PD, O'Brien WD Jr, Rhyne TL, Warltier DC, Sagar KB) Circulation 1995 Jan 1;91(1):171-5 PMID 7805199
  • Acoustic propagation properties of normal, stunned, and infarcted myocardium. Morphological and biochemical determinants. (O'Brien WD, Sagar KB, Warltier DC, Rhyne TL) Circulation 1995 Jan 1;91(1):154-60 PMID 7805196
  • Dexmedetomidine partially attenuates the sympathetically mediated systemic and coronary hemodynamic effects of cocaine. (Kersten JR, Pagel PS, Hettrick DA, Warltier DC) Anesth Analg 1995 Jan;80(1):114-21 PMID 7802267
  • Perfusion of ischemic myocardium during anesthesia with sevoflurane. (Kersten JR, Brayer AP, Pagel PS, Tessmer JP, Warltier DC) Anesthesiology 1994 Oct;81(4):995-1004 PMID 7943851
  • Levosimendan (OR-1259), a myofilament calcium sensitizer, enhances myocardial contractility but does not alter isovolumic relaxation in conscious and anesthetized dogs. (Pagel PS, Harkin CP, Hettrick DA, Warltier DC) Anesthesiology 1994 Oct;81(4):974-87 PMID 7943849
  • Cultured endothelial cells restore vasodilator responses to coronary arteries with impaired endothelial function and alter the response to a nitric oxide donor. (Kenny D, Coughlan MG, Kampine JP, Montgomery RR, Bosnjak ZJ, Warltier DC) Pharmacology 1994 Oct;49(4):249-56 PMID 7831388
  • Systemic and coronary hemodynamic effects of repetitive cocaine administration in conscious dogs. (Pagel PS, Tessmer JP, Warltier DC) J Cardiovasc Pharmacol 1994 Sep;24(3):443-53 PMID 7528301
  • Oral dexmedetomidine preserves baroreceptor function and decreases anesthetic requirements of halothane-anesthetized dogs. (Devcic A, Schmeling WT, Kampine JP, Warltier DC) Anesthesiology 1994 Aug;81(2):419-30 PMID 8053593
  • Direct negative inotropic and lusitropic effects of sevoflurane. (Harkin CP, Pagel PS, Kersten JR, Hettrick DA, Warltier DC) Anesthesiology 1994 Jul;81(1):156-67 PMID 8042785
  • Left ventricular mechanical consequences of dihydropyridine calcium channel modulation in conscious and anesthetized chronically instrumented dogs. (Pagel PS, Hettrick DA, Warltier DC) Anesthesiology 1994 Jul;81(1):190-208 PMID 7519000
  • Transforming growth factor beta 1 preserves endothelial function after multiple brief coronary artery occlusions and reperfusion. (Kenny D, Coughlan MG, Pagel PS, Kampine JP, Warltier DC) Am Heart J 1994 Jun;127(6):1456-61 PMID 8197968
  • Zatebradine, a specific bradycardic agent, enhances the positive inotropic actions of dobutamine in ischemic myocardium. (Wynsen JC, O'Brien PD, Warltier DC) J Am Coll Cardiol 1994 Jan;23(1):233-41 PMID 8277087
  • Volatile anesthetics and coronary collateral circulation. (Kersten JR, Hartman JC, Pagel PS, Warltier DC) Adv Pharmacol 1994;31:269-84 PMID 7873418
  • Mechanical consequences of calcium channel modulation during volatile anesthetic-induced left ventricular systolic and diastolic dysfunction. (Pagel PS, Warltier DC) Adv Pharmacol 1994;31:125-43 PMID 7532986
  • Quantitation of volatile anesthetic-induced depression of myocardial contractility using a single beat index derived from maximal ventricular power. (Pagel PS, Nijhawan N, Warltier DC) J Cardiothorac Vasc Anesth 1993 Dec;7(6):688-95 PMID 8305659
  • Intraoperative bronchospasm caused by adenosine. (Aggarwal A, Farber NE, Warltier DC) Anesthesiology 1993 Nov;79(5):1132-5 PMID 8238991
  • Left ventricular diastolic function in the normal and diseased heart. Perspectives for the anesthesiologist (2). (Pagel PS, Grossman W, Haering JM, Warltier DC) Anesthesiology 1993 Nov;79(5):1104-20 PMID 8238987
  • Dexmedetomidine alters the hemodynamic effects of desflurane and isoflurane in chronically instrumented dogs. (Kersten J, Pagel PS, Tessmer JP, Roerig DL, Schmeling WT, Warltier DC) Anesthesiology 1993 Nov;79(5):1022-32 PMID 7902030
  • Left ventricular diastolic function in the normal and diseased heart. Perspectives for the anesthesiologist (1). (Pagel PS, Grossman W, Haering JM, Warltier DC) Anesthesiology 1993 Oct;79(4):836-54 PMID 8214764
  • Amrinone enhances myocardial contractility and improves left ventricular diastolic function in conscious and anesthetized chronically instrumented dogs. (Pagel PS, Hettrick DA, Warltier DC) Anesthesiology 1993 Oct;79(4):753-65 PMID 8214755
  • Differential sensitivity of proximal and distal coronary arteries to a nitric oxide donor following reperfusion injury or inhibition of nitric oxide synthesis. (Coughlan MG, Kenny D, Kampine JP, Bosnjak ZJ, Warltier DC) Cardiovasc Res 1993 Aug;27(8):1444-8 PMID 8221797
  • Recovery of contractile function of postischemic, reperfused myocardium: influence of 2,3-butanedione-2-monoxime. (O'Brien P, Bosnjak Z, Warltier DC) J Cardiovasc Pharmacol 1993 May;21(5):693-700 PMID 7685437
  • Relationship of severity of myocardial stunning to ATP dependent potassium channel modulation. (Warltier DC, Auchampach JA, Gross GJ) J Card Surg 1993 Mar;8(2 Suppl):279-83 PMID 8461517
  • Evaluation of myocardial contractility in the chronically instrumented dog with intact autonomic nervous system function: effects of desflurane and isoflurane. (Pagel PS, Kampine JP, Schmeling WT, Warltier DC) Acta Anaesthesiol Scand 1993 Feb;37(2):203-10 PMID 8447212
  • Reversal of volatile anesthetic-induced depression of myocardial contractility by extracellular calcium also enhances left ventricular diastolic function. (Pagel PS, Kampine JP, Schmeling WT, Warltier DC) Anesthesiology 1993 Jan;78(1):141-54 PMID 8424547
  • Negative inotropic effects of propofol as evaluated by the regional preload recruitable stroke work relationship in chronically instrumented dogs. (Pagel PS, Warltier DC) Anesthesiology 1993 Jan;78(1):100-8 PMID 8424542
  • Myocardial and endothelial dysfunction after multiple, brief coronary occlusions: role of oxygen radicals. (Gross GJ, O'Rourke ST, Pelc LR, Warltier DC) Am J Physiol 1992 Dec;263(6 Pt 2):H1703-9 PMID 1481896
  • Effect of omega-3 fatty acids on the vascular response to angiotensin in normotensive men. (Kenny D, Warltier DC, Pleuss JA, Hoffmann RG, Goodfriend TL, Egan BM) Am J Cardiol 1992 Nov 15;70(15):1347-52 PMID 1442589
  • Direct coronary and cerebral vascular responses to dexmedetomidine. Significance of endogenous nitric oxide synthesis. (Coughlan MG, Lee JG, Bosnjak ZJ, Schmeling WT, Kampine JP, Warltier DC) Anesthesiology 1992 Nov;77(5):998-1006 PMID 1359812
  • Nitrous oxide impairs functional recovery of stunned myocardium in barbiturate-anesthetized, acutely instrumented dogs. (Siker D, Pagel PS, Pelc LR, Kampine JP, Schmeling WT, Warltier DC) Anesth Analg 1992 Oct;75(4):539-48 PMID 1530167
  • Cardiovascular and respiratory actions of desflurane: is desflurane different from isoflurane? (Warltier DC, Pagel PS) Anesth Analg 1992 Oct;75(4 Suppl):S17-29; discussion S29-31 PMID 1524236
  • ASA Award: John P. Kampine. (Warltier DC) Anesthesiology 1992 Oct;77(4):623-5 PMID 1416158
  • Influence of desflurane, isoflurane and halothane on regional tissue perfusion in dogs. (Hartman JC, Pagel PS, Proctor LT, Kampine JP, Schmeling WT, Warltier DC) Can J Anaesth 1992 Oct;39(8):877-87 PMID 1288912
  • Premedication with oral dexmedetomidine alters hemodynamic actions of intravenous anesthetic agents in chronically instrumented dogs. (Proctor LT, Schmeling WT, Warltier DC) Anesthesiology 1992 Sep;77(3):554-62 PMID 1355639
  • Attenuation of the systemic and coronary hemodynamic effects of cocaine in conscious dogs: propranolol versus labetalol. (Kenny D, Pagel PS, Warltier DC) Basic Res Cardiol 1992 Sep-Oct;87(5):465-77 PMID 1334401
  • Cocaine depresses myocardial contractility and prolongs isovolumetric relaxation in conscious dogs with partial autonomic nervous system blockade. (Pagel PS, Power MW, Kenny D, Warltier DC) J Cardiovasc Pharmacol 1992 Jul;20(1):25-34 PMID 1383628
  • Ketamine depresses myocardial contractility as evaluated by the preload recruitable stroke work relationship in chronically instrumented dogs with autonomic nervous system blockade. (Pagel PS, Kampine JP, Schmeling WT, Warltier DC) Anesthesiology 1992 Apr;76(4):564-72 PMID 1550282
  • Alteration of canine left ventricular diastolic function by intravenous anesthetics in vivo. Ketamine and propofol. (Pagel PS, Schmeling WT, Kampine JP, Warltier DC) Anesthesiology 1992 Mar;76(3):419-25 PMID 1539854
  • Differential relaxant effect of high concentrations of intravenous anesthetics on endothelin-constricted proximal and distal canine coronary arteries. (Coughlan MG, Flynn NM, Kenny D, Warltier DC, Kampine JP) Anesth Analg 1992 Mar;74(3):378-83 PMID 1539819
  • Regional redistribution of myocardial perfusion by UL-FS 49, a selective bradycardic agent. (O'Brien P, Drage D, Saeian K, Brooks HL, Warltier DC) Am Heart J 1992 Mar;123(3):566-74 PMID 1539507
  • Cardioprotective effects of nicorandil. (Gross GJ, Auchampach JA, Maruyama M, Warltier DC, Pieper GM) J Cardiovasc Pharmacol 1992;20 Suppl 3:S22-8 PMID 1282172
  • Endothelium-dependent vasodilation of canine coronary collateral vessels. (Flynn NM, Kenny D, Pelc LR, Warltier DC, Bosnjak ZJ, Kampine JP) Am J Physiol 1991 Dec;261(6 Pt 2):H1797-801 PMID 1750535
  • Isoflurane causes only minimal increases in coronary blood flow independent of oxygen demand. (Kenny D, Proctor LT, Schmeling WT, Kampine JP, Warltier DC) Anesthesiology 1991 Oct;75(4):640-9 PMID 1928773
  • The effects of the stereoisomers of the alpha 2-adrenergic agonist medetomidine on systemic and coronary hemodynamics in conscious dogs. (Schmeling WT, Kampine JP, Roerig DL, Warltier DC) Anesthesiology 1991 Sep;75(3):499-511 PMID 1679615
  • Alteration of left ventricular diastolic function by desflurane, isoflurane, and halothane in the chronically instrumented dog with autonomic nervous system blockade. (Pagel PS, Kampine JP, Schmeling WT, Warltier DC) Anesthesiology 1991 Jun;74(6):1103-14 PMID 2042762
  • Mechanism of coronary vasodilation produced by bradykinin. (Pelc LR, Gross GJ, Warltier DC) Circulation 1991 Jun;83(6):2048-56 PMID 1645623
  • Dipyridamole-induced decrement of functional recovery of postischemic reperfused myocardium in conscious dogs with well-developed coronary collateral circulation. (Kenny D, Wynsen JC, Brooks HL, Warltier DC) Am Heart J 1991 May;121(5):1339-47 PMID 2017968
  • Influence of volatile anesthetics on myocardial contractility in vivo: desflurane versus isoflurane. (Pagel PS, Kampine JP, Schmeling WT, Warltier DC) Anesthesiology 1991 May;74(5):900-7 PMID 2021208
  • Regional myocardial function after repetitive brief episodes of ischemia: effect of altering the duration of the reperfusion period. (Wynsen JC, Kenny D, Brooks HL, Warltier DC) Am Heart J 1991 May;121(5):1331-8 PMID 2017967
  • Estimation of myocardial infarct size with ultrasonic tissue characterization. (Sagar KB, Pelc LR, Rhyne TL, Howard J, Warltier DC) Circulation 1991 Apr;83(4):1419-28 PMID 2013158
  • Steal-prone coronary circulation in chronically instrumented dogs: isoflurane versus adenosine. (Hartman JC, Kampine JP, Schmeling WT, Warltier DC) Anesthesiology 1991 Apr;74(4):744-56 PMID 2008956
  • Comparison of the systemic and coronary hemodynamic actions of desflurane, isoflurane, halothane, and enflurane in the chronically instrumented dog. (Pagel PS, Kampine JP, Schmeling WT, Warltier DC) Anesthesiology 1991 Mar;74(3):539-51 PMID 2001033
  • Influence of desflurane on regional distribution of coronary blood flow in a chronically instrumented canine model of multivessel coronary artery obstruction. (Hartman JC, Pagel PS, Kampine JP, Schmeling WT, Warltier DC) Anesth Analg 1991 Mar;72(3):289-99 PMID 1994756
  • Prolongation of the QT interval by enflurane, isoflurane, and halothane in humans. (Schmeling WT, Warltier DC, McDonald DJ, Madsen KE, Atlee JL, Kampine JP) Anesth Analg 1991 Feb;72(2):137-44 PMID 1898684
  • Alterations in collateral blood flow produced by isoflurane in a chronically instrumented canine model of multivessel coronary artery disease. (Hartman JC, Kampine JP, Schmeling WT, Warltier DC) Anesthesiology 1991 Jan;74(1):120-33 PMID 1986637
  • Oral dexmedetomidine attenuates hemodynamic responses during emergence from general anesthesia in chronically instrumented dogs. (Proctor LT, Schmeling WT, Roerig D, Kampine JP, Warltier DC) Anesthesiology 1991 Jan;74(1):108-14 PMID 1670911
  • A model of multivessel coronary artery disease using conscious, chronically instrumented dogs. (Hartman JC, Warltier DC) J Pharmacol Methods 1990 Dec;24(4):297-310 PMID 2292881
  • Effects of nitrous oxide on myocardial contractility as evaluated by the preload recruitable stroke work relationship in chronically instrumented dogs. (Pagel PS, Kampine JP, Schmeling WT, Warltier DC) Anesthesiology 1990 Dec;73(6):1148-57 PMID 2147368
  • Actions of isoflurane on myocardial perfusion in chronically instrumented dogs with poor, moderate, or well-developed coronary collaterals. (Hartman JC, Kampine JP, Schmeling WT, Warltier DC) J Cardiothorac Anesth 1990 Dec;4(6):715-25 PMID 2131901
  • Role of ultrasonic tissue characterization to distinguish reversible from irreversible myocardial injury. (Sagar KB, Pelc LR, Rhyne TL, Komorowski RA, Wann LS, Warltier DC) J Am Soc Echocardiogr 1990 Nov-Dec;3(6):471-7 PMID 1703768
  • Volatile anesthetics and regional myocardial perfusion in chronically instrumented dogs: halothane versus isoflurane in a single-vessel disease model with enhanced collateral development. (Hartman JC, Kampine JP, Schmeling WT, Warltier DC) J Cardiothorac Anesth 1990 Oct;4(5):588-603 PMID 2132138
  • Comparison of end-systolic pressure-length relations and preload recruitable stroke work as indices of myocardial contractility in the conscious and anesthetized, chronically instrumented dog. (Pagel PS, Kampine JP, Schmeling WT, Warltier DC) Anesthesiology 1990 Aug;73(2):278-90 PMID 2382851
  • Alteration of endothelium-dependent distribution of myocardial blood flow after coronary occlusion and reperfusion. (Pelc LR, Garancis JC, Gross GJ, Warltier DC) Circulation 1990 Jun;81(6):1928-37 PMID 2344685
  • Quantitative ultrasonic assessment of normal and ischaemic myocardium with an acoustic microscope: relationship to integrated backscatter. (Sagar KB, Agemura DH, O'Brien WD Jr, Pelc LR, Rhyne TL, Wann LS, Komorowski RA, Warltier DC) Cardiovasc Res 1990 Jun;24(6):447-55 PMID 2201447
  • Enhanced alpha-adrenergic vasoconstriction by n-3 fatty acids in conscious dogs. (Kenny D, Brooks HL, Warltier DC) Am J Physiol 1990 Jun;258(6 Pt 2):H1660-7 PMID 1972867
  • Vasodilator actions of interleukin-1 in the canine coronary circulation. (Kenny D, McCarthy-Kenny G, Pelc LR, Cheung HS, Brooks HL, Warltier DC) Basic Res Cardiol 1990 May-Jun;85(3):279-84 PMID 2383221
  • Calcium channel modulation of alpha 1- and alpha 2-adrenergic pressor responses in conscious and anesthetized dogs. (Kenny D, Pelc LR, Brooks HL, Kampine JP, Schmeling WT, Warltier DC) Anesthesiology 1990 May;72(5):874-81 PMID 1692673
  • Ultrasonic tissue characterization of normal and ischemic myocardium. (Sagar KB, Pelc LR, Saeian K, Rhyne TL, Wann LS, Warltier DC) Echocardiography 1990 Jan;7(1):11-9 PMID 10149187
  • Alterations of alpha 1 and alpha 2 adrenoceptor-mediated pressor responses by halothane and isoflurane anesthesia. (Kenny D, Pelc LR, Brooks HL, Kampine JP, Schmeling WT, Warltier DC) Anesthesiology 1989 Aug;71(2):224-34 PMID 2569281
  • Negative chronotropic actions of sufentanil and vecuronium in chronically instrumented dogs pretreated with propranolol and/or diltiazem. (Schmeling WT, Kampine JP, Warltier DC) Anesth Analg 1989 Jul;69(1):4-14 PMID 2568103
  • Improvement in functional recovery of stunned canine myocardium by long-term pretreatment with oral propranolol. (al-Wathiqui MH, Farber N, Pelc L, Gross GJ, Brooks HL, Warltier DC) Am Heart J 1989 Apr;117(4):791-8 PMID 2929396
  • Reduction of myocardial ischemia-reperfusion injury by KT-362, a new intracellular calcium antagonist in anesthetized dogs. (Pelc LR, Farber NE, Warltier DC, Gross GJ) J Cardiovasc Pharmacol 1989 Apr;13(4):586-93 PMID 2470996
  • Effects of nisoldipine on coronary collateral perfusion and hemodynamics in chronically instrumented dogs. (Kenny D, Hartman JC, Brooks HL, Warltier DC) Pharmacology 1989;38(4):263-71 PMID 2755966
  • Cyclical carotid artery flow reduction in conscious dogs: effect of a new thromboxane receptor antagonist. (al-Wathiqui MH, Hartman JC, Brooks HL, Gross GJ, Warltier DC) Am Heart J 1988 Dec;116(6 Pt 1):1482-7 PMID 3195431
  • Alpha adrenoceptor subtypes and receptor reserve in human versus canine saphenous vein: sensitivity to blockade by nitroglycerin. (Eskinder H, Hillard CJ, Olinger GN, Christensen CW, Baker JE, Warltier DC, Gross GJ) J Pharmacol Exp Ther 1988 Dec;247(3):941-8 PMID 2905005
  • Recovery of contractile function of stunned myocardium in chronically instrumented dogs is enhanced by halothane or isoflurane. (Warltier DC, al-Wathiqui MH, Kampine JP, Schmeling WT) Anesthesiology 1988 Oct;69(4):552-65 PMID 3177915
  • Steroid-induced enhancement of functional recovery of postischemic, reperfused myocardium in conscious dogs. (Wynsen JC, Preuss KC, Gross GJ, Brooks HL, Warltier DC) Am Heart J 1988 Oct;116(4):915-25 PMID 3051986
  • Induction of cyclic flow reduction in the coronary, carotid, and femoral arteries of conscious, chronically instrumented dogs. A model for investigating the role of platelets in severely constricted arteries. (Al-Wathiqui MH, Hartman JC, Brooks HL, Warltier DC) J Pharmacol Methods 1988 Aug;20(1):85-92 PMID 3411977
  • Prolongation of the QT interval by volatile anesthetics in chronically instrumented dogs. (Riley DC, Schmeling WT, al-Wathiqui MH, Kampine JP, Warltier DC) Anesth Analg 1988 Aug;67(8):741-9 PMID 3394961
  • Mechanisms of enhanced canine subendocardial perfusion. A comparison of adenosine triphosphate and sodium nitroprusside. (Pelc LR, Gross GJ, Kampine JP, Warltier DC) Anesth Analg 1988 Jun;67(6):514-20 PMID 3259847
  • Muscarinic receptor subtypes mediating myocardial blood flow redistribution. (Pelc LR, Daemmgen JW, Gross GJ, Warltier DC) J Cardiovasc Pharmacol 1988 Apr;11(4):424-31 PMID 2453745
  • Comparative effects of inotropic agents on coronary and systemic hemodynamics of conscious dogs: actions of milrinone, dopamine, ouabain and MCI-154. (Al-Wathiqui MH, Shimshak TM, Brooks HL, Preuss KC, Wynsen JC, Gross GJ, Warltier DC) Pharmacology 1988;36(4):217-27 PMID 3380877
  • Hemodynamic and electrocardiographic actions of the new intracellular calcium antagonist, KT-362, in the conscious dog. (Hartman JC, Al-Wathiqui MH, Brooks HL, Gross GJ, Warltier DC) Pharmacology 1988;37(6):376-84 PMID 3244744
  • Improvement of postischemic, contractile function by the calcium channel blocking agent nitrendipine in conscious dogs. (Warltier DC, Gross GJ, Brooks HL, Preuss KC) J Cardiovasc Pharmacol 1988;12 Suppl 4:S120-4 PMID 2468853
  • A canine model of thrombin-induced coronary artery thrombosis: effects of intracoronary streptokinase on regional myocardial blood flow, contractile function, and infarct size. (Warltier DC, Lamping KA, Pelc LR, Gross GJ) J Pharmacol Methods 1987 Dec;18(4):305-18 PMID 3695539
  • Specific bradycardic agents, a new therapeutic modality for anesthesiology: hemodynamic effects of UL-FS 49 and propranolol in conscious and isoflurane-anesthetized dogs. (Riley DC, Gross GJ, Kampine JP, Warltier DC) Anesthesiology 1987 Nov;67(5):707-16 PMID 3674471
  • Comparative effects of nicorandil, a nicotinamide nitrate derivative, and nifedipine on myocardial reperfusion injury in dogs. (Gross GJ, Warltier DC, Hardman HF) J Cardiovasc Pharmacol 1987 Nov;10(5):535-42 PMID 2447402
  • Time course of recovery of "stunned" myocardium following variable periods of ischemia in conscious and anesthetized dogs. (Preuss KC, Gross GJ, Brooks HL, Warltier DC) Am Heart J 1987 Oct;114(4 Pt 1):696-703 PMID 2959132
  • Changes in adrenergic pressor responses by calcium channel modulation in conscious dogs. (Wynsen JC, Gross GJ, Brooks HL, Warltier DC) Am J Physiol 1987 Sep;253(3 Pt 2):H531-9 PMID 2443022
  • Preferential increase in subendocardial perfusion produced by endothelium-dependent vasodilators. (Pelc LR, Gross GJ, Warltier DC) Circulation 1987 Jul;76(1):191-200 PMID 3594767
  • Cardiovascular actions of a new dihydropyridine calcium antagonist, 8363-S: comparison with nifedipine and nicardipine in awake, unsedated dogs. (Wynsen JC, Shimshak TM, Preuss KC, Hardman HF, Warltier DC) J Cardiovasc Pharmacol 1987 Jul;10(1):30-7 PMID 2441151
  • Differential effects of nifedipine, nicorandil and nitroglycerin on the pressor responses elicited by selective alpha-1 and alpha-adrenoceptor agonists in conscious dogs. (Wynsen JC, Gross GJ, Brooks HL, Warltier DC) J Pharmacol Exp Ther 1987 Jun;241(3):846-54 PMID 2885410
  • Regional distribution of blood flow at the onset of right ventricular diastolic collapse during cardiac tamponade. (Bernath GA, Cogswell TL, Shimshak TM, Warltier DC, Klopfenstein HS) Am Heart J 1987 May;113(5):1129-32 PMID 3578007
  • Intramyocardial variability in integrated backscatter: effects of coronary occlusion and reperfusion. (Sagar KB, Rhyne TL, Warltier DC, Pelc L, Wann LS) Circulation 1987 Feb;75(2):436-42 PMID 3542284
  • Stimulation of myocardium during reperfusion injury by a new inotrope-vasodilator agent, MCI-154. (Wynsen JC, Shimshak TM, Preuss KC, Gross GJ, Brooks HL, Warltier DC) Fundam Clin Pharmacol 1987;1(5):335-45 PMID 3443426
  • Comparative effects of nicorandil, nitroglycerin, nicotinic acid, and SG-86 on the metabolic status and functional recovery of the ischemic-reperfused myocardium. (Gross GJ, Pieper GM, Warltier DC) J Cardiovasc Pharmacol 1987;10 Suppl 8:S76-84 PMID 2447429
  • Effects of intracoronary Bay k 8644, a calcium channel agonist, in anesthetized dogs. (Pelc LR, Gross GJ, Brooks HL, Warltier DC) J Cardiovasc Pharmacol 1986 Nov-Dec;8(6):1223-8 PMID 2434750
  • Recovery of contractile function in post-ischaemic reperfused myocardium of conscious dogs: influence of nicorandil, a new antianginal agent. (Shimshak TM, Preuss KC, Gross GJ, Brooks HL, Warltier DC) Cardiovasc Res 1986 Aug;20(8):621-6 PMID 2947685
  • Changes in regional myocardial perfusion by muscarinic receptor subtypes in dogs. (Pelc LR, Gross GJ, Warltier DC) Cardiovasc Res 1986 Jul;20(7):482-9 PMID 3779744
  • Effects of KB-944, a novel calcium antagonist, in several models of canine myocardial ischemia. (Pelc LR, Gross GJ, Warltier DC) J Pharmacol Exp Ther 1986 Jul;238(1):113-8 PMID 3723394
  • Beneficial actions of superoxide dismutase and catalase in stunned myocardium of dogs. (Gross GJ, Farber NE, Hardman HF, Warltier DC) Am J Physiol 1986 Mar;250(3 Pt 2):H372-7 PMID 3953834
  • Importance of retrograde coronary flow in the prediction of experimental myocardial infarct size. (Warltier DC, Zyvoloski MG, Gross GJ, Brooks HL) Cardiology 1986;73(6):333-46 PMID 3791333
  • Slow channel calcium activators, a new group of pharmacological agents. (Preuss KC, Gross GJ, Brooks HL, Warltier DC) Life Sci 1985 Oct 7;37(14):1271-8 PMID 2413326
  • Enhanced subendocardial perfusion distal to a flow-limiting coronary artery stenosis in dogs: comparative effects of nicorandil, a potential new antianginal agent, and nitroglycerin. (Gross GJ, Warltier DC, Hardman HF, Lamping KA) J Cardiovasc Pharmacol 1985 Sep-Oct;7(5):977-82 PMID 2413311
  • Effects of AQ-AH 208, a new specific bradycardic agent, on myocardial ischemia-reperfusion injury in anesthetized dogs. (Gross GJ, Warltier DC, Daemmgen JW) J Cardiovasc Pharmacol 1985 Sep-Oct;7(5):929-36 PMID 2413303
  • Hemodynamic actions of nicorandil, a new antianginal agent, in the conscious dog. (Preuss KC, Gross GJ, Brooks HL, Warltier DC) J Cardiovasc Pharmacol 1985 Jul-Aug;7(4):709-14 PMID 2410712
  • Positive inotropic actions of the calcium channel stimulator, Bay k 8644, in awake, unsedated dogs. (Preuss KC, Brooks HL, Gross GJ, Warltier DC) Basic Res Cardiol 1985 May-Jun;80(3):326-32 PMID 2411255
  • Cardiotonic effects of anthopleurin-A (AP-A), a polypeptide from a sea anemone, in dogs with a coronary artery stenosis. (Gross GJ, Warltier DC, Hardman HF, Shibata S) Eur J Pharmacol 1985 Apr 2;110(2):271-6 PMID 3987818
  • Direct cardiac actions of the H2 receptor agonists, impromidine and dimaprit. (Pelc LR, Christensen CW, Gross GJ, Warltier DC) Eur J Pharmacol 1985 Jan 8;107(3):379-84 PMID 3156752
  • Cardiac and systemic hemodynamic actions of the slow channel calcium blocking agent, KB-944. (Pelc LR, Gross GJ, Warltier DC) Gen Pharmacol 1985;16(6):585-90 PMID 4085780
  • Cardiovascular effects of the nifedipine analog, CGP 28 392, in the conscious dog. (Preuss KC, Cheung NL, Brooks HL, Warltier DC) J Cardiovasc Pharmacol 1984 Sep-Oct;6(5):949-53 PMID 6209505
  • Comparative actions of dihydropyridine slow channel calcium blocking agents in conscious dogs: alterations in baroreflex sensitivity. (Warltier DC, Zyvoloski MG, Gross GJ, Brooks HL) J Pharmacol Exp Ther 1984 Aug;230(2):376-82 PMID 6747841
  • A microcomputer-based package for determination of regional and global cardiac function and coronary hemodynamics. (Wilkison DM, Preuss KC, Warltier DC) J Pharmacol Methods 1984 Aug;12(1):59-67 PMID 6536815
  • Comparative actions of dihydropyridine slow channel calcium blocking agents in conscious dogs: systemic and coronary hemodynamics with and without combined beta adrenergic blockade. (Warltier DC, Zyvoloski MG, Gross GJ, Brooks HL) J Pharmacol Exp Ther 1984 Aug;230(2):367-75 PMID 6146711
  • Effects of nicorandil, a new antianginal agent, and nifedipine on collateral blood flow in a chronic coronary occlusion model. (Lamping KA, Warltier DC, Hardman HF, Gross GJ) J Pharmacol Exp Ther 1984 May;229(2):359-63 PMID 6232374
  • Effects of nicorandil and nifedipine on protection of ischemic myocardium. (Lamping KA, Christensen CW, Pelc LR, Warltier DC, Gross GJ) J Cardiovasc Pharmacol 1984 May-Jun;6(3):536-42 PMID 6202983
  • Selective improvement in subendocardial perfusion distal to a flow-limiting coronary artery stenosis: effects of the new calcium channel blocking agent, FR 34235, nifedipine and diltiazem. (Gross GJ, Warltier DC) J Pharmacol Exp Ther 1984 Mar;228(3):531-6 PMID 6707908
  • Effects of three bradycardiac drugs on regional myocardial blood flow and function in areas distal to a total or partial coronary occlusion in dogs. (Gross GJ, Lamping KG, Warltier DC, Hardman HF) Circulation 1984 Feb;69(2):391-9 PMID 6690105
  • Contrasting effects of pharmacologic vasodilation on true collateral and overlap perfusion in ischemic myocardium. (Keelan KE, Gross GJ, Brooks HL, Warltier DC) Gen Pharmacol 1984;15(6):471-7 PMID 6526259
  • Comparative effects of two slow channel calcium entry blockers, FR 34235 and nifedipine, on true coronary collateral blood flow. (Gross GJ, Warltier DC, Hardman HF) J Cardiovasc Pharmacol 1984 Jan-Feb;6(1):61-7 PMID 6199613
  • Transmural gradient of coronary blood flow following dihydropyridine calcium antagonists and other vasodilator drugs. (Warltier DC, Hardman HF, Brooks HL, Gross GJ) Basic Res Cardiol 1983 Nov-Dec;78(6):644-53 PMID 6661160
  • Coronary hemodynamics and subendocardial perfusion distal to stenoses. (Warltier DC, Buck JD, Brooks HL, Gross GJ) Int J Cardiol 1983 Sep;4(2):173-83 PMID 6629531
  • Effects of histamine receptor stimulation on regional myocardial blood flow. (Christensen CW, Gross GJ, Hardman HF, Brooks HL, Warltier DC) Am J Physiol 1983 Sep;245(3):H461-7 PMID 6225343
  • The slow-channel calcium blocking agent, nitrendipine, and coronary collateral blood flow. (Warltier DC, Lamping KA, Zyvoloski MG, Gross GJ, Brooks HL) J Cardiovasc Pharmacol 1983 Mar-Apr;5(2):272-7 PMID 6188902
  • The effect of diltiazem, a calcium channel blocking agent, on vasoconstrictor responses to norepinephrine, serotonin and potassium depolarization in canine coronary and femoral arteries. (Mullett M, Gharaibeh M, Warltier DC, Gross GJ) Gen Pharmacol 1983;14(2):259-64 PMID 6840509
  • Comparative effects of FR 34235, a new slow channel calcium blocker, and nifedipine on hemodynamics and myocardial oxygen consumption in the anesthetized dog. (Gross GJ, Warltier DC, Hardman HF) Gen Pharmacol 1983;14(6):677-80 PMID 6662348
  • Subendocardial versus transmural myocardial infarction: relationship to the collateral circulation in canine and porcine hearts. (Warltier DC, Zyvoloski MG, Gross GJ, Brooks HL) Can J Physiol Pharmacol 1982 Dec;60(12):1700-6 PMID 7165863
  • Role of autoregulation in the beneficial action of propranolol on ischemic blood flow distribution and stenosis severity in the canine myocardium. (Gross GJ, Buck JD, Warltier DC, Hardman HF) J Pharmacol Exp Ther 1982 Sep;222(3):635-40 PMID 7108768
  • Myocardial perfusion distal to an acute or chronic coronary artery occlusion: effects of diltiazem and nifedipine. (Zyvoloski MG, Brooks HL, Gross GJ, Warltier DC) J Pharmacol Exp Ther 1982 Aug;222(2):494-500 PMID 7097568
  • Beneficial effects of the dihydropyridine calcium antagonist, FR 34235, in a chronic coronary occlusion model. (Warltier DC, Zyvoloski MG, Brooks HL, Gross GJ) Eur J Pharmacol 1982 May 7;80(1):149-53 PMID 7095001
  • Separation of overlap and collateral perfusion of ischemic canine myocardium: important considerations in the analysis of vasodilator-induced coronary steal. (Gross GJ, Buck JD, Warltier DC, Hardman HF) J Cardiovasc Pharmacol 1982 Mar-Apr;4(2):254-63 PMID 6175809
  • Determination of experimental myocardial infarct size. (Warltier DC, Zyvoloski MG, Gross GJ, Hardman HF, Brooks HL) J Pharmacol Methods 1981 Nov;6(3):199-210 PMID 7329069
  • Changes in ischemic blood flow distribution and dynamic severity of a coronary stenosis induced by beta blockade in the canine heart. (Buck JD, Hardman HF, Warltier DC, Gross GJ) Circulation 1981 Oct;64(4):708-15 PMID 6115724
  • Redistribution of myocardial blood flow distal to a dynamic coronary arterial stenosis by sympathomimetic amines: comparison of dopamine, dobutamine and isoproterenol. (Warltier DC, Zyvoloski M, Gross GJ, Hardman HF, Brooks HL) Am J Cardiol 1981 Aug;48(2):269-79 PMID 7270436
  • Blood flow in normal and acutely ischemic myocardium after verapamil, diltiazem and nisoldipine (Bay k 5552), a new dihydropyridine calcium antagonist. (Warltier DC, Meils CM, Gross GJ, Brooks HL) J Pharmacol Exp Ther 1981 Jul;218(1):296-302 PMID 7248040
  • Coronary steal in four models of single or multiple vessel obstruction in dogs. (Gross GJ, Warltier DC) Am J Cardiol 1981 Jul;48(1):84-92 PMID 7246448
  • Transmural distribution of blood flow during activation of coronary muscarinic receptors. (Gross GJ, Buck JD, Warltier DC) Am J Physiol 1981 Jun;240(6):H941-6 PMID 7246756
  • Pharmacologic- vs. ischemia-induced coronary artery vasodilation. (Warltier DC, Gross GJ, Brooks HL) Am J Physiol 1981 May;240(5):H767-74 PMID 7235035
  • Effects of sotalol and vagal stimulation on ischemic myocardial blood flow distribution in the canine heart. (Buck JD, Warltier DC, Hardman HF, Gross GJ) J Pharmacol Exp Ther 1981 Feb;216(2):347-51 PMID 7463353
  • Reduction of myocardial infarct size by the calcium antagonist fr 7534. (Meils CM, Gross GJ, Brooks HL, Warltier DC) Cardiology 1981;68(3):146-60 PMID 7317884
  • Relaxation of potassium-depolarized canine, bovine and porcine large coronary arteries by nitroglycerin, chromonar and two dihydropyridine calcium antagonists. (Gross GJ, Diemer MJ, Warltier DC, Hardman HF) Gen Pharmacol 1981;12(3):199-204 PMID 6786956
  • Comparative effects of a new calcium antagonist, FR 7534, nitroglycerin, and dipyridamole on regional myocardial blood flow and cardiac contractility during partial coronary artery occlusion in the dog. (Gross GJ, Warltier DC, Jolly SR, Hardman HF) J Cardiovasc Pharmacol 1980 Nov-Dec;2(6):797-813 PMID 6160329
  • Subepicardial steal and reduction of myocardial oxygen consumption by adenosine. (Warltier DC, Gross GJ, Hardman HF) Eur J Pharmacol 1980 Oct 3;67(1):101-4 PMID 7418726
  • Coronary steal-induced increase in myocardial infarct size after pharmacologic coronary vasodilation. (Warltier DC, Gross GJ, Brooks HL) Am J Cardiol 1980 Jul;46(1):83-90 PMID 7386397
  • Protection of ischemic myocardium: comparison of effects of propranolol, bevantolol and N-dimethyl propranolol on infarct size following coronary artery occlusion in anesthetized dogs. (Warltier DC, Gross GJ, Jesmok GJ, Brooks HL, Hardman HF) Cardiology 1980;66(3):133-46 PMID 6105914
  • Comparative effects of cardioselective versus noncardioselective beta blockade on subendocardial blood flow and contractile function in ischemic myocardium. (Buck JD, Gross GJ, Warltier DC, Jolly SR, Hardman HF) Am J Cardiol 1979 Oct;44(4):657-63 PMID 39449
  • Transmural perfusion gradients distal to various degrees of coronary artery stenosis during resting flow or at maximal vasodilation. (Warltier DC, Hardman HF, Gross GJ) Basic Res Cardiol 1979 Sep-Oct;74(5):494-508 PMID 526256
  • Beneficial actions of bevantolol on subendocardial blood flow and contractile function in ischemic myocardium. (Gross GJ, Buck JD, Warltier DC, Hardman HF) J Cardiovasc Pharmacol 1979 Jan-Feb;1(1):139-47 PMID 94375
  • Transmural triglycerides in acute myocardial ischaemia. (Jesmok GJ, Warltier DC, Gross GJ, Hardman HF) Cardiovasc Res 1978 Nov;12(11):659-65 PMID 750079
  • Effect of propranolol on enzymatic and histochemical estimates of infarct size in experimental myocardial infarction. (Jesmok GJ, Warltier DC, Gross GJ, Hardman HF) Basic Res Cardiol 1978 Nov-Dec;73(6):559-70 PMID 747615
  • Beneficial actions of N-dimethyl propranolol on myocardial oxygen balance and transmural perfusion gradients distal to a severe coronary artery stenosis in the canine heart. (Gross GJ, Warltier DC, Hardman HF) Circulation 1978 Oct;58(4):663-9 PMID 688577
  • Endocardial viability ratio on effect of nitroglycerin and propranolol on regional myocardial blood flow in intact canine hearts. (Gross GJ, Warltier DC) J Pharmacol Exp Ther 1977 Dec;203(3):664-74 PMID 411913
  • Technique for precise, graded arterial stenosis and occlusion. (Hosko MJ, Gross GJ, Warltier DC) Basic Res Cardiol 1977 Nov-Dec;72(6):651-9 PMID 607934
  • Intracoronary versus intravenous nitroglycerin on the transmural distribution of coronary blood flow. (Gross GJ, Warltier DC) Cardiovasc Res 1977 Nov;11(6):499-506 PMID 414838
  • Effect of ortho-iodo sodium benzoate on hemoglobin-oxygen affinity in normal and ischemic myocardium. (Gross GJ, Warltier DC, Hardman HF) J Pharmacol Exp Ther 1977 Oct;203(1):72-81 PMID 909059
  • The effect of ouabain on nutritional circulation and regional myocardial blood flow. (Gross GJ, Warltier DC, Hardman HF, Somani P) Am Heart J 1977 Apr;93(4):487-95 PMID 842444
  • Effect of propranolol on regional myocardial blood flow and oxygen consumption. (Warltier DC, Gross GJ, Hardman HF) J Pharmacol Exp Ther 1976 Aug;198(2):435-43 PMID 948034
  • The isolated supported canine heart: a model for the evaluation of drug effects on regional myocardial blood flow. (Warltier DC, Gross GJ, Hardman HF) J Pharmacol Exp Ther 1976 Aug;198(2):420-34 PMID 948033
  • Adenosine on myocardial oxygen consumption. (Gross GJ, Hardman HF, Warltier DC) Br J Pharmacol 1976 Jul;57(3):409-12 PMID 974320
  • Effect of propranolol and nitroglycerin on hemoglobin--oxygen affinity. (Gross GJ, Warltier DC, Hardman HF) Eur J Pharmacol 1976 Mar;36(1):267-71 PMID 816659
  • Effect of adenosine on myocardial oxygen balance. (Gross GJ, Warltier DC, Hardman HF) J Pharmacol Exp Ther 1976 Feb;196(2):445-54 PMID 1255487
  • Effect of right atrial pacing and nitroglycerin on myocardial oxygen balance. (Warltier DC, Gross GJ, Hardman HF) Eur J Pharmacol 1975 Nov;34(1):229-32 PMID 826400
  • Myocardial distribution of coronary blood flow in the isolated supported heart preparation. (Warltier DC, Hardman HF, Laddu AR, Somani P, Gross GJ) Cardiovasc Res 1975 Sep;9(5):634-9 PMID 1201572
  • Grants and Awards

  • WCBR-Residual Account (#9206862 04/01/2011 - 06/30/2017) Sponsor: Wisconsin Corporation for Biomedical Research
  • Anesthesiology Research Training (#9202261 07/01/2001 - 06/30/2007) Sponsor: NIH General Medical Sciences
  • Effects of Anesthetics on Ischemic Myocardium (#9203377 08/01/2004 - 07/31/2010) Sponsor: NIH Heart Lung and Blood Institute
  • Anesthetic-Induced Cardiac Preconditioning (#9202848 05/05/2003 - 04/30/2009) PI of Project I: Anesthetic-Induced Cardiace Preconditioning in Vivo (#2204559)
  • Anesthetic-Induced Cardiac Preconditioning (#9205281 08/01/2008 - 07/31/2014) PI of Project I: Mechanisms of Anesthetic Preconditioning (#2207652)