David F. Stowe MD, PhD Online Profile
Professor
Medical College of Wisconsin
Department: Anesthesiology
Division: Clinical
Program: Operating Room Service
Publications
Tyrosine nitration of voltage-dependent anion channels in cardiac ischemia-reperfusion: reduction by peroxynitrite scavenging. (Yang M, Camara AK, Wakim BT, Zhou Y, Gadicherla AK, Kwok WM, Stowe DF) Biochim Biophys Acta 2012 Nov;1817(11):2049-59 PMID 22709907 Damage to mitochondrial complex I during cardiac ischemia reperfusion injury is reduced indirectly by anti-anginal drug ranolazine. (Gadicherla AK, Stowe DF, Antholine WE, Yang M, Camara AK) Biochim Biophys Acta 2012 Mar;1817(3):419-29 PMID 22178605 Enhanced charge-independent mitochondrial free Ca(2+) and attenuated ADP-induced NADH oxidation by isoflurane: Implications for cardioprotection. (Agarwal B, Camara AK, Stowe DF, Bosnjak ZJ, Dash RK) Biochim Biophys Acta 2012 Mar;1817(3):453-65 PMID 22155157 Reduced mitochondrial Ca2+ loading and improved functional recovery after ischemia-reperfusion injury in old vs. young guinea pig hearts. (Rhodes SS, Camara AK, Heisner JS, Riess ML, Aldakkak M, Stowe DF) Am J Physiol Heart Circ Physiol 2012 Feb 1;302(3):H855-63 PMID 22140052 Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts. (Aldakkak M, Camara AK, Heisner JS, Yang M, Stowe DF) Pharmacol Res 2011 Oct;64(4):381-92 PMID 21741479 Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury. (Camara AK, Bienengraeber M, Stowe DF) Front Physiol 2011;2:13 PMID 21559063 Adding ROS quenchers to cold K+ cardioplegia reduces superoxide emission during 2-hour global cold cardiac ischemia. (Aldakkak M, Stowe DF, Heisner JS, Riess ML, Camara AK) J Cardiovasc Pharmacol Ther 2012 Mar;17(1):93-101 PMID 21282477 Mitochondrial free [Ca2+] increases during ATP/ADP antiport and ADP phosphorylation: exploration of mechanisms. (Haumann J, Dash RK, Stowe DF, Boelens AD, Beard DA, Camara AK) Biophys J 2010 Aug 9;99(4):997-1006 PMID 20712982 Mitochondrial matrix K+ flux independent of large-conductance Ca2+-activated K+ channel opening. (Aldakkak M, Stowe DF, Cheng Q, Kwok WM, Camara AK) Am J Physiol Cell Physiol 2010 Mar;298(3):C530-41 PMID 20053924 Potential therapeutic benefits of strategies directed to mitochondria. (Camara AK, Lesnefsky EJ, Stowe DF) Antioxid Redox Signal 2010 Aug 1;13(3):279-347 PMID 20001744 Comparison of cumulative planimetry versus manual dissection to assess experimental infarct size in isolated hearts. (Riess ML, Rhodes SS, Stowe DF, Aldakkak M, Camara AK) J Pharmacol Toxicol Methods 2009 Nov-Dec;60(3):275-80 PMID 19732842 Modulation of mitochondrial bioenergetics in the isolated Guinea pig beating heart by potassium and lidocaine cardioplegia: implications for cardioprotection. (Aldakkak M, Stowe DF, Lesnefsky EJ, Heisner JS, Chen Q, Camara AK) J Cardiovasc Pharmacol 2009 Oct;54(4):298-309 PMID 19620879 Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function. (Stowe DF, Camara AK) Antioxid Redox Signal 2009 Jun;11(6):1373-414 PMID 19187004 Enhanced Na+/H+ exchange during ischemia and reperfusion impairs mitochondrial bioenergetics and myocardial function. (Aldakkak M, Stowe DF, Heisner JS, Spence M, Camara AK) J Cardiovasc Pharmacol 2008 Sep;52(3):236-44 PMID 18806604 Low-flow perfusion of guinea pig isolated hearts with 26 degrees C air-saturated Lifor solution for 20 hours preserves function and metabolism. (Stowe DF, Camara AK, Heisner JS, Aldakkak M, Harder DR) J Heart Lung Transplant 2008 Sep;27(9):1008-15 PMID 18765194 KATP channel openers have opposite effects on mitochondrial respiration under different energetic conditions. (Riess ML, Camara AK, Heinen A, Eells JT, Henry MM, Stowe DF) J Cardiovasc Pharmacol 2008 May;51(5):483-91 PMID 18437094 Differential increase of mitochondrial matrix volume by sevoflurane in isolated cardiac mitochondria. (Riess ML, Costa AD, Carlson R Jr, Garlid KD, Heinen A, Stowe DF) Anesth Analg 2008 Apr;106(4):1049-55, table of contents PMID 18349172 Inhibited mitochondrial respiration by amobarbital during cardiac ischaemia improves redox state and reduces matrix Ca2+ overload and ROS release. (Aldakkak M, Stowe DF, Chen Q, Lesnefsky EJ, Camara AK) Cardiovasc Res 2008 Jan 15;77(2):406-15 PMID 17900548 Isoflurane activates human cardiac mitochondrial adenosine triphosphate-sensitive K+ channels reconstituted in lipid bilayers. (Jiang MT, Nakae Y, Ljubkovic M, Kwok WM, Stowe DF, Bosnjak ZJ) Anesth Analg 2007 Oct;105(4):926-32, table of contents PMID 17898367 Reverse electron flow-induced ROS production is attenuated by activation of mitochondrial Ca2+-sensitive K+ channels. (Heinen A, Aldakkak M, Stowe DF, Rhodes SS, Riess ML, Varadarajan SG, Camara AK) Am J Physiol Heart Circ Physiol 2007 Sep;293(3):H1400-7 PMID 17513497 beta-Blockade abolishes anesthetic preconditioning: impact on clinical applicability. (Riess ML, Stowe DF) Anesthesiology 2007 May;106(5):1061-2; author reply 1062 PMID 17457142 Ten-hour preservation of guinea pig isolated hearts perfused at low flow with air-saturated Lifor solution at 26{degrees}C: comparison to ViaSpan solution. (Stowe DF, Camara AK, Heisner JS, Aldakkak M, Harder DR) Am J Physiol Heart Circ Physiol 2007 Jul;293(1):H895-901 PMID 17434975 Mitochondrial inner membrane electrophysiology assessed by rhodamine-123 transport and fluorescence. (Huang M, Camara AK, Stowe DF, Qi F, Beard DA) Ann Biomed Eng 2007 Jul;35(7):1276-85 PMID 17372838 ROS scavenging before 27 degrees C ischemia protects hearts and reduces mitochondrial ROS, Ca2+ overload, and changes in redox state. (Camara AK, Aldakkak M, Heisner JS, Rhodes SS, Riess ML, An J, Heinen A, Stowe DF) Am J Physiol Cell Physiol 2007 Jun;292(6):C2021-31 PMID 17287367 Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion. (Chen Q, Camara AK, Stowe DF, Hoppel CL, Lesnefsky EJ) Am J Physiol Cell Physiol 2007 Jan;292(1):C137-47 PMID 16971498 Anesthetic preconditioning enhances Ca2+ handling and mechanical and metabolic function elicited by Na+-Ca2+ exchange inhibition in isolated hearts. (An J, Rhodes SS, Jiang MT, Bosnjak ZJ, Tian M, Stowe DF) Anesthesiology 2006 Sep;105(3):541-9 PMID 16931987 Mitochondrial Ca2+-induced K+ influx increases respiration and enhances ROS production while maintaining membrane potential. (Heinen A, Camara AK, Aldakkak M, Rhodes SS, Riess ML, Stowe DF) Am J Physiol Cell Physiol 2007 Jan;292(1):C148-56 PMID 16870831 A comparison of three phosphodiesterase type III inhibitors on mechanical and metabolic function in guinea pig isolated hearts. (Zausig YA, Stowe DF, Zink W, Grube C, Martin E, Graf BM) Anesth Analg 2006 Jun;102(6):1646-52 PMID 16717301 Ischemia reperfusion dysfunction changes model-estimated kinetics of myofilament interaction due to inotropic drugs in isolated hearts. (Rhodes SS, Camara AK, Ropella KM, Audi SH, Riess ML, Pagel PS, Stowe DF) Biomed Eng Online 2006;5:16 PMID 16512898 Characterization of human cardiac mitochondrial ATP-sensitive potassium channel and its regulation by phorbol ester in vitro. (Jiang MT, Ljubkovic M, Nakae Y, Shi Y, Kwok WM, Stowe DF, Bosnjak ZJ) Am J Physiol Heart Circ Physiol 2006 May;290(5):H1770-6 PMID 16361367 Increasing heart size and age attenuate anesthetic preconditioning in guinea pig isolated hearts. (Riess ML, Camara AK, Rhodes SS, McCormick J, Jiang MT, Stowe DF) Anesth Analg 2005 Dec;101(6):1572-6 PMID 16301221 Ischemia-reperfusion injury changes the dynamics of Ca2+-contraction coupling due to inotropic drugs in isolated hearts. (Rhodes SS, Ropella KM, Camara AK, Chen Q, Riess ML, Pagel PS, Stowe DF) J Appl Physiol 2006 Mar;100(3):940-50 PMID 16282437 Reactive oxygen species as mediators of cardiac injury and protection: the relevance to anesthesia practice. (Kevin LG, Novalija E, Stowe DF) Anesth Analg 2005 Nov;101(5):1275-87 PMID 16243980 Cardiac mitochondrial preconditioning by Big Ca2+-sensitive K+ channel opening requires superoxide radical generation. (Stowe DF, Aldakkak M, Camara AK, Riess ML, Heinen A, Varadarajan SG, Jiang MT) Am J Physiol Heart Circ Physiol 2006 Jan;290(1):H434-40 PMID 16126810 Improved mitochondrial bioenergetics by anesthetic preconditioning during and after 2 hours of 27 degrees C ischemia in isolated hearts. (An J, Camara AK, Riess ML, Rhodes SS, Varadarajan SG, Stowe DF) J Cardiovasc Pharmacol 2005 Sep;46(3):280-7 PMID 16116332 Cardioprotection with volatile anesthetics: mechanisms and clinical implications. (De Hert SG, Turani F, Mathur S, Stowe DF) Anesth Analg 2005 Jun;100(6):1584-93 PMID 15920178 Warm ischemic preconditioning improves mitochondrial redox balance during and after mild hypothermic ischemia in guinea pig isolated hearts. (An J, Camara AK, Rhodes SS, Riess ML, Stowe DF) Am J Physiol Heart Circ Physiol 2005 Jun;288(6):H2620-7 PMID 15653757 Anesthetic preconditioning: the role of free radicals in sevoflurane-induced attenuation of mitochondrial electron transport in Guinea pig isolated hearts. (Riess ML, Kevin LG, McCormick J, Jiang MT, Rhodes SS, Stowe DF) Anesth Analg 2005 Jan;100(1):46-53 PMID 15616050 Reactive oxygen species and cardiac preconditioning: many questions remain. (Stowe DF, Riess ML) Cardiovasc Drugs Ther 2004 Mar;18(2):87-90 PMID 15293369 Attenuation of mitochondrial respiration by sevoflurane in isolated cardiac mitochondria is mediated in part by reactive oxygen species. (Riess ML, Eells JT, Kevin LG, Camara AK, Henry MM, Stowe DF) Anesthesiology 2004 Mar;100(3):498-505 PMID 15108961 Dual exposure to sevoflurane improves anesthetic preconditioning in intact hearts. (Riess ML, Kevin LG, Camara AK, Heisner JS, Stowe DF) Anesthesiology 2004 Mar;100(3):569-74 PMID 15108970 Cardiac pharmacological preconditioning with volatile anesthetics: from bench to bedside? (Riess ML, Stowe DF, Warltier DC) Am J Physiol Heart Circ Physiol 2004 May;286(5):H1603-7 PMID 15072968 Negative inotropic drugs alter indexes of cytosolic [Ca(2+)]-left ventricular pressure relationships after ischemia. (Camara AK, Chen Q, Rhodes SS, Riess ML, Stowe DF) Am J Physiol Heart Circ Physiol 2004 Aug;287(2):H667-80 PMID 15059780 Comparison of hyperkalemic cardioplegia with altered [CaCl2] and [MgCl2] on [Ca2+]i transients and function after warm global ischemia in isolated hearts. (Camara AK, Chen Q, An J, Novalija E, Riess ML, Rhodes SS, Stowe DF) J Cardiovasc Surg (Torino) 2004 Feb;45(1):1-13 PMID 15041929 Cardiac preconditioning by volatile anesthetic agents: a defining role for altered mitochondrial bioenergetics. (Stowe DF, Kevin LG) Antioxid Redox Signal 2004 Apr;6(2):439-48 PMID 15025946 Reduced reactive O2 species formation and preserved mitochondrial NADH and [Ca2+] levels during short-term 17 degrees C ischemia in intact hearts. (Riess ML, Camara AK, Kevin LG, An J, Stowe DF) Cardiovasc Res 2004 Feb 15;61(3):580-90 PMID 14962488 Effect of low [CaCl2] and high [MgCl2] cardioplegia and moderate hypothermic ischemia on myoplasmic [Ca2+] and cardiac function in intact hearts. (An J, Camara AK, Chen Q, Stowe DF) Eur J Cardiothorac Surg 2003 Dec;24(6):974-85 PMID 14643817 Hypothermia augments reactive oxygen species detected in the guinea pig isolated perfused heart. (Camara AK, Riess ML, Kevin LG, Novalija E, Stowe DF) Am J Physiol Heart Circ Physiol 2004 Apr;286(4):H1289-99 PMID 14644763 Ischemic preconditioning: triggering role of nitric oxide-derived oxidants in isolated hearts. (Novalija E, Hogg N, Kevin LG, Camara AK, Stowe DF) J Cardiovasc Pharmacol 2003 Nov;42(5):593-600 PMID 14576506 Cardiotonic drugs differentially alter cytosolic [Ca2+] to left ventricular relationships before and after ischemia in isolated guinea pig hearts. (Chen Q, Camara AK, Rhodes SS, Riess ML, Novalija E, Stowe DF) Cardiovasc Res 2003 Oct 1;59(4):912-25 PMID 14553831 How inotropic drugs alter dynamic and static indices of cyclic myoplasmic [Ca2+] to contractility relationships in intact hearts. (Rhodes SS, Ropella KM, Camara AK, Chen Q, Riess ML, Stowe DF) J Cardiovasc Pharmacol 2003 Oct;42(4):539-53 PMID 14508241 Reactive oxygen species precede the epsilon isoform of protein kinase C in the anesthetic preconditioning signaling cascade. (Novalija E, Kevin LG, Camara AK, Bosnjak ZJ, Kampine JP, Stowe DF) Anesthesiology 2003 Aug;99(2):421-8 PMID 12883415 Anesthetic preconditioning: effects on latency to ischemic injury in isolated hearts. (Kevin LG, Katz P, Camara AK, Novalija E, Riess ML, Stowe DF) Anesthesiology 2003 Aug;99(2):385-91 PMID 12883411 Anesthetic preconditioning improves adenosine triphosphate synthesis and reduces reactive oxygen species formation in mitochondria after ischemia by a redox dependent mechanism. (Novalija E, Kevin LG, Eells JT, Henry MM, Stowe DF) Anesthesiology 2003 May;98(5):1155-63 PMID 12717137 Na+/H+ exchange inhibition with cardioplegia reduces cytosolic [Ca2+] and myocardial damage after cold ischemia. (Camara AK, An J, Chen Q, Novalija E, Varadarajan SG, Schelling P, Stowe DF) J Cardiovasc Pharmacol 2003 May;41(5):686-98 PMID 12717098 Sevoflurane exposure generates superoxide but leads to decreased superoxide during ischemia and reperfusion in isolated hearts. (Kevin LG, Novalija E, Riess ML, Camara AK, Rhodes SS, Stowe DF) Anesth Analg 2003 Apr;96(4):949-55, table of contents PMID 12651639 Preconditioning with sevoflurane reduces changes in nicotinamide adenine dinucleotide during ischemia-reperfusion in isolated hearts: reversal by 5-hydroxydecanoic acid. (Riess ML, Novalija E, Camara AK, Eells JT, Chen Q, Stowe DF) Anesthesiology 2003 Feb;98(2):387-95 PMID 12552198 Cross-bridge kinetics modeled from myoplasmic [Ca2+] and LV pressure at 17 degrees C and after 37 degrees C and 17 degrees C ischemia. (Rhodes SS, Ropella KM, Audi SH, Camara AK, Kevin LG, Pagel PS, Stowe DF) Am J Physiol Heart Circ Physiol 2003 Apr;284(4):H1217-29 PMID 12531735 Anesthetic preconditioning attenuates mitochondrial Ca2+ overload during ischemia in Guinea pig intact hearts: reversal by 5-hydroxydecanoic acid. (Riess ML, Camara AK, Novalija E, Chen Q, Rhodes SS, Stowe DF) Anesth Analg 2002 Dec;95(6):1540-6, table of contents PMID 12456413 Ischemic preconditioning alters real-time measure of O2 radicals in intact hearts with ischemia and reperfusion. (Kevin LG, Camara AK, Riess ML, Novalija E, Stowe DF) Am J Physiol Heart Circ Physiol 2003 Feb;284(2):H566-74 PMID 12414448 Sevoflurane preconditioning before moderate hypothermic ischemia protects against cytosolic [Ca(2+)] loading and myocardial damage in part via mitochondrial K(ATP) channels. (Chen Q, Camara AK, An J, Novalija E, Riess ML, Stowe DF) Anesthesiology 2002 Oct;97(4):912-20 PMID 12357159 Differences in cardiotoxicity of bupivacaine and ropivacaine are the result of physicochemical and stereoselective properties. (Graf BM, Abraham I, Eberbach N, Kunst G, Stowe DF, Martin E) Anesthesiology 2002 Jun;96(6):1427-34 PMID 12170056 Altered NADH and improved function by anesthetic and ischemic preconditioning in guinea pig intact hearts. (Riess ML, Camara AK, Chen Q, Novalija E, Rhodes SS, Stowe DF) Am J Physiol Heart Circ Physiol 2002 Jul;283(1):H53-60 PMID 12063274 Anesthetic preconditioning: triggering role of reactive oxygen and nitrogen species in isolated hearts. (Novalija E, Varadarajan SG, Camara AK, An J, Chen Q, Riess ML, Hogg N, Stowe DF) Am J Physiol Heart Circ Physiol 2002 Jul;283(1):H44-52 PMID 12063273 Cardiac preconditioning with 4-h, 17 degrees C ischemia reduces [Ca(2+)](i) load and damage in part via K(ATP) channel opening. (Chen Q, Camara AK, An J, Riess ML, Novalija E, Stowe DF) Am J Physiol Heart Circ Physiol 2002 Jun;282(6):H1961-9 PMID 12003799 Inhibition of Na(+)/H(+) isoform-1 exchange protects hearts perfused after 6-hour cardioplegic cold storage. (Stowe DF, Heisner JS, An J, Camara A, Varadarajan SG, Novalija E, Chen Q, Schelling P) J Heart Lung Transplant 2002 Mar;21(3):374-82 PMID 11897527 Sevoflurane before or after ischemia improves contractile and metabolic function while reducing myoplasmic Ca(2+) loading in intact hearts. (Varadarajan SG, An J, Novalija E, Stowe DF) Anesthesiology 2002 Jan;96(1):125-33 PMID 11753012 Blocking Na(+)/H(+) exchange reduces [Na(+)](i) and [Ca(2+)](i) load after ischemia and improves function in intact hearts. (An J, Varadarajan SG, Camara A, Chen Q, Novalija E, Gross GJ, Stowe DF) Am J Physiol Heart Circ Physiol 2001 Dec;281(6):H2398-409 PMID 11709405 Ischemic and anesthetic preconditioning reduces cytosolic [Ca2+] and improves Ca(2+) responses in intact hearts. (An J, Varadarajan SG, Novalija E, Stowe DF) Am J Physiol Heart Circ Physiol 2001 Oct;281(4):H1508-23 PMID 11557539 Volatile anaesthetics restore bradykinin and serotonin-induced coronary vasodilation after blocking nitric oxide synthase: lack of anaesthetic effects on KATP channels and prostaglandin pathways. (Stowe DF, Heisner JS, Chung WW, Fujita S) Eur J Anaesthesiol 2001 Apr;18(4):219-30 PMID 11350459 Changes in [Na(+)](i), compartmental [Ca(2+)], and NADH with dysfunction after global ischemia in intact hearts. (Varadarajan SG, An J, Novalija E, Smart SC, Stowe DF) Am J Physiol Heart Circ Physiol 2001 Jan;280(1):H280-93 PMID 11123243 Reduced cytosolic Ca(2+) loading and improved cardiac function after cardioplegic cold storage of guinea pig isolated hearts. (Stowe DF, Varadarajan SG, An J, Smart SC) Circulation 2000 Sep 5;102(10):1172-7 PMID 10973848 Enhanced contractile responsiveness to cytosolic Ca(2+) by delta-2 opioid agonist deltorphin in intact guinea pig hearts. (Fujita S, Smart SC, Stowe DF) J Mol Cell Cardiol 2000 Sep;32(9):1647-59 PMID 10966827 Uneventful propofol anesthesia in a patient with coexisting hereditary coproporphyria and hereditary angioneurotic edema. (Sarantopoulos CD, Bratanow NC, Stowe DF, Kampine JP) Anesthesiology 2000 Feb;92(2):607-9 PMID 10691250 Xenon does not alter cardiac function or major cation currents in isolated guinea pig hearts or myocytes. (Stowe DF, Rehmert GC, Kwok WM, Weigt HU, Georgieff M, Bosnjak ZJ) Anesthesiology 2000 Feb;92(2):516-22 PMID 10691240 Modulation of myocardial function and [Ca2+] sensitivity by moderate hypothermia in guinea pig isolated hearts. (Stowe DF, Fujita S, An J, Paulsen RA, Varadarajan SG, Smart SC) Am J Physiol 1999 Dec;277(6 Pt 2):H2321-32 PMID 10600852 Understanding the temporal relationship of ATP loss, calcium loading, and rigor contracture during anoxia, and hypercontracture after anoxia in cardiac myocytes. (Stowe DF) Cardiovasc Res 1999 Aug 1;43(2):285-7 PMID 10536657 Airway obstruction due to late-onset angioneurotic edema from angiotensin-converting enzyme inhibition. (Mchaourab A, Sarantopoulos C, Stowe DF) Can J Anaesth 1999 Oct;46(10):975-8 PMID 10522586 Sevoflurane mimics ischemic preconditioning effects on coronary flow and nitric oxide release in isolated hearts. (Novalija E, Fujita S, Kampine JP, Stowe DF) Anesthesiology 1999 Sep;91(3):701-12 PMID 10485782 Prior preconditioning by ischemia or sevoflurane improves cardiac work per oxygen use in isolated guinea pig hearts after global ischemia. (Novalija E, Stowe DF) Adv Exp Med Biol 1998;454:533-42 PMID 9889933 Effects of vasodilators and perfusion pressure on coronary flow and simultaneous release of nitric oxide from guinea pig isolated hearts. (Fujita S, Roerig DL, Bosnjak ZJ, Stowe DF) Cardiovasc Res 1998 Jun;38(3):655-67 PMID 9747433 Volatile anesthetics do not alter bradykinin-induced release of nitric oxide or L-citrulline in crystalloid perfused guinea pig hearts. (Fujita S, Roerig DL, Chung WW, Bosnjak ZJ, Stowe DF) Anesthesiology 1998 Aug;89(2):421-33 PMID 9710401 Reversal of hypothermia-induced action potential lengthening by the KATP channel agonist bimakalim in isolated guinea pig ventricular muscle. (Lathrop DA, Contney SJ, Bosnjak ZJ, Stowe DF) Gen Pharmacol 1998 Jul;31(1):125-31 PMID 9595290 Improved contractility and coronary flow in isolated hearts after 1-day hypothermic preservation with isoflurane is not dependent on K(ATP) channel activation. (Stowe DF, Fujita S, Bosnjak ZJ) Anesthesiology 1998 Jan;88(1):233-44 PMID 9447877 Reversal of endothelin-induced vasoconstriction by endothelium-dependent and -independent vasodilators in isolated hearts and vascular rings. (Stowe DF, O'Brien WC, Chang D, Knop CS, Kampine JP) J Cardiovasc Pharmacol 1997 Jun;29(6):747-54 PMID 9234655 Effects of L-arginine and N omega-nitro-L-arginine methyl ester on cardiac perfusion and function after 1-day cold preservation of isolated hearts. (Stowe DF, Boban M, Roerig DL, Chang D, Palmisano BW, Bosnjak ZJ) Circulation 1997 Mar 18;95(6):1623-34 PMID 9118533 Synthetic 8-ornithine-vasopressin, a clinically used vasoconstrictor, causes cardiac effects mainly via changes in coronary flow. (Graf BM, Fischer B, Stowe DF, Bosnjak ZJ, Martin EO) Acta Anaesthesiol Scand 1997 Mar;41(3):414-21 PMID 9113189 Stereospecific effect of bupivacaine isomers on atrioventricular conduction in the isolated perfused guinea pig heart. (Graf BM, Martin E, Bosnjak ZJ, Stowe DF) Anesthesiology 1997 Feb;86(2):410-9 PMID 9054259 Differential effects of arginine vasopressin on isolated guinea pig heart function during perfusion at constant flow and constant pressure. (Graf BM, Fischer B, Martin E, Bosnjak ZJ, Stowe DF) J Cardiovasc Pharmacol 1997 Jan;29(1):1-7 PMID 9007663 One-day cold perfusion of bimakalim and butanedione monoxime restores ex situ cardiac function. (Stowe DF, Graf BM, Fujita S, Gross GJ) Am J Physiol 1996 Nov;271(5 Pt 2):H1884-92 PMID 8945905 Initial reperfusion with 2,3 butanedione monoxime is better than hyperkalemic reperfusion after cardioplegic arrest in isolated guinea pig hearts. (Habazettl H, Palmisano BW, Bosnjak ZJ, Stowe DF) Eur J Cardiothorac Surg 1996;10(10):897-904 PMID 8911845 Improvement in functional recovery of the isolated guinea pig heart after hyperkalemic reperfusion with adenosine. (Habazettl H, Palmisano BW, Graf BM, Roerig DL, Bosnjak ZJ, Stowe DF) J Thorac Cardiovasc Surg 1996 Jan;111(1):74-84 PMID 8551791 Neural and endothelial control of the peripheral circulation--implications for anesthesia: Part I. Neural control of the peripheral vasculature. (Ebert TJ, Stowe DF) J Cardiothorac Vasc Anesth 1996 Jan;10(1):147-58 PMID 8634380 Neural and endothelial control of the peripheral circulation--implications for anesthesia: Part II, Endothelium-mediated effects in the normal and diseased circulation. (Stowe DF, Ebert TJ) J Cardiothorac Vasc Anesth 1996 Jan;10(1):159-71 PMID 8634382 One-day hypothermic preservation of isolated hearts with halothane improves cardiac function better than low calcium. (Stowe DF, Habazettl H, Graf BM, Kampine JP, Bosnjak ZJ) Anesthesiology 1995 Nov;83(5):1065-77 PMID 7486157 The comparative effects of equimolar sevoflurane and isoflurane in isolated hearts. (Graf BM, Vicenzi MN, Bosnjak ZJ, Stowe DF) Anesth Analg 1995 Nov;81(5):1026-32 PMID 7486042 Ketamine has stereospecific effects in the isolated perfused guinea pig heart. (Graf BM, Vicenzi MN, Martin E, Bosnjak ZJ, Stowe DF) Anesthesiology 1995 Jun;82(6):1426-37; discussion 25A PMID 7793656 Direct effects of halothane and isoflurane in infant rabbit hearts with right ventricular hypertrophy secondary to chronic hypoxemia. (Palmisano BW, Mehner RW, Baker JE, Stowe DF, Bosnjak ZJ, Kampine JP) Anesth Analg 1995 Jun;80(6):1122-8 PMID 7762838 Isotonic versus hypertonic initial hyperkalemic reperfusion after cardioplegic arrest in isolated hearts. (Habazettl H, Palmisano BW, Bosnjak ZJ, Graf BM, Stowe DF) Thorac Cardiovasc Surg 1995 Jun;43(3):123-8 PMID 7570562 Additive cardiac depression by volatile anesthetics in isolated hearts after chronic amiodarone treatment. (Rooney RT, Marijic J, Stommel KA, Bosnjak ZJ, Aggarwal A, Kampine JP, Stowe DF) Anesth Analg 1995 May;80(5):917-24 PMID 7726434 Direct myocardial effects of halothane and isoflurane. Comparison between adult and infant rabbits. (Palmisano BW, Mehner RW, Stowe DF, Bosnjak ZJ, Kampine JP) Anesthesiology 1994 Sep;81(3):718-29 PMID 8092518 Hypothermia modifies anesthetic effect on contractile force and Ca2+ transients in cardiac Purkinje fibers. (Sprung J, Stowe DF, Kampine JP, Bosnjak ZJ) Am J Physiol 1994 Aug;267(2 Pt 2):H725-33 PMID 8067428 Lack of stereospecific effects of isoflurane and desflurane isomers in isolated guinea pig hearts. (Graf BM, Boban M, Stowe DF, Kampine JP, Bosnjak ZJ) Anesthesiology 1994 Jul;81(1):129-36 PMID 8042781 Differential effects of halothane and isoflurane on contractile force and calcium transients in cardiac Purkinje fibers. (Stowe DF, Sprung J, Turner LA, Kampine JP, Bosnjak ZJ) Anesthesiology 1994 Jun;80(6):1360-8 PMID 8010480 Contraction uncoupling with butanedione monoxime versus low calcium or high potassium solutions on flow and contractile function of isolated hearts after prolonged hypothermic perfusion. (Stowe DF, Boban M, Graf BM, Kampine JP, Bosnjak ZJ) Circulation 1994 May;89(5):2412-20 PMID 8181166 Excitation-contraction uncoupling and vasodilators for long-term cold preservation of isolated hearts. (Stowe DF) Adv Pharmacol 1994;31:39-61 PMID 7873427 Effects of nifedipine with isoflurane, halothane, or enflurane on automaticity, conduction, and contractility in isolated guinea pig hearts. (Gallenberg LA, Stowe DF, Kampine JP, Bosnjak ZJ) Anesthesiology 1993 Jun;78(6):1112-9; discussion 23A-24A PMID 8512104 Potassium channel openers attenuate atrioventricular block by bupivacaine in isolated hearts. (Boban M, Stowe DF, Gross GJ, Pieper GM, Kampine JP, Bosnjak ZJ) Anesth Analg 1993 Jun;76(6):1259-65 PMID 8498663 Reperfusion with adenosine and nitroprusside improves preservation of isolated guinea pig hearts after 22 hours of cold perfusion with 2,3 butanedione monoxime. (Stowe DF, Boban M, Kampine JP, Bosnjak ZJ) J Cardiovasc Pharmacol 1993 Apr;21(4):578-86 PMID 7681903 Effects of 2,3-butanedione monoxime in isolated hearts: protection during reperfusion after global ischemia. (Boban M, Stowe DF, Kampine JP, Goldberg AH, Bosnjak ZJ) J Thorac Cardiovasc Surg 1993 Mar;105(3):532-40 PMID 8445931 Halothane reduces release of adenosine, inosine, and lactate with ischemia and reperfusion in isolated hearts. (Buljubasic N, Stowe DF, Marijic J, Roerig DL, Kampine JP, Bosnjak ZJ) Anesth Analg 1993 Jan;76(1):54-62 PMID 8418741 Direct comparative effects of isoflurane and desflurane in isolated guinea pig hearts. (Boban M, Stowe DF, Buljubasic N, Kampine JP, Bosnjak ZJ) Anesthesiology 1992 May;76(5):775-80 PMID 1575346 Comparison of etomidate, ketamine, midazolam, propofol, and thiopental on function and metabolism of isolated hearts. (Stowe DF, Bosnjak ZJ, Kampine JP) Anesth Analg 1992 Apr;74(4):547-58 PMID 1554122 Halothane reduces dysrhythmias and improves contractile function after global hypoperfusion in isolated hearts. (Buljubasic N, Marijic J, Stowe DF, Kampine JP, Bosnjak ZJ) Anesth Analg 1992 Mar;74(3):384-94 PMID 1539820 Comparison of halothane, enflurane, and isoflurane with nitrous oxide on contractility and oxygen supply and demand in isolated hearts. (Stowe DF, Monroe SM, Marijic J, Bosnjak ZJ, Kampine JP) Anesthesiology 1991 Dec;75(6):1062-74 PMID 1741498 Comparative cardiac effects of KT-362 and verapamil in isolated heart--correlation to calcium channel current depression. (Buljubasic N, Marijic J, Stowe DF, Gross GJ, Kampine JP, Bosnjak ZJ) J Cardiovasc Pharmacol 1991 Oct;18(4):594-604 PMID 1724538 Direct comparative effects of halothane, enflurane, and isoflurane on oxygen supply and demand in isolated hearts. (Stowe DF, Marijic J, Bosnjak ZJ, Kampine JP) Anesthesiology 1991 Jun;74(6):1087-95 PMID 2042761 Opposing effects of diacetyl monoxime on contractility and calcium transients in isolated myocardium. (Marijic J, Buljubasic N, Stowe DF, Turner LA, Kampine JP, Bosnjak ZJ) Am J Physiol 1991 Apr;260(4 Pt 2):H1153-9 PMID 2012220 Additive depressant effects of amiodarone given with halothane in isolated hearts. (Rooney RT, Stowe DF, Marijic J, Kampine JP, Bosnjak ZJ) Anesth Analg 1991 Apr;72(4):474-81 PMID 2006739 Chronic verapamil treatment depresses automaticity and contractility in isolated cardiac tissues. (Bosnjak ZJ, Marijic J, Roerig DL, Stowe DF, Murthy VS, Kampine JP) Anesth Analg 1991 Apr;72(4):462-8 PMID 2006737 Amrinone reverses cardiac depression and augments coronary vasodilation with isoflurane in the isolated heart. (Rooney RT, Stowe DF, Marijic J, Bosnjak ZJ, Kampine JP) Anesthesiology 1991 Mar;74(3):559-67 PMID 2001035 Depression of atrial rate, atrioventricular nodal conduction, and cardiac contraction by diltiazem and volatile anesthetics in isolated hearts. (Gallenberg LA, Stowe DF, Marijic J, Kampine JP, Bosnjak ZJ) Anesthesiology 1991 Mar;74(3):519-30 PMID 2001031 Effects of nitrous oxide on contractile function and metabolism of the isolated heart. (Stowe DF, Monroe SM, Marijic J, Rooney RT, Bosnjak ZJ, Kampine JP) Anesthesiology 1990 Dec;73(6):1220-6 PMID 2248399 Differential protective effects of halothane and isoflurane against hypoxic and reoxygenation injury in the isolated guinea pig heart. (Marijic J, Stowe DF, Turner LA, Kampine JP, Bosnjak ZJ) Anesthesiology 1990 Nov;73(5):976-83 PMID 2240687 A comparison of epidural narcotics, with and without a test dose, to epidural lidocaine for extracorporeal shock wave lithotripsy. (Madsen KE, Stowe DF, McDonald DJ, Ebert TJ, Kampine JP) Reg Anesth 1990 Nov-Dec;15(6):288-94 PMID 2149829 Attenuation of hemodynamic responses to rapid sequence induction and intubation in healthy patients with a single bolus of esmolol. (Ebert TJ, Bernstein JS, Stowe DF, Roerig D, Kampine JP) J Clin Anesth 1990 Jul-Aug;2(4):243-52 PMID 1975189 Autonomic hyperreflexia in spinal cord injured patients during extracorporeal shock wave lithotripsy. (Stowe DF, Bernstein JS, Madsen KE, McDonald DJ, Ebert TJ) Anesth Analg 1989 Jun;68(6):788-91 PMID 2735544 Partial attenuation of hemodynamic responses to rapid sequence induction and intubation with labetalol. (Bernstein JS, Ebert TJ, Stowe DF, Schmeling WT, Nelson MA, Woods MP) J Clin Anesth 1989;1(6):444-51 PMID 2696507 Effects and interaction of verapamil and volatile anesthetics on the isolated perfused guinea pig heart. (Marijic J, Bosnjak ZJ, Stowe DF, Kampine JP) Anesthesiology 1988 Dec;69(6):914-22 PMID 3195762 Volatile anesthetics attenuate sympathomimetic actions on the guinea pig SA node. (Stowe DF, Dujic Z, Bosnjak ZJ, Kalbfleisch JH, Kampine JP) Anesthesiology 1988 Jun;68(6):887-94 PMID 2897808 Effects of halothane with and without histamine and/or epinephrine on automaticity, intracardiac conduction times, and development of dysrhythmias in the isolated guinea pig heart. (Stowe DF, Bosnjak ZJ, Marijic J, Kampine JP) Anesthesiology 1988 May;68(5):695-706 PMID 3369714 Comparison of lidocaine and bupivacaine depression of sinoatrial nodal activity during hypoxia and acidosis in adult and neonatal guinea pigs. (Bosnjak ZJ, Stowe DF, Kampine JP) Anesth Analg 1986 Sep;65(9):911-7 PMID 3740490 Cardiac cell action potential duration is dependent upon induced changes in free Ca2+ activity during pH changes in vitro. (Stowe DF, Bosnjak ZJ, Kampine JP) J Electrocardiol 1986 Apr;19(2):143-54 PMID 2423627 Effects of hypoxia on adult and neonatal pacemaker rates. (Stowe DF, Bosnjak ZJ, Kampine JP) Obstet Gynecol 1985 Nov;66(5):649-56 PMID 4058823 Halothane diminishes changes in cardiac fiber action potential duration induced by hypocarbia and hypercarbia. (Stowe DF, Bosnjak ZJ, Kampine JP) Anesthesiology 1984 Sep;61(3):245-53 PMID 6433748 Adenosine potentiates coronary flow and inhibits oxygen consumption during isoprenaline infusion in isolated perfused guinea pig hearts. (Beranek AE, Stowe DF) Cardiovasc Res 1983 Jun;17(6):353-62 PMID 6883411 Control of coronary flow by local factors during hypoxia with and without a fall in O2 consumption. (Stowe DF) Blood Vessels 1982;19(3):148-64 PMID 7074228 Summated circulatory responses of thermal and baroreflexes in humans. (Ebert TJ, Stowe DF, Barney JA, Kalbfleisch JH, Smith JJ) J Appl Physiol 1982 Jan;52(1):184-9 PMID 7061264 Heart bioassay of effluent of isolated, perfused guinea pig hearts to examine the role of metabolites regulating coronary flow during hypoxia. (Stowe DF) Basic Res Cardiol 1981 Jul-Aug;76(4):359-64 PMID 7283937 Vasodilator responses to moderate hypoxia after submaximal adenosine injection or coronary occlusion in isolated perfused guinea pig hearts. (Stowe DF) Circ Res 1980 Sep;47(3):392-9 PMID 7408121 Heart rate-systemic blood pressure relationship in dogs during halothane anesthesia. (Wilkinson PL, Stowe DF, Glantz SA, Tyberg JV) Acta Anaesthesiol Scand 1980 Jun;24(3):181-6 PMID 7445934 Pronounced dependence of ventricular endocardial QRS potentials on ventricular volume. (Lekven J, Chatterjee K, Tyberg JV, Stowe DF, Mathey DG, Parmley WW) Br Heart J 1978 Aug;40(8):891-901 PMID 687490 Evaluation of the heart rate response to the Valsalva maneuver. (Kalbfleisch JH, Stowe DF, Smith JJ) Am Heart J 1978 Jun;95(6):707-15 PMID 655084 Segment stroke work and metabolism depend on coronary blood flow in the pig. (Stowe DF, Mathey DG, Moores WY, Glantz SA, Townsend RM, Kabra P, Chatterjee K, Parmley WW, Tyberg JV) Am J Physiol 1978 May;234(5):H597-607 PMID 645926 The pericardium substantially affects the left ventricular diastolic pressure-volume relationship in the dog. (Glantz SA, Misbach GA, Moores WY, Mathey DG, Lekven J, Stowe DF, Parmley WW, Tyberg JV) Circ Res 1978 Mar;42(3):433-41 PMID 624151 Pressure and flow changes during Valsalva-like maneuvers in dogs following volume infusion. (Wilkinson PL, Stowe DF, Tyberg JV, Parmley WW) Am J Physiol 1977 Jul;233(1):H93-9 PMID 879339 Interaction of O2 and CO2 in sustained exercise hyperemia of canine skeletal muscle. (Stowe DF, Owen TL, Anderson DK, Haddy FJ, Scott JB) Am J Physiol 1975 Jul;229(1):28-33 PMID 238405 Role of gastric acid in the development of duodenal ulcers in the rat. (Robert A, Nezamis JE, Dale JE, Stowe DF) Digestion 1972;6(1):34-45 PMID 5031809 Possible relationship between smoking and peptic ulcer. (Robert A, Stowe DF, Nezamis JE) Nature 1971 Oct 15;233(5320):497-8 PMID 4939552 Inhibition by prostaglandin E 1 of gastric secretion in the dog. (Nezamis JE, Robert A, Stowe DF) J Physiol 1971 Oct;218(2):369-83 PMID 4399409 Prevention of duodenal ulcers by administration of prostaglandin E 2 (PGE 2 ). (Robert A, Stowe DF, Nezamis JE) Scand J Gastroenterol 1971;6(4):303-5 PMID 5561174 Grants and Awards
Temperature Dependent Free Radicals Reduce Cold Cardiac Protection (#9205435 10/01/2008 - 02/15/2013) Sponsor: Zablocki Veterans Affairs Medical CenterMitochondrial Ca-sensitive K Channel-induced Superoxide and Cardiac Protection (#9205509 02/01/2009 - 12/31/2013) Sponsor: NIH Heart Lung and Blood InstituteRole of Mitochondrial Bioenergetics in Cardioprotection (#9202889 07/01/2003 - 06/30/2006) Sponsor: American Heart Association Wisconsin
