David L. Mattson PhD Online Profile
Professor
Medical College of Wisconsin
Department: Physiology
Publications
Role of cellular L-arginine uptake and nitric oxide production on renal blood flow and arterial pressure regulation. (Rajapakse NW, Mattson DL) Curr Opin Nephrol Hypertens 2013 Jan;22(1):45-50 PMID 23095292 Evidence that renal arginine transport is impaired in spontaneously hypertensive rats. (Rajapakse NW, Kuruppu S, Hanchapola I, Venardos K, Mattson DL, Smith AI, Kaye DM, Evans RG) Am J Physiol Renal Physiol 2012 Jun 15;302(12):F1554-62 PMID 22442214 Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension. (Feng D, Yang C, Geurts AM, Kurth T, Liang M, Lazar J, Mattson DL, O'Connor PM, Cowley AW Jr) Cell Metab 2012 Feb 8;15(2):201-8 PMID 22326221 Prematurity in mice leads to reduction in nephron number, hypertension, and proteinuria. (Stelloh C, Allen KP, Mattson DL, Lerch-Gaggl A, Reddy S, El-Meanawy A) Transl Res 2012 Feb;159(2):80-9 PMID 22243792 Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC). (Pavlov TS, Ilatovskaya DV, Levchenko V, Mattson DL, Roman RJ, Staruschenko A) Am J Physiol Renal Physiol 2011 Sep;301(3):F672-81 PMID 21697242 Role of L-arginine uptake mechanisms in renal blood flow responses to angiotensin II in rats. (Rajapakse NW, Mattson DL) Acta Physiol (Oxf) 2011 Nov;203(3):391-400 PMID 21649863 High dietary protein exacerbates hypertension and renal damage in Dahl SS rats by increasing infiltrating immune cells in the kidney. (De Miguel C, Lund H, Mattson DL) Hypertension 2011 Feb;57(2):269-74 PMID 21173345 Infiltrating T lymphocytes in the kidney increase oxidative stress and participate in the development of hypertension and renal disease. (De Miguel C, Guo C, Lund H, Feng D, Mattson DL) Am J Physiol Renal Physiol 2011 Mar;300(3):F734-42 PMID 21159736 Effector memory T lymphocytes in renal disease. (Mattson DL) Am J Physiol Renal Physiol 2010 Dec;299(6):F1257 PMID 20739395 T lymphocytes mediate hypertension and kidney damage in Dahl salt-sensitive rats. (De Miguel C, Das S, Lund H, Mattson DL) Am J Physiol Regul Integr Comp Physiol 2010 Apr;298(4):R1136-42 PMID 20147611 Measuring kidney function in conscious mice. (Mattson DL) Methods Mol Biol 2009;573:75-94 PMID 19763923 Recovery from renal ischemia-reperfusion injury is associated with altered renal hemodynamics, blunted pressure natriuresis, and sodium-sensitive hypertension. (Pechman KR, De Miguel C, Lund H, Leonard EC, Basile DP, Mattson DL) Am J Physiol Regul Integr Comp Physiol 2009 Nov;297(5):R1358-63 PMID 19710386 Role of L-arginine in nitric oxide production in health and hypertension. (Rajapakse NW, Mattson DL) Clin Exp Pharmacol Physiol 2009 Mar;36(3):249-55 PMID 19076168 Exogenous L-arginine ameliorates angiotensin II-induced hypertension and renal damage in rats. (Rajapakse NW, De Miguel C, Das S, Mattson DL) Hypertension 2008 Dec;52(6):1084-90 PMID 18981330 The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. (Toyama K, Wulff H, Chandy KG, Azam P, Raman G, Saito T, Fujiwara Y, Mattson DL, Das S, Melvin JE, Pratt PF, Hatoum OA, Gutterman DD, Harder DR, Miura H) J Clin Invest 2008 Sep;118(9):3025-37 PMID 18688283 Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease. (Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Jacob HJ, Cowley AW Jr) Am J Physiol Renal Physiol 2008 Sep;295(3):F837-42 PMID 18653478 Immune suppression blocks sodium-sensitive hypertension following recovery from ischemic acute renal failure. (Pechman KR, Basile DP, Lund H, Mattson DL) Am J Physiol Regul Integr Comp Physiol 2008 Apr;294(4):R1234-9 PMID 18256138 Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats. (Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Cowley AW Jr, Jacob HJ) Am J Physiol Renal Physiol 2007 Dec;293(6):F1905-14 PMID 17898042 Recovery from acute renal failure predisposes hypertension and secondary renal disease in response to elevated sodium. (Spurgeon-Pechman KR, Donohoe DL, Mattson DL, Lund H, James L, Basile DP) Am J Physiol Renal Physiol 2007 Jul;293(1):F269-78 PMID 17507599 Immune suppression attenuates hypertension and renal disease in the Dahl salt-sensitive rat. (Mattson DL, James L, Berdan EA, Meister CJ) Hypertension 2006 Jul;48(1):149-56 PMID 16754791 Amino acids as modulators of endothelium-derived nitric oxide. (Kakoki M, Kim HS, Edgell CJ, Maeda N, Smithies O, Mattson DL) Am J Physiol Renal Physiol 2006 Aug;291(2):F297-304 PMID 16571593 Sodium sensitivity of arterial blood pressure in L-NAME hypertensive but not eNOS knockout mice. (Mattson DL, Meister CJ) Am J Hypertens 2006 Mar;19(3):327-9 PMID 16500522 BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat. (Kwitek AE, Jacob HJ, Baker JE, Dwinell MR, Forster HV, Greene AS, Kunert MP, Lombard JH, Mattson DL, Pritchard KA Jr, Roman RJ, Tonellato PJ, Cowley AW Jr) Physiol Genomics 2006 Apr 13;25(2):303-13 PMID 16478827 Renal cortical and medullary blood flow responses to L-NAME and ANG II in wild-type, nNOS null mutant, and eNOS null mutant mice. (Mattson DL, Meister CJ) Am J Physiol Regul Integr Comp Physiol 2005 Oct;289(4):R991-7 PMID 15961532 Influence of elevated renin substrate on angiotensin II and arterial blood pressure in conscious mice. (Cholewa BC, Mattson DL) Exp Physiol 2005 Jul;90(4):607-12 PMID 15833753 Importance of the renin-angiotensin system in the regulation of arterial blood pressure in conscious mice and rats. (Cholewa BC, Meister CJ, Mattson DL) Acta Physiol Scand 2005 Mar;183(3):309-20 PMID 15743391 Dietary protein source determines the degree of hypertension and renal disease in the Dahl salt-sensitive rat. (Mattson DL, Meister CJ, Marcelle ML) Hypertension 2005 Apr;45(4):736-41 PMID 15699463 Substitution of chromosome 1 ameliorates L-NAME hypertension and renal disease in the fawn-hooded hypertensive rat. (Mattson DL, Kunert MP, Roman RJ, Jacob HJ, Cowley AW Jr) Am J Physiol Renal Physiol 2005 May;288(5):F1015-22 PMID 15644486 L-Arginine uptake affects nitric oxide production and blood flow in the renal medulla. (Kakoki M, Kim HS, Arendshorst WJ, Mattson DL) Am J Physiol Regul Integr Comp Physiol 2004 Dec;287(6):R1478-85 PMID 15319219 Endothelial cell PECAM-1 confers protection against endotoxic shock. (Maas M, Stapleton M, Bergom C, Mattson DL, Newman DK, Newman PJ) Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H159-64 PMID 15319204 Inhibition of cyclooxygenase-2 in the rat renal medulla leads to sodium-sensitive hypertension. (Zewde T, Mattson DL) Hypertension 2004 Oct;44(4):424-8 PMID 15314032 Influence of diet and genetics on hypertension and renal disease in Dahl salt-sensitive rats. (Mattson DL, Kunert MP, Kaldunski ML, Greene AS, Roman RJ, Jacob HJ, Cowley AW Jr) Physiol Genomics 2004 Jan 15;16(2):194-203 PMID 14600213 Influence of dietary NaCl on L-arginine transport in the renal medulla. (Zewde T, Wu F, Mattson DL) Am J Physiol Regul Integr Comp Physiol 2004 Jan;286(1):R89-93 PMID 14512271 Importance of the renal medullary circulation in the control of sodium excretion and blood pressure. (Mattson DL) Am J Physiol Regul Integr Comp Physiol 2003 Jan;284(1):R13-27 PMID 12482743 Chronic renal hypoxia after acute ischemic injury: effects of L-arginine on hypoxia and secondary damage. (Basile DP, Donohoe DL, Roethe K, Mattson DL) Am J Physiol Renal Physiol 2003 Feb;284(2):F338-48 PMID 12388385 Renal medullary nitric oxide deficit of Dahl S rats enhances hypertensive actions of angiotensin II. (Szentiványi M Jr, Zou AP, Mattson DL, Soares P, Moreno C, Roman RJ, Cowley AW Jr) Am J Physiol Regul Integr Comp Physiol 2002 Jul;283(1):R266-72 PMID 12069953 Cationic amino acid transport in the renal medulla and blood pressure regulation. (Kakoki M, Wang W, Mattson DL) Hypertension 2002 Feb;39(2):287-92 PMID 11847199 Brain activity in ventromedial prefrontal cortex correlates with individual differences in negative affect. (Zald DH, Mattson DL, Pardo JV) Proc Natl Acad Sci U S A 2002 Feb 19;99(4):2450-4 PMID 11842195 Role of nitric oxide in regulation of the renal medulla in normal and hypertensive kidneys. (Pallone TL, Mattson DL) Curr Opin Nephrol Hypertens 2002 Jan;11(1):93-8 PMID 11753093 Role of the renin-angiotensin system during alterations of sodium intake in conscious mice. (Cholewa BC, Mattson DL) Am J Physiol Regul Integr Comp Physiol 2001 Sep;281(3):R987-93 PMID 11507017 The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney. (Kakoki M, Zou AP, Mattson DL) Am J Physiol Regul Integr Comp Physiol 2001 Jul;281(1):R91-7 PMID 11404282 Comparison of arterial blood pressure in different strains of mice. (Mattson DL) Am J Hypertens 2001 May;14(5 Pt 1):405-8 PMID 11368457 Measurement of regional blood flow in the kidney using laser-Doppler flowmetry. (Roman RJ, Mattson DL, Cowley AW Jr) Methods Mol Med 2001;51:407-26 PMID 21331733 Characterization of L-arginine transporters in rat renal inner medullary collecting duct. (Wu F, Cholewa B, Mattson DL) Am J Physiol Regul Integr Comp Physiol 2000 Jun;278(6):R1506-12 PMID 10848517 Control of arterial blood pressure and renal sodium excretion by nitric oxide synthase in the renal medulla. (Mattson DL, Wu F) Acta Physiol Scand 2000 Jan;168(1):149-54 PMID 10691793 Increase in renal medullary nitric oxide synthase activity protects from norepinephrine-induced hypertension. (Szentiványi M Jr, Zou AP, Maeda CY, Mattson DL, Cowley AW Jr) Hypertension 2000 Jan;35(1 Pt 2):418-23 PMID 10642335 Nitric oxide synthase activity and isoforms in rat renal vasculature. (Mattson DL, Wu F) Hypertension 2000 Jan;35(1 Pt 2):337-41 PMID 10642321 Use of antisense techniques in rat renal medulla. (Mattson DL) Methods Enzymol 2000;314:389-400 PMID 10565027 Quantification of nitric oxide synthase activity in microdissected segments of the rat kidney. (Wu F, Park F, Cowley AW Jr, Mattson DL) Am J Physiol 1999 Jun;276(6 Pt 2):F874-81 PMID 10362776 Chronic sodium balance and blood pressure response to captopril in conscious mice. (Mattson DL, Krauski KR) Hypertension 1998 Nov;32(5):923-8 PMID 9822454 Renal medullary interstitial infusion of L-arginine prevents hypertension in Dahl salt-sensitive rats. (Miyata N, Zou AP, Mattson DL, Cowley AW Jr) Am J Physiol 1998 Nov;275(5 Pt 2):R1667-73 PMID 9791089 Effects of daily sodium intake and ANG II on cortical and medullary renal blood flow in conscious rats. (Gross V, Kurth TM, Skelton MM, Mattson DL, Cowley AW Jr) Am J Physiol 1998 May;274(5 Pt 2):R1317-23 PMID 9644045 Iron attenuates nitric oxide level and iNOS expression in endotoxin-treated mice. (Komarov AM, Mattson DL, Mak IT, Weglicki WB) FEBS Lett 1998 Mar 13;424(3):253-6 PMID 9539161 Long-term measurement of arterial blood pressure in conscious mice. (Mattson DL) Am J Physiol 1998 Feb;274(2 Pt 2):R564-70 PMID 9486319 Inducible nitric oxide synthase and blood pressure. (Mattson DL, Maeda CY, Bachman TD, Cowley AW Jr) Hypertension 1998 Jan;31(1):15-20 PMID 9449384 Evidence for the presence of smooth muscle alpha-actin within pericytes of the renal medulla. (Park F, Mattson DL, Roberts LA, Cowley AW Jr) Am J Physiol 1997 Nov;273(5 Pt 2):R1742-8 PMID 9374818 Role of nitric oxide in the control of the renal medullary circulation. (Mattson DL, Lu S, Cowley AW Jr) Clin Exp Pharmacol Physiol 1997 Aug;24(8):587-90 PMID 9269532 Localization of the vasopressin V1a and V2 receptors within the renal cortical and medullary circulation. (Park F, Mattson DL, Skelton MM, Cowley AW Jr) Am J Physiol 1997 Jul;273(1 Pt 2):R243-51 PMID 9249556 Vasopressin modulation of medullary blood flow and pressure-natriuresis-diuresis in the decerebrated rat. (Franchini KG, Mattson DL, Cowley AW Jr) Am J Physiol 1997 May;272(5 Pt 2):R1472-9 PMID 9176339 Inhibition of renal outer medullary 20-HETE production produces hypertension in Lewis rats. (Stec DE, Mattson DL, Roman RJ) Hypertension 1997 Jan;29(1 Pt 2):315-9 PMID 9039121 Comparison of three chemiluminescent horseradish peroxidase substrates for immunoblotting. (Mattson DL, Bellehumeur TG) Anal Biochem 1996 Sep 5;240(2):306-8 PMID 8811928 Neural nitric oxide synthase in the renal medulla and blood pressure regulation. (Mattson DL, Bellehumeur TG) Hypertension 1996 Aug;28(2):297-303 PMID 8707397 Influence of dietary sodium intake on renal medullary nitric oxide synthase. (Mattson DL, Higgins DJ) Hypertension 1996 Mar;27(3 Pt 2):688-92 PMID 8613226 Control of renal medullary blood flow by vasopressin V1 and V2 receptors. (Nakanishi K, Mattson DL, Gross V, Roman RJ, Cowley AW Jr) Am J Physiol 1995 Jul;269(1 Pt 2):R193-200 PMID 7631893 Role of changes in renal hemodynamics and P-450 metabolites of arachidonic acid in the reversal of one-kidney, one clip hypertension. (Zou AP, Muirhead EE, Cowley AW, Mattson DL, Falck JR, Jiang J, Roman RJ) J Hypertens 1995 May;13(5):557-66 PMID 7561014 The renal medulla and hypertension. (Cowley AW Jr, Mattson DL, Lu S, Roman RJ) Hypertension 1995 Apr;25(4 Pt 2):663-73 PMID 7721413 In vivo diuretic actions of renal vasopressin V1 receptor stimulation in rats. (Ledderhos C, Mattson DL, Skelton MM, Cowley AW Jr) Am J Physiol 1995 Mar;268(3 Pt 2):R796-807 PMID 7900923 Role of renal medullary blood flow in the development of L-NAME hypertension in rats. (Nakanishi K, Mattson DL, Cowley AW Jr) Am J Physiol 1995 Feb;268(2 Pt 2):R317-23 PMID 7864223 Effect of chronic renal medullary nitric oxide inhibition on blood pressure. (Mattson DL, Lu S, Nakanishi K, Papanek PE, Cowley AW Jr) Am J Physiol 1994 May;266(5 Pt 2):H1918-26 PMID 8203591 Renal medullary captopril delivery lowers blood pressure in spontaneously hypertensive rats. (Lu S, Mattson DL, Cowley AW Jr) Hypertension 1994 Mar;23(3):337-45 PMID 8125560 Assessment of changes in intrarenal blood flow in conscious rats using laser-Doppler flowmetry. (Lu S, Mattson DL, Roman RJ, Becker CG, Cowley AW Jr) Am J Physiol 1993 Jun;264(6 Pt 2):F956-62 PMID 8322898 Kinin actions on renal papillary blood flow and sodium excretion. (Mattson DL, Cowley AW Jr) Hypertension 1993 Jun;21(6 Pt 2):961-5 PMID 8505107 Relationship between renal perfusion pressure and blood flow in different regions of the kidney. (Mattson DL, Lu S, Roman RJ, Cowley AW Jr) Am J Physiol 1993 Mar;264(3 Pt 2):R578-83 PMID 8457011 Effect of renal medullary circulation on arterial pressure. (Cowley AW, Roman RJ, Fenoy FJ, Mattson DL) J Hypertens Suppl 1992 Dec;10(7):S187-93 PMID 1291653 Renal medullary interstitial infusion of diltiazem alters sodium and water excretion in rats. (Lu S, Roman RJ, Mattson DL, Cowley AW Jr) Am J Physiol 1992 Nov;263(5 Pt 2):R1064-70 PMID 1443224 Role of nitric oxide in renal papillary blood flow and sodium excretion. (Mattson DL, Roman RJ, Cowley AW Jr) Hypertension 1992 Jun;19(6 Pt 2):766-9 PMID 1592478 Influence of angiotensin II on pressure natriuresis and renal hemodynamics in volume-expanded rats. (Mattson DL, Raff H, Roman RJ) Am J Physiol 1991 Jun;260(6 Pt 2):R1200-9 PMID 2058747 Role of kinins and angiotensin II in the renal hemodynamic response to captopril. (Mattson DL, Roman RJ) Am J Physiol 1991 May;260(5 Pt 2):F670-9 PMID 2035654 Influence of eicosanoids on renal function of DOCA-salt hypertensive rats. (Roman RJ, Kaldunski ML, Mattson DL, Mistry M, Nasjletti A) Hypertension 1988 Sep;12(3):287-94 PMID 3169943 Grants and Awards
Role of CD247 in Salt-Sensitive Hypertension and Renal Disease (#9207665 09/01/2012 - 08/31/2017) Sponsor: NIH Diabetes, Digestive and Kidney DiseasesArginine Uptake Mechanisms Regulate Nitric Oxide in the Renal Vasculature (#9204814 09/30/2007 - 02/28/2013) Sponsor: NIH Diabetes, Digestive and Kidney DiseasesArterial Blood Pressure in eNOS Knockout Mice (#9202897 07/01/2003 - 08/31/2008) Sponsor: NIH Diabetes, Digestive and Kidney DiseasesBlood Pressure: Determinants and Controllers (#9204950 03/10/2008 - 08/31/2013) PI of Project 2: Blood Pressure: Determinants and Controllers Renal Infiltration of Immune Cells Mediates (#2207337)Blood Pressure: Determinants and Controllers (#9204950 03/10/2008 - 08/31/2013) PI of Core B: Blood Pressure: Determinants and Controllers Biochemical and Analytical Core (#2207334)Blood Pressure: Determinants and Controllers (#9204950 03/10/2008 - 08/31/2013) PI of Core B: Blood Pressure: Determinants and Controllers Biochemical and Analytical Core (#2206780)Blood Pressure: Determinants and Controllers (#9204950 03/10/2008 - 08/31/2013) PI of Project 2: Blood Pressure: Determinants and Controllers Renal Infiltration of Immune Cells Mediates (#2206783)Blood Pressure: Determinants and Controllers (#9204950 03/10/2008 - 08/31/2013) PI of Core B: Blood Pressure: Determinants and Controllers Biochemical and Analytical Core (#2206101)Blood Pressure: Determinants and Controllers (#9204950 03/10/2008 - 08/31/2013) PI of Project 2: Blood Pressure: Determinants and Controllers Renal Infiltration of Immune Cells Mediates (#2206100)
