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Donghai Xiong PhD Online Profile

Assistant Professor
Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Cancer Center


Publications

  • Pathway-based genome-wide association analysis identified the importance of regulation-of-autophagy pathway for ultradistal radius BMD. (Zhang L, Guo YF, Liu YZ, Liu YJ, Xiong DH, Liu XG, Wang L, Yang TL, Lei SF, Guo Y, Yan H, Pei YF, Zhang F, Papasian CJ, Recker RR, Deng HW) J Bone Miner Res 2010 Jul;25(7):1572-80 PMID 20200951
  • Genome-wide association study for femoral neck bone geometry. (Zhao LJ, Liu XG, Liu YZ, Liu YJ, Papasian CJ, Sha BY, Pan F, Guo YF, Wang L, Yan H, Xiong DH, Tang ZH, Yang TL, Chen XD, Guo Y, Li J, Shen H, Zhang F, Lei SF, Recker RR, Deng HW) J Bone Miner Res 2010 Feb;25(2):320-9 PMID 20175129
  • IL21R and PTH may underlie variation of femoral neck bone mineral density as revealed by a genome-wide association study. (Guo Y, Zhang LS, Yang TL, Tian Q, Xiong DH, Pei YF, Deng HW) J Bone Miner Res 2010 May;25(5):1042-8 PMID 19874204
  • Pathway-based genome-wide association analysis identified the importance of EphrinA-EphR pathway for femoral neck bone geometry. (Chen Y, Xiong DH, Guo YF, Pan F, Zhou Q, Zhang F, Deng HW) Bone 2010 Jan;46(1):129-36 PMID 19786129
  • Association analyses of vitamin D-binding protein gene with compression strength index variation in Caucasian nuclear families. (Xu XH, Xiong DH, Liu XG, Guo Y, Chen Y, Zhao J, Recker RR, Deng HW) Osteoporos Int 2010 Jan;21(1):99-107 PMID 19543766
  • Association analyses of RANKL/RANK/OPG gene polymorphisms with femoral neck compression strength index variation in Caucasians. (Dong SS, Liu XG, Chen Y, Guo Y, Wang L, Zhao J, Xiong DH, Xu XH, Recker RR, Deng HW) Calcif Tissue Int 2009 Aug;85(2):104-12 PMID 19458885
  • Genome-wide association analyses identify SPOCK as a key novel gene underlying age at menarche. (Liu YZ, Guo YF, Wang L, Tan LJ, Liu XG, Pei YF, Yan H, Xiong DH, Deng FY, Yu N, Zhang YP, Zhang L, Lei SF, Chen XD, Liu HB, Zhu XZ, Levy S, Papasian CJ, Drees BM, Hamilton JJ, Recker RR, Deng HW) PLoS Genet 2009 Mar;5(3):e1000420 PMID 19282985
  • Genome-wide association and replication studies identified TRHR as an important gene for lean body mass. (Liu XG, Tan LJ, Lei SF, Liu YJ, Shen H, Wang L, Yan H, Guo YF, Xiong DH, Chen XD, Pan F, Yang TL, Zhang YP, Guo Y, Tang NL, Zhu XZ, Deng HY, Levy S, Recker RR, Papasian CJ, Deng HW) Am J Hum Genet 2009 Mar;84(3):418-23 PMID 19268274
  • Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups. (Xiong DH, Liu XG, Guo YF, Tan LJ, Wang L, Sha BY, Tang ZH, Pan F, Yang TL, Chen XD, Lei SF, Yerges LM, Zhu XZ, Wheeler VW, Patrick AL, Bunker CH, Guo Y, Yan H, Pei YF, Zhang YP, Levy S, Papasian CJ, Xiao P, Lundberg YW, Recker RR, Liu YZ, Liu YJ, Zmuda JM, Deng HW) Am J Hum Genet 2009 Mar;84(3):388-98 PMID 19249006
  • Genome-wide association analyses suggested a novel mechanism for smoking behavior regulated by IL15. (Liu YZ, Pei YF, Guo YF, Wang L, Liu XG, Yan H, Xiong DH, Zhang YP, Levy S, Li J, Haddock CK, Papasian CJ, Xu Q, Ma JZ, Payne TJ, Recker RR, Li MD, Deng HW) Mol Psychiatry 2009 Jul;14(7):668-80 PMID 19188921
  • Genome-wide association study identifies two novel loci containing FLNB and SBF2 genes underlying stature variation. (Lei SF, Tan LJ, Liu XG, Wang L, Yan H, Guo YF, Liu YZ, Xiong DH, Li J, Yang TL, Chen XD, Guo Y, Deng FY, Zhang YP, Zhu XZ, Levy S, Papasian CJ, Hamilton JJ, Recker RR, Deng HW) Hum Mol Genet 2009 May 1;18(9):1661-9 PMID 19039035
  • Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study. (Liu YZ, Wilson SG, Wang L, Liu XG, Guo YF, Li J, Yan H, Deloukas P, Soranzo N, Chinappen-Horsley U, Cervino A, Williams FM, Xiong DH, Zhang YP, Jin TB, Levy S, Papasian CJ, Drees BM, Hamilton JJ, Recker RR, Spector TD, Deng HW) PLoS One 2008;3(9):e3160 PMID 18776929
  • Polymorphisms of the tumor necrosis factor-alpha receptor 2 gene are associated with obesity phenotypes among 405 Caucasian nuclear families. (Zhao LJ, Xiong DH, Pan F, Liu XG, Recker RR, Deng HW) Hum Genet 2008 Sep;124(2):171-7 PMID 18685868
  • A bivariate whole genome linkage study identified genomic regions influencing both BMD and bone structure. (Liu XG, Liu YJ, Liu J, Pei Y, Xiong DH, Shen H, Deng HY, Papasian CJ, Drees BM, Hamilton JJ, Recker RR, Deng HW) J Bone Miner Res 2008 Nov;23(11):1806-14 PMID 18597637
  • Comprehensive association analyses of IGF1, ESR2, and CYP17 genes with adult height in Caucasians. (Yang TL, Xiong DH, Guo Y, Recker RR, Deng HW) Eur J Hum Genet 2008 Nov;16(11):1380-7 PMID 18560445
  • Genetic determination of osteoporosis: lessons learned from a large genome-wide linkage study. (Xiong DH, Wang JT, Wang W, Guo YF, Xiao P, Shen H, Jiang H, Chen Y, Deng H, Drees B, Recker RR, Deng HW) Hum Biol 2007 Dec;79(6):593-608 PMID 18494371
  • Quantitative trait loci mapping. (Xiong DH, Liu JF, Guo YF, Guo Y, Yang TL, Jiang H, Chen Y, Yang F, Recker RR, Deng HW) Methods Mol Biol 2008;455:203-35 PMID 18463822
  • Association study of the oestrogen signalling pathway genes in relation to age at natural menopause. (He LN, Xiong DH, Liu YJ, Zhang F, Recker RR, Deng HW) J Genet 2007 Dec;86(3):269-76 PMID 18305346
  • The MTHFR gene polymorphism is associated with lean body mass but not fat body mass. (Liu X, Zhao LJ, Liu YJ, Xiong DH, Recker RR, Deng HW) Hum Genet 2008 Mar;123(2):189-96 PMID 18180959
  • Sex-specific association of the glucocorticoid receptor gene with extreme BMD. (Peng YM, Lei SF, Guo Y, Xiong DH, Yan H, Wang L, Guo YF, Deng HW) J Bone Miner Res 2008 Feb;23(2):247-52 PMID 17937535
  • A whole genome linkage scan for QTLs underlying peak bone mineral density. (Zhang F, Xiao P, Yang F, Shen H, Xiong DH, Deng HY, Papasian CJ, Drees BM, Hamilton JJ, Recker RR, Deng HW) Osteoporos Int 2008 Mar;19(3):303-10 PMID 17882466
  • Variations in RANK gene are associated with adult height in Caucasians. (Chen Y, Xiong DH, Yang TL, Yang F, Jiang H, Zhang F, Shen H, Xiao P, Recker RR, Deng HW) Am J Hum Biol 2007 Jul-Aug;19(4):559-65 PMID 17546619
  • A bivariate whole-genome linkage scan suggests several shared genomic regions for obesity and osteoporosis. (Tang ZH, Xiao P, Lei SF, Deng FY, Zhao LJ, Deng HY, Tan LJ, Shen H, Xiong DH, Recker RR, Deng HW) J Clin Endocrinol Metab 2007 Jul;92(7):2751-7 PMID 17473065
  • Genetic determination in onset age of wrist fracture. (Xiong D, Wang W, Chen Y, Jiang H, Deng HW) J Hum Genet 2007;52(6):481-4 PMID 17457512
  • Polymorphism in the insulin-like growth factor 1 gene is associated with age at menarche in caucasian females. (Zhao J, Xiong DH, Guo Y, Yang TL, Recker RR, Deng HW) Hum Reprod 2007 Jun;22(6):1789-94 PMID 17376820
  • Association analysis of vitamin D-binding protein gene polymorphisms with variations of obesity-related traits in Caucasian nuclear families. (Jiang H, Xiong DH, Guo YF, Shen H, Xiao P, Yang F, Chen Y, Zhang F, Recker RR, Deng HW) Int J Obes (Lond) 2007 Aug;31(8):1319-24 PMID 17342072
  • Epistatic interactions between genomic regions containing the COL1A1 gene and genes regulating osteoclast differentiation may influence femoral neck bone mineral density. (Yang TL, Shen H, Xiong DH, Xiao P, Guo Y, Guo YF, Liu YZ, Recker RR, Deng HW) Ann Hum Genet 2007 Mar;71(Pt 2):152-9 PMID 17331078
  • Low-density lipoprotein receptor-related protein 5 (LRP5) gene polymorphisms are associated with bone mass in both Chinese and whites. (Xiong DH, Lei SF, Yang F, Wang L, Peng YM, Wang W, Recker RR, Deng HW) J Bone Miner Res 2007 Mar;22(3):385-93 PMID 17241106
  • The chemokine (C-C-motif) receptor 3 (CCR3) gene is linked and associated with age at menarche in Caucasian females. (Yang F, Xiong DH, Guo Y, Shen H, Xiao P, Zhang F, Jiang H, Recker RR, Deng HW) Hum Genet 2007 Mar;121(1):35-42 PMID 17146638
  • A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian families. (Zhao LJ, Xiao P, Liu YJ, Xiong DH, Shen H, Recker RR, Deng HW) Hum Genet 2007 Mar;121(1):145-8 PMID 17115187
  • Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. (Xiong DH, Shen H, Zhao LJ, Xiao P, Yang TL, Guo Y, Wang W, Guo YF, Liu YJ, Recker RR, Deng HW) J Bone Miner Res 2006 Nov;21(11):1678-95 PMID 17002564
  • Genomic regions identified for BMD in a large sample including epistatic interactions and gender-specific effects. (Xiao P, Shen H, Guo YF, Xiong DH, Liu YZ, Liu YJ, Zhao LJ, Long JR, Guo Y, Recker RR, Deng HW) J Bone Miner Res 2006 Oct;21(10):1536-44 PMID 16995807
  • Molecular genetic studies of gene identification for osteoporosis: a 2004 update. (Liu YJ, Shen H, Xiao P, Xiong DH, Li LH, Recker RR, Deng HW) J Bone Miner Res 2006 Oct;21(10):1511-35 PMID 16995806
  • Is a gene important for bone resorption a candidate for obesity? An association and linkage study on the RANK (receptor activator of nuclear factor-kappaB) gene in a large Caucasian sample. (Zhao LJ, Guo YF, Xiong DH, Xiao P, Recker RR, Deng HW) Hum Genet 2006 Nov;120(4):561-70 PMID 16960694
  • HDC gene polymorphisms are associated with age at natural menopause in Caucasian women. (Zhang F, Xiong DH, Wang W, Shen H, Xiao P, Yang F, Recker RR, Deng HW) Biochem Biophys Res Commun 2006 Oct 6;348(4):1378-82 PMID 16919600
  • Epistasis between loci on chromosomes 2 and 6 influences human height. (Liu YZ, Guo YF, Xiao P, Xiong DH, Zhao LJ, Shen H, Liu YJ, Dvornyk V, Long JR, Deng HY, Li JL, Deng HW) J Clin Endocrinol Metab 2006 Oct;91(10):3821-5 PMID 16849413
  • Assessment of genetic linkage and parent-of-origin effects on obesity. (Guo YF, Shen H, Liu YJ, Wang W, Xiong DH, Xiao P, Liu YZ, Zhao LJ, Recker RR, Deng HW) J Clin Endocrinol Metab 2006 Oct;91(10):4001-5 PMID 16835282
  • A genomewide scan for quantitative trait loci underlying areal bone size variation in 451 Caucasian families. (Shen H, Long JR, Xiong DH, Guo YF, Xiao P, Liu YZ, Zhao LJ, Liu YJ, Deng HY, Li JL, Recker RR, Deng HW) J Med Genet 2006 Nov;43(11):873-80 PMID 16825438
  • Polymorphisms of estrogen-biosynthesis genes CYP17 and CYP19 may influence age at menarche: a genetic association study in Caucasian females. (Guo Y, Xiong DH, Yang TL, Guo YF, Recker RR, Deng HW) Hum Mol Genet 2006 Aug 15;15(16):2401-8 PMID 16782804
  • Association analyses of CYP19 gene polymorphisms with height variation in a large sample of Caucasian nuclear families. (Yang TL, Xiong DH, Guo Y, Recker RR, Deng HW) Hum Genet 2006 Aug;120(1):119-25 PMID 16733710
  • Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association study. (Guo YF, Xiong DH, Shen H, Zhao LJ, Xiao P, Guo Y, Wang W, Yang TL, Recker RR, Deng HW) J Med Genet 2006 Oct;43(10):798-803 PMID 16723389
  • Ethnic difference in osteoporosis-related phenotypes and its potential underlying genetic determination. (Lei SF, Chen Y, Xiong DH, Li LM, Deng HW) J Musculoskelet Neuronal Interact 2006 Jan-Mar;6(1):36-46 PMID 16675888
  • Genome-wide scan identified QTLs underlying femoral neck cross-sectional geometry that are novel studied risk factors of osteoporosis. (Xiong DH, Shen H, Xiao P, Guo YF, Long JR, Zhao LJ, Liu YZ, Deng HY, Li JL, Recker RR, Deng HW) J Bone Miner Res 2006 Mar;21(3):424-37 PMID 16491291
  • Genetic linkage of human height is confirmed to 9q22 and Xq24. (Liu YZ, Xiao P, Guo YF, Xiong DH, Zhao LJ, Shen H, Liu YJ, Dvornyk V, Long JR, Deng HY, Li JL, Recker RR, Deng HW) Hum Genet 2006 Apr;119(3):295-304 PMID 16446976
  • Genomewide linkage scan for quantitative trait loci underlying variation in age at menarche. (Guo Y, Shen H, Xiao P, Xiong DH, Yang TL, Guo YF, Long JR, Recker RR, Deng HW) J Clin Endocrinol Metab 2006 Mar;91(3):1009-14 PMID 16394082
  • Association analysis of estrogen receptor alpha gene polymorphisms with cross-sectional geometry of the femoral neck in Caucasian nuclear families. (Xiong DH, Liu YZ, Liu PY, Zhao LJ, Deng HW) Osteoporos Int 2005 Dec;16(12):2113-22 PMID 16292600
  • Mapping quantitative trait loci for cross-sectional geometry at the femoral neck. (Shen H, Long JR, Xiong DH, Liu YJ, Liu YZ, Xiao P, Zhao LJ, Dvornyk V, Zhang YY, Rocha-Sanchez S, Liu PY, Li JL, Deng HW) J Bone Miner Res 2005 Nov;20(11):1973-82 PMID 16234971
  • The oestrogen receptor alpha gene is linked and/or associated with age of menarche in different ethnic groups. (Long JR, Xu H, Zhao LJ, Liu PY, Shen H, Liu YJ, Xiong DH, Xiao P, Liu YZ, Dvornyk V, Li JL, Recker RR, Deng HW) J Med Genet 2005 Oct;42(10):796-800 PMID 16199553
  • Searching for obesity genes: progress and prospects. (Liu YJ, Xiao P, Xiong DH, Recker RR, Deng HW) Drugs Today (Barc) 2005 May;41(5):345-62 PMID 16082432
  • Association tests of interleukin-6 (IL-6) and type II tumor necrosis factor receptor (TNFR2) genes with bone mineral density in Caucasians using a re-sampling approach. (Xiao P, Liu PY, Lu Y, Guo YF, Xiong DH, Li LH, Recker RR, Deng HW) Hum Genet 2005 Aug;117(4):340-8 PMID 15906094
  • The genetics of osteoporosis. (Long JR, Xiong DH, Recker RR, Deng HW) Drugs Today (Barc) 2005 Mar;41(3):205-18 PMID 15883617
  • Vitamin D receptor gene polymorphisms are linked to and associated with adult height. (Xiong DH, Xu FH, Liu PY, Shen H, Long JR, Elze L, Recker RR, Deng HW) J Med Genet 2005 Mar;42(3):228-34 PMID 15744036
  • A survey of haplotype variants at several disease candidate genes: the importance of rare variants for complex diseases. (Liu PY, Zhang YY, Lu Y, Long JR, Shen H, Zhao LJ, Xu FH, Xiao P, Xiong DH, Liu YJ, Recker RR, Deng HW) J Med Genet 2005 Mar;42(3):221-7 PMID 15744035
  • Association between VDR ApaI polymorphism and hip bone mineral density can be modified by body mass index: a study on postmenopausal Chinese women. (Xu H, Xiong DH, Xu FH, Zhang YY, Lei SF, Deng HW) Acta Biochim Biophys Sin (Shanghai) 2005 Jan;37(1):61-7 PMID 15645083
  • APOE haplotypes influence bone mineral density in Caucasian males but not females. (Long JR, Liu PY, Liu YJ, Lu Y, Shen H, Zhao LJ, Xiong DH, Deng HW) Calcif Tissue Int 2004 Oct;75(4):299-304 PMID 15549644
  • Genetic dissection of human stature in a large sample of multiplex pedigrees. (Liu YZ, Xu FH, Shen H, Liu YJ, Zhao LJ, Long JR, Zhang YY, Xiao P, Xiong DH, Dvornyk V, Li JL, Conway T, Davies KM, Recker RR, Deng HW) Ann Hum Genet 2004 Sep;68(Pt 5):472-88 PMID 15469424
  • A genome-wide linkage scan for bone mineral density in an extended sample: evidence for linkage on 11q23 and Xq27. (Shen H, Zhang YY, Long JR, Xu FH, Liu YZ, Xiao P, Zhao LJ, Xiong DH, Liu YJ, Dvornyk V, Rocha-Sanchez S, Liu PY, Li JL, Conway T, Davies KM, Recker RR, Deng HW) J Med Genet 2004 Oct;41(10):743-51 PMID 15466007
  • Tests of linkage and/or association of TGF-beta1 and COL1A1 genes with bone mass. (Long JR, Liu PY, Lu Y, Dvornyk V, Xiong DH, Zhao LJ, Deng HW) Osteoporos Int 2005 Jan;16(1):86-92 PMID 15164160
  • Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes. (Long JR, Zhao LJ, Liu PY, Lu Y, Dvornyk V, Shen H, Liu YJ, Zhang YY, Xiong DH, Xiao P, Deng HW) BMC Genet 2004 May 24;5:11 PMID 15157284
  • Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis. (Dvornyk V, Long JR, Xiong DH, Liu PY, Zhao LJ, Shen H, Zhang YY, Liu YJ, Rocha-Sanchez S, Xiao P, Recker RR, Deng HW) BMC Genet 2004 Feb 25;5:4 PMID 15113403
  • Association between COL1A1 gene polymorphisms and bone size in Caucasians. (Long JR, Liu PY, Lu Y, Xiong DH, Zhao LJ, Zhang YY, Elze L, Recker RR, Deng HW) Eur J Hum Genet 2004 May;12(5):383-8 PMID 14722584
  • APOE and TGF-beta1 genes are associated with obesity phenotypes. (Long JR, Liu PY, Liu YJ, Lu Y, Xiong DH, Elze L, Recker RR, Deng HW) J Med Genet 2003 Dec;40(12):918-24 PMID 14684691
  • Pharmacogenomic approaches to osteoporosis. (Xiong DH, Long JR, Recker RR, Deng HW) Pharmacogenomics J 2003;3(5):261-3 PMID 14583795