Edward J. Zuperku PhD Online Profile
Professor
Medical College of Wisconsin
Department: Anesthesiology
Division: Research
Program: Zablocki Veterans Affairs Medical Center
Publications
Effects of anesthetics, sedatives, and opioids on ventilatory control. (Stuth EA, Stucke AG, Zuperku EJ) Compr Physiol 2012 Oct 1;2(4):2281-367 PMID 23720250 Pontine μ-opioid receptors mediate bradypnea caused by intravenous remifentanil infusions at clinically relevant concentrations in dogs. (Prkic I, Mustapic S, Radocaj T, Stucke AG, Stuth EA, Hopp FA, Dean C, Zuperku EJ) J Neurophysiol 2012 Nov;108(9):2430-41 PMID 22875901 The effect of caudal vs intravenous morphine on early extubation and postoperative analgesic requirements for stage 2 and 3 single-ventricle palliation: a double blind randomized trial. (Stuth EA, Berens RJ, Staudt SR, Robertson FA, Scott JP, Stucke AG, Hoffman GM, Troshynski TJ, Tweddell JS, Zuperku EJ) Paediatr Anaesth 2011 Apr;21(4):441-53 PMID 21306473 Clinically relevant infusion rates of mu-opioid agonist remifentanil cause bradypnea in decerebrate dogs but not via direct effects in the pre-Bötzinger complex region. (Mustapic S, Radocaj T, Sanchez A, Dogas Z, Stucke AG, Hopp FA, Stuth EA, Zuperku EJ) J Neurophysiol 2010 Jan;103(1):409-18 PMID 19906886 Role of inhibitory neurotransmission in the control of canine hypoglossal motoneuron activity in vivo. (Sanchez A, Mustapic S, Zuperku EJ, Stucke AG, Hopp FA, Stuth EA) J Neurophysiol 2009 Mar;101(3):1211-21 PMID 19091929 Opioid receptors on bulbospinal respiratory neurons are not activated during neuronal depression by clinically relevant opioid concentrations. (Stucke AG, Zuperku EJ, Sanchez A, Tonkovic-Capin M, Tonkovic-Capin V, Mustapic S, Stuth EA) J Neurophysiol 2008 Nov;100(5):2878-88 PMID 18815346 Anesthetic effects on synaptic transmission and gain control in respiratory control. (Stuth EA, Stucke AG, Brandes IF, Zuperku EJ) Respir Physiol Neurobiol 2008 Dec 10;164(1-2):151-9 PMID 18583201 Major components of endogenous neurotransmission underlying the discharge activity of hypoglossal motoneurons in vivo. (Zuperku EJ, Brandes IF, Stucke AG, Sanchez A, Hopp FA, Stuth EA) Adv Exp Med Biol 2008;605:279-84 PMID 18085286 Isoflurane depresses the response of inspiratory hypoglossal motoneurons to serotonin in vivo. (Brandes IF, Zuperku EJ, Stucke AG, Hopp FA, Jakovcevic D, Stuth EA) Anesthesiology 2007 Apr;106(4):736-45 PMID 17413911 Retrograde labeling reveals extensive distribution of genioglossal motoneurons possessing 5-HT2A receptors throughout the hypoglossal nucleus of adult dogs. (Brandes IF, Zuperku EJ, Dean C, Hopp FA, Jakovcevic D, Stuth EA) Brain Res 2007 Feb 9;1132(1):110-9 PMID 17188659 Central pathways of pulmonary and lower airway vagal afferents. (Kubin L, Alheid GF, Zuperku EJ, McCrimmon DR) J Appl Physiol 2006 Aug;101(2):618-27 PMID 16645192 Serotonergic modulation of inspiratory hypoglossal motoneurons in decerebrate dogs. (Brandes IF, Zuperku EJ, Stucke AG, Jakovcevic D, Hopp FA, Stuth EA) J Neurophysiol 2006 Jun;95(6):3449-59 PMID 16495364 Sevoflurane enhances gamma-aminobutyric acid type A receptor function and overall inhibition of inspiratory premotor neurons in a decerebrate dog model. (Stucke AG, Zuperku EJ, Krolo M, Brandes IF, Hopp FA, Kampine JP, Stuth EA) Anesthesiology 2005 Jul;103(1):57-64 PMID 15983457 Sevoflurane depresses glutamatergic neurotransmission to brainstem inspiratory premotor neurons but not postsynaptic receptor function in a decerebrate dog model. (Stucke AG, Zuperku EJ, Tonkovic-Capin V, Krolo M, Hopp FA, Kampine JP, Stuth EA) Anesthesiology 2005 Jul;103(1):50-6 PMID 15983456 Subtype composition and responses of respiratory neurons in the pre-botzinger region to pulmonary afferent inputs in dogs. (Krolo M, Tonkovic-Capin V, Stucke AG, Stuth EA, Hopp FA, Dean C, Zuperku EJ) J Neurophysiol 2005 May;93(5):2674-87 PMID 15601729 Halothane enhances gamma-aminobutyric acid receptor type A function but does not change overall inhibition in inspiratory premotor neurons in a decerebrate dog model. (Stucke AG, Zuperku EJ, Tonkovic-Capin V, Krolo M, Hopp FA, Kampine JP, Stuth EA) Anesthesiology 2003 Dec;99(6):1303-12 PMID 14639142 Halothane depresses glutamatergic neurotransmission to brain stem inspiratory premotor neurons in a decerebrate dog model. (Stucke AG, Zuperku EJ, Tonkovic-Capin V, Tonkovic-Capin M, Hopp FA, Kampine JP, Stuth EA) Anesthesiology 2003 Apr;98(4):897-905 PMID 12657851 Differential processing of excitation by GABAergic gain modulation in canine caudal ventral respiratory group neurons. (Tonkovic-Capin V, Stucke AG, Stuth EA, Tonkovic-Capin M, Hopp FA, McCrimmon DR, Zuperku EJ) J Neurophysiol 2003 Feb;89(2):862-70 PMID 12574464 Gain modulation of respiratory neurons. (Zuperku EJ, McCrimmon DR) Respir Physiol Neurobiol 2002 Jul;131(1-2):121-33 PMID 12107000 Respiratory rhythm generation: converging concepts from in vitro and in vivo approaches? (Ramirez JM, Zuperku EJ, Alheid GF, Lieske SP, Ptak K, McCrimmon DR) Respir Physiol Neurobiol 2002 Jul;131(1-2):43-56 PMID 12106994 Effects of halothane and sevoflurane on inhibitory neurotransmission to medullary expiratory neurons in a decerebrate dog model. (Stucke AG, Stuth EA, Tonkovic-Capin V, Tonkovic-Capin M, Hopp FA, Kampine JP, Zuperku EJ) Anesthesiology 2002 Apr;96(4):955-62 PMID 11964605 Differential modulation of respiratory neuronal discharge patterns by GABA(A) receptor and apamin-sensitive K(+) channel antagonism. (Tonkovic-Capin V, Stucke AG, Stuth EA, Tonkovic-Capin M, Krolo M, Hopp FA, McCrimmon DR, Zuperku EJ) J Neurophysiol 2001 Nov;86(5):2363-73 PMID 11698526 Effects of sevoflurane on excitatory neurotransmission to medullary expiratory neurons and on phrenic nerve activity in a decerebrate dog model. (Stucke AG, Stuth EA, Tonkovic-Capin V, Tonkovic-Capin M, Hopp FA, Kampine JP, Zuperku EJ) Anesthesiology 2001 Aug;95(2):485-91 PMID 11506124 Effects of halothane on excitatory neurotransmission to medullary expiratory neurons in a decerebrate dog model. (Stuth EA, Krolo M, Stucke AG, Tonkovic-Capin M, Tonkovic-Capin V, Hopp FA, Kampine JP, Zuperku EJ) Anesthesiology 2000 Dec;93(6):1474-81 PMID 11149443 Effect of central CO(2) drive on lung inflation responses of expiratory bulbospinal neurons in dogs. (Tonkovic-Capin M, Zuperku EJ, Stuth EA, Bajic J, Dogas Z, Hopp FA) Am J Physiol Regul Integr Comp Physiol 2000 Nov;279(5):R1606-18 PMID 11049842 Relative magnitude of tonic and phasic synaptic excitation of medullary inspiratory neurons in dogs. (Krolo M, Stuth EA, Tonkovic-Capin M, Hopp FA, McCrimmon DR, Zuperku EJ) Am J Physiol Regul Integr Comp Physiol 2000 Aug;279(2):R639-49 PMID 10938255 Pattern formation and rhythm generation in the ventral respiratory group. (McCrimmon DR, Monnier A, Hayashi F, Zuperku EJ) Clin Exp Pharmacol Physiol 2000 Jan-Feb;27(1-2):126-31 PMID 10696541 Unraveling the mechanism for respiratory rhythm generation. (McCrimmon DR, Ramirez JM, Alford S, Zuperku EJ) Bioessays 2000 Jan;22(1):6-9 PMID 10649284 Effects of halothane on synaptic neurotransmission to medullary expiratory neurons in the ventral respiratory group of dogs. (Stuth EA, Krolo M, Tonkovic-Capin M, Hopp FA, Kampine JP, Zuperku EJ) Anesthesiology 1999 Sep;91(3):804-14 PMID 10485792 Differential roles of ionotropic glutamate receptors in canine medullary inspiratory neurons of the ventral respiratory group. (Krolo M, Stuth EA, Tonkovic-Capin M, Dogas Z, Hopp FA, McCrimmon DR, Zuperku EJ) J Neurophysiol 1999 Jul;82(1):60-8 PMID 10400935 Differential effects of GABAA receptor antagonists in the control of respiratory neuronal discharge patterns. (Dogas Z, Krolo M, Stuth EA, Tonkovic-Capin M, Hopp FA, McCrimmon DR, Zuperku EJ) J Neurophysiol 1998 Nov;80(5):2368-77 PMID 9819249 Improved method of canine decerebration. (Tonkovic-Capin M, Krolo M, Stuth EA, Hopp FA, Zuperku EJ) J Appl Physiol 1998 Aug;85(2):747-50 PMID 9688755 Effects of halothane on the phrenic nerve responses to carbon dioxide mediated by carotid body chemoreceptors in vagotomized dogs. (Stuth EA, Dogas Z, Krolo M, Kampine JP, Hopp FA, Zuperku EJ) Anesthesiology 1997 Dec;87(6):1440-9 PMID 9416729 Dose-dependent effects of halothane on the phrenic nerve responses to acute hypoxia in vagotomized dogs. (Stuth EA, Dogas Z, Krolo M, Kampine JP, Hopp FA, Zuperku EJ) Anesthesiology 1997 Dec;87(6):1428-39 PMID 9416728 Modulation of the synaptic drive to respiratory premotor and motor neurons. (McCrimmon DR, Zuperku EJ, Hayashi F, Dogas Z, Hinrichsen CF, Stuth EA, Tonkovic-Capin M, Krolo M, Hopp FA) Respir Physiol 1997 Nov;110(2-3):161-76 PMID 9407609 Reflex effects of stimulation of sympathetic afferents on the triangularis sterni. (Coon RL, Hopp FA, Zuperku EJ) Respir Physiol 1995 Dec;102(2-3):187-94 PMID 8904010 NMDA receptor-mediated transmission of carotid body chemoreceptor input to expiratory bulbospinal neurones in dogs. (Dogas Z, Stuth EA, Hopp FA, McCrimmon DR, Zuperku EJ) J Physiol 1995 Sep 15;487 ( Pt 3):639-51 PMID 8544127 Dose-dependent effects of halothane on the carbon dioxide responses of expiratory and inspiratory bulbospinal neurons and the phrenic nerve activities in dogs. (Stuth EA, Tonkovic-Capin M, Kampine JP, Bajic J, Zuperku EJ) Anesthesiology 1994 Dec;81(6):1470-83 PMID 7992917 Interaction between chemoreceptor and stretch receptor inputs at medullary respiratory neurons. (Bajić J, Zuperku EJ, Tonković-Capin M, Hopp FA) Am J Physiol 1994 Jun;266(6 Pt 2):R1951-61 PMID 8024052 Expiratory bulbospinal neurons of dogs. II. Laterality of responses to spatial and temporal pulmonary vagal inputs. (Tonković-Capin M, Zuperku EJ, Bajić J, Hopp FA) Am J Physiol 1992 Jun;262(6 Pt 2):R1087-95 PMID 1621862 Expiratory bulbospinal neurons of dogs. I. Control of discharge patterns by pulmonary stretch receptors. (Bajić J, Zuperku EJ, Tonković-Capin M, Hopp FA) Am J Physiol 1992 Jun;262(6 Pt 2):R1075-86 PMID 1621861 Dose-dependent effects of isoflurane on the CO2 responses of expiratory medullary neurons and the phrenic nerve activities in dogs. (Stuth EA, Tonkovic-Capin M, Kampine JP, Zuperku EJ) Anesthesiology 1992 May;76(5):763-74 PMID 1575345 Respiratory responses to aortic and carotid chemoreceptor activation in the dog. (Hopp FA, Seagard JL, Bajić J, Zuperku EJ) J Appl Physiol 1991 Jun;70(6):2539-50 PMID 1885448 Reflex ventilatory effects of KCl stimulation of lung receptors with sympathetic afferents. (Coon RL, Clifford PS, Hopp FA, Zuperku EJ) Respir Physiol 1990 Dec;82(3):349-58 PMID 1964240 Processing of pulmonary afferent input patterns by respiratory I-beta neurons. (Bajić J, Zuperku EJ, Hopp FA) Am J Physiol 1989 Feb;256(2 Pt 2):R379-93 PMID 2492772 Control of discharge patterns of medullary respiratory neurons by pulmonary vagal afferent inputs. (Zuperku EJ, Hopp FA) Am J Physiol 1987 Dec;253(6 Pt 2):R809-20 PMID 3425759 Effect of arterial PCO2 on 2-[1-14C]deoxy-D-glucose uptake by feline cerebral arteries. (Kostreva DR, McNeely J, Zuperku EJ) J Appl Physiol 1986 Oct;61(4):1288-92 PMID 3096936 Mechanical effects of vasoactive drugs on carotid sinus. (Bell LB, Seagard JL, Zuperku EJ, Kampine JP) Am J Physiol 1986 Jun;250(6 Pt 2):R1074-80 PMID 3717381 Respiratory arrhythmias and airway CO2, lung receptors, and central inspiratory activity. (Coon RL, Zuperku EJ, Kampine JP) J Appl Physiol 1986 May;60(5):1713-21 PMID 3086282 Technique for continuous measurement of compliance in isolated vascular segments. (Bell LB, Zuperku EJ, Kampine JP) Am J Physiol 1986 Jan;250(1 Pt 2):R142-9 PMID 3942248 Autonomic modulation of refractoriness in canine specialized His-Purkinje system. (Turner LA, Zuperku EJ, Bosnjak ZJ, Kampine JP) Am J Physiol 1985 May;248(5 Pt 2):R515-23 PMID 3993811 On the relation between expiratory duration and subsequent inspiratory duration. (Zuperku EJ, Hopp FA) J Appl Physiol 1985 Feb;58(2):419-30 PMID 2984159 Systemic arterial pH servocontrolled ventilator simulation of the respiratory control system. (Coon RL, Zuperku EJ, Kampine JP) Respir Physiol 1984 Dec;58(3):345-50 PMID 6441984 Pulmonary denervation in the dog. (Clifford PS, Coon RL, von Colditz JH, Zuperku EJ, Kampine JP) J Appl Physiol 1983 Jun;54(6):1451-6 PMID 6874467 A programmable electrical stimulator suitable for control of respiration studies. (Hopp FA, Zuperku EJ, Kampine JP) J Appl Physiol 1983 Apr;54(4):1149-56 PMID 6687882 Central integration of pulmonary stretch receptor input in the control of expiration. (Zuperku EJ, Hopp FA, Kampine JP) J Appl Physiol 1982 May;52(5):1296-315 PMID 7096154 Interrelationships among airway CO2, airway pressure, and breathing frequency. (Nilsestuen JO, Coon RL, Zuperku EJ, Kampine JP) J Appl Physiol 1982 Jan;52(1):190-7 PMID 6800986 Measurement of dead space ventilation using a pHa servo-controlled ventilator. (Coon RL, Zuperku EJ, Kampine JP) J Appl Physiol 1981 Jul;51(1):154-9 PMID 7263410 Coarctation of the aorta and baroreceptor resetting. A study of carotid baroreceptor stimulus-response characteristics before and after surgical repair in the dog. (Igler FO, Boerboom LE, Werner PH, Donegan JH, Zuperku EJ, Bonchek LI, Kampine JP) Circ Res 1981 Mar;48(3):365-71 PMID 7460210 Segmental ventricular adjustments to brief periods of ischemia in the dog. (Bosnjak ZJ, Seagard JL, Zuperku EJ, Coon RL, Singh HM, Bamrah VS, Kampine JP) Can J Physiol Pharmacol 1981 Mar;59(3):287-92 PMID 6261904 Effect of anodal blockade of myelinated fibers on vagal C-fiber afferents. (Hopp FA, Zuperku EJ, Coon RL, Kampine JP) Am J Physiol 1980 Nov;239(5):R454-62 PMID 7435661 In vivo changes in canine ventricular cardiac conduction during halothane anesthesia. (Turner LA, Zuperku EJ, Purtock RV, Kampine JP) Anesth Analg 1980 May;59(5):327-34 PMID 7189379 Effect of sympathetic nerve stimulation on hypocapnic airway constriction. (Coon RL, Zuperku EJ, Kampine JP) Proc Soc Exp Biol Med 1980 May;164(1):63-8 PMID 6769131 Cardiac, aortic, pericardial, and pulmonary receptors in the dog. (Peters SR, Kostreva DR, Armour JA, Zuperku EJ, Igler FO, Coon RL, Kampine JP) Cardiology 1980;65(2):85-100 PMID 7363286 Breathing frequency responses to pulmonary CO2 in an isolated lobe of the canine lung. (Nilsestuen JO, Coon RL, Igler FO, Zuperku EJ, Kampine JP) J Appl Physiol 1979 Dec;47(6):1201-6 PMID 536290 Apnea, tachypnea, and hypotension elicited by cardiac vagal afferents. (Kostreva DR, Hopp FA, Zuperku EJ, Kampine JP) J Appl Physiol 1979 Aug;47(2):312-8 PMID 468686 Acute coronary artery occlusion and cardiac sympathetic afferent nerve activity. (Bosnjak ZJ, Zuperku EJ, Coon RL, Kampine JP) Proc Soc Exp Biol Med 1979 Jun;161(2):142-8 PMID 450919 Halothane, tracheal compliance and upper-airway mechanoreceptors. (Palmer SK, Zuperku EJ, Bosnjak Z, Coon RL, Kampine JP) Anesthesiology 1978 Oct;49(4):260-5 PMID 697080 Systemic arterial blood pH servocontrol of mechanical ventilation. (Coon RL, Zuperku EJ, Kampine JP) Anesthesiology 1978 Sep;49(3):201-4 PMID 28683 Respiratory inhibition with sympathetic afferent stimulation in the canine and primate. (Kostreva DR, Hopp FA, Zuperku EJ, Igler FO, Coon RL, Kampine JP) J Appl Physiol 1978 May;44(5):718-24 PMID 418050 Receptors in the canine lung which respond to vascular pressure changes. (Igler FO, Coon RL, Zuperku EJ, Kampine JP) Proc Soc Exp Biol Med 1978 Jan;157(1):36-40 PMID 202970 Reflex effects of thoracic sympathetic afferent nerve stimulation on the kidney. (Purtock RV, von Colditz JH, Seagard JL, Igler FO, Zuperku EJ, Kampine JP) Am J Physiol 1977 Nov;233(5):H580-6 PMID 920821 Ventral root mapping of cardiac nerves in the canine using evoked potentials. (Kostreva DR, Zuperku EJ, Cusick JF, Kampine JP) Am J Physiol 1977 Jun;232(6):H590-5 PMID 879297 Response of left ventricular mechanoreceptors to changes in pressure and muscle length. (Purtock RV, Zuperku EJ, Peters SR, Coon RL, Kampine JP) Proc Soc Exp Biol Med 1977 Apr;154(4):500-4 PMID 859855 Cardiac responses to stimulation of thoracic afferents in the primate and canine. (Kostreva DR, Hess GL, Zuperku EJ, Neumark J, Coon RL, Kampine JP) Am J Physiol 1976 Oct;231(4):1279-84 PMID 984213 Tracheal afferent nerves. (Traxel RM, Prudlow WF, Kampine JP, Coon RL, Zuperku EJ) Ann Otol Rhinol Laryngol 1976 Sep-Oct;85(5 Pt.1):664-9 PMID 984658 Sympathetic afferent nerve activity of right heart origin. (Kostreva DR, Zuperku EJ, Purtock RV, Coon RL, Kampine JP) Am J Physiol 1975 Oct;229(4):911-5 PMID 1190333 Pulmonary afferent activity recorded from sympathetic nerves. (Kostreva DR, Zuperku EJ, Hess GL, Coon RL, Kampine JP) J Appl Physiol 1975 Jul;39(1):37-40 PMID 1150589 Sympathetic afferent nerve activity of left ventricular origin. (Hess GL, Zuperku EJ, Coon RL, Kampine JP) Am J Physiol 1974 Sep;227(3):543-6 PMID 4416008 Upper airway protective reflexes. (Frisk JL, Titulaer RJ, Kampine J, Zuperku EJ) Surg Forum 1974;25(0):501-3 PMID 4439245 An on-line circuit for extraction of average evoked potentials from periodic noise. (Benoit HJ, Zuperku EJ, Sances A Jr, Larson SJ) J Assoc Adv Med Instrum 1972 Jul-Aug;6(4):279-82 PMID 4626443 Grants and Awards
Mu-Opioid Effects on the Central Mechanisms that Control Breathing (#9206196 04/01/2010 - 03/31/2014) Sponsor: Zablocki Veterans Affairs Medical Center
