Medical College of Wisconsin
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Ellis D. Avner MD

Ellis D. Avner MD

Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Nephrology

Member of the MCW Cancer Center


Leadership Positions

  • Associate Dean for Research
  • Founding Director, Children's Research Institute
  • Director, Research Center of Excellence in Pediatric Nephrology
  • Publications

  • Pathophysiology of childhood polycystic kidney diseases: new insights into disease-specific therapy. (Sweeney WE Jr, Avner ED) Pediatr Res 2014 Jan;75(1-2):148-57 PMID 24336431
  • Smac-mimetic-induced epithelial cell death reduces the growth of renal cysts. (Fan LX, Zhou X, Sweeney WE Jr, Wallace DP, Avner ED, Grantham JJ, Li X) J Am Soc Nephrol 2013 Dec;24(12):2010-22 PMID 23990677
  • Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease. (Zhou X, Fan LX, Sweeney WE Jr, Denu JM, Avner ED, Li X) J Clin Invest 2013 Jul 1;123(7):3084-98 PMID 23778143
  • New approaches to the autosomal recessive polycystic kidney disease patient with dual kidney-liver complications. (Telega G, Cronin D, Avner ED) Pediatr Transplant 2013 Jun;17(4):328-35 PMID 23593929
  • G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease. (Kwon M, Pavlov TS, Nozu K, Rasmussen SA, Ilatovskaya DV, Lerch-Gaggl A, North LM, Kim H, Qian F, Sweeney WE Jr, Avner ED, Blumer JB, Staruschenko A, Park F) Proc Natl Acad Sci U S A 2012 Dec 26;109(52):21462-7 PMID 23236168
  • HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells. (Liu W, Fan LX, Zhou X, Sweeney WE Jr, Avner ED, Li X) PLoS One 2012;7(11):e49418 PMID 23152903
  • Role of genetic modifiers in an orthologous rat model of ARPKD. (O'Meara CC, Hoffman M, Sweeney WE Jr, Tsaih SW, Xiao B, Jacob HJ, Avner ED, Moreno C) Physiol Genomics 2012 Aug 1;44(15):741-53 PMID 22669842
  • Transport, cilia, and PKD: must we in (cyst) on interrelationships? Focus on "Increased Na+/H+ exchanger activity on the apical surface of a cilium-deficient cortical collecting duct principal cell model of polycystic kidney disease". (Avner ED, McDonough AA, Sweeney WE Jr) Am J Physiol Cell Physiol 2012 May 15;302(10):C1434-5 PMID 22403786
  • Loss of activator of G-protein signaling 3 impairs renal tubular regeneration following acute kidney injury in rodents. (Regner KR, Nozu K, Lanier SM, Blumer JB, Avner ED, Sweeney WE Jr, Park F) FASEB J 2011 Jun;25(6):1844-55 PMID 21343176
  • Diagnosis and management of childhood polycystic kidney disease. (Sweeney WE Jr, Avner ED) Pediatr Nephrol 2011 May;26(5):675-92 PMID 21046169
  • Birth of a healthy infant following preimplantation PKHD1 haplotyping for autosomal recessive polycystic kidney disease using multiple displacement amplification. (Lau EC, Janson MM, Roesler MR, Avner ED, Strawn EY, Bick DP) J Assist Reprod Genet 2010 Jul;27(7):397-407 PMID 20490649
  • 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism. (Akbulut T, Regner KR, Roman RJ, Avner ED, Falck JR, Park F) Am J Physiol Renal Physiol 2009 Sep;297(3):F662-70 PMID 19570883
  • Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD. (Park F, Sweeney WE Jr, Jia G, Akbulut T, Mueller B, Falck JR, Birudaraju S, Roman RJ, Avner ED) Am J Physiol Renal Physiol 2009 Mar;296(3):F575-82 PMID 19129252
  • 20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease. (Park F, Sweeney WE, Jia G, Roman RJ, Avner ED) J Am Soc Nephrol 2008 Oct;19(10):1929-39 PMID 18596124
  • Src inhibition ameliorates polycystic kidney disease. (Sweeney WE Jr, von Vigier RO, Frost P, Avner ED) J Am Soc Nephrol 2008 Jul;19(7):1331-41 PMID 18385429
  • Renal cystic disease: new insights for the clinician. (Avner ED, Sweeney WE Jr) Pediatr Clin North Am 2006 Oct;53(5):889-909, ix PMID 17027616
  • Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: summary statement of a first National Institutes of Health/Office of Rare Diseases conference. (Gunay-Aygun M, Avner ED, Bacallao RL, Choyke PL, Flynn JT, Germino GG, Guay-Woodford L, Harris P, Heller T, Ingelfinger J, Kaskel F, Kleta R, LaRusso NF, Mohan P, Pazour GJ, Shneider BL, Torres VE, Wilson P, Zak C, Zhou J, Gahl WA) J Pediatr 2006 Aug;149(2):159-64 PMID 16887426
  • Molecular and cellular pathophysiology of autosomal recessive polycystic kidney disease (ARPKD). (Sweeney WE Jr, Avner ED) Cell Tissue Res 2006 Dec;326(3):671-85 PMID 16767405
  • Haplotype analysis improves molecular diagnostics of autosomal recessive polycystic kidney disease. (Consugar MB, Anderson SA, Rossetti S, Pankratz VS, Ward CJ, Torra R, Coto E, El-Youssef M, Kantarci S, Utsch B, Hildebrandt F, Sweeney WE, Avner ED, Torres VE, Cunningham JM, Harris PC) Am J Kidney Dis 2005 Jan;45(1):77-87 PMID 15696446
  • Epidermal growth factor receptor tyrosine kinase inhibition is not protective in PCK rats. (Torres VE, Sweeney WE Jr, Wang X, Qian Q, Harris PC, Frost P, Avner ED) Kidney Int 2004 Nov;66(5):1766-73 PMID 15496147
  • EGF-related growth factors in the pathogenesis of murine ARPKD. (MacRae Dell K, Nemo R, Sweeney WE Jr, Avner ED) Kidney Int 2004 Jun;65(6):2018-29 PMID 15149315
  • Survival of childhood polycystic kidney disease following renal transplantation: the impact of advanced hepatobiliary disease. (Davis ID, Ho M, Hupertz V, Avner ED) Pediatr Transplant 2003 Oct;7(5):364-9 PMID 14738296
  • EGF receptor tyrosine kinase inhibition attenuates the development of PKD in Han:SPRD rats. (Torres VE, Sweeney WE Jr, Wang X, Qian Q, Harris PC, Frost P, Avner ED) Kidney Int 2003 Nov;64(5):1573-9 PMID 14531789
  • Combination treatment of PKD utilizing dual inhibition of EGF-receptor activity and ligand bioavailability. (Sweeney WE Jr, Hamahira K, Sweeney J, Garcia-Gatrell M, Frost P, Avner ED) Kidney Int 2003 Oct;64(4):1310-9 PMID 12969149
  • Effect of the peritoneal dialysis prescription on pentosidine in children. (Bayazit AK, Vogt BA, Dell KM, Davis ID, Noyan A, Anarat A, Avner ED, Erhard P, Weiss MF) Pediatr Nephrol 2003 Oct;18(10):1049-54 PMID 12898376
  • Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells. (Grimm DH, Cai Y, Chauvet V, Rajendran V, Zeltner R, Geng L, Avner ED, Sweeney W, Somlo S, Caplan MJ) J Biol Chem 2003 Sep 19;278(38):36786-93 PMID 12840011
  • Complications of peritoneal dialysis in children with Eagle-Barrett syndrome. (Wisanuyotin S, Dell KM, Vogt BA, O'Riordan MA, Avner ED, Davis ID) Pediatr Nephrol 2003 Feb;18(2):159-63 PMID 12579407
  • Critical choices in mentoring the next generation of academic pediatricians: nine circles of hell or salvation? (Drotar D, Avner ED) J Pediatr 2003 Jan;142(1):1-2 PMID 12520243
  • Refinement of the autosomal recessive polycystic kidney disease (PKHD1) interval and exclusion of an EF hand-containing gene as a PKHD1 candidate gene. (Onuchic LF, Mrug M, Hou X, Eggermann T, Bergmann C, Zerres K, Avner ED, Furu L, Somlo S, Nagasawa Y, Germino GG, Guay-Woodford LM) Am J Med Genet 2002 Jul 15;110(4):346-52 PMID 12116208
  • PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats. (Onuchic LF, Furu L, Nagasawa Y, Hou X, Eggermann T, Ren Z, Bergmann C, Senderek J, Esquivel E, Zeltner R, Rudnik-Schöneborn S, Mrug M, Sweeney W, Avner ED, Zerres K, Guay-Woodford LM, Somlo S, Germino GG) Am J Hum Genet 2002 May;70(5):1305-17 PMID 11898128
  • Phenotypic analysis of conditionally immortalized cells isolated from the BPK model of ARPKD. (Sweeney WE Jr, Kusner L, Carlin CR, Chang S, Futey L, Cotton CU, Dell KM, Avner ED) Am J Physiol Cell Physiol 2001 Nov;281(5):C1695-705 PMID 11600434
  • A novel inhibitor of tumor necrosis factor-alpha converting enzyme ameliorates polycystic kidney disease. (Dell KM, Nemo R, Sweeney WE Jr, Levin JI, Frost P, Avner ED) Kidney Int 2001 Oct;60(4):1240-8 PMID 11576338
  • Can progression of autosomal dominant or autosomal recessive polycystic kidney disease be prevented? (Davis ID, MacRae Dell K, Sweeney WE, Avner ED) Semin Nephrol 2001 Sep;21(5):430-40 PMID 11559884
  • Expression of the orpk disease gene during kidney development and maturation. (Nakanishi K, Sweeney WE Jr, Avner ED, Murcia NS) Pediatr Nephrol 2001 Mar;16(3):219-26 PMID 11322368
  • Childhood ADPKD: answers and more questions. (Avner ED) Kidney Int 2001 May;59(5):1979-80 PMID 11318972
  • Role of CFTR in autosomal recessive polycystic kidney disease. (Nakanishi K, Sweeney WE Jr, Macrae Dell K, Cotton CU, Avner ED) J Am Soc Nephrol 2001 Apr;12(4):719-25 PMID 11274233
  • Renal dysfunction but not cystic change is ameliorated by neonatal epidermal growth factor in bpk mice. (Nakanishi K, Gattone VH 2nd, Sweeney WE, Avner ED) Pediatr Nephrol 2001 Jan;16(1):45-50 PMID 11198603
  • Segment-specific c-ErbB2 expression in human autosomal recessive polycystic kidney disease. (Nakanishi K, Sweeney W Jr, Avner ED) J Am Soc Nephrol 2001 Feb;12(2):379-84 PMID 11158230
  • Generation and phenotype of cell lines derived from CF and non-CF mice that carry the H-2K(b)-tsA58 transgene. (Takacs-Jarrett M, Sweeney WE, Avner ED, Cotton CU) Am J Physiol Cell Physiol 2001 Jan;280(1):C228-36 PMID 11121394
  • Genomic structure of the gene for the human P1 protein (MCM3) and its exclusion as a candidate for autosomal recessive polycystic kidney disease. (Hofmann Y, Becker J, Wright F, Avner ED, Mrug M, Guay-Woodford LM, Somlo S, Zerres K, Germino GG, Onuchic LF) Eur J Hum Genet 2000 Mar;8(3):163-6 PMID 10780780
  • Proximal tubular cysts in fetal human autosomal recessive polycystic kidney disease. (Nakanishi K, Sweeney WE Jr, Zerres K, Guay-Woodford LM, Avner ED) J Am Soc Nephrol 2000 Apr;11(4):760-3 PMID 10752536
  • Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor. (Sweeney WE, Chen Y, Nakanishi K, Frost P, Avner ED) Kidney Int 2000 Jan;57(1):33-40 PMID 10620185
  • Genomic organization of the KIAA0057 gene that encodes a TRAM-like protein and its exclusion as a polycystic kidney and hepatic disease 1 (PKHD1) candidate gene. (Onuchic LF, Mrug M, Lakings AL, Muecher G, Becker J, Zerres K, Avner ED, Dixit M, Somlo S, Germino GG, Guay-Woodford LM) Mamm Genome 1999 Dec;10(12):1175-8 PMID 10594243
  • Glomerulosclerosis and hypoplasia--a common theme? (Avner ED) Kidney Int 1999 Nov;56(5):1962-3 PMID 10571808
  • Cellular pathophysiology of cystic kidney disease: insight into future therapies. (Avner ED, Woychik RP, Dell KM, Sweeney WE) Int J Dev Biol 1999;43(5):457-61 PMID 10535324
  • In vitro modulation of cyst formation by a novel tyrosine kinase inhibitor. (Sweeney WE, Futey L, Frost P, Avner ED) Kidney Int 1999 Aug;56(2):406-13 PMID 10432378
  • Safety and efficacy of erythropoietin in children with chronic renal failure. (Brandt JR, Avner ED, Hickman RO, Watkins SL) Pediatr Nephrol 1999 Feb;13(2):143-7 PMID 10229004
  • New insights into the molecular pathophysiology of polycystic kidney disease. (Murcia NS, Sweeney WE Jr, Avner ED) Kidney Int 1999 Apr;55(4):1187-97 PMID 10200981
  • A 1-Mb BAC/PAC-based physical map of the autosomal recessive polycystic kidney disease gene (PKHD1) region on chromosome 6. (Park JH, Dixit MP, Onuchic LF, Wu G, Goncharuk AN, Kneitz S, Santarina LB, Hayashi T, Avner ED, Guay-Woodford L, Zerres K, Germino GG, Somlo S) Genomics 1999 Apr 15;57(2):249-55 PMID 10198164
  • Pediatric renal transplantation: indications and special considerations. A position paper from the Pediatric Committee of the American Society of Transplant Physicians. (Davis ID, Bunchman TE, Grimm PC, Benfield MR, Briscoe DM, Harmon WE, Alexander SR, Avner ED) Pediatr Transplant 1998 May;2(2):117-29 PMID 10082443
  • The molecular biology of polycystic kidney disease. (Murcia NS, Woychik RP, Avner ED) Pediatr Nephrol 1998 Nov;12(9):721-6 PMID 9874315
  • PKD and CF: an interesting family provides insight into the molecular pathophysiology of polycystic kidney disease. (Cotton CU, Avner ED) Am J Kidney Dis 1998 Dec;32(6):1081-3 PMID 9856528
  • Morphological and functional characterization of a conditionally immortalized collecting tubule cell line. (Takacs-Jarrett M, Sweeney WE, Avner ED, Cotton CU) Am J Physiol 1998 Nov;275(5 Pt 2):F802-11 PMID 9815138
  • Functional activity of epidermal growth factor receptors in autosomal recessive polycystic kidney disease. (Sweeney WE Jr, Avner ED) Am J Physiol 1998 Sep;275(3 Pt 2):F387-94 PMID 9729511
  • Functional genomics in the post-genome era. (Woychik RP, Klebig ML, Justice MJ, Magnuson TR, Avner ED) Mutat Res 1998 May 25;400(1-2):3-14 PMID 9685569
  • Cholelithiasis following Escherichia coli O157:H7-associated hemolytic uremic syndrome. (Brandt JR, Joseph MW, Fouser LS, Tarr PI, Zelikovic I, McDonald RA, Avner ED, McAfee NG, Watkins SL) Pediatr Nephrol 1998 Apr;12(3):222-5 PMID 9630042
  • Cell and molecular biology of kidney development. (Orellana SA, Avner ED) Semin Nephrol 1998 May;18(3):233-43 PMID 9613864
  • The role of hepatocyte growth factor (HGF) at progressive stages of metanephric development. (Sweeney WE Jr, Avner ED) In Vitro Cell Dev Biol Anim 1998 Feb;34(2):189-94 PMID 9542659
  • Pediatric renal biopsy: should this procedure be performed in an outpatient setting? (Davis ID, Oehlenschlager W, O'Riordan MA, Avner ED) Pediatr Nephrol 1998 Feb;12(2):96-100 PMID 9543363
  • Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease. (Richards WG, Sweeney WE, Yoder BK, Wilkinson JE, Woychik RP, Avner ED) J Clin Invest 1998 Mar 1;101(5):935-9 PMID 9486961
  • Prenatal diagnosis of autosomal recessive polycystic kidney disease (ARPKD): molecular genetics, clinical experience, and fetal morphology. (Zerres K, Mücher G, Becker J, Steinkamm C, Rudnik-Schöneborn S, Heikkilä P, Rapola J, Salonen R, Germino GG, Onuchic L, Somlo S, Avner ED, Harman LA, Stockwin JM, Guay-Woodford LM) Am J Med Genet 1998 Mar 5;76(2):137-44 PMID 9511976
  • Improved outcome of young children on nightly automated peritoneal dialysis. (Becker N, Brandt JR, Sutherland TA, Avner ED, Watkins SL) Pediatr Nephrol 1997 Dec;11(6):676-9 PMID 9438640
  • Efficacy of taxol in the orpk mouse model of polycystic kidney disease. (Sommardahl CS, Woychik RP, Sweeney WE, Avner ED, Wilkinson JE) Pediatr Nephrol 1997 Dec;11(6):728-33 PMID 9438653
  • Differential rescue of the renal and hepatic disease in an autosomal recessive polycystic kidney disease mouse mutant. A new model to study the liver lesion. (Yoder BK, Richards WG, Sommardahl C, Sweeney WE, Michaud EJ, Wilkinson JE, Avner ED, Woychik RP) Am J Pathol 1997 Jun;150(6):2231-41 PMID 9176412
  • An integrated genetic and physical map of the autosomal recessive polycystic kidney disease region. (Lens XM, Onuchic LF, Wu G, Hayashi T, Daoust M, Mochizuki T, Santarina LB, Stockwin JM, Mücher G, Becker J, Sweeny WE Jr, Avner ED, Guay-Woodford L, Zerres K, Somlo S, Germino GG) Genomics 1997 May 1;41(3):463-6 PMID 9169147
  • Evidence that two phenotypically distinct mouse PKD mutations, bpk and jcpk, are allelic. (Guay-Woodford LM, Bryda EC, Christine B, Lindsey JR, Collier WR, Avner ED, D'Eustachio P, Flaherty L) Kidney Int 1996 Oct;50(4):1158-65 PMID 8887273
  • Functional correction of renal defects in a mouse model for ARPKD through expression of the cloned wild-type Tg737 cDNA. (Yoder BK, Richards WG, Sommardahl C, Sweeney WE, Michaud EJ, Wilkinson JE, Avner ED, Woychik RP) Kidney Int 1996 Oct;50(4):1240-8 PMID 8887283
  • Novel Madin Darby canine kidney cell clones exhibit unique phenotypes in response to morphogens. (Orellana SA, Neff CD, Sweeney WE, Avner ED) In Vitro Cell Dev Biol Anim 1996 Jun;32(6):329-39 PMID 8842747
  • Alternate-day steroid dosing improves growth without adversely affecting graft survival or long-term graft function. A report of the North American Pediatric Renal Transplant Cooperative Study. (Jabs K, Sullivan EK, Avner ED, Harmon WE) Transplantation 1996 Jan 15;61(1):31-6 PMID 8560569
  • Clinical quiz. Differential diagnosis of a patient with hypertension. (Holleman R, Avner ED) Pediatr Nephrol 1995 Dec;9(6):783-4 PMID 8747126
  • Clinical quiz. Differential diagnosis of a patient with Wegener's granulomatosis. (Becker N, Rutledge JC, Avner ED) Pediatr Nephrol 1995 Dec;9(6):785-7 PMID 8747127
  • Congenital nephropathies and uropathies. (Becker N, Avner ED) Pediatr Clin North Am 1995 Dec;42(6):1319-41 PMID 8614589
  • 1 alpha, 25-dihydroxyvitamin D3 receptor ontogenesis in fetal renal development. (Johnson JA, Grande JP, Roche PC, Sweeney WE Jr, Avner ED, Kumar R) Am J Physiol 1995 Sep;269(3 Pt 2):F419-28 PMID 7573491
  • Metabolic studies of rat renal tubule cells loaded with cystine: the cystine dimethylester model of cystinosis. (Foreman JW, Benson LL, Wellons M, Avner ED, Sweeney W, Nissim I, Nissim I) J Am Soc Nephrol 1995 Aug;6(2):269-72 PMID 7579095
  • Cystic maldevelopment of the kidney. (Orellana SA, Avner ED) Semin Nephrol 1995 Jul;15(4):341-52 PMID 7569413
  • Biliary epithelial cells from mice with congenital polycystic kidney disease are hyperresponsive to epidermal growth factor. (Nauta J, Sweeney WE, Rutledge JC, Avner ED) Pediatr Res 1995 Jun;37(6):755-63 PMID 7651760
  • The severe perinatal form of autosomal recessive polycystic kidney disease maps to chromosome 6p21.1-p12: implications for genetic counseling. (Guay-Woodford LM, Muecher G, Hopkins SD, Avner ED, Germino GG, Guillot AP, Herrin J, Holleman R, Irons DA, Primack W) Am J Hum Genet 1995 May;56(5):1101-7 PMID 7726165
  • Hypercalciuria and nephrocalcinosis in the oculocerebrorenal syndrome. (Sliman GA, Winters WD, Shaw DW, Avner ED) J Urol 1995 Apr;153(4):1244-6 PMID 7869519
  • Tyrosine kinase activity of the EGF receptor in murine metanephric organ culture. (Pugh JL, Sweeney WE Jr, Avner ED) Kidney Int 1995 Mar;47(3):774-81 PMID 7752576
  • Renal transplantation and chronic dialysis in children and adolescents: the 1993 annual report of the North American Pediatric Renal Transplant Cooperative Study. (Avner ED, Chavers B, Sullivan EK, Tejani A) Pediatr Nephrol 1995 Feb;9(1):61-73 PMID 7742226
  • Epidermal growth factor receptor expression is abnormal in murine polycystic kidney. (Orellana SA, Sweeney WE, Neff CD, Avner ED) Kidney Int 1995 Feb;47(2):490-9 PMID 7723235
  • Clinical disorders of water metabolism: hyponatremia and hypernatremia. (Avner ED) Pediatr Ann 1995 Jan;24(1):23-30 PMID 7715960
  • Introduction: Fluid and Electrolytes. (Avner ED) Pediatr Ann 1995 Jan 1;24(1):15 PMID 24856964
  • Escherichia coli O 157:H7-associated hemolytic-uremic syndrome after ingestion of contaminated hamburgers. (Brandt JR, Fouser LS, Watkins SL, Zelikovic I, Tarr PI, Nazar-Stewart V, Avner ED) J Pediatr 1994 Oct;125(4):519-26 PMID 7931869
  • Gene time for polycystic kidney disease. (Avner ED) Lancet 1994 Sep 24;344(8926):833-4 PMID 7916394
  • Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice. (Moyer JH, Lee-Tischler MJ, Kwon HY, Schrick JJ, Avner ED, Sweeney WE, Godfrey VL, Cacheiro NL, Wilkinson JE, Woychik RP) Science 1994 May 27;264(5163):1329-33 PMID 8191288
  • Renal developmental diseases. (Avner ED) Semin Nephrol 1993 Sep;13(5):427-35 PMID 8210806
  • Renal and biliary abnormalities in a new murine model of autosomal recessive polycystic kidney disease. (Nauta J, Ozawa Y, Sweeney WE Jr, Rutledge JC, Avner ED) Pediatr Nephrol 1993 Apr;7(2):163-72 PMID 8476712
  • A new murine model of autosomal recessive polycystic kidney disease. (Ozawa Y, Nauta J, Sweeney WE, Avner ED) Nihon Jinzo Gakkai Shi 1993 Apr;35(4):349-54 PMID 8341011
  • Normal and abnormal nephrogenesis. (Fouser L, Avner ED) Am J Kidney Dis 1993 Jan;21(1):64-70 PMID 8418629
  • Epithelial polarity and differentiation in polycystic kidney disease. (Avner ED) J Cell Sci Suppl 1993;17:217-22 PMID 8144700
  • Abnormal sodium pump distribution during renal tubulogenesis in congenital murine polycystic kidney disease. (Avner ED, Sweeney WE Jr, Nelson WJ) Proc Natl Acad Sci U S A 1992 Aug 15;89(16):7447-51 PMID 1323837
  • The case against screening urinalyses for asymptomatic bacteriuria in children. (Kemper KJ, Avner ED) Am J Dis Child 1992 Mar;146(3):343-6 PMID 1543183
  • Pathophysiology of renal tubular cyst formation in murine models of polycystic kidney disease. (Sweeney WE Jr, Avner ED) Contrib Nephrol 1992;97:23-34 PMID 1633715
  • Inherited polycystic kidney disease in children. (McDonald RA, Avner ED) Semin Nephrol 1991 Nov;11(6):632-42 PMID 1767136
  • Localization of arginine biosynthetic enzymes in renal proximal tubules and abundance of mRNA during development. (Morris SM Jr, Sweeney WE Jr, Kepka DM, O'Brien WE, Avner ED) Pediatr Res 1991 Feb;29(2):151-4 PMID 2014150
  • Polypeptide growth factors in metanephric growth and segmental nephron differentiation. (Avner ED, Sweeney WE Jr) Pediatr Nephrol 1990 Jul;4(4):372-7 PMID 2206907
  • Polypeptide growth factors and the kidney: a developmental perspective. (Avner ED) Pediatr Nephrol 1990 Jul;4(4):345-53 PMID 2206902
  • In vitro modulation of tubular cyst regression in murine polycystic kidney disease. (Avner ED, Sweeney WE Jr, Ellis D) Kidney Int 1989 Dec;36(6):960-8 PMID 2557482
  • Choice of urine sample predictive of microalbuminuria in patients with insulin-dependent diabetes mellitus. (Ellis D, Coonrod BA, Dorman JS, Kelsey SF, Becker DJ, Avner ED, Orchard TJ) Am J Kidney Dis 1989 Apr;13(4):321-8 PMID 2705450
  • Abundance of mRNAs encoding urea cycle enzymes in fetal and neonatal mouse liver. (Morris SM Jr, Kepka DM, Sweeney WE Jr, Avner ED) Arch Biochem Biophys 1989 Feb 15;269(1):175-80 PMID 2464968
  • Regulation of glucocorticoid receptors and Na-K ATPase activity by hydrocortisone in proximal tubular epithelial cells. (Ellis D, Sothi TD, Curthoys NP, Ballou B, Avner ED) In Vitro Cell Dev Biol 1988 Aug;24(8):811-6 PMID 2900828
  • Congenital murine polycystic kidney disease. II. Pathogenesis of tubular cyst formation. (Avner ED, Sweeney WE Jr, Young MC, Ellis D) Pediatr Nephrol 1988 Apr;2(2):210-8 PMID 2856368
  • Immunocytochemical localization of gamma-glutamyltranspeptidase during fetal development of mouse kidney. (Curto KA, Sweeney WE, Avner ED, Piesco NP, Curthoys NP) J Histochem Cytochem 1988 Feb;36(2):159-66 PMID 2891746
  • Renal cystic disease. Insights from recent experimental investigations. (Avner ED) Nephron 1988;48(2):89-93 PMID 3278246
  • Renal epithelial development in organotypic culture. (Avner ED, Piesco NP, Sweeney WE Jr, Ellis D) Pediatr Nephrol 1988 Jan;2(1):92-9 PMID 3153007
  • Glucocorticoids modulate renal glucocorticoid receptors and Na-K ATPase activity. (Ellis D, Sothi TD, Avner ED) Kidney Int 1987 Oct;32(4):464-71 PMID 2828745
  • Congenital murine polycystic kidney disease. I. The ontogeny of tubular cyst formation. (Avner ED, Studnicki FE, Young MC, Sweeney WE Jr, Piesco NP, Ellis D, Fettermann GH) Pediatr Nephrol 1987 Oct;1(4):587-96 PMID 3153336
  • Triiodothyronine-induced cyst formation in metanephric organ culture: the role of increased Na-K-adenosine triphosphatase activity. (Avner ED, Sweeney WE Jr, Piesco NP, Ellis D) J Lab Clin Med 1987 Apr;109(4):441-53 PMID 3029256
  • Silica and glomerulonephritis: case report and review of the literature. (Osorio AM, Thun MJ, Novak RF, Van Cura EJ, Avner ED) Am J Kidney Dis 1987 Mar;9(3):224-30 PMID 3030097
  • Reversible inhibition of cytosolic glucocorticoid receptors by mercurial agents. Application in the measurement of total and unoccupied receptors. (Ellis D, Tran SD, Eagon PK, Avner ED) J Recept Res 1987;7(5):761-74 PMID 3656273
  • Renal failure and dialysis therapy in children with hepatic failure in the perioperative period of orthotopic liver transplantation. (Ellis D, Avner ED) Clin Nephrol 1986 Jun;25(6):295-303 PMID 3524924
  • Partial characterization and ontogeny of renal cytosolic glucocorticoid receptors in mouse kidney. (Ellis D, Turocy JF, Sweeney WE Jr, Avner ED) J Steroid Biochem 1986 May;24(5):997-1003 PMID 3724151
  • Renal failure in children with hepatic failure undergoing liver transplantation. (Ellis D, Avner ED, Starzl TE) J Pediatr 1986 Mar;108(3):393-8 PMID 3512808
  • Regression of genetically determined polycystic kidney disease in murine organ culture. (Avner ED, Sweeney WE Jr, Piesco NP, Ellis D) Experientia 1986 Jan 15;42(1):77-80 PMID 3943602
  • Effects of improved glycemic control on microalbuminuria in adolescents with insulin-dependent diabetes mellitus. (Ellis D, Avner ED, Kurs-Lasky M, Richards M, Becker DJ) Int J Pediatr Nephrol 1986 Jan-Mar;7(1):31-8 PMID 3957559
  • Renal function and somatic growth in pediatric cadaveric renal transplantation with cyclosporine-prednisone immunosuppression. (Ellis D, Avner ED, Rosenthal JT, Taylor RJ, Young LW, Palumbi MA, Hakala TR) Am J Dis Child 1985 Nov;139(11):1161-7 PMID 3904407
  • Sodium-potassium ATPase activity mediates cyst formation in metanephric organ culture. (Avner ED, Sweeney WE Jr, Finegold DN, Piesco NP, Ellis D) Kidney Int 1985 Sep;28(3):447-55 PMID 2999498
  • Growth factor requirements of organogenesis in serum-free metanephric organ culture. (Avner ED, Sweeney WE Jr, Piesco NP, Ellis D) In Vitro Cell Dev Biol 1985 May;21(5):297-304 PMID 3894316
  • A new model of glucocorticoid-induced metanephric maldevelopment. (Avner ED, Sweeney WE Jr, Piesco NP, Ellis D) Experientia 1984 May 15;40(5):489-90 PMID 6723915
  • Hydrocortisone-induced cystic metanephric maldevelopment in serum-free organ culture. (Avner ED, Piesco NP, Sweeney WE Jr, Studnicki FM, Fetterman GH, Ellis D) Lab Invest 1984 Feb;50(2):208-18 PMID 6694360
  • Veno-occlusive disease of the liver associated with cysteamine treatment of nephropathic cystinosis. (Avner ED, Ellis D, Jaffe R) J Pediatr 1983 May;102(5):793-6 PMID 6842343
  • Diabetic nephropathy in adolescence: appearance during improved glycemic control. (Ellis D, Avner ED, Transue D, Yunis EJ, Drash AL, Becker DJ) Pediatrics 1983 May;71(5):824-9 PMID 6340051
  • Single-dose amoxicillin therapy of uncomplicated pediatric urinary tract infections. (Avner ED, Ingelfinger JR, Herrin JT, Link DA, Marcus E, Tolkoff-Rubin NE, Russell-Getz L, Rubin RH) J Pediatr 1983 Apr;102(4):623-7 PMID 6339708
  • An organ culture model for the study of metanephric development. (Avner ED, Villee DB, Schneeberger EE, Grupe WE) J Urol 1983 Mar;129(3):660-4 PMID 6834572
  • Development of renal basement membrane glycoproteins in metanephric organ culture. (Avner ED, Jaffe R, Temple T, Ellis D, Chung AE) Lab Invest 1983 Mar;48(3):263-8 PMID 6827806
  • Cyst formation in metanephric organ culture induced by cis-dichlorodiammineplatinum (II). (Avner ED, Sweeney WE Jr, Ellis D) Experientia 1983 Jan 15;39(1):74-6 PMID 6681778
  • Metanephric development in serum-free organ culture. (Avner ED, Ellis D, Temple T, Jaffe R) In Vitro 1982 Aug;18(8):675-82 PMID 7129481
  • Neonatal radiocontrast nephropathy simulating infantile polycystic kidney disease. (Avner ED, Ellis D, Jaffe R, Bowen A) J Pediatr 1982 Jan;100(1):85-7 PMID 7199081
  • Mortality of chronic hemodialysis and renal transplantation in pediatric end-stage renal disease. (Avner ED, Harmon WE, Grupe WE, Ingelfinger JR, Eraklis AJ, Levey RH) Pediatrics 1981 Mar;67(3):412-6 PMID 7017579
  • Mortality of chronic hemodialysis comparable to that of renal transplantation in pediatric end-stage renal disease. (Avner ED, Harmon WE, Ingelfinger JR, Levey RH, Grupe WE) Proc Clin Dial Transplant Forum 1979;9:1-4 PMID 399499
  • Letter: Hypoglycorrachia in young infants with viral meningitis. (Avner ED, Satz J, Plotkin SA) J Pediatr 1975 Nov;87(5):833-4 PMID 1185362
  • Grants and Awards

  • Integrative Biology of Childhood Kidney Disease (#9204838 08/10/2007 - 05/31/2013) Sponsor: NIH Diabetes, Digestive and Kidney Diseases
  • 20-HETE Inhibition in Polycystic Kidney Disease (#9306030 02/26/2013 - 09/08/2014) Sponsor: Taisho Pharmaceutical