Garrett J. Gross PhD Online Profile
Professor
Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Pharmacology
Publications
Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. (Gross GJ, Hsu A, Pfeiffer AW, Nithipatikom K) J Mol Cell Cardiol 2013 Jun;59:20-9 PMID 23419451 Response. (Lam V, Su J, Koprowski S, Hsu A, Tweddell JS, Rafiee P, Gross GJ, Salzman NH, Baker JE) FASEB J 2012 Nov;26(11):4388-9 PMID 23118151 Acute and chronic cardioprotection by the enkephalin analogue, Eribis peptide 94, is mediated via activation of nitric oxide synthase and adenosine triphosphate-regulated potassium channels. (Gross GJ, Hsu A, Nithipatikom K, Pfeiffer AW, Bobrova I, Bissessar E) Pharmacology 2012;90(1-2):110-6 PMID 22814415 Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction. (Gross GJ, Hsu A, Gross ER, Falck JR, Nithipatikom K) J Cardiovasc Pharmacol Ther 2013 Jan;18(1):38-45 PMID 22407888 Intestinal microbiota determine severity of myocardial infarction in rats. (Lam V, Su J, Koprowski S, Hsu A, Tweddell JS, Rafiee P, Gross GJ, Salzman NH, Baker JE) FASEB J 2012 Apr;26(4):1727-35 PMID 22247331 Eribis peptide 94 reduces infarct size in rat hearts via activation of centrally located μ opioid receptors. (Gross GJ, Hsu A, Nithipatikom K, Bobrova I, Bissessar E) J Cardiovasc Pharmacol 2012 Feb;59(2):194-7 PMID 22130105 Dose-dependent cardioprotection of enkephalin analogue Eribis peptide 94 and cardiac expression of opioid receptors in a porcine model of ischaemia and reperfusion. (Karlsson LO, Bergh N, Li L, Bissessar E, Bobrova I, Gross GJ, Akyürek LM, Grip L) Eur J Pharmacol 2012 Jan 15;674(2-3):378-83 PMID 22119384 Protection from myocardial ischemia/reperfusion injury by a positive allosteric modulator of the A₃ adenosine receptor. (Du L, Gao ZG, Nithipatikom K, Ijzerman AP, Veldhoven JP, Jacobson KA, Gross GJ, Auchampach JA) J Pharmacol Exp Ther 2012 Jan;340(1):210-7 PMID 22011434 Abdominal surgical incision induces remote preconditioning of trauma (RPCT) via activation of bradykinin receptors (BK2R) and the cytochrome P450 epoxygenase pathway in canine hearts. (Gross GJ, Baker JE, Moore J, Falck JR, Nithipatikom K) Cardiovasc Drugs Ther 2011 Dec;25(6):517-22 PMID 21786213 Characterization of a critical role for CFTR chloride channels in cardioprotection against ischemia/reperfusion injury. (Xiang SY, Ye LL, Duan LL, Liu LH, Ge ZD, Auchampach JA, Gross GJ, Duan DD) Acta Pharmacol Sin 2011 Jun;32(6):824-33 PMID 21642951 Evidence for pleiotropic effects of phosphodiesterase-5 (PDE5) inhibitors: emerging concepts in cancer and cardiovascular medicine. (Gross GJ) Circ Res 2011 Apr 29;108(9):1040-1 PMID 21527741 Are we putting too much stock in mice? (Auchampach JA, Maas JE, Wan TC, Figler RA, Gross GJ) J Mol Cell Cardiol 2011 Mar;50(3):584-5 PMID 21129379 Effect on ex vivo platelet aggregation and in vivo cyclic flow with Na+/H+ exchange inhibition: Gumina, NHE-1 inhibition and platelet aggregation. (Gumina RJ, Newman PJ, Gross GJ) J Thromb Thrombolysis 2011 May;31(4):431-5 PMID 21082215 Sustained ligand-activated preconditioning via δ-opioid receptors. (Peart JN, Hoe LE, Gross GJ, Headrick JP) J Pharmacol Exp Ther 2011 Jan;336(1):274-81 PMID 20947639 Evidence that the acute phase of ischemic preconditioning does not require signaling by the A 2B adenosine receptor. (Maas JE, Wan TC, Figler RA, Gross GJ, Auchampach JA) J Mol Cell Cardiol 2010 Nov;49(5):886-93 PMID 20797398 Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts. (Gross GJ, Baker JE, Hsu A, Wu HE, Falck JR, Nithipatikom K) Am J Physiol Heart Circ Physiol 2010 Jun;298(6):H2201-7 PMID 20400686 Review article: epoxyeicosatrienoic acids: novel mediators of cardioprotection. (Nithipatikom K, Gross GJ) J Cardiovasc Pharmacol Ther 2010 Jun;15(2):112-9 PMID 20200327 Isoflurane postconditioning protects against reperfusion injury by preventing mitochondrial permeability transition by an endothelial nitric oxide synthase-dependent mechanism. (Ge ZD, Pravdic D, Bienengraeber M, Pratt PF Jr, Auchampach JA, Gross GJ, Kersten JR, Warltier DC) Anesthesiology 2010 Jan;112(1):73-85 PMID 19996950 Acute methadone treatment reduces myocardial infarct size via the delta-opioid receptor in rats during reperfusion. (Gross ER, Hsu AK, Gross GJ) Anesth Analg 2009 Nov;109(5):1395-402 PMID 19843777 Evidence for role of epoxyeicosatrienoic acids in mediating ischemic preconditioning and postconditioning in dog. (Gross GJ, Gauthier KM, Moore J, Campbell WB, Falck JR, Nithipatikom K) Am J Physiol Heart Circ Physiol 2009 Jul;297(1):H47-52 PMID 19448143 Soluble epoxide hydrolase: a new target for cardioprotection. (Gross GJ, Nithipatikom K) Curr Opin Investig Drugs 2009 Mar;10(3):253-8 PMID 19333883 Ischemic Preconditioning And Myocardial Infarction: An Update and Perspective. (Gross ER, Gross GJ) Drug Discov Today Dis Mech 2007;4(3):165-174 PMID 18701939 Activation of kappa-opioid receptors at reperfusion affords cardioprotection in both rat and mouse hearts. (Peart JN, Gross ER, Reichelt ME, Hsu A, Headrick JP, Gross GJ) Basic Res Cardiol 2008 Sep;103(5):454-63 PMID 18500486 A neutralizing leptin receptor antibody mitigates hypertrophy and hemodynamic dysfunction in the postinfarcted rat heart. (Purdham DM, Rajapurohitam V, Zeidan A, Huang C, Gross GJ, Karmazyn M) Am J Physiol Heart Circ Physiol 2008 Jul;295(1):H441-6 PMID 18469142 Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. (Gross GJ, Gauthier KM, Moore J, Falck JR, Hammock BD, Campbell WB, Nithipatikom K) Am J Physiol Heart Circ Physiol 2008 Jun;294(6):H2838-44 PMID 18441205 Delayed cardioprotection afforded by the glycogen synthase kinase 3 inhibitor SB-216763 occurs via a KATP- and MPTP-dependent mechanism at reperfusion. (Gross ER, Hsu AK, Gross GJ) Am J Physiol Heart Circ Physiol 2008 Mar;294(3):H1497-500 PMID 18223186 Roles of epoxyeicosatrienoic acids in vascular regulation and cardiac preconditioning. (Gauthier KM, Yang W, Gross GJ, Campbell WB) J Cardiovasc Pharmacol 2007 Dec;50(6):601-8 PMID 18091575 Gadolinium limits myocardial infarction in the rat: dose-response, temporal relations and mechanisms. (Nicolosi AC, Strande JL, Hsu A, Fu X, Su J, Gross GJ, Baker JE) J Mol Cell Cardiol 2008 Feb;44(2):345-51 PMID 18083188 Inhibiting protease-activated receptor 4 limits myocardial ischemia/reperfusion injury in rat hearts by unmasking adenosine signaling. (Strande JL, Hsu A, Su J, Fu X, Gross GJ, Baker JE) J Pharmacol Exp Ther 2008 Mar;324(3):1045-54 PMID 18055876 Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia. (Dhanasekaran A, Gruenloh SK, Buonaccorsi JN, Zhang R, Gross GJ, Falck JR, Patel PK, Jacobs ER, Medhora M) Am J Physiol Heart Circ Physiol 2008 Feb;294(2):H724-35 PMID 18055514 Human thrombopoietin reduces myocardial infarct size, apoptosis, and stunning following ischaemia/reperfusion in rats. (Baker JE, Su J, Hsu A, Shi Y, Zhao M, Strande JL, Fu X, Xu H, Eis A, Komorowski R, Jensen ES, Tweddell JS, Rafiee P, Gross GJ) Cardiovasc Res 2008 Jan;77(1):44-53 PMID 18006466 The A3 adenosine receptor agonist CP-532,903 [N6-(2,5-dichlorobenzyl)-3'-aminoadenosine-5'-N-methylcarboxamide] protects against myocardial ischemia/reperfusion injury via the sarcolemmal ATP-sensitive potassium channel. (Wan TC, Ge ZD, Tampo A, Mio Y, Bienengraeber MW, Tracey WR, Gross GJ, Kwok WM, Auchampach JA) J Pharmacol Exp Ther 2008 Jan;324(1):234-43 PMID 17906066 Remote preconditioning-endocrine factors in organ protection against ischemic injury. (Bolte CS, Liao S, Gross GJ, Schultz Jel J) Endocr Metab Immune Disord Drug Targets 2007 Sep;7(3):167-75 PMID 17897043 Pharmacologic therapeutics for cardiac reperfusion injury. (Gross ER, Gross GJ) Expert Opin Emerg Drugs 2007 Sep;12(3):367-88 PMID 17874967 Nitrite confers protection against myocardial infarction: role of xanthine oxidoreductase, NADPH oxidase and K(ATP) channels. (Baker JE, Su J, Fu X, Hsu A, Gross GJ, Tweddell JS, Hogg N) J Mol Cell Cardiol 2007 Oct;43(4):437-44 PMID 17765919 Darbepoetin alfa protects the rat heart against infarction: dose-response, phase of action, and mechanisms. (Baker JE, Kozik D, Hsu AK, Fu X, Tweddell JS, Gross GJ) J Cardiovasc Pharmacol 2007 Jun;49(6):337-45 PMID 17577097 Opioids and myocardial reperfusion injury. (Gross GJ, Peart JN) Arch Mal Coeur Vaiss 2007 Mar;100(3):231-7 PMID 17536429 SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts. (Strande JL, Hsu A, Su J, Fu X, Gross GJ, Baker JE) Basic Res Cardiol 2007 Jul;102(4):350-8 PMID 17468933 GSK3beta inhibition and K(ATP) channel opening mediate acute opioid-induced cardioprotection at reperfusion. (Gross ER, Hsu AK, Gross GJ) Basic Res Cardiol 2007 Jul;102(4):341-9 PMID 17450314 Impaired p38 MAPK/HSP27 signaling underlies aging-related failure in opioid-mediated cardioprotection. (Peart JN, Gross ER, Headrick JP, Gross GJ) J Mol Cell Cardiol 2007 May;42(5):972-80 PMID 17407780 Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts. (Gross GJ, Hsu A, Falck JR, Nithipatikom K) J Mol Cell Cardiol 2007 Mar;42(3):687-91 PMID 17217955 Diabetes abolishes morphine-induced cardioprotection via multiple pathways upstream of glycogen synthase kinase-3beta. (Gross ER, Hsu AK, Gross GJ) Diabetes 2007 Jan;56(1):127-36 PMID 17192474 Role of epoxyeicosatrienoic acids in protecting the myocardium following ischemia/reperfusion injury. (Seubert JM, Zeldin DC, Nithipatikom K, Gross GJ) Prostaglandins Other Lipid Mediat 2007 Jan;82(1-4):50-9 PMID 17164132 Retrometabolic syntheses of astaxanthin (3,3'-dihydroxy-beta,beta-carotene-4,4'-dione) conjugates: a novel approach to oral and parenteral cardio-protection. (Lockwood SF, Jackson HL, Gross GJ) Cardiovasc Hematol Agents Med Chem 2006 Oct;4(4):335-49 PMID 17073610 Reperfusion injury: does it exist? (Gross GJ, Auchampach JA) J Mol Cell Cardiol 2007 Jan;42(1):12-8 PMID 17069848 Cl-IB-MECA [2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide] reduces ischemia/reperfusion injury in mice by activating the A3 adenosine receptor. (Ge ZD, Peart JN, Kreckler LM, Wan TC, Jacobson MA, Gross GJ, Auchampach JA) J Pharmacol Exp Ther 2006 Dec;319(3):1200-10 PMID 16985166 Cardioprotective effects of acute and chronic opioid treatment are mediated via different signaling pathways. (Peart JN, Gross GJ) Am J Physiol Heart Circ Physiol 2006 Oct;291(4):H1746-53 PMID 16731654 The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta. (Gross ER, Hsu AK, Gross GJ) Am J Physiol Heart Circ Physiol 2006 Aug;291(2):H827-34 PMID 16517948 Protection of adult rat cardiac myocytes from ischemic cell death: role of caveolar microdomains and delta-opioid receptors. (Patel HH, Head BP, Petersen HN, Niesman IR, Huang D, Gross GJ, Insel PA, Roth DM) Am J Physiol Heart Circ Physiol 2006 Jul;291(1):H344-50 PMID 16501018 Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury. (Nithipatikom K, Moore JM, Isbell MA, Falck JR, Gross GJ) Am J Physiol Heart Circ Physiol 2006 Aug;291(2):H537-42 PMID 16473964 Ligand triggers of classical preconditioning and postconditioning. (Gross ER, Gross GJ) Cardiovasc Res 2006 May 1;70(2):212-21 PMID 16448635 Seven day oral supplementation with Cardax (disodium disuccinate astaxanthin) provides significant cardioprotection and reduces oxidative stress in rats. (Gross GJ, Hazen SL, Lockwood SF) Mol Cell Biochem 2006 Feb;283(1-2):23-30 PMID 16444582 Cardioprotective-mimetics reduce myocardial infarct size in animals resistant to ischemic preconditioning. (Gumina RJ, El Schultz J, Moore J, Beier N, Schelling P, Gross GJ) Cardiovasc Drugs Ther 2005 Oct;19(5):315-22 PMID 16382293 Remote preconditioning and delayed cardioprotection in skeletal muscle. (Gross GJ) Am J Physiol Regul Integr Comp Physiol 2005 Dec;289(6):R1562-3 PMID 16278340 Disodium disuccinate astaxanthin (Cardax): antioxidant and antiinflammatory cardioprotection. (Lockwood SF, Gross GJ) Cardiovasc Drug Rev 2005;23(3):199-216 PMID 16252014 Effects of selective inhibition of cytochrome P-450 omega-hydroxylases and ischemic preconditioning in myocardial protection. (Nithipatikom K, Endsley MP, Moore JM, Isbell MA, Falck JR, Campbell WB, Gross GJ) Am J Physiol Heart Circ Physiol 2006 Feb;290(2):H500-5 PMID 16214838 [Contribution of the endogenous opioid system to regulation of heart resistance to the arrhythmogenic effect of short-term ischemia and reperfusio]. (Maslov LN, Liishmanov AIu, Budankova EV, Stakheev DL, Solenkova NV, Barzakh EI, Oeltgen PR, Gross GJ, Chang WS) Izv Akad Nauk Ser Biol 2005 Jul-Aug(4):453-9 PMID 16212267 ARD-353 [4-((2R,5S)-4-(R)-(4-diethylcarbamoylphenyl)(3-hydroxyphenyl)methyl)-2,5-dimethylpiperazin-1-ylmethyl)benzoic acid], a novel nonpeptide delta receptor agonist, reduces myocardial infarct size without central effects. (Watson MJ, Holt JD, O'Neill SJ, Wei K, Pendergast W, Gross GJ, Gengo PJ, Chang KJ) J Pharmacol Exp Ther 2006 Jan;316(1):423-30 PMID 16188952 Postischemic administration of CGX-1051, a peptide from cone snail venom, reduces infarct size in both rat and dog models of myocardial ischemia and reperfusion. (Lubbers NL, Campbell TJ, Polakowski JS, Bulaj G, Layer RT, Moore J, Gross GJ, Cox BF) J Cardiovasc Pharmacol 2005 Aug;46(2):141-6 PMID 16044024 Cross-talk between adenosine and opioid receptors. (Peart JN, Gross GJ) Drug News Perspect 2005 May;18(4):237-42 PMID 16034479 Role of endogenous opioid receptor agonists in regulation of heart resistance to the arrhythmogenic action of short-term ischemia and reperfusion. (Maslov LN, Lishmanov YB, Naryzhnaya NV, Budankova EV, Stakheev DL, Solenkova NV, Barzakh EI, Oeltgen PR, Gross GJ) Bull Exp Biol Med 2005 Feb;139(2):172-5 PMID 16027798 Acute and chronic administration of disodium disuccinate astaxanthin (Cardax) produces marked cardioprotection in dog hearts. (Gross GJ, Lockwood SF) Mol Cell Biochem 2005 Apr;272(1-2):221-7 PMID 16010990 Cytochrome P450 and arachidonic acid metabolites: role in myocardial ischemia/reperfusion injury revisited. (Gross GJ, Falck JR, Gross ER, Isbell M, Moore J, Nithipatikom K) Cardiovasc Res 2005 Oct 1;68(1):18-25 PMID 15993870 Opioid-induced preconditioning: recent advances and future perspectives. (Peart JN, Gross ER, Gross GJ) Vascul Pharmacol 2005 Apr-May;42(5-6):211-8 PMID 15922254 Pharmacological preconditioning: Potential new treatment modalities for the ischemic myocardium. (Gross GJ) Vascul Pharmacol 2005 Apr-May;42(5-6):199 PMID 15922252 Cardioprotection following adenosine kinase inhibition in rat hearts. (Peart JN, Gross GJ) Basic Res Cardiol 2005 Jul;100(4):328-36 PMID 15795795 Sildenafil and endothelial dysfunction in humans. (Gross GJ) Circulation 2005 Feb 15;111(6):721-3 PMID 15710774 Mitochondrial ATP-sensitive potassium channels and myocardial hypertrophy. (Gross GJ) J Mol Cell Cardiol 2005 Feb;38(2):237-9 PMID 15698829 Extending the cardioprotective window using a novel delta-opioid agonist fentanyl isothiocyanate via the PI3-kinase pathway. (Gross ER, Peart JN, Hsu AK, Auchampach JA, Gross GJ) Am J Physiol Heart Circ Physiol 2005 Jun;288(6):H2744-9 PMID 15653765 Cytochrome P450 omega-hydroxylase inhibition reduces infarct size during reperfusion via the sarcolemmal KATP channel. (Gross ER, Nithipatikom K, Hsu AK, Peart JN, Falck JR, Campbell WB, Gross GJ) J Mol Cell Cardiol 2004 Dec;37(6):1245-9 PMID 15572055 [Endogenic opioid peptides and antiarrhythmic effect of adaptation to stress]. (Maslov LN, Naryzhnaia NV, Krylatov AV, Gross GJ) Patol Fiziol Eksp Ter 2004 Oct-Dec(4):11-4 PMID 15568495 Sarcolemmal KATP channel triggers delayed ischemic preconditioning in rats. (Patel HH, Gross ER, Peart JN, Hsu AK, Gross GJ) Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H445-7 PMID 15563543 Anandamide content is increased and CB1 cannabinoid receptor blockade is protective during transient, focal cerebral ischemia. (Muthian S, Rademacher DJ, Roelke CT, Gross GJ, Hillard CJ) Neuroscience 2004;129(3):743-50 PMID 15541895 [Antiarrhythmic and cardioprotective effect of stimulation of delta1-opiate receptors in myocardial ischemia and reperfusion]. (Lasukova TV, Krylatov AV, Maslov LN, Lishmanov IuB, Gross GJ, Podoksenov IuK, Podoksenov AIu) Patol Fiziol Eksp Ter 2004 Jul-Sep(3):12-5 PMID 15446414 Inhibition of cytochrome P450omega-hydroxylase: a novel endogenous cardioprotective pathway. (Nithipatikom K, Gross ER, Endsley MP, Moore JM, Isbell MA, Falck JR, Campbell WB, Gross GJ) Circ Res 2004 Oct 15;95(8):e65-71 PMID 15388642 [The effect of K(ATP)-channel activation on the electrical stability of myocardium in rats with postinfarction cardiosclerosis]. (Solenkova NV, Maslov LN, Serebrov VIu, Lishmanov AIu, Bogomaz SA, Gross GJ, Grover GJ) Eksp Klin Farmakol 2004 May-Jun;67(3):10-3 PMID 15341059 Cardioprotection in chronically hypoxic rabbits persists on exposure to normoxia: role of NOS and KATP channels. (Fitzpatrick CM, Shi Y, Hutchins WC, Su J, Gross GJ, Ostadal B, Tweddell JS, Baker JE) Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H62-8 PMID 15319200 Chronic exposure to morphine produces a marked cardioprotective phenotype in aged mouse hearts. (Peart JN, Gross GJ) Exp Gerontol 2004 Jul;39(7):1021-6 PMID 15236761 Effect of COX-1/COX-2 inhibition versus selective COX-2 inhibition on coronary vasodilator responses to arachidonic acid and acetylcholine. (Gross GJ, Moore J) Pharmacology 2004 Jul;71(3):135-42 PMID 15161995 Cardioprotection and myocardial salvage by a disodium disuccinate astaxanthin derivative (Cardax). (Gross GJ, Lockwood SF) Life Sci 2004 May 28;75(2):215-24 PMID 15120573 COX-2 and iNOS in opioid-induced delayed cardioprotection in the intact rat. (Patel HH, Hsu AK, Gross GJ) Life Sci 2004 May 28;75(2):129-40 PMID 15120566 Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction. (Peart JN, Gross ER, Gross GJ) J Cardiovasc Pharmacol 2004 Mar;43(3):410-5 PMID 15076225 [The role of delta-1 opiate receptors in regulation of contractility in isolated rat heart during normal oxygenation and ischemia-reperfusion]. (Lasukova TV, Maslov LN, Lishmanov IuB, Gross GJ) Izv Akad Nauk Ser Biol 2004 Jan-Feb(1):92-9 PMID 15049074 [The role of opiate receptors and ATP-dependent potassium channels of mitochondria in the formation of myocardial adaptive resistance to the arrhythmogenic effect of ischemia and reperfusion]. (Lishmanov IuB, Naryzhnaia NV, Krylatov AV, Maslov LN, Bogomaz SA, Ugdyzhekova DS, Gross GJ, Stefano JB) Izv Akad Nauk Ser Biol 2003 Nov-Dec(6):720-7 PMID 14994477 Acute aspirin treatment abolishes, whereas acute ibuprofen treatment enhances morphine-induced cardioprotection: role of 12-lipoxygenase. (Gross ER, Hsu AK, Gross GJ) J Pharmacol Exp Ther 2004 Jul;310(1):185-91 PMID 14993258 Morphine-tolerant mice exhibit a profound and persistent cardioprotective phenotype. (Peart JN, Gross GJ) Circulation 2004 Mar 16;109(10):1219-22 PMID 14993125 Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts. (Gross ER, Hsu AK, Gross GJ) Circ Res 2004 Apr 16;94(7):960-6 PMID 14976126 Delayed cardioprotection is mediated via a non-peptide delta opioid agonist, SNC-121, independent of opioid receptor stimulation. (Patel HH, Hsu A, Gross GJ) Basic Res Cardiol 2004 Jan;99(1):38-45 PMID 14685704 Exogenous activation of delta- and kappa-opioid receptors affords cardioprotection in isolated murine heart. (Peart JN, Gross GJ) Basic Res Cardiol 2004 Jan;99(1):29-37 PMID 14685703 Comparison of three different A1 adenosine receptor antagonists on infarct size and multiple cycle ischemic preconditioning in anesthetized dogs. (Auchampach JA, Jin X, Moore J, Wan TC, Kreckler LM, Ge ZD, Narayanan J, Whalley E, Kiesman W, Ticho B, Smits G, Gross GJ) J Pharmacol Exp Ther 2004 Mar;308(3):846-56 PMID 14634049 Selective ATP-sensitive potassium channel openers: fact or fiction. (Gross GJ) J Mol Cell Cardiol 2003 Sep;35(9):1005-7 PMID 12967620 KATP channels and myocardial preconditioning: an update. (Gross GJ, Peart JN) Am J Physiol Heart Circ Physiol 2003 Sep;285(3):H921-30 PMID 12915383 K(ATP) opener-induced delayed cardioprotection: involvement of sarcolemmal and mitochondrial K(ATP) channels, free radicals and MEK1/2. (Gross ER, Peart JN, Hsu AK, Grover GJ, Gross GJ) J Mol Cell Cardiol 2003 Aug;35(8):985-92 PMID 12878485 Delta-opioid receptor activation mimics ischemic preconditioning in the canine heart. (Peart JN, Patel HH, Gross GJ) J Cardiovasc Pharmacol 2003 Jul;42(1):78-81 PMID 12827030 Role of opioids in acute and delayed preconditioning. (Gross GJ) J Mol Cell Cardiol 2003 Jul;35(7):709-18 PMID 12818560 Activation of peripheral delta opioid receptors eliminates cardiac electrical instability in a rat model of post-infarction cardiosclerosis via mitochondrial ATP-dependent K+ channels. (Maslov LN, Lishmanov YB, Solenkova NV, Gross GJ, Stefano GB, Tam SW) Life Sci 2003 Jul 4;73(7):947-52 PMID 12798419 A3 adenosine receptor agonist IB-MECA reduces myocardial ischemia-reperfusion injury in dogs. (Auchampach JA, Ge ZD, Wan TC, Moore J, Gross GJ) Am J Physiol Heart Circ Physiol 2003 Aug;285(2):H607-13 PMID 12689858 [The opiatergic link between the antiarrhythmic effect of adaptation and hypoxia in the model of ischemia and reperfusion in vivo]. (Lishmanov IuB, Naryzhnaia NV, Maslov LN, Gross GJ) Patol Fiziol Eksp Ter 2003 Jan-Mar(1):19-21 PMID 12652938 Adenosine and opioid receptor-mediated cardioprotection in the rat: evidence for cross-talk between receptors. (Peart JN, Gross GJ) Am J Physiol Heart Circ Physiol 2003 Jul;285(1):H81-9 PMID 12637353 12-lipoxygenase in opioid-induced delayed cardioprotection: gene array, mass spectrometric, and pharmacological analyses. (Patel HH, Fryer RM, Gross ER, Bundey RA, Hsu AK, Isbell M, Eusebi LO, Jensen RV, Gullans SR, Insel PA, Nithipatikom K, Gross GJ) Circ Res 2003 Apr 4;92(6):676-82 PMID 12623876 Sarcolemmal and mitochondrial K(ATP) channels and myocardial ischemic preconditioning. (Peart JN, Gross GJ) J Cell Mol Med 2002 Oct-Dec;6(4):453-64 PMID 12611635 Morphine enhances pharmacological preconditioning by isoflurane: role of mitochondrial K(ATP) channels and opioid receptors. (Ludwig LM, Patel HH, Gross GJ, Kersten JR, Pagel PS, Warltier DC) Anesthesiology 2003 Mar;98(3):705-11 PMID 12606915 Comparison of cardioprotective efficacy of two thromboxane A2 receptor antagonists. (Ge ZD, Auchampach JA, Piper GM, Gross GJ) J Cardiovasc Pharmacol 2003 Mar;41(3):481-8 PMID 12605028 Effect of in vivo and in vitro stimulation of delta1-opioid receptors on myocardial resistance to arrhythmogenic action of ischemia and reperfusion. (Lasukova TV, Krylatov AV, Maslov LN, Lishmanov YB, Gross GJ, Stefano GB) Bull Exp Biol Med 2002 Oct;134(4):359-62 PMID 12533759 The role of mitochondrial K(ATP) channels in the antiarrhythmic effects of ischaemic preconditioning in dogs. (Gross GJ) Br J Pharmacol 2002 Dec;137(7):939-40 PMID 12429563 Cardioprotection at a distance: mesenteric artery occlusion protects the myocardium via an opioid sensitive mechanism. (Patel HH, Moore J, Hsu AK, Gross GJ) J Mol Cell Cardiol 2002 Oct;34(10):1317-23 PMID 12392992 [Interactions of peripheral mu-opioid receptors and K(ATP)-channels in regulation of cardiac electrical stability in ischemia, reperfusion, and postinfarction cardiosclerosis]. (Maslov LN, Krylatov AV, Naryzhaia NV, Solenkova NV, Lishmanov AIu, Bogomaz SA, Gross GJ, Stefano JB, Loktiushina BA) Ross Fiziol Zh Im I M Sechenova 2002 Jul;88(7):842-50 PMID 12238351 Delta opioid agonists and volatile anesthetics facilitate cardioprotection via potentiation of K(ATP) channel opening. (Patel HH, Ludwig LM, Fryer RM, Hsu AK, Warltier DC, Gross GJ) FASEB J 2002 Sep;16(11):1468-70 PMID 12205051 Sarcolemmal K(ATP) channel triggers opioid-induced delayed cardioprotection in the rat. (Patel HH, Hsu AK, Peart JN, Gross GJ) Circ Res 2002 Aug 9;91(3):186-8 PMID 12169643 Therapeutic receptor targets of ischemic preconditioning. (Fryer RM, Auchampach JA, Gross GJ) Cardiovasc Res 2002 Aug 15;55(3):520-5 PMID 12160948 Editorial view: anesthetic preconditioning: serendipity and science. (Warltier DC, Kersten JR, Pagel PS, Gross GJ) Anesthesiology 2002 Jul;97(1):1-3 PMID 12131096 Receptor specificity of the antiarrhythmic effect produced by opioid peptides Dalargin and DADLE during myocardial reperfusion. (Naryzhnaya NV, Maslov LN, Lishmanov YB, Gross GJ) Bull Exp Biol Med 2002 Apr;133(4):336-8 PMID 12124638 Myocardial ischemia and reperfusion reduce the levels of cyclic ADP-ribose in rat myocardium. (Ge ZD, Li PL, Chen YF, Gross GJ, Zou AP) Basic Res Cardiol 2002 Jul;97(4):312-9 PMID 12111041 Delayed cardioprotection by isoflurane: role of K(ATP) channels. (Tonkovic-Capin M, Gross GJ, Bosnjak ZJ, Tweddell JS, Fitzpatrick CM, Baker JE) Am J Physiol Heart Circ Physiol 2002 Jul;283(1):H61-8 PMID 12063275 Attenuation of heat shock-induced cardioprotection by treatment with the opiate receptor antagonist naloxone. (Patel HH, Hsu A, Gross GJ) Am J Physiol Heart Circ Physiol 2002 Jun;282(6):H2011-7 PMID 12003805 Prologue: nonclassical modalities of myocardial preconditioning. (Gross GJ, Warltier DC) Am J Physiol Heart Circ Physiol 2002 Jun;282(6):H1951-2 PMID 12003797 PKC-delta inhibition does not block preconditioning-induced preservation in mitochondrial ATP synthesis and infarct size reduction in rats. (Fryer RM, Hsu AK, Wang Y, Henry M, Eells J, Gross GJ) Basic Res Cardiol 2002 Jan;97(1):47-54 PMID 11998977 Models of cardiac ischemia-reperfusion injury in dogs and rats. (Gross GJ) Curr Protoc Pharmacol 2002 May 1;Chapter 5:Unit 5.27 PMID 22294078 [Stimulation of peripheral delta1-opioid receptors as a method of preventing ischemic and reperfusion arrhythmia: role of K(ATP)-channels]. (Maslov LN, Krylatov AV, Lishmanov AIu, Podoksenov IuK, Solenkova NV, Bogomaz SA, Tam SW, Gross GJ) Eksp Klin Farmakol 2001 Nov-Dec;64(6):27-30 PMID 11871232 [Role of delta opioid receptors and their ligands in the development of adaptive heart protection against arrhythmogenesis]. (Naryzhnaia NV, Krylatov AV, Maslov LN, Lishmanov IuB, Gross GJ, Stephano JB) Ross Fiziol Zh Im I M Sechenova 2001 Dec;87(12):1617-25 PMID 11845802 The disputed role of COX-2 in myocardial infarction, is the jury still out? (Patel HH, Gross GJ) J Mol Cell Cardiol 2002 Jan;34(1):1-3 PMID 11812159 [Participation of K(ATP)-channels in cardioprotective effect of mu-opioid receptor agonists in acute ischemia and reperfusion of the isolated heart]. (Maslov LN, Lasukova TV, Solenkova NV, Lishmanov AIu, Bogomaz SA, Tam SV, Gross GJ) Eksp Klin Farmakol 2001 Sep-Oct;64(5):23-7 PMID 11764493 Characteristics and superoxide-induced activation of reconstituted myocardial mitochondrial ATP-sensitive potassium channels. (Zhang DX, Chen YF, Campbell WB, Zou AP, Gross GJ, Li PL) Circ Res 2001 Dec 7;89(12):1177-83 PMID 11739283 Blocking Na(+)/H(+) exchange reduces [Na(+)](i) and [Ca(2+)](i) load after ischemia and improves function in intact hearts. (An J, Varadarajan SG, Camara A, Chen Q, Novalija E, Gross GJ, Stowe DF) Am J Physiol Heart Circ Physiol 2001 Dec;281(6):H2398-409 PMID 11709405 Dependence of delta1-opioid receptor-induced cardioprotection on a tyrosine kinase-dependent but not a Src-dependent pathway. (Fryer RM, Wang Y, Hsu AK, Nagase H, Gross GJ) J Pharmacol Exp Ther 2001 Nov;299(2):477-82 PMID 11602657 Diazoxide induced cardioprotection: what comes first, K(ATP) channels or reactive oxygen species? (Patel HH, Gross GJ) Cardiovasc Res 2001 Sep;51(4):633-6 PMID 11530096 Do NHE inhibition and ischemic preconditioning convey cardioprotection through a common mechanism? (Gumina RJ, Terzic A, Gross GJ) Basic Res Cardiol 2001 Jul;96(4):318-24 PMID 11518187 Sodium/hydrogen exchange and cardioprotection. (Gross GJ) Basic Res Cardiol 2001 Jul;96(4):299-300 PMID 11518183 Stress-activated protein kinase phosphorylation during cardioprotection in the ischemic myocardium. (Fryer RM, Patel HH, Hsu AK, Gross GJ) Am J Physiol Heart Circ Physiol 2001 Sep;281(3):H1184-92 PMID 11514286 Na(+)/H(+) exchange inhibition prevents endothelial dysfunction after I/R injury. (Gumina RJ, Moore J, Schelling P, Beier N, Gross GJ) Am J Physiol Heart Circ Physiol 2001 Sep;281(3):H1260-6 PMID 11514295 [Effect of stimulation of mu-opiate receptors on contractility of the isolated heart in normal oxygenation and during ischemia-reperfusion]. (Lasukova TV, Maslov LN, Lishmanov IuB, Tam SV, Gross GJ) Ross Fiziol Zh Im I M Sechenova 2001 May;87(5):649-58 PMID 11452799 BW373U86, a delta opioid agonist, partially mediates delayed cardioprotection via a free radical mechanism that is independent of opioid receptor stimulation. (Patel HH, Hsu A, Moore J, Gross GJ) J Mol Cell Cardiol 2001 Aug;33(8):1455-65 PMID 11448134 Production and metabolism of ceramide in normal and ischemic-reperfused myocardium of rats. (Zhang DX, Fryer RM, Hsu AK, Zou AP, Gross GJ, Campbell WB, Li PL) Basic Res Cardiol 2001 May-Jun;96(3):267-74 PMID 11403420 Sarcolemmal and mitochondrial K(atp)channels mediate cardioprotection in chronically hypoxic hearts. (Kong X, Tweddell JS, Gross GJ, Baker JE) J Mol Cell Cardiol 2001 May;33(5):1041-5 PMID 11343425 Cardioprotection: emerging pharmacotherapy. (Gumina RJ, Jahangir A, Gross GJ, Terzic A) Expert Opin Pharmacother 2001 May;2(5):739-52 PMID 11336619 ERK and p38 MAP kinase activation are components of opioid-induced delayed cardioprotection. (Fryer RM, Hsu AK, Gross GJ) Basic Res Cardiol 2001 Apr;96(2):136-42 PMID 11327331 Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs. (Nithipatikom K, DiCamelli RF, Kohler S, Gumina RJ, Falck JR, Campbell WB, Gross GJ) Anal Biochem 2001 May 1;292(1):115-24 PMID 11319825 Opioids and cardioprotection. (Schultz JE, Gross GJ) Pharmacol Ther 2001 Feb;89(2):123-37 PMID 11316516 Mitochondrial K(ATP) channel opening is important during index ischemia and following myocardial reperfusion in ischemic preconditioned rat hearts. (Fryer RM, Hsu AK, Gross GJ) J Mol Cell Cardiol 2001 Apr;33(4):831-4 PMID 11273735 Cardioprotection is strain dependent in rat in response to whole body hyperthermia. (Patel HH, Hsu A, Gross GJ) Am J Physiol Heart Circ Physiol 2001 Mar;280(3):H1208-14 PMID 11179065 Essential activation of PKC-delta in opioid-initiated cardioprotection. (Fryer RM, Wang Y, Hsu AK, Gross GJ) Am J Physiol Heart Circ Physiol 2001 Mar;280(3):H1346-53 PMID 11179083 Differential activation of extracellular signal regulated kinase isoforms in preconditioning and opioid-induced cardioprotection. (Fryer RM, Pratt PF, Hsu AK, Gross GJ) J Pharmacol Exp Ther 2001 Feb;296(2):642-9 PMID 11160653 Protection of cardiac myocytes via delta(1)-opioid receptors, protein kinase C, and mitochondrial K(ATP) channels. (Huh J, Gross GJ, Nagase H, Liang BT) Am J Physiol Heart Circ Physiol 2001 Jan;280(1):H377-83 PMID 11123254 Increased mitochondrial K(ATP) channel activity during chronic myocardial hypoxia: is cardioprotection mediated by improved bioenergetics? (Eells JT, Henry MM, Gross GJ, Baker JE) Circ Res 2000 Nov 10;87(10):915-21 PMID 11073888 Na(+)/H(+) exchange inhibition-induced cardioprotection in dogs: effects on neutrophils versus cardiomyocytes. (Gumina RJ, Auchampach J, Wang R, Buerger E, Eickmeier C, Moore J, Daemmgen J, Gross GJ) Am J Physiol Heart Circ Physiol 2000 Oct;279(4):H1563-70 PMID 11009442 The role of mitochondrial KATP channels in cardioprotection. (Gross GJ) Basic Res Cardiol 2000 Aug;95(4):280-4 PMID 11005582 Mitochondrial K(ATP) channels: triggers or distal effectors of ischemic or pharmacological preconditioning? (Gross GJ, Fryer RM) Circ Res 2000 Sep 15;87(6):431-3 PMID 10988232 Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels. (Fryer RM, Hsu AK, Nagase H, Gross GJ) J Pharmacol Exp Ther 2000 Aug;294(2):451-7 PMID 10900218 The novel glycolipid RC-552 attenuates myocardial stunning and reduces infarct size in dogs. (Elliott GT, Sowell CG, Walker EB, Weber PA, Moore J, Gross GJ) J Mol Cell Cardiol 2000 Jul;32(7):1327-39 PMID 10860773 Sarcolemmal and mitochondrial adenosine triphosphate- dependent potassium channels: mechanism of desflurane-induced cardioprotection. (Toller WG, Gross ER, Kersten JR, Pagel PS, Gross GJ, Warltier DC) Anesthesiology 2000 Jun;92(6):1731-9 PMID 10839925 Inhibitors of ischemic preconditioning do not attenuate Na+/H+ exchange inhibitor mediated cardioprotection. (Gumina RJ, Beier N, Schelling P, Gross GJ) J Cardiovasc Pharmacol 2000 Jun;35(6):949-53 PMID 10836732 Inhibition of the Na(+)/H(+) exchanger attenuates phase 1b ischemic arrhythmias and reperfusion-induced ventricular fibrillation. (Gumina RJ, Daemmgen J, Gross GJ) Eur J Pharmacol 2000 May 19;396(2-3):119-24 PMID 10822064 Ischemic preconditioning in rats: role of mitochondrial K(ATP) channel in preservation of mitochondrial function. (Fryer RM, Eells JT, Hsu AK, Henry MM, Gross GJ) Am J Physiol Heart Circ Physiol 2000 Jan;278(1):H305-12 PMID 10644614 Inhibition of the Na(+)/H(+) exchanger confers greater cardioprotection against 90 minutes of myocardial ischemia than ischemic preconditioning in dogs. (Gumina RJ, Buerger E, Eickmeier C, Moore J, Daemmgen J, Gross GJ) Circulation 1999 Dec 21-28;100(25):2519-26; discussion 2469-72 PMID 10604890 Prologue: ischemic preconditioning in cardiac vascular muscle. (Chilian WM, Gross GJ) Am J Physiol 1999 Dec;277(6 Pt 2):H2416-7 PMID 10600863 Mechanisms of postischemic contractile dysfunction. (Gross GJ, Kersten JR, Warltier DC) Ann Thorac Surg 1999 Nov;68(5):1898-904 PMID 10585101 If ischemic preconditioning is the gold standard, has a platinum standard of cardioprotection arrived? Comparison with NHE inhibition. (Gumina RJ, Gross GJ) J Thromb Thrombolysis 1999 Jul;8(1):39-44 PMID 10481213 Direct preconditioning of cardiac myocytes via opioid receptors and KATP channels. (Liang BT, Gross GJ) Circ Res 1999 Jun 25;84(12):1396-400 PMID 10381891 Sarcolemmal versus mitochondrial ATP-sensitive K+ channels and myocardial preconditioning. (Gross GJ, Fryer RM) Circ Res 1999 May 14;84(9):973-9 PMID 10325234 Opioid-induced second window of cardioprotection: potential role of mitochondrial KATP channels. (Fryer RM, Hsu AK, Eells JT, Nagase H, Gross GJ) Circ Res 1999 Apr 16;84(7):846-51 PMID 10205153 Importance of PKC and tyrosine kinase in single or multiple cycles of preconditioning in rat hearts. (Fryer RM, Schultz JE, Hsu AK, Gross GJ) Am J Physiol 1999 Apr;276(4 Pt 2):H1229-35 PMID 10199847 Preconditioning in immature rabbit hearts: role of KATP channels. (Baker JE, Holman P, Gross GJ) Circulation 1999 Mar 9;99(9):1249-54 PMID 10069795 Pretreatment with tyrosine kinase inhibitors partially attenuates ischemic preconditioning in rat hearts. (Fryer RM, Schultz JE, Hsu AK, Gross GJ) Am J Physiol 1998 Dec;275(6 Pt 2):H2009-15 PMID 9843799 Effect of the platelet-activating factor antagonist RP 59227 (Tulopafant) on myocardial ischemia/reperfusion injury and neutrophil function. (Auchampach JA, Pieper GM, Cavero I, Gross GJ) Basic Res Cardiol 1998 Oct;93(5):361-71 PMID 9833148 Recombinant cardiac ATP-sensitive potassium channels and cardioprotection. (Gross GJ) Circulation 1998 Oct 13;98(15):1479-80 PMID 9769299 Terikalant, an inward-rectifier potassium channel blocker, does not abolish the cardioprotection induced by ischemic preconditioning in the rat. (Schultz JE, Kwok WM, Hsu AK, Gross GJ) J Mol Cell Cardiol 1998 Sep;30(9):1817-25 PMID 9769237 Myocardial preconditioning produced by ischemia, hypoxia, and a KATP channel opener: effects on interstitial adenosine in dogs. (Mei DA, Nithipatikom K, Lasley RD, Gross GJ) J Mol Cell Cardiol 1998 Jun;30(6):1225-36 PMID 9689596 Pertussis toxin abolishes the cardioprotective effect of ischemic preconditioning in intact rat heart. (Schultz JE, Hsu AK, Barbieri JT, Li PL, Gross GJ) Am J Physiol 1998 Aug;275(2 Pt 2):H495-500 PMID 9683437 Monophosphoryl lipid A attenuates myocardial stunning in dogs: role of ATP-sensitive potassium channels. (Elliott GT, Mei DA, Gross GJ) J Cardiovasc Pharmacol 1998 Jul;32(1):49-56 PMID 9676720 A new sodium/hydrogen exchange inhibitor, EMD 85131, limits infarct size in dogs when administered before or after coronary artery occlusion. (Gumina RJ, Mizumura T, Beier N, Schelling P, Schultz JJ, Gross GJ) J Pharmacol Exp Ther 1998 Jul;286(1):175-83 PMID 9655858 Ischemic preconditioning in the intact rat heart is mediated by delta1- but not mu- or kappa-opioid receptors. (Schultz JE, Hsu AK, Gross GJ) Circulation 1998 Apr 7;97(13):1282-9 PMID 9570199 TAN-67, a delta 1-opioid receptor agonist, reduces infarct size via activation of Gi/o proteins and KATP channels. (Schultz J el-J, Hsu AK, Nagase H, Gross GJ) Am J Physiol 1998 Mar;274(3 Pt 2):H909-14 PMID 9530203 Activation of adenosine triphosphate-regulated potassium channels: mediation of cellular and organ protection. (Kersten JR, Gross GJ, Pagel PS, Warltier DC) Anesthesiology 1998 Feb;88(2):495-513 PMID 9477071 The leukocyte cell adhesion cascade and its role in myocardial ischemia-reperfusion injury. (Gumina RJ, Newman PJ, Kenny D, Warltier DC, Gross GJ) Basic Res Cardiol 1997 Aug;92(4):201-13 PMID 9342427 Isoflurane mimics ischemic preconditioning via activation of K(ATP) channels: reduction of myocardial infarct size with an acute memory phase. (Kersten JR, Schmeling TJ, Pagel PS, Gross GJ, Warltier DC) Anesthesiology 1997 Aug;87(2):361-70 PMID 9286901 Ischemic preconditioning and morphine-induced cardioprotection involve the delta (delta)-opioid receptor in the intact rat heart. (Schultz JJ, Hsu AK, Gross GJ) J Mol Cell Cardiol 1997 Aug;29(8):2187-95 PMID 9281450 Glibenclamide-induced blockade of ischemic preconditioning is time dependent in intact rat heart. (Schultz JE, Yao Z, Cavero I, Gross GJ) Am J Physiol 1997 Jun;272(6 Pt 2):H2607-15 PMID 9227537 Ischemic preconditioning is mediated by a peripheral opioid receptor mechanism in the intact rat heart. (Schultz JJ, Hsu AK, Gross GJ) J Mol Cell Cardiol 1997 May;29(5):1355-62 PMID 9201621 Role of adenosine in isoflurane-induced cardioprotection. (Kersten JR, Orth KG, Pagel PS, Mei DA, Gross GJ, Warltier DC) Anesthesiology 1997 May;86(5):1128-39 PMID 9158363 Increased tolerance of the chronically hypoxic immature heart to ischemia. Contribution of the KATP channel. (Baker JE, Curry BD, Olinger GN, Gross GJ) Circulation 1997 Mar 4;95(5):1278-85 PMID 9054860 The ischemia-selective KATP channel antagonist, 5-hydroxydecanoate, blocks ischemic preconditioning in the rat heart. (Schultz JE, Qian YZ, Gross GJ, Kukreja RC) J Mol Cell Cardiol 1997 Mar;29(3):1055-60 PMID 9152866 KATP channel activation in a rabbit model of chronic myocardial hypoxia. (Baker JE, Contney SJ, Gross GJ, Bosnjak ZJ) J Mol Cell Cardiol 1997 Feb;29(2):845-8 PMID 9140841 Adenosine A1 receptor blockade does not abolish the cardioprotective effects of the adenosine triphosphate-sensitive potassium channel opener bimakalim. (Gross GJ, Mei DA, Sleph PG, Grover GJ) J Pharmacol Exp Ther 1997 Feb;280(2):533-40 PMID 9023261 An ATP-sensitive potassium (KATP) channel opener, nicorandil, lowers the threshold for ischemic preconditioning in barbital-anesthetized dogs. (Mizumura T, Saito S, Ozawa Y, Kanmatsuse K, Gross GJ) Heart Vessels 1997;Suppl 12:175-7 PMID 9476575 KATP channels and memory of ischemic preconditioning in dogs: synergism between adenosine and KATP channels. (Yao Z, Mizumura T, Mei DA, Gross GJ) Am J Physiol 1997 Jan;272(1 Pt 2):H334-42 PMID 9038954 Antibody to platelet/endothelial cell adhesion molecule-1 reduces myocardial infarct size in a rat model of ischemia-reperfusion injury. (Gumina RJ, el Schultz J, Yao Z, Kenny D, Warltier DC, Newman PJ, Gross GJ) Circulation 1996 Dec 15;94(12):3327-33 PMID 8989147 KATP channels mediate late preconditioning against infarction produced by monophosphoryl lipid A. (Mei DA, Elliott GT, Gross GJ) Am J Physiol 1996 Dec;271(6 Pt 2):H2723-9 PMID 8997336 One-day cold perfusion of bimakalim and butanedione monoxime restores ex situ cardiac function. (Stowe DF, Graf BM, Fujita S, Gross GJ) Am J Physiol 1996 Nov;271(5 Pt 2):H1884-92 PMID 8945905 Mechanism of myocardial protection by isoflurane. Role of adenosine triphosphate-regulated potassium (KATP) channels. (Kersten JR, Schmeling TJ, Hettrick DA, Pagel PS, Gross GJ, Warltier DC) Anesthesiology 1996 Oct;85(4):794-807; discussion 27A PMID 8873550 PD 81,723, an allosteric enhancer of the A1 adenosine receptor, lowers the threshold for ischemic preconditioning in dogs. (Mizumura T, Auchampach JA, Linden J, Bruns RF, Gross GJ) Circ Res 1996 Sep;79(3):415-23 PMID 8781475 Infarct size-reducing effect of nicorandil is mediated by the KATP channel but not by its nitrate-like properties in dogs. (Mizumura T, Nithipatikom K, Gross GJ) Cardiovasc Res 1996 Aug;32(2):274-85 PMID 8796114 Glyburide, a KATP channel antagonist, attenuates the cardioprotective effects of isoflurane in stunned myocardium. (Kersten JR, Lowe D, Hettrick DA, Pagel PS, Gross GJ, Warltier DC) Anesth Analg 1996 Jul;83(1):27-33 PMID 8659760 Simultaneous determination of adenosine, inosine, hypoxanthine, xanthine, and uric acid in microdialysis samples using microbore column high-performance liquid chromatography with a diode array detector. (Mei DA, Gross GJ, Nithipatikom K) Anal Biochem 1996 Jun 15;238(1):34-9 PMID 8660582 Morphine mimics the cardioprotective effect of ischemic preconditioning via a glibenclamide-sensitive mechanism in the rat heart. (Schultz JE, Hsu AK, Gross GJ) Circ Res 1996 Jun;78(6):1100-4 PMID 8635241 Criteria for a mediator or effector of myocardial preconditioning: do KATP channels meet the requirements? (Gross GJ, Mei DA, Schultz JJ, Mizumura T) Basic Res Cardiol 1996 Jan-Feb;91(1):31-4 PMID 8660253 Bimakalim, an ATP-sensitive potassium channel opener, mimics the effects of ischemic preconditioning to reduce infarct size, adenosine release, and neutrophil function in dogs. (Mizumura T, Nithipatikom K, Gross GJ) Circulation 1995 Sep 1;92(5):1236-45 PMID 7648671 Monophosphoryl lipid A preserves myocardial contractile function following multiple, brief periods of coronary occlusion in dogs. (Yao Z, Elliott GT, Gross GJ) Pharmacology 1995 Sep;51(3):152-9 PMID 7501700 Evidence for the involvement of the ATP-sensitive potassium channel in a novel model of hypoxic preconditioning in dogs. (Mei DA, Gross GJ) Cardiovasc Res 1995 Aug;30(2):222-30 PMID 7585809 Do ATP-sensitive potassium channels play a role in myocardial stunning? (Gross GJ) Basic Res Cardiol 1995 Jul-Aug;90(4):266-8 PMID 8534242 Evidence for involvement of opioid receptors in ischemic preconditioning in rat hearts. (Schultz JE, Rose E, Yao Z, Gross GJ) Am J Physiol 1995 May;268(5 Pt 2):H2157-61 PMID 7771566 Effects of nicorandil and glyceryl trinitrate on infarct size, adenosine release, and neutrophil infiltration in the dog. (Mizumura T, Nithipatikom K, Gross GJ) Cardiovasc Res 1995 Apr;29(4):482-9 PMID 7796441 ATP-sensitive potassium channels and myocardial preconditioning. (Gross GJ) Basic Res Cardiol 1995 Mar-Apr;90(2):85-8 PMID 7646421 The definition of myocardial ischemia. (Gross GJ) Cardiovasc Res 1995 Jan;29(1):141 PMID 7748260 Determination of plasma adenosine by high-performance liquid chromatography with column switching and fluorometric detection. (Nithipatikom K, Mizumura T, Gross GJ) Anal Biochem 1994 Dec;223(2):280-4 PMID 7887474 Activation of ATP-sensitive potassium channels lowers threshold for ischemic preconditioning in dogs. (Yao Z, Gross GJ) Am J Physiol 1994 Nov;267(5 Pt 2):H1888-94 PMID 7977819 Cardioprotective actions of potassium channel openers. (Auchampach JA, Maruyama M, Gross GJ) Eur Heart J 1994 Aug;15 Suppl C:89-94 PMID 7995278 Monophosphoryl lipid A protects against endotoxic shock via inhibiting neutrophil infiltration and preventing disseminated intravascular coagulation. (Yao Z, Foster PA, Gross GJ) Circ Shock 1994 Jul;43(3):107-14 PMID 7850930 The ATP-regulated potassium channel in ischemia-reperfusion injury. (Gross GJ, Yao Z, Pieper GM, Auchampach JA) Ann N Y Acad Sci 1994 Jun 17;723:71-81 PMID 8030926 Stimulatory and inhibitory action of nitric oxide donor agents vs. nitrovasodilators on reactive oxygen production by isolated polymorphonuclear leukocytes. (Pieper GM, Clarke GA, Gross GJ) J Pharmacol Exp Ther 1994 May;269(2):451-6 PMID 8182511 Effects of the KATP channel opener bimakalim on coronary blood flow, monophasic action potential duration, and infarct size in dogs. (Yao Z, Gross GJ) Circulation 1994 Apr;89(4):1769-75 PMID 8149542 Reduction in myocardial infarct size by the new potassium channel opener bimakalim. (Auchampach JA, Gross GJ) J Cardiovasc Pharmacol 1994 Apr;23(4):554-61 PMID 7516004 A comparison of adenosine-induced cardioprotection and ischemic preconditioning in dogs. Efficacy, time course, and role of KATP channels. (Yao Z, Gross GJ) Circulation 1994 Mar;89(3):1229-36 PMID 8124811 ATP sensitive potassium channels and ischemic heart disease. (Gross GJ) Cardiovasc Res 1994 Jan;28(1):139-40 PMID 8111784 The ATP-dependent potassium channel: an endogenous cardioprotective mechanism. (Yao Z, Gross GJ) J Cardiovasc Pharmacol 1994;24 Suppl 4:S28-34 PMID 7898105 Role of nitric oxide, muscarinic receptors, and the ATP-sensitive K+ channel in mediating the effects of acetylcholine to mimic preconditioning in dogs. (Yao Z, Gross GJ) Circ Res 1993 Dec;73(6):1193-201 PMID 8222090 Effects of monophosphoryl lipid A on myocardial ischemia/reperfusion injury in dogs. (Yao Z, Rasmussen JL, Hirt JL, Mei DA, Pieper GM, Gross GJ) J Cardiovasc Pharmacol 1993 Oct;22(4):653-63 PMID 7505370 Anti-ischaemic actions of potassium channel openers in experimental myocardial ischaemia/reperfusion injury in dogs. (Auchampach JA, Gross GJ) Eur Heart J 1993 Jul;14 Suppl B:10-5 PMID 8370365 Glibenclamide antagonizes adenosine A1 receptor-mediated cardioprotection in stunned canine myocardium. (Yao Z, Gross GJ) Circulation 1993 Jul;88(1):235-44 PMID 8319338 Acetylcholine mimics ischemic preconditioning via a glibenclamide-sensitive mechanism in dogs. (Yao Z, Gross GJ) Am J Physiol 1993 Jun;264(6 Pt 2):H2221-5 PMID 8322953 Hydroxyl radicals mediate injury to endothelium-dependent relaxation in diabetic rat. (Pieper GM, Langenstroer P, Gross GJ) Mol Cell Biochem 1993 May 26;122(2):139-45 PMID 8232245 Adenosine A1 receptors, KATP channels, and ischemic preconditioning in dogs. (Auchampach JA, Gross GJ) Am J Physiol 1993 May;264(5 Pt 2):H1327-36 PMID 8498546 Cardioprotective effects of monophosphoryl lipid A, a novel endotoxin analogue, in the dog. (Yao Z, Auchampach JA, Pieper GM, Gross GJ) Cardiovasc Res 1993 May;27(5):832-8 PMID 8394211 Relationship of severity of myocardial stunning to ATP dependent potassium channel modulation. (Warltier DC, Auchampach JA, Gross GJ) J Card Surg 1993 Mar;8(2 Suppl):279-83 PMID 8461517 Activation of cardiac KATP channels: an endogenous protective mechanism during repetitive ischemia. (Yao Z, Cavero I, Gross GJ) Am J Physiol 1993 Feb;264(2 Pt 2):H495-504 PMID 8447462 Myocardial and endothelial dysfunction after multiple, brief coronary occlusions: role of oxygen radicals. (Gross GJ, O'Rourke ST, Pelc LR, Warltier DC) Am J Physiol 1992 Dec;263(6 Pt 2):H1703-9 PMID 1481896 Blockade of ischaemic preconditioning in dogs by the novel ATP dependent potassium channel antagonist sodium 5-hydroxydecanoate. (Auchampach JA, Grover GJ, Gross GJ) Cardiovasc Res 1992 Nov;26(11):1054-62 PMID 1291082 Role of ATP dependent potassium channels in myocardial ischaemia. (Gross GJ, Auchampach JA) Cardiovasc Res 1992 Nov;26(11):1011-6 PMID 1291076 Pharmacological evidence for a role of ATP-dependent potassium channels in myocardial stunning. (Auchampach JA, Maruyama M, Cavero I, Gross GJ) Circulation 1992 Jul;86(1):311-9 PMID 1301066 Anti-free-radical and neutrophil-modulating properties of the nitrovasodilator, nicorandil. (Pieper GM, Gross GJ) Cardiovasc Drugs Ther 1992 Jun;6(3):225-32 PMID 1322163 EMD 52692 (bimakalim), a new potassium channel opener, attenuates luminol-enhanced chemiluminescence and superoxide anion radical formation by zymosan-activated polymorphonuclear leukocytes. (Pieper GM, Gross GJ) Immunopharmacology 1992 May-Jun;23(3):191-7 PMID 1323556 Beneficial actions of amlodipine in the multiple-stunned canine myocardium. (Gross GJ, Pieper GM) Cardiovasc Drugs Ther 1992 Feb;6(1):67-75 PMID 1533534 Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. (Gross GJ, Auchampach JA) Circ Res 1992 Feb;70(2):223-33 PMID 1310443 Cardioprotective effects of nicorandil. (Gross GJ, Auchampach JA, Maruyama M, Warltier DC, Pieper GM) J Cardiovasc Pharmacol 1992;20 Suppl 3:S22-8 PMID 1282172 Nicorandil attenuates myocardial dysfunction associated with transient ischemia by opening ATP-dependent potassium channels. (Auchampach JA, Cavero I, Gross GJ) J Cardiovasc Pharmacol 1992;20(5):765-71 PMID 1280739 The new K+ channel opener Aprikalim (RP 52891) reduces experimental infarct size in dogs in the absence of hemodynamic changes. (Auchampach JA, Maruyama M, Cavero I, Gross GJ) J Pharmacol Exp Ther 1991 Dec;259(3):961-7 PMID 1762089 Comparative cardiac effects of KT-362 and verapamil in isolated heart--correlation to calcium channel current depression. (Buljubasic N, Marijic J, Stowe DF, Gross GJ, Kampine JP, Bosnjak ZJ) J Cardiovasc Pharmacol 1991 Oct;18(4):594-604 PMID 1724538 Mechanism of coronary vasodilation produced by bradykinin. (Pelc LR, Gross GJ, Warltier DC) Circulation 1991 Jun;83(6):2048-56 PMID 1645623 Effects of hydroxyethyl starch conjugated deferoxamine on myocardial functional recovery following coronary occlusion and reperfusion in dogs. (Maruyama M, Pieper GM, Kalyanaraman B, Hallaway PE, Hedlund BE, Gross GJ) J Cardiovasc Pharmacol 1991 Jan;17(1):166-75 PMID 1708051 Evidence for a role of platelet activating factor in the pathogenesis of irreversible but not reversible myocardial injury after reperfusion in dogs. (Maruyama M, Farber NE, Vercellotti GM, Jacob HS, Gross GJ) Am Heart J 1990 Sep;120(3):510-20 PMID 2389687 Augmented vascular relaxation to KT-362 in diabetic rat aorta: comparison to diltiazem. (Pieper GM, Gross GJ) J Cardiovasc Pharmacol 1990 Sep;16(3):394-400 PMID 1700209 Alteration of endothelium-dependent distribution of myocardial blood flow after coronary occlusion and reperfusion. (Pelc LR, Garancis JC, Gross GJ, Warltier DC) Circulation 1990 Jun;81(6):1928-37 PMID 2344685 Prostaglandin redirection by thromboxane synthetase inhibition. Attenuation of myocardial stunning in canine heart. (Farber NE, Gross GJ) Circulation 1990 Jan;81(1):369-80 PMID 2297841 Differential response of postischemic diabetic myocardium to a thromboxane-mimetic. (Pieper GM, Gross GJ) Eicosanoids 1990;3(3):127-33 PMID 2242272 An ESR study of the nitroxide radical of pentastarch-conjugated deferoxamine. (Pieper GM, Gross GJ, Kalyanaraman B) Free Radic Biol Med 1990;9(3):211-8 PMID 2177027 Effects of amlodipine on myocardial ischemia-reperfusion injury in dogs. (Gross GJ, Farber NE, Pieper GM) Am J Cardiol 1989 Nov 7;64(17):94I-100I PMID 2530891 Effect of amlodipine on myocardial functional and metabolic recovery following coronary occlusion and reperfusion in dogs. (Gross GJ, Farber NE, Pieper GM) Cardiovasc Drugs Ther 1989 Aug;3(4):535-43 PMID 2535101 Prostaglandin E1 attenuates postischemic contractile dysfunction after brief coronary occlusion and reperfusion. (Farber NE, Gross GJ) Am Heart J 1989 Jul;118(1):17-24 PMID 2741783 Collateral blood flow following acute coronary artery occlusion: comparison of a new intracellular calcium antagonist (KT-362) and diltiazem. (Farber NE, Gross GJ) J Cardiovasc Pharmacol 1989 Jul;14(1):66-72 PMID 2475718 Diabetes alters postischemic response to a prostacyclin mimetic. (Pieper GM, Gross GJ) Am J Physiol 1989 May;256(5 Pt 2):H1353-60 PMID 2470263 Reduction of myocardial ischemia-reperfusion injury by KT-362, a new intracellular calcium antagonist in anesthetized dogs. (Pelc LR, Farber NE, Warltier DC, Gross GJ) J Cardiovasc Pharmacol 1989 Apr;13(4):586-93 PMID 2470996 Improvement in functional recovery of stunned canine myocardium by long-term pretreatment with oral propranolol. (al-Wathiqui MH, Farber N, Pelc L, Gross GJ, Brooks HL, Warltier DC) Am Heart J 1989 Apr;117(4):791-8 PMID 2929396 Effect of KT-362, a putative intracellular calcium antagonist, on norepinephrine-induced contractions and inositol monophosphate accumulation in canine femoral artery. (Eskinder H, Hillard CJ, Wilke RA, Gross GJ) J Cardiovasc Pharmacol 1989 Mar;13(3):502-7 PMID 2471898 Cardioprotective effects of a new vascular intracellular calcium antagonist, KT-362, in the stunned myocardium. (Farber NE, Gross GJ) J Pharmacol Exp Ther 1989 Jan;248(1):39-43 PMID 2536431 Effect of cyclooxygenase blockade on the beneficial actions of nicorandil in the stunned myocardium of dogs. (Gross GJ, Pieper GM) Pharmacology 1989;38(6):341-51 PMID 2530592 Selective impairment of endothelium-dependent relaxation by oxygen-derived free radicals: distinction between receptor versus nonreceptor mediators. (Pieper GM, Gross GJ) Blood Vessels 1989;26(1):44-7 PMID 2496777 Protective effect of nicorandil on postischemic function and tissue adenine nucleotides following a brief period of low-flow global ischemia in the isolated perfused rat heart. (Pieper GM, Gross GJ) Pharmacology 1989;38(4):205-13 PMID 2526951 Diabetes enhances vasoreactivity to calcium entry blockers. (Pieper GM, Gross GJ) Artery 1989;16(5):263-71 PMID 2764731 Cyclical carotid artery flow reduction in conscious dogs: effect of a new thromboxane receptor antagonist. (al-Wathiqui MH, Hartman JC, Brooks HL, Gross GJ, Warltier DC) Am Heart J 1988 Dec;116(6 Pt 1):1482-7 PMID 3195431 Alpha adrenoceptor subtypes and receptor reserve in human versus canine saphenous vein: sensitivity to blockade by nitroglycerin. (Eskinder H, Hillard CJ, Olinger GN, Christensen CW, Baker JE, Warltier DC, Gross GJ) J Pharmacol Exp Ther 1988 Dec;247(3):941-8 PMID 2905005 Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta. (Pieper GM, Gross GJ) Am J Physiol 1988 Oct;255(4 Pt 2):H825-33 PMID 3140677 Steroid-induced enhancement of functional recovery of postischemic, reperfused myocardium in conscious dogs. (Wynsen JC, Preuss KC, Gross GJ, Brooks HL, Warltier DC) Am Heart J 1988 Oct;116(4):915-25 PMID 3051986 Postischemic recovery in the stunned myocardium after reperfusion in the presence or absence of a flow-limiting coronary artery stenosis. (Farber NE, Pieper GM, Gross GJ) Am Heart J 1988 Aug;116(2 Pt 1):407-20 PMID 3400566 Lack of involvement of thromboxane A2 in postischemic recovery of stunned canine myocardium. (Farber NE, Pieper GM, Gross GJ) Circulation 1988 Aug;78(2):450-61 PMID 3396181 Evidence for a role of iron-catalyzed oxidants in functional and metabolic stunning in the canine heart. (Farber NE, Vercellotti GM, Jacob HS, Pieper GM, Gross GJ) Circ Res 1988 Aug;63(2):351-60 PMID 3396156 Metabolic protection of the reperfused canine endocardium by the thromboxane synthetase inhibitor, dazoxiben. (Pieper GM, Farber NE, Gross GJ) Prostaglandins Leukot Essent Fatty Acids 1988 Jul;33(1):13-22 PMID 3054935 Mechanisms of enhanced canine subendocardial perfusion. A comparison of adenosine triphosphate and sodium nitroprusside. (Pelc LR, Gross GJ, Kampine JP, Warltier DC) Anesth Analg 1988 Jun;67(6):514-20 PMID 3259847 Muscarinic receptor subtypes mediating myocardial blood flow redistribution. (Pelc LR, Daemmgen JW, Gross GJ, Warltier DC) J Cardiovasc Pharmacol 1988 Apr;11(4):424-31 PMID 2453745 Beneficial effects of iloprost in the stunned canine myocardium. (Farber NE, Pieper GM, Thomas JP, Gross GJ) Circ Res 1988 Feb;62(2):204-15 PMID 2448057 Comparative effects of inotropic agents on coronary and systemic hemodynamics of conscious dogs: actions of milrinone, dopamine, ouabain and MCI-154. (Al-Wathiqui MH, Shimshak TM, Brooks HL, Preuss KC, Wynsen JC, Gross GJ, Warltier DC) Pharmacology 1988;36(4):217-27 PMID 3380877 Hemodynamic and electrocardiographic actions of the new intracellular calcium antagonist, KT-362, in the conscious dog. (Hartman JC, Al-Wathiqui MH, Brooks HL, Gross GJ, Warltier DC) Pharmacology 1988;37(6):376-84 PMID 3244744 8-Bromo cyclic GMP mimics the actions of nitroglycerin in modulating responses produced by full and partial alpha-adrenoceptor agonists in canine saphenous vein. (Eskinder H, Gross GJ) Eur Heart J 1988 Jan;9 Suppl A:11-5 PMID 2900765 Improvement of postischemic, contractile function by the calcium channel blocking agent nitrendipine in conscious dogs. (Warltier DC, Gross GJ, Brooks HL, Preuss KC) J Cardiovasc Pharmacol 1988;12 Suppl 4:S120-4 PMID 2468853 A canine model of thrombin-induced coronary artery thrombosis: effects of intracoronary streptokinase on regional myocardial blood flow, contractile function, and infarct size. (Warltier DC, Lamping KA, Pelc LR, Gross GJ) J Pharmacol Methods 1987 Dec;18(4):305-18 PMID 3695539 Effects of bradycardic agents on ischaemic myocardium and perfusion in anesthetized dogs. (Gross GJ, Daemmgen JW) Eur Heart J 1987 Dec;8 Suppl L:69-74 PMID 3451885 Specific bradycardic agents, a new therapeutic modality for anesthesiology: hemodynamic effects of UL-FS 49 and propranolol in conscious and isoflurane-anesthetized dogs. (Riley DC, Gross GJ, Kampine JP, Warltier DC) Anesthesiology 1987 Nov;67(5):707-16 PMID 3674471 Regional differences in postischemic recovery in the stunned canine myocardium. (Farber NE, Pieper GM, Gross GJ) Am Heart J 1987 Nov;114(5):1086-95 PMID 3673875 Comparative effects of nicorandil, a nicotinamide nitrate derivative, and nifedipine on myocardial reperfusion injury in dogs. (Gross GJ, Warltier DC, Hardman HF) J Cardiovasc Pharmacol 1987 Nov;10(5):535-42 PMID 2447402 Time course of recovery of "stunned" myocardium following variable periods of ischemia in conscious and anesthetized dogs. (Preuss KC, Gross GJ, Brooks HL, Warltier DC) Am Heart J 1987 Oct;114(4 Pt 1):696-703 PMID 2959132 Salutary action of nicorandil, a new antianginal drug, on myocardial metabolism during ischemia and on postischemic function in a canine preparation of brief, repetitive coronary artery occlusions: comparison with isosorbide dinitrate. (Pieper GM, Gross GJ) Circulation 1987 Oct;76(4):916-28 PMID 2958176 Changes in adrenergic pressor responses by calcium channel modulation in conscious dogs. (Wynsen JC, Gross GJ, Brooks HL, Warltier DC) Am J Physiol 1987 Sep;253(3 Pt 2):H531-9 PMID 2443022 Preferential increase in subendocardial perfusion produced by endothelium-dependent vasodilators. (Pelc LR, Gross GJ, Warltier DC) Circulation 1987 Jul;76(1):191-200 PMID 3594767 Effect of the new specific bradycardia agent AQ-A39 (falipamil) on coronary collateral blood flow in dogs. (Gross GJ, Daemmgen JW) J Cardiovasc Pharmacol 1987 Jul;10(1):123-7 PMID 2441148 Differential effects of nifedipine, nicorandil and nitroglycerin on the pressor responses elicited by selective alpha-1 and alpha-adrenoceptor agonists in conscious dogs. (Wynsen JC, Gross GJ, Brooks HL, Warltier DC) J Pharmacol Exp Ther 1987 Jun;241(3):846-54 PMID 2885410 Stimulation of myocardium during reperfusion injury by a new inotrope-vasodilator agent, MCI-154. (Wynsen JC, Shimshak TM, Preuss KC, Gross GJ, Brooks HL, Warltier DC) Fundam Clin Pharmacol 1987;1(5):335-45 PMID 3443426 8-Bromo cyclic guanosine monophosphate mimics the actions of nitroglycerin on alpha-adrenergic mechanisms in canine saphenous vein. (Eskinder H, Gross GJ) Pharmacology 1987;35(1):16-23 PMID 2819902 Sensitivity of alpha-adrenoceptor agonists to the calcium channel activator, Bay K 8644, in canine saphenous vein. (Eskinder H, Gross GJ) Pharmacology 1987;35(5):272-8 PMID 2447595 Comparative effects of nicorandil, nitroglycerin, nicotinic acid, and SG-86 on the metabolic status and functional recovery of the ischemic-reperfused myocardium. (Gross GJ, Pieper GM, Warltier DC) J Cardiovasc Pharmacol 1987;10 Suppl 8:S76-84 PMID 2447429 Effects of intracoronary Bay k 8644, a calcium channel agonist, in anesthetized dogs. (Pelc LR, Gross GJ, Brooks HL, Warltier DC) J Cardiovasc Pharmacol 1986 Nov-Dec;8(6):1223-8 PMID 2434750 Beneficial effects of two specific bradycardic agents AQ-A39 (falipamil) and AQ-AH 208 on reversible myocardial reperfusion damage in anesthetized dogs. (Gross GJ, Daemmgen JW) J Pharmacol Exp Ther 1986 Aug;238(2):422-8 PMID 3735124 Differential inhibition of alpha-1 vs. alpha-2 adrenoceptor-mediated responses in canine saphenous vein by nitroglycerin. (Eskinder H, Gross GJ) J Pharmacol Exp Ther 1986 Aug;238(2):515-21 PMID 3016240 Recovery of contractile function in post-ischaemic reperfused myocardium of conscious dogs: influence of nicorandil, a new antianginal agent. (Shimshak TM, Preuss KC, Gross GJ, Brooks HL, Warltier DC) Cardiovasc Res 1986 Aug;20(8):621-6 PMID 2947685 Changes in regional myocardial perfusion by muscarinic receptor subtypes in dogs. (Pelc LR, Gross GJ, Warltier DC) Cardiovasc Res 1986 Jul;20(7):482-9 PMID 3779744 Effects of KB-944, a novel calcium antagonist, in several models of canine myocardial ischemia. (Pelc LR, Gross GJ, Warltier DC) J Pharmacol Exp Ther 1986 Jul;238(1):113-8 PMID 3723394 Beneficial actions of superoxide dismutase and catalase in stunned myocardium of dogs. (Gross GJ, Farber NE, Hardman HF, Warltier DC) Am J Physiol 1986 Mar;250(3 Pt 2):H372-7 PMID 3953834 Importance of retrograde coronary flow in the prediction of experimental myocardial infarct size. (Warltier DC, Zyvoloski MG, Gross GJ, Brooks HL) Cardiology 1986;73(6):333-46 PMID 3791333 Evidence for the site of action of glycerol trinitrate and diltiazem in inhibiting vasoconstrictor responses to norepinephrine in isolated renal arteries. (Gross GJ, Gharaibeh MN) Pharmacology 1986;32(1):1-10 PMID 2418448 AQ-AH 208, a new bradycardic agent, increases coronary collateral blood flow to ischemic myocardium. (Daemmgen JW, Gross GJ) J Cardiovasc Pharmacol 1985 Nov-Dec;7(6):1048-54 PMID 2418287 Slow channel calcium activators, a new group of pharmacological agents. (Preuss KC, Gross GJ, Brooks HL, Warltier DC) Life Sci 1985 Oct 7;37(14):1271-8 PMID 2413326 Enhanced subendocardial perfusion distal to a flow-limiting coronary artery stenosis in dogs: comparative effects of nicorandil, a potential new antianginal agent, and nitroglycerin. (Gross GJ, Warltier DC, Hardman HF, Lamping KA) J Cardiovasc Pharmacol 1985 Sep-Oct;7(5):977-82 PMID 2413311 Effects of AQ-AH 208, a new specific bradycardic agent, on myocardial ischemia-reperfusion injury in anesthetized dogs. (Gross GJ, Warltier DC, Daemmgen JW) J Cardiovasc Pharmacol 1985 Sep-Oct;7(5):929-36 PMID 2413303 Hemodynamic actions of nicorandil, a new antianginal agent, in the conscious dog. (Preuss KC, Gross GJ, Brooks HL, Warltier DC) J Cardiovasc Pharmacol 1985 Jul-Aug;7(4):709-14 PMID 2410712 Positive inotropic actions of the calcium channel stimulator, Bay k 8644, in awake, unsedated dogs. (Preuss KC, Brooks HL, Gross GJ, Warltier DC) Basic Res Cardiol 1985 May-Jun;80(3):326-32 PMID 2411255 Cardiotonic effects of anthopleurin-A (AP-A), a polypeptide from a sea anemone, in dogs with a coronary artery stenosis. (Gross GJ, Warltier DC, Hardman HF, Shibata S) Eur J Pharmacol 1985 Apr 2;110(2):271-6 PMID 3987818 Direct cardiac actions of the H2 receptor agonists, impromidine and dimaprit. (Pelc LR, Christensen CW, Gross GJ, Warltier DC) Eur J Pharmacol 1985 Jan 8;107(3):379-84 PMID 3156752 Cardiac and systemic hemodynamic actions of the slow channel calcium blocking agent, KB-944. (Pelc LR, Gross GJ, Warltier DC) Gen Pharmacol 1985;16(6):585-90 PMID 4085780 Actions of two new bradycardic agents, AQ-AH 208 and UL-FS 49, on ischemic myocardial perfusion and function. (Dämmgen JW, Lamping KA, Gross GJ) J Cardiovasc Pharmacol 1985 Jan-Feb;7(1):71-9 PMID 2580154 Improved recovery of myocardial segment function following a short coronary occlusion in dogs by nicorandil, a potential new antianginal agent, and nifedipine. (Lamping KA, Gross GJ) J Cardiovasc Pharmacol 1985 Jan-Feb;7(1):158-66 PMID 2580137 Nicotinic acid, free fatty acids and myocardial function during coronary occlusion and reperfusion in the dog. (Lamping KA, Menahan LA, Gross GJ) J Pharmacol Exp Ther 1984 Dec;231(3):532-8 PMID 6502512 Comparative actions of dihydropyridine slow channel calcium blocking agents in conscious dogs: alterations in baroreflex sensitivity. (Warltier DC, Zyvoloski MG, Gross GJ, Brooks HL) J Pharmacol Exp Ther 1984 Aug;230(2):376-82 PMID 6747841 Comparative actions of dihydropyridine slow channel calcium blocking agents in conscious dogs: systemic and coronary hemodynamics with and without combined beta adrenergic blockade. (Warltier DC, Zyvoloski MG, Gross GJ, Brooks HL) J Pharmacol Exp Ther 1984 Aug;230(2):367-75 PMID 6146711 Comparative effects of a new nicotinamide nitrate derivative, nicorandil (SG 75), with nifedipine and nitroglycerin on true collateral blood flow following an acute coronary occlusion in dogs. (Lamping KA, Gross GJ) J Cardiovasc Pharmacol 1984 Jul-Aug;6(4):601-8 PMID 6206313 Effects of nicorandil, a new antianginal agent, and nifedipine on collateral blood flow in a chronic coronary occlusion model. (Lamping KA, Warltier DC, Hardman HF, Gross GJ) J Pharmacol Exp Ther 1984 May;229(2):359-63 PMID 6232374 Effects of nicorandil and nifedipine on protection of ischemic myocardium. (Lamping KA, Christensen CW, Pelc LR, Warltier DC, Gross GJ) J Cardiovasc Pharmacol 1984 May-Jun;6(3):536-42 PMID 6202983 Selective improvement in subendocardial perfusion distal to a flow-limiting coronary artery stenosis: effects of the new calcium channel blocking agent, FR 34235, nifedipine and diltiazem. (Gross GJ, Warltier DC) J Pharmacol Exp Ther 1984 Mar;228(3):531-6 PMID 6707908 Effects of three bradycardiac drugs on regional myocardial blood flow and function in areas distal to a total or partial coronary occlusion in dogs. (Gross GJ, Lamping KG, Warltier DC, Hardman HF) Circulation 1984 Feb;69(2):391-9 PMID 6690105 Differential effects of intravenous vs. intracoronary nifedipine on myocardial segment function in ischemic canine hearts. (Lamping KA, Gross GJ) J Pharmacol Exp Ther 1984 Jan;228(1):28-32 PMID 6694108 Contrasting effects of pharmacologic vasodilation on true collateral and overlap perfusion in ischemic myocardium. (Keelan KE, Gross GJ, Brooks HL, Warltier DC) Gen Pharmacol 1984;15(6):471-7 PMID 6526259 Comparative relaxant effects of nitroglycerin in isolated rings from various canine vascular beds. (Gharaibeh MN, Gross GJ) Gen Pharmacol 1984;15(3):217-21 PMID 6428967 Comparative effects of two slow channel calcium entry blockers, FR 34235 and nifedipine, on true coronary collateral blood flow. (Gross GJ, Warltier DC, Hardman HF) J Cardiovasc Pharmacol 1984 Jan-Feb;6(1):61-7 PMID 6199613 Transmural gradient of coronary blood flow following dihydropyridine calcium antagonists and other vasodilator drugs. (Warltier DC, Hardman HF, Brooks HL, Gross GJ) Basic Res Cardiol 1983 Nov-Dec;78(6):644-53 PMID 6661160 Coronary hemodynamics and subendocardial perfusion distal to stenoses. (Warltier DC, Buck JD, Brooks HL, Gross GJ) Int J Cardiol 1983 Sep;4(2):173-83 PMID 6629531 Effects of histamine receptor stimulation on regional myocardial blood flow. (Christensen CW, Gross GJ, Hardman HF, Brooks HL, Warltier DC) Am J Physiol 1983 Sep;245(3):H461-7 PMID 6225343 The slow-channel calcium blocking agent, nitrendipine, and coronary collateral blood flow. (Warltier DC, Lamping KA, Zyvoloski MG, Gross GJ, Brooks HL) J Cardiovasc Pharmacol 1983 Mar-Apr;5(2):272-7 PMID 6188902 The effect of diltiazem, a calcium channel blocking agent, on vasoconstrictor responses to norepinephrine, serotonin and potassium depolarization in canine coronary and femoral arteries. (Mullett M, Gharaibeh M, Warltier DC, Gross GJ) Gen Pharmacol 1983;14(2):259-64 PMID 6840509 Comparative effects of FR 34235, a new slow channel calcium blocker, and nifedipine on hemodynamics and myocardial oxygen consumption in the anesthetized dog. (Gross GJ, Warltier DC, Hardman HF) Gen Pharmacol 1983;14(6):677-80 PMID 6662348 Subendocardial versus transmural myocardial infarction: relationship to the collateral circulation in canine and porcine hearts. (Warltier DC, Zyvoloski MG, Gross GJ, Brooks HL) Can J Physiol Pharmacol 1982 Dec;60(12):1700-6 PMID 7165863 Role of autoregulation in the beneficial action of propranolol on ischemic blood flow distribution and stenosis severity in the canine myocardium. (Gross GJ, Buck JD, Warltier DC, Hardman HF) J Pharmacol Exp Ther 1982 Sep;222(3):635-40 PMID 7108768 Myocardial perfusion distal to an acute or chronic coronary artery occlusion: effects of diltiazem and nifedipine. (Zyvoloski MG, Brooks HL, Gross GJ, Warltier DC) J Pharmacol Exp Ther 1982 Aug;222(2):494-500 PMID 7097568 Beneficial effects of the dihydropyridine calcium antagonist, FR 34235, in a chronic coronary occlusion model. (Warltier DC, Zyvoloski MG, Brooks HL, Gross GJ) Eur J Pharmacol 1982 May 7;80(1):149-53 PMID 7095001 Separation of overlap and collateral perfusion of ischemic canine myocardium: important considerations in the analysis of vasodilator-induced coronary steal. (Gross GJ, Buck JD, Warltier DC, Hardman HF) J Cardiovasc Pharmacol 1982 Mar-Apr;4(2):254-63 PMID 6175809 Determination of experimental myocardial infarct size. (Warltier DC, Zyvoloski MG, Gross GJ, Hardman HF, Brooks HL) J Pharmacol Methods 1981 Nov;6(3):199-210 PMID 7329069 Changes in ischemic blood flow distribution and dynamic severity of a coronary stenosis induced by beta blockade in the canine heart. (Buck JD, Hardman HF, Warltier DC, Gross GJ) Circulation 1981 Oct;64(4):708-15 PMID 6115724 Redistribution of myocardial blood flow distal to a dynamic coronary arterial stenosis by sympathomimetic amines: comparison of dopamine, dobutamine and isoproterenol. (Warltier DC, Zyvoloski M, Gross GJ, Hardman HF, Brooks HL) Am J Cardiol 1981 Aug;48(2):269-79 PMID 7270436 Blood flow in normal and acutely ischemic myocardium after verapamil, diltiazem and nisoldipine (Bay k 5552), a new dihydropyridine calcium antagonist. (Warltier DC, Meils CM, Gross GJ, Brooks HL) J Pharmacol Exp Ther 1981 Jul;218(1):296-302 PMID 7248040 Coronary steal in four models of single or multiple vessel obstruction in dogs. (Gross GJ, Warltier DC) Am J Cardiol 1981 Jul;48(1):84-92 PMID 7246448 Transmural distribution of blood flow during activation of coronary muscarinic receptors. (Gross GJ, Buck JD, Warltier DC) Am J Physiol 1981 Jun;240(6):H941-6 PMID 7246756 Pharmacologic- vs. ischemia-induced coronary artery vasodilation. (Warltier DC, Gross GJ, Brooks HL) Am J Physiol 1981 May;240(5):H767-74 PMID 7235035 Diltiazem in myocardial recovery from global ischemia and reperfusion. (Jolly SR, Menahan LA, Gross GJ) J Mol Cell Cardiol 1981 Apr;13(4):359-72 PMID 7265250 Comparison of two dihydropyridine calcium antagonists on coronary collateral blood flow in acute myocardial ischemia. (Jolly SR, Hardman HF, Gross GJ) J Pharmacol Exp Ther 1981 Apr;217(1):20-5 PMID 7205654 Effects of sotalol and vagal stimulation on ischemic myocardial blood flow distribution in the canine heart. (Buck JD, Warltier DC, Hardman HF, Gross GJ) J Pharmacol Exp Ther 1981 Feb;216(2):347-51 PMID 7463353 Reduction of myocardial infarct size by the calcium antagonist fr 7534. (Meils CM, Gross GJ, Brooks HL, Warltier DC) Cardiology 1981;68(3):146-60 PMID 7317884 Relaxation of potassium-depolarized canine, bovine and porcine large coronary arteries by nitroglycerin, chromonar and two dihydropyridine calcium antagonists. (Gross GJ, Diemer MJ, Warltier DC, Hardman HF) Gen Pharmacol 1981;12(3):199-204 PMID 6786956 Effects of several calcium antagonists and dipyridamole in the isolated perfused guinea pig heart. (Jolly SR, Menahan LA, Gross GJ) Life Sci 1980 Dec 15;27(24):2339-46 PMID 7207022 Comparative effects of a new calcium antagonist, FR 7534, nitroglycerin, and dipyridamole on regional myocardial blood flow and cardiac contractility during partial coronary artery occlusion in the dog. (Gross GJ, Warltier DC, Jolly SR, Hardman HF) J Cardiovasc Pharmacol 1980 Nov-Dec;2(6):797-813 PMID 6160329 Subepicardial steal and reduction of myocardial oxygen consumption by adenosine. (Warltier DC, Gross GJ, Hardman HF) Eur J Pharmacol 1980 Oct 3;67(1):101-4 PMID 7418726 Effect of molsidomine on coronary collateral blood flow in acute myocardial ischemia. (Gross GJ, Gharaibeh M) Eur J Pharmacol 1980 Oct 3;67(1):111-4 PMID 6893436 Improvement in ischemic myocardial blood flow following a new calcium antagonist. (Jolly SR, Gross GJ) Am J Physiol 1980 Aug;239(2):H163-71 PMID 6773426 Coronary steal-induced increase in myocardial infarct size after pharmacologic coronary vasodilation. (Warltier DC, Gross GJ, Brooks HL) Am J Cardiol 1980 Jul;46(1):83-90 PMID 7386397 Protection of ischemic myocardium: comparison of effects of propranolol, bevantolol and N-dimethyl propranolol on infarct size following coronary artery occlusion in anesthetized dogs. (Warltier DC, Gross GJ, Jesmok GJ, Brooks HL, Hardman HF) Cardiology 1980;66(3):133-46 PMID 6105914 Comparative effects of cardioselective versus noncardioselective beta blockade on subendocardial blood flow and contractile function in ischemic myocardium. (Buck JD, Gross GJ, Warltier DC, Jolly SR, Hardman HF) Am J Cardiol 1979 Oct;44(4):657-63 PMID 39449 Transmural perfusion gradients distal to various degrees of coronary artery stenosis during resting flow or at maximal vasodilation. (Warltier DC, Hardman HF, Gross GJ) Basic Res Cardiol 1979 Sep-Oct;74(5):494-508 PMID 526256 Effect of FR 7534, a new calcium antagonist, on myocardial oxygen demand. (Jolly SR, Gross GJ) Eur J Pharmacol 1979 Mar 1;54(3):289-93 PMID 107031 Beneficial actions of bevantolol on subendocardial blood flow and contractile function in ischemic myocardium. (Gross GJ, Buck JD, Warltier DC, Hardman HF) J Cardiovasc Pharmacol 1979 Jan-Feb;1(1):139-47 PMID 94375 Transmural triglycerides in acute myocardial ischaemia. (Jesmok GJ, Warltier DC, Gross GJ, Hardman HF) Cardiovasc Res 1978 Nov;12(11):659-65 PMID 750079 Effect of propranolol on enzymatic and histochemical estimates of infarct size in experimental myocardial infarction. (Jesmok GJ, Warltier DC, Gross GJ, Hardman HF) Basic Res Cardiol 1978 Nov-Dec;73(6):559-70 PMID 747615 Effect of propranolol and nitroglycerin plus methoxamine on transmural creatine kinase activity after acute coronary occlusion. (Jesmok GJ, Gross GJ, Hardman HF) Am J Cardiol 1978 Nov;42(5):769-73 PMID 101067 Beneficial actions of N-dimethyl propranolol on myocardial oxygen balance and transmural perfusion gradients distal to a severe coronary artery stenosis in the canine heart. (Gross GJ, Warltier DC, Hardman HF) Circulation 1978 Oct;58(4):663-9 PMID 688577 The effect of a decrease in blood pressure, associated with extracorporeal blood pumping on myocardial metabolism in the isolated dog heart preparation. (Jesmok GJ, Gross GJ, Hardman HF) Life Sci 1978 Jul 3;23(1):75-81 PMID 682870 The effect of adenosine on myocardial metabolism and oxygen consumption in the isolated dog heart preparation. (Jesmok GJ, Gross GJ, Hardman HF) J Mol Cell Cardiol 1978 Mar;10(3):249-61 PMID 642017 Effect of N-dimethyl propranolol on regional myocardial blood flow and oxygen consumption in the canine heart. (Warltier WC, Gross GJ, Hardman HF) J Pharmacol Exp Ther 1978 Feb;204(2):294-302 PMID 621665 Endocardial viability ratio on effect of nitroglycerin and propranolol on regional myocardial blood flow in intact canine hearts. (Gross GJ, Warltier DC) J Pharmacol Exp Ther 1977 Dec;203(3):664-74 PMID 411913 Technique for precise, graded arterial stenosis and occlusion. (Hosko MJ, Gross GJ, Warltier DC) Basic Res Cardiol 1977 Nov-Dec;72(6):651-9 PMID 607934 Intracoronary versus intravenous nitroglycerin on the transmural distribution of coronary blood flow. (Gross GJ, Warltier DC) Cardiovasc Res 1977 Nov;11(6):499-506 PMID 414838 Effect of ortho-iodo sodium benzoate on hemoglobin-oxygen affinity in normal and ischemic myocardium. (Gross GJ, Warltier DC, Hardman HF) J Pharmacol Exp Ther 1977 Oct;203(1):72-81 PMID 909059 The effect of ouabain on nutritional circulation and regional myocardial blood flow. (Gross GJ, Warltier DC, Hardman HF, Somani P) Am Heart J 1977 Apr;93(4):487-95 PMID 842444 Effect of propranolol on regional myocardial blood flow and oxygen consumption. (Warltier DC, Gross GJ, Hardman HF) J Pharmacol Exp Ther 1976 Aug;198(2):435-43 PMID 948034 The isolated supported canine heart: a model for the evaluation of drug effects on regional myocardial blood flow. (Warltier DC, Gross GJ, Hardman HF) J Pharmacol Exp Ther 1976 Aug;198(2):420-34 PMID 948033 Adenosine on myocardial oxygen consumption. (Gross GJ, Hardman HF, Warltier DC) Br J Pharmacol 1976 Jul;57(3):409-12 PMID 974320 Effect of propranolol and nitroglycerin on hemoglobin--oxygen affinity. (Gross GJ, Warltier DC, Hardman HF) Eur J Pharmacol 1976 Mar;36(1):267-71 PMID 816659 Effect of adenosine on myocardial oxygen balance. (Gross GJ, Warltier DC, Hardman HF) J Pharmacol Exp Ther 1976 Feb;196(2):445-54 PMID 1255487 Effect of right atrial pacing and nitroglycerin on myocardial oxygen balance. (Warltier DC, Gross GJ, Hardman HF) Eur J Pharmacol 1975 Nov;34(1):229-32 PMID 826400 Myocardial distribution of coronary blood flow in the isolated supported heart preparation. (Warltier DC, Hardman HF, Laddu AR, Somani P, Gross GJ) Cardiovasc Res 1975 Sep;9(5):634-9 PMID 1201572 Analysis of coronary vascular beta receptors in situ. (Gross GJ, Feigl EO) Am J Physiol 1975 Jun;228(6):1909-13 PMID 1155621 Alteration in oxyhemoglobin equilibrium (P-50) and myocardial oxygen consumption (MVO2) by nitroglycerin (GTN). (Gross GJ, Hardman HF) J Pharmacol Exp Ther 1975 May;193(2):346-55 PMID 806676 Beta adrenergic blockade on intramyocardial distribution of coronary blood flow. (Gross GJ, Winbury MM) J Pharmacol Exp Ther 1973 Dec;187(3):451-64 PMID 4149128 Effects of pentylenetetrazol on ion transport in the isolated toad bladder. (Gross GJ, Woodbury DM) J Pharmacol Exp Ther 1972 May;181(2):257-72 PMID 4624124 The uptake of 14C-THAM in various rat tissues. (Gross GJ, Withrow CD) Arch Int Pharmacodyn Ther 1971 Apr;190(2):267-77 PMID 5575581 The effect of norethandrolone on liver microsomal N-demethylase activity. (Gross GJ, Hietbrink BE) Arch Int Pharmacodyn Ther 1971 Apr;190(2):340-6 PMID 5575588 PHARMACY--A CHOICE PROFESSION. (GROSS GJ) S D J Med 1965 Feb;18:51-2 PMID 14270361 Grants and Awards
Cytochrome P450 Eicosanoids and Myocardial Injury (#9202903 07/01/2003 - 06/30/2008) Sponsor: NIH Heart Lung and Blood InstituteCytochrome P450 Eicosanoids and Myocardial Injury (#9205376 07/01/2008 - 06/30/2013) Sponsor: NIH Heart Lung and Blood InstituteEET- Induced Cardioprotection: Role of Opioids and Nitric Oxide (NO) (#9207331 02/21/2012 - 12/31/2016) Sponsor: NIH Heart Lung and Blood Institute
