Medical College of Wisconsin
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Guan Chen MD, PhD

Guan Chen MD, PhD

Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Program Development

Member of the Cancer Center


Research Experience

  • Cancer Signaling, Ras Oncogenesis, Nuclear Receptors
  • Publications

  • p38γ Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response. (Hou S, Suresh PS, Qi X, Lepp A, Mirza SP, Chen G) J Biol Chem 2012 Aug 10;287(33):27895-905 PMID 22730326
  • p38γ mitogen-activated protein kinase (MAPK) confers breast cancer hormone sensitivity by switching estrogen receptor (ER) signaling from classical to nonclassical pathway via stimulating ER phosphorylation and c-Jun transcription. (Qi X, Zhi H, Lepp A, Wang P, Huang J, Basir Z, Chitambar CR, Myers CR, Chen G) J Biol Chem 2012 Apr 27;287(18):14681-91 PMID 22399296
  • Phosphorylation and stabilization of topoisomerase IIα protein by p38γ mitogen-activated protein kinase sensitize breast cancer cells to its poisons. (Qi X, Hou S, Lepp A, Li R, Basir Z, Lou Z, Chen G) J Biol Chem 2011 Oct 14;286(41):35883-90 PMID 21878638
  • PTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization. (Zhi HY, Hou SW, Li RS, Basir Z, Xiang Q, Szabo A, Chen G) Oncogene 2011 Apr 7;30(14):1706-15 PMID 21119599
  • PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction. (Hou SW, Zhi HY, Pohl N, Loesch M, Qi XM, Li RS, Basir Z, Chen G) Cancer Res 2010 Apr 1;70(7):2901-10 PMID 20332238
  • p38gamma MAPK cooperates with c-Jun in trans-activating matrix metalloproteinase 9. (Loesch M, Zhi HY, Hou SW, Qi XM, Li RS, Basir Z, Iftner T, Cuenda A, Chen G) J Biol Chem 2010 May 14;285(20):15149-58 PMID 20231272
  • The p38 MAPK stress pathway as a tumor suppressor or more? (Loesch M, Chen G) Front Biosci 2008;13:3581-93 PMID 18508457
  • p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response. (Qi X, Pohl NM, Loesch M, Hou S, Li R, Qin JZ, Cuenda A, Chen G) J Biol Chem 2007 Oct 26;282(43):31398-408 PMID 17724032
  • Stress-induced c-Jun-dependent Vitamin D receptor (VDR) activation dissects the non-classical VDR pathway from the classical VDR activity. (Li QP, Qi X, Pramanik R, Pohl NM, Loesch M, Chen G) J Biol Chem 2007 Jan 19;282(3):1544-51 PMID 17121851
  • p38gamma mitogen-activated protein kinase integrates signaling crosstalk between Ras and estrogen receptor to increase breast cancer invasion. (Qi X, Tang J, Loesch M, Pohl N, Alkan S, Chen G) Cancer Res 2006 Aug 1;66(15):7540-7 PMID 16885352
  • Essential role of p38gamma in K-Ras transformation independent of phosphorylation. (Tang J, Qi X, Mercola D, Han J, Chen G) J Biol Chem 2005 Jun 24;280(25):23910-7 PMID 15851477
  • p38 MAPK activation selectively induces cell death in K-ras-mutated human colon cancer cells through regulation of vitamin D receptor. (Qi X, Tang J, Pramanik R, Schultz RM, Shirasawa S, Sasazuki T, Han J, Chen G) J Biol Chem 2004 May 21;279(21):22138-44 PMID 15037631
  • Estrogen receptor inhibits c-Jun-dependent stress-induced cell death by binding and modifying c-Jun activity in human breast cancer cells. (Qi X, Borowicz S, Pramanik R, Schultz RM, Han J, Chen G) J Biol Chem 2004 Feb 20;279(8):6769-77 PMID 14638681
  • p38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun. The determinant roles of the isoforms in the p38 MAPK signal specificity. (Pramanik R, Qi X, Borowicz S, Choubey D, Schultz RM, Han J, Chen G) J Biol Chem 2003 Feb 14;278(7):4831-9 PMID 12475989
  • The p38 and JNK pathways cooperate to trans-activate vitamin D receptor via c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D(3)-induced growth inhibition. (Qi X, Pramanik R, Wang J, Schultz RM, Maitra RK, Han J, DeLuca HF, Chen G) J Biol Chem 2002 Jul 19;277(29):25884-92 PMID 11983707
  • The p38 pathway provides negative feedback for Ras proliferative signaling. (Chen G, Hitomi M, Han J, Stacey DW) J Biol Chem 2000 Dec 15;275(50):38973-80 PMID 10978313
  • Grants and Awards

  • Estrogen Receptor Regulates C-Jun Activity in Breast (#9204135 07/01/2006 - 09/30/2015) Sponsor: Zablocki Veterans Affairs Medical Center
  • Regulation of Ras Activity by the p38 Pathway (#9204253 08/15/2006 - 12/31/2011) Sponsor: NIH Cancer Institute
  • Development of Novel Therapeutics for Triple Negative Breast Cancer (#9306072 04/01/2013 - 03/31/2015) Sponsor: Cancer Center
  • Regulation of Breast Cancer Hormone Sensitivity (#9950023 07/01/2012 - 12/31/2014) Sponsor: State of Wisconsin