Medical College of Wisconsin
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Haris G. Vikis PhD

Haris G. Vikis PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Cancer Center


Publications

  • CRR9/CLPTM1L regulates cell survival signaling and is required for Ras transformation and lung tumorigenesis. (James MA, Vikis HG, Tate E, Rymaszewski AL, You M) Cancer Res 2014 Feb 15;74(4):1116-27 PMID 24366883
  • Mouse models of chemically-induced lung carcinogenesis. (Vikis HG, Rymaszewski AL, Tichelaar JW) Front Biosci (Elite Ed) 2013;5:939-46 PMID 23747909
  • Strain-specific variation in murine natural killer gene complex contributes to differences in immunosurveillance for urethane-induced lung cancer. (Kreisel D, Gelman AE, Higashikubo R, Lin X, Vikis HG, White JM, Toth KA, Deshpande C, Carreno BM, You M, Taffner SM, Yokoyama WM, Bui JD, Schreiber RD, Krupnick AS) Cancer Res 2012 Sep 1;72(17):4311-7 PMID 22751136
  • Quantitative monitoring of mouse lung tumors by magnetic resonance imaging. (Krupnick AS, Tidwell VK, Engelbach JA, Alli VV, Nehorai A, You M, Vikis HG, Gelman AE, Kreisel D, Garbow JR) Nat Protoc 2012 Jan;7(1):128-42 PMID 22222788
  • Neutrophils are required for 3-methylcholanthrene-initiated, butylated hydroxytoluene-promoted lung carcinogenesis. (Vikis HG, Gelman AE, Franklin A, Stein L, Rymaszewski A, Zhu J, Liu P, Tichelaar JW, Krupnick AS, You M) Mol Carcinog 2012 Dec;51(12):993-1002 PMID 22006501
  • Principles for the post-GWAS functional characterization of cancer risk loci. (Freedman ML, Monteiro AN, Gayther SA, Coetzee GA, Risch A, Plass C, Casey G, De Biasi M, Carlson C, Duggan D, James M, Liu P, Tichelaar JW, Vikis HG, You M, Mills IG) Nat Genet 2011 Jun;43(6):513-8 PMID 21614091
  • Strain-specific susceptibility for pulmonary metastasis of sarcoma 180 cells in inbred mice. (Vikis HG, Jackson EN, Krupnick AS, Franklin A, Gelman AE, Chen Q, Piwnica-Worms D, You M) Cancer Res 2010 Jun 15;70(12):4859-67 PMID 20501835
  • A second genetic variant on chromosome 15q24-25.1 associates with lung cancer. (Liu P, Yang P, Wu X, Vikis HG, Lu Y, Wang Y, Schwartz AG, Pinney SM, de Andrade M, Gazdar A, Gaba C, Mandal D, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Spitz M, Amos CI, Anderson MW, You M) Cancer Res 2010 Apr 15;70(8):3128-35 PMID 20395203
  • Cumulative effect of multiple loci on genetic susceptibility to familial lung cancer. (Liu P, Vikis HG, Lu Y, Wang Y, Schwartz AG, Pinney SM, Yang P, de Andrade M, Gazdar A, Gaba C, Mandal D, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW, You M) Cancer Epidemiol Biomarkers Prev 2010 Feb;19(2):517-24 PMID 20142248
  • Genetic variants cis-regulating Xrn2 expression contribute to the risk of spontaneous lung tumor. (Lu Y, Liu P, James M, Vikis HG, Liu H, Wen W, Franklin A, You M) Oncogene 2010 Feb 18;29(7):1041-9 PMID 19915612
  • Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus. (Liu PY, Vikis H, James M, Lu Y, Wang DL, Liu HB, Wen WD, Wang Y, You M) Cancer Res 2009 Aug 1;69(15):6290-8 PMID 19622765
  • Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. (Wang JC, Cruchaga C, Saccone NL, Bertelsen S, Liu P, Budde JP, Duan W, Fox L, Grucza RA, Kern J, Mayo K, Reyes O, Rice J, Saccone SF, Spiegel N, Steinbach JH, Stitzel JA, Anderson MW, You M, Stevens VL, Bierut LJ, Goate AM, COGEND collaborators and GELCC collaborators) Hum Mol Genet 2009 Aug 15;18(16):3125-35 PMID 19443489
  • Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene. (You M, Wang D, Liu P, Vikis H, James M, Lu Y, Wang Y, Wang M, Chen Q, Jia D, Liu Y, Wen W, Yang P, Sun Z, Pinney SM, Zheng W, Shu XO, Long J, Gao YT, Xiang YB, Chow WH, Rothman N, Petersen GM, de Andrade M, Wu Y, Cunningham JM, Wiest JS, Fain PR, Schwartz AG, Girard L, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW) Clin Cancer Res 2009 Apr 15;15(8):2666-74 PMID 19351763
  • RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway. (James MA, Lu Y, Liu Y, Vikis HG, You M) Cancer Res 2009 Mar 1;69(5):2108-16 PMID 19244110
  • Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. (Liu P, Vikis HG, Wang D, Lu Y, Wang Y, Schwartz AG, Pinney SM, Yang P, de Andrade M, Petersen GM, Wiest JS, Fain PR, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Wu X, Spitz MR, Eisen T, Houlston RS, Amos CI, Anderson MW, You M) J Natl Cancer Inst 2008 Sep 17;100(18):1326-30 PMID 18780872
  • Degradation of lung adenoma susceptibility 1, a major candidate mouse lung tumor modifier, is required for cell cycle progression. (Liu Y, Vikis HG, Yi Y, Futamura M, Wang Y, You M) Cancer Res 2007 Nov 1;67(21):10207-13 PMID 17974961
  • Large-scale in silico mapping of complex quantitative traits in inbred mice. (Liu P, Vikis H, Lu Y, Wang D, You M) PLoS One 2007;2(7):e651 PMID 17653278
  • EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity. (Vikis H, Sato M, James M, Wang D, Wang Y, Wang M, Jia D, Liu Y, Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Yang P, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Kupert E, Seminara D, Viswanathan A, Govindan R, Minna J, Anderson MW, You M) Cancer Res 2007 May 15;67(10):4665-70 PMID 17510392
  • Fine mapping and candidate gene analyses of pulmonary adenoma resistance 1, a major genetic determinant of mouse lung adenoma resistance. (Wang M, Zhang Z, Zhang Z, Vikis H, Yan Y, Wang Y, You M) Cancer Res 2007 Mar 15;67(6):2508-16 PMID 17363568
  • Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1. (Wang M, Vikis HG, Wang Y, Jia D, Wang D, Bierut LJ, Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Yang P, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Minna J, Gaba C, Rothschild H, Mandal D, Kupert E, Seminara D, Liu Y, Viswanathan A, Govindan R, Anderson MW, You M) Cancer Res 2007 Jan 1;67(1):93-9 PMID 17210687
  • Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer. (Yan Y, Lu Y, Wang M, Vikis H, Yao R, Wang Y, Lubet RA, You M) Mol Cancer Res 2006 Dec;4(12):971-81 PMID 17189387
  • Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice. (Liu P, Wang Y, Vikis H, Maciag A, Wang D, Lu Y, Liu Y, You M) Nat Genet 2006 Aug;38(8):888-95 PMID 16862160
  • Measurements of TSC2 GAP activity toward Rheb. (Li Y, Inoki K, Vikis H, Guan KL) Methods Enzymol 2006;407:46-54 PMID 16757313
  • Activation of FAK and Src are receptor-proximal events required for netrin signaling. (Li W, Lee J, Vikis HG, Lee SH, Liu G, Aurandt J, Shen TL, Fearon ER, Guan JL, Han M, Rao Y, Hong K, Guan KL) Nat Neurosci 2004 Nov;7(11):1213-21 PMID 15494734
  • Glutathione-S-transferase-fusion based assays for studying protein-protein interactions. (Vikis HG, Guan KL) Methods Mol Biol 2004;261:175-86 PMID 15064458
  • Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia. (Wang M, Devereux TR, Vikis HG, McCulloch SD, Holliday W, Anna C, Wang Y, Bebenek K, Kunkel TA, Guan K, You M) Cancer Res 2004 Mar 15;64(6):1924-31 PMID 15026325
  • Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice. (Zhang Z, Futamura M, Vikis HG, Wang M, Li J, Wang Y, Guan KL, You M) Proc Natl Acad Sci U S A 2003 Oct 28;100(22):12642-7 PMID 14583591
  • Mechanisms of regulating the Raf kinase family. (Chong H, Vikis HG, Guan KL) Cell Signal 2003 May;15(5):463-9 PMID 12639709
  • Regulation of the Ras-MAPK pathway at the level of Ras and Raf. (Vikis H, Guan KL) Genet Eng (N Y) 2002;24:49-66 PMID 12416300
  • The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. (Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL) Proc Natl Acad Sci U S A 2002 Sep 17;99(19):12085-90 PMID 12196628
  • SmgGDS displays differential binding and exchange activity towards different Ras isoforms. (Vikis HG, Stewart S, Guan KL) Oncogene 2002 Apr 4;21(15):2425-32 PMID 11948427
  • The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. (Vikis HG, Li W, Guan KL) Genes Dev 2002 Apr 1;16(7):836-45 PMID 11937491
  • Wildtype Kras2 can inhibit lung carcinogenesis in mice. (Zhang Z, Wang Y, Vikis HG, Johnson L, Liu G, Li J, Anderson MW, Sills RC, Hong HL, Devereux TR, Jacks T, Guan KL, You M) Nat Genet 2001 Sep;29(1):25-33 PMID 11528387
  • The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner. (Vikis HG, Li W, He Z, Guan KL) Proc Natl Acad Sci U S A 2000 Nov 7;97(23):12457-62 PMID 11035813
  • Regulation of STAT3 by direct binding to the Rac1 GTPase. (Simon AR, Vikis HG, Stewart S, Fanburg BL, Cochran BH, Guan KL) Science 2000 Oct 6;290(5489):144-7 PMID 11021801
  • Grants and Awards

  • Evaluation of Myeloperoxidase in Mediating the Anti-Metastatic Effects of Neutrophils in Breast Cancer (#9306381 06/01/2013 - 06/30/2014) Sponsor: Cancer Center
  • Cancer Center Chemoprevention Program (#9520180 11/01/2010 - 10/31/2016) PI of AHW Chemoprevention Program- Recruitment of Haris Vikis, Ph.D (#5520184)
  • Cancer Center Infrastructure Grant (#9520181 11/01/2010 - 10/31/2016) PI of Prevention of Lung Cancer Through Inhibition of Neutrophil Trafficking and Myeloperoxidase Activity (#5520220)